Structural Diversity of Copper(II) Complexes with N-(2-Pyridyl)Imidazolidin-2-Ones(Thiones) and Their in Vitro Antitumor Activity
| العنوان: | Structural Diversity of Copper(II) Complexes with N-(2-Pyridyl)Imidazolidin-2-Ones(Thiones) and Their in Vitro Antitumor Activity |
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| المؤلفون: | Łukasz Balewski, Franciszek Sączewski, Maria Gdaniec, Patrick J. Bednarski, Anna Makowska, Ewa Borys |
| المصدر: | Molecules, Vol 19, Iss 10, Pp 17026-17051 (2014) Molecules Volume 19 Issue 10 Pages 17026-17051 |
| بيانات النشر: | MDPI AG, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Models, Molecular, Stereochemistry, Pharmaceutical Science, chemistry.chemical_element, Antineoplastic Agents, 1-(2-pyridyl)imidazolidin-2-ones, Crystallography, X-Ray, Article, Analytical Chemistry, X-ray crystal structure analysis, lcsh:QD241-441, chemistry.chemical_compound, X-Ray Diffraction, lcsh:Organic chemistry, Coordination Complexes, Neoplasms, copper(II) complexes, Drug Discovery, Pyridine, Organometallic Compounds, Tumor Cells, Cultured, in vitro antitumor activity, Humans, Viability assay, Crystal violet, Physical and Theoretical Chemistry, Alkyl, Group 2 organometallic chemistry, chemistry.chemical_classification, Organic Chemistry, Thiones, Copper, In vitro, chemistry, Chemistry (miscellaneous), X-ray crystallography, 1-(2-pyridyl)imidazolidine-2-thiones, Molecular Medicine |
| الوصف: | Six series of structurally different mono- and binuclear copper(II) complexes 5–10 were obtained by reacting N-(2-pyridyl)imidazolidin-2-ones (1a–l), N,N'-bis(2-pyridyl)imidazolidin-2-ones (2a,b), N-acyl-N'(2-pyridyl)imidazolodin-2-ones (3a–j) and N-(2-pyridyl)imidazolidine-2-thiones (4a–g) with copper(II) chloride at an ambient temperature. The coordination modes of the complexes obtained were established by elemental analysis, IR spectroscopic data and single crystal X-ray diffraction studies. The in vitro cytotoxic activities of both the free ligands and copper(II) complexes were evaluated using a crystal violet microtiter plate assay on five human tumor cell lines: LCLC-103H, A-427, SISO, RT-4 and DAN-G. The free ligands 1–4 at concentration attainable in cancer cells of 20 μM showed no meaningful cytotoxic effect with cell viability in the range of 88%–100%. The most potent copper(II) complex of 1-(6-ethoxy-2-pyridyl)imidazolidin-2-one (6b) exhibited selective cytotoxicity against A-427 lung cancer cell line, while the complexes of 1-(5-methyl-2-pyridyl)imidazolidine-2-thione (5h) and 1-(4-tert-butyl-2-pyridyl)imidazolidine-2-thione (5j) showed cytostatic effect against a whole panel of five human tumor cell lines. In conclusion, the only complexes that showed remarkably increased activity in comparison to the free ligands were those obtained from N-(2-pyridyl)imidazolidine-2-thiones 4c and 4e substituted with alkyl group at position 4 or 5 of pyridine ring. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1420-3049 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::444461dc96c1061544f8a1c82fa2fe59Test http://www.mdpi.com/1420-3049/19/10/17026Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....444461dc96c1061544f8a1c82fa2fe59 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14203049 |
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