المؤلفون: Lopez-Collado, J., Jacinto-Padilla, J., Rodríguez-Aguilar, O., Hidalgo-Contreras, J.V.

المصدر: Ecological Informatics; Mar2024, Vol. 79, pN.PAG-N.PAG, 1p

مصطلحات موضوعية: NUMBERS of species, SPECIES distribution, FEATURE selection, POPULATION ecology, SPECIES, ECOLOGICAL risk assessment

مستخلص: Species distribution modeling is an active research topic with applications in conservation management, pest risk assessment, and population ecology. Several machine-learning methods have been applied to estimate species distribution. Non-linear dimensionality reduction techniques aim to preserve the similarity among objects at a reduced dimension for visualization, clustering, and feature selection. We propose a framework that uses Uniform Manifold Approximation and Projection (UMAP) to analyze bioclimatic variables associated with environmental (background) and species samples. Our objective was to identify geographic areas similar to those inhabited by the species. We hypothesize that the similarity between species locations and their environment in the reduced dimension will reflect similarity in the multivariate bioclimatic space. We estimated the probability of background points near a species point utilizing the latent nearest neighbor distance distribution. We tested this procedure with ten insect pest species of global importance and found that UMAP was able to generate a gradient of similarity between geographic areas and species occurrence. We also found that background-species latent distance tends to have a convergent non-linear relationship with the mean value of bioclimatic variables, thus supporting our key assumption. The performance of UMAP as a binary classifier and comparison with MaxEnt supports its use in modeling of species distribution. Potential applications are discussed for multi-species and multi-scenario analysis, as well as projection to new regions. [Display omitted] • UMAP modeled similarity between species and its background by using bioclimatic variables. • Latent distance reflects similarity in the multivariate space between species and its environment. • Closeness of background to species observations translate to suitable geographic areas. • UMAP can be used as a binary classifier of species distribution. • Potential applications include climate change, pest invasions, and multi-species analysis. [ABSTRACT FROM AUTHOR]

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المؤلفون: Cruz González, Ignacio, Antúnez Muiños, Pablo J., López Tejero, Sergio, Núñez García, Jean Carlos, Rodríguez Collado, Javier, Martín Moreiras, Javier, Diego Nieto, Alejandro, Herrero Garibi, Jesús, Díaz Peláez, Elena, Sánchez Fernández, Pedro Luis

المصدر: JACC: Cardiovascular Interventions; Nov2021, Vol. 14 Issue 21, pe301-e304, 4p

المؤلفون: Núñez García, Jean C., Barreiro-Perez, Manuel, Martin-Moreiras, Javier, Antúnez-Muiños, Pablo, López-Tejero, Sergio, Diego-Nieto, Alejandro, Collado, Javier Rodriguez, Herrero-Gabiri, Jesus, Sanchez, Pedro L., Cruz-Gonzalez, Ignacio

المصدر: JACC: Cardiovascular Interventions; May2022, Vol. 15 Issue 9, p996-998, 3p

المؤلفون: Aguilar, Ruth, Cruz, Angeline, Jiménez, Alfons, Almuedo, Alex, Saumell, Carme Roca, Lopez, Marina Gigante, Gasch, Oriol, Falcó, Gemma, Jiménez-Lozano, Ana, Martínez-Perez, Angela, Sanchez-Collado, Consol, Tedesco, Andrea, López, Manuel Carlos, Pinazo, María Jesús, Leonel, Thais, Bisoffi, Zeno, Färnert, Anna, Dobaño, Carlota, Requena-Méndez, Ana

المصدر: Travel Medicine & Infectious Disease; Jan2024, Vol. 57, pN.PAG-N.PAG, 1p

مستخلص: We aimed to evaluate the performance of a novel multiplex serological assay, able to simultaneously detect IgG of six infections, as a screening tool for imported diseases in migrants. Six panels of 40 (n = 240) anonymized serum samples with confirmed infections were used as positive controls to assess the multiplex assay's sensitivity. One panel of 40 sera from non-infected subjects was used to estimate the seropositivity cutoffs, and 32 non-infected sera were used as negative controls to estimate each serology's sensitivity and specificity. The multi-infection screening test was validated in a prospective cohort of 48 migrants from endemic areas. The sensitivity of the Luminex assay was calculated as the proportion of positive results over all positive samples identified by reference tests. The specificity was calculated using 32 negative samples. Uncertainty was quantified with 95 % confidence intervals using receiver operating characteristic analyses. The sensitivity/specificity were 100 %/100 % for HIV (gp41 antigen), 97.5 %/100 % for Hepatitis B virus (HBV-core antigen), 100 %/100 % for Hepatitis C virus (HCV-core antigen), 92.5 %/90.6 % for strongyloidiasis [31-kDa recombinant antigen (NIE)], 97.5 %/100 % for schistosomiasis (combined serpin Schistosoma mansoni and S.haematobium antigens) and 95 %/90.6 % for Chagas disease [combined Trypanosoma cruzi kinetoplastid membrane protein-11 (KMP11) and paraflagellar rod proteins 2 (PFR2) antigens]. In the migrant cohort, antibody response to the combination of the T.cruzi antigens correctly identified 100 % individuals, whereas HBV-core antigen correctly identified 91.7 % and Strongyloides -NIE antigen 86.4 %. We developed a new, robust and accurate 8-plex Luminex assay that could facilitate the implementation of screening programmes targeting migrant populations. • Diagnostic utility of a multiplex test targeting infections prevalent in migrants. • An 8-plex Luminex assay that simultaneously detects viral and parasitic infections. • The sensitivity was high (>90 %) for the majority of the antigens utilized. • A promising screening tool for migrants coming from endemic countries. [ABSTRACT FROM AUTHOR]

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المؤلفون: López-Tejero, Sergio, Núñez-García, Jean C., Antúnez-Muiños, Pablo, González-Calle, David, Martín-Moreiras, Javier, Diego-Nieto, Alejandro, Rodríguez-Collado, Javier, Herrero-Garibi, Jesús, Sánchez-Fernández, Pedro Luis, Cruz-González, Ignacio

المصدر: JACC: Cardiovascular Interventions; Mar2022, Vol. 15 Issue 6, pe65-e67, 3p

المؤلفون: Sabater-Martos, M., Garcia Oltra, E., Collado Saenz, F., Martínez-Pastor, J.C., Hernandez Hermoso, J.A.

المصدر: Revista Española de Cirugía Ortopédica y Traumatologia (English Edition); Jan2021, Vol. 65 Issue 1, p3-8, 6p

الملخص (بالإنجليزية): 40%–50% of this septic arthritis occurs in the knee, despite rapid medical surgical treatment, 24%–50% will have a poor clinical outcome. It is not clear which debridement technique, by arthrotomy or arthroscopy, is more effective in controlling infection, or whether or not previous osteoarthritis worsens the outcome. The objective of this study on septic arthritis of the osteoarthritic knee was to analyse which surgical debridement technique, arthroscopy or arthrotomy, is more effective, the clinical and radiographic outcomes of the patients, and how many go on to require a TKR after the infection has healed. A retrospective study was performed in 27 patients with native septic arthritis of the knee. Eighteen were men and the mean age was 64.8 years (30–89 years). Fifteen patients were debrided by arthrotomy and 12 by arthroscopy. The effectiveness of debridement in controlling infection, the radiographic progression of the osteoarthritis on the Ahlbäch scale, the need for subsequent replacement, and pain and functional status were analysed using the VAS and WOMAC scales at 52.8 ± 11.2-month follow-up. The infection was controlled in 93% and 92% of the patients, 13% and 42% required 2 or more surgeries for infection control, 18% and 44.4% showed progression of arthritis in the arthrotomy and arthroscopy groups, respectively. One patient in each group required a knee replacement. The VAS score was superior in the arthrotomy group and there were no differences in WOMAC score. Debridement by arthrotomy in the emergency department by non-sub-specialist knee surgeons is more effective than arthroscopic debridement in controlling septic arthritis of the knee. Surgical debridement of septic arthritis in knees with previous osteoarthritis enabled control of the infection with no pain despite the progression of the osteoarthritis. [ABSTRACT FROM AUTHOR]

Abstract (Spanish): Un 40%–50% de estas artritis sépticas se producen en la rodilla, a pesar del rápido tratamiento médico quirúrgico, un 24% a 50% van a acabar en un pobre resultado clínico. No está claro que técnica de desbridamiento por artrotomía o por artroscopia es más eficaz para el control de la infección, ni si la artrosis previa empeora o no el resultado. El objetivo de este estudio en artritis séptica de rodilla artrósica es analizar que técnica de desbridamiento quirúrgico, artroscopia o artrotomía, es más eficaz, cual es la evolución clínica y radiográfica de los pacientes y cuantos van a necesitar la implantación de una PTR tras la curación de la infección. Se realizó un estudio retrospectivo en 27 pacientes con artritis séptica nativa de rodilla. Dieciocho eran hombres y la edad media 64,8 años (30–89 años), Quince pacientes fueron desbridados por artrotomía y 12 por artroscopia. Se analizó la eficacia del desbridamiento para el control de la infección, la progresión radiográfica de la artrosis en la escala de Ahlbäch, la necesidad de protetización posterior y el dolor y el estado funcional mediante la escala EVA y WOMAC a los 52,8 ± 11,2 meses de evolución. El 93% y 92% de los pacientes controlaron la infección, un 13% y un 42% requirieron 2 o mas cirugías para el control de la infección, un 18% y un 44.4% mostraron progresión de la artrosis en el grupo artrotomía y artroscopia, respectivamente. Un paciente de cada grupo requirió que se le implantara una prótesis de rodilla. La escala EVA fue superior en el grupo artrotomía y no hubo diferencias en la escala de WOMAC. El desbridamiento por artrotomía en el área de urgencias por cirujanos no subespecializados en rodilla es más eficaz que el artroscópico para controlar la artritis séptica de rodilla. El desbridamiento quirúrgico de las artritis sépticas en rodillas con artrosis previa permite controlar la infección con ausencia de dolor a pesar de la progresión de la artrosis. [ABSTRACT FROM AUTHOR]

: Copyright of Revista Española de Cirugía Ortopédica y Traumatologia (English Edition) is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Cruz-González, Ignacio, González Ferreiro, Rocío, Martín Moreiras, Javier, Trejo Velasco, Blanca, Barreiro Pérez, Manuel, Diego Nieto, Alejandro, Herrero Garibi, Jesús, Rodríguez Collado, Javier, Sánchez Fernández, Pedro Luis

المصدر: JACC: Cardiovascular Interventions; Mar2019, Vol. 12 Issue 5, pe35-e38, 4p

المؤلفون: Fernández-Susavila, Héctor, Mora, Cristina, Aramburu-Núñez, Marta, Quintas-Rey, Rita, Arias, Susana, Collado, Manuel, López-Arias, Esteban, Sobrino, Tomás, Castillo, José, Dell'Era, Patrizia, Campos, Francisco

المصدر: Stem Cell Research; Apr2018, Vol. 28, p16-20, 5p

مستخلص: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy ( CADASIL) is the most common form of hereditary stroke disorder. It is caused by mutations in NOTCH3 that lead to progressive degeneration of the smooth muscle cells in blood vessels. There is currently no treatment for this disorder. We reprogrammed to pluripotency blood mononuclear cells isolated from a patient carrying a NOTCH3 mutation by using a commercially available non-integrating system. The success in the generation of this iPSC line (IDISi001-A) suggests that the NOTCH3 mutation did not limit cell reprogramming and offers an unprecedented opportunity for studying and modeling CADASIL pathology. [ABSTRACT FROM AUTHOR]

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المؤلفون: Navarro-Esbrí, Joaquín, Molés, Francisco, Peris, Bernardo, Mota-Babiloni, Adrián, Pascual Martí, José, Collado, Roberto, González, Manuel

المصدر: Energy Procedia; Sep2017, Vol. 129, p652-659, 8p

مستخلص: Supermarkets are recognized worldwide as great energy consumers, especially in developed countries. Typically, energy consumptions are due to cold, heat and electricity requirements. So a Combined Cold, Heat and Power (CCHP) system (also called trigeneration system) can be used to reduce energy demands and, hence, greenhouse gas emissions to the atmosphere. In this way, this work proposes a small-scale Organic Rankine Cycle (ORC) CCHP application in a supermarket. The ORC has been designed to be used with a biomass boiler, and to produce electricity and useful heat at two different temperature levels related to an absorption chiller and supermarket heating demand. With this in mind, this work conducts the experimental characterization of the CCHP system in a test bench. Thereby, the experimental results obtained are used to predict the expected performance of the system under the supermarket conditions, as well as to quantify the energy, environmental and economic benefits of the application. [ABSTRACT FROM AUTHOR]

: Copyright of Energy Procedia is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Sanchez-Puchol, Felix, Pastor-Collado, Joan A., Borrell, Baptista

المصدر: Procedia Computer Science; 2017, Vol. 121, p542-553, 12p

مصطلحات موضوعية: HIGHER education, UNIVERSITIES & colleges, NONPROFIT organizations, BUSINESS planning, BUSINESS information services

مستخلص: Higher education institutions are currently facing many challenges that are making them to start compete strategically, like other not-for-profit firm. To adequately support such new approach, their information systems and business strategies should be totally aligned. However, the current existing landscape of heterogeneous information systems and applications deployed in many institutions can compromise such aim. Recently, reference architectures and models have emerged as instruments suitable to help company’s decision-makers to cope with such tensions. However, whilst many of such architectural models already exist for several industries, little has been done so far in higher education. In this paper, we briefly review major existing developments in such way before to inductively derive a unified information systems reference model tailored for higher education institutions. [ABSTRACT FROM AUTHOR]

: Copyright of Procedia Computer Science is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)