Assessment of cisplatin concentration and depth of penetration in human lung tissue after hyperthermic exposure†
| العنوان: | Assessment of cisplatin concentration and depth of penetration in human lung tissue after hyperthermic exposure† |
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| المؤلفون: | Zsolt Sziklavari, Patrick J. Bednarski, Reiner Neu, Michael Ried, Hans-Stefan Hofmann, Claudius Diez, Karla Lehle |
| المصدر: | European Journal of Cardio-Thoracic Surgery. 47:563-566 |
| بيانات النشر: | Oxford University Press (OUP), 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Mesothelioma, Pulmonary and Respiratory Medicine, Hyperthermia, Lung Neoplasms, Pleural Neoplasms, medicine.medical_treatment, Antineoplastic Agents, Models, Biological, Human lung, Parenchyma, Humans, Medicine, Pneumonectomy, Lung, Cisplatin, Chemotherapy, business.industry, Hyperthermia, Induced, General Medicine, Penetration (firestop), medicine.disease, medicine.anatomical_structure, Chemotherapy, Cancer, Regional Perfusion, Surgery, Cardiology and Cardiovascular Medicine, business, Nuclear medicine, Perfusion, Ex vivo, medicine.drug |
| الوصف: | OBJECTIVES The effects of cisplatin on the lung parenchyma during hyperthermic intrathoracic chemotherapy perfusion have not been analysed in detail. The objective of this study was to evaluate both the concentration and depth of the penetration of cisplatin in human lung tissue after hyperthermic exposure under ex vivo conditions. METHODS This experimental study was approved by the local ethics committee. Twelve patients underwent pulmonary wedge resections after elective thoracic lobectomies were performed (resected lobe), and the lung tissue (approximately 1-2 cm(3)) was incubated (in vitro) with cisplatin (0.05 mg/ml; 60 min, 42°C). Subsequent tissue beds (depth, 0.5 mm; median weight, 70-92 mg) were prepared from the outside to the middle, and the amount of cisplatin per tissue weight was analysed using atomic absorption spectrometry. Afterwards, the penetration of cisplatin depth was calculated and related to the different concentrations per tissue. RESULTS Cisplatin penetrated into the human lung tissue after ex vivo hyperthermic exposure. The median amount of platinum [nmol cisplatin/g lung tissue] decreased significantly (P ≤ 0.05) depending on the penetration depth: 32 nmol/g (1 mm), 20 nmol/g (2 mm) and 6.8 nmol/g (4 mm). The calculated median concentrations of cisplatin (µg/ml) were 2.4 µg/ml (1 mm), 1.4 µg/ml (2 mm) and 0.5 µg/ml (4 mm), respectively. CONCLUSIONS Under ex vivo hyperthermic conditions, cisplatin diffused into human lung tissue. The median penetration depth of the cisplatin was approximately 3-4 mm. The penetration of cisplatin into lung tissue may affect the local therapy of residual tumour cells on the lung surface using hyperthermic intrathoracic chemotherapy perfusion in patients with malignant pleural tumours. |
| تدمد: | 1873-734X 1010-7940 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4f8a28bdaff00c401ab033b2a1d5be6Test https://doi.org/10.1093/ejcts/ezu217Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c4f8a28bdaff00c401ab033b2a1d5be6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1873734X 10107940 |
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