التفاصيل البيبلوغرافية
| العنوان: |
Knowledge Gaps and Research Priorities in Immune Checkpoint Inhibitor–related Pneumonitis. An Official American Thoracic Society Research Statement |
| المؤلفون: |
Sears, Catherine R., Peikert, Tobias, Possick, Jennifer D., Naidoo, Jarushka, Nishino, Mizuki, Patel, Sandip P., Camus, Philippe, Gaga, Mina, Garon, Edward B., Gould, Michael K., Limper, Andrew H., Montgrain, Philippe R., Travis, William D., Rivera, M. Patricia |
| المساهمون: |
Medicine, School of Medicine |
| المصدر: |
PMC |
| بيانات النشر: |
American Thoracic Society - AJRCCM |
| سنة النشر: |
2019 |
| المجموعة: |
Indiana University - Purdue University Indianapolis: IUPUI Scholar Works |
| مصطلحات موضوعية: |
lung cancer, immunotherapy, interstitial lung disease, NSCLC |
| الوصف: |
Rationale: Immune checkpoint inhibitors (ICIs) have revolutionized cancer care but are associated with unique adverse events, including potentially life-threatening pneumonitis. The diagnosis of ICI-pneumonitis is increasing; however, the biological mechanisms, clinical and radiologic features, and the diagnosis and management have not been well defined. Objectives: To summarize evidence, identify knowledge and research gaps, and prioritize topics and propose methods for future research on ICI-pneumonitis. Methods: A multidisciplinary group of international clinical researchers reviewed available data on ICI-pneumonitis to develop and refine research questions pertaining to ICI-pneumonitis. Results: This statement identifies gaps in knowledge and develops potential research questions to further expand knowledge regarding risk, biologic mechanisms, clinical and radiologic presentation, and management of ICI-pneumonitis. Conclusions: Gaps in knowledge of the basic biological mechanisms of ICI-pneumonitis, coupled with a precipitous increase in the use of ICIs alone or combined with other therapies, highlight the importance in triaging research priorities for ICI-pneumonitis. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| تدمد: |
1073-449X |
| العلاقة: |
American Journal of Respiratory and Critical Care Medicine; Sears, C. R., Peikert, T., Possick, J. D., Naidoo, J., Nishino, M., Patel, S. P., Camus, P., Gaga, M., Garon, E. B., Gould, M. K., Limper, A. H., Montgrain, P. R., Travis, W. D., & Rivera, M. P. (2019). Knowledge Gaps and Research Priorities in Immune Checkpoint Inhibitor–related Pneumonitis. An Official American Thoracic Society Research Statement. American Journal of Respiratory and Critical Care Medicine, 200(6), e31–e43. https://doi.org/10.1164/rccm.201906-1202STTest; https://hdl.handle.net/1805/26045Test |
| الإتاحة: |
https://hdl.handle.net/1805/26045Test |
| رقم الانضمام: |
edsbas.41BD2B3D |
| قاعدة البيانات: |
BASE |
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