المؤلفون: Kjøtrød, S.B., Carlsen, S.M., Rasmussen, P.E., Holst-Larsen, T., Mellembakken, J., Thurin-Kjellberg, A., HaapaniemiKouru, K., Morin-Papunen, L., Humaidan, P., Sunde, A., von Düring, V.

مصطلحات موضوعية: Infertility

الوصف: BACKGROUND To study the effect of metformin before and during assisted reproductive technology (ART) on the clinical pregnancy rate (CPR) in non-obese women with polycystic ovary syndrome (PCOS). METHODS A multi-centre, prospective, randomized, double-blind study was conducted in eight IVF clinics in four Nordic countries. We enrolled 150 PCOS women with a body mass index <28 kg/m2, and treated them with 2000 mg/day metformin or identical placebo tablets for ≥12 weeks prior to and during long protocol IVF or ICSI and until the day of pregnancy testing. The primary outcome measure was CPR. Secondary outcome measures included spontaneous pregnancy rates during the pretreatment period, and the live birth rate (LBR). RESULTS Among IVF treated women ( n = 112), biochemical pregnancy rates were identical in both groups (42.9%), and there were no significant differences in the metformin versus the placebo group in CPR [39.3 versus 30.4%; 95% confidence interval (CI): −8.6 to 26.5]. The LBR was 37.5 versus 28.6% (95% CI: −8.4 to 26.3). However, prior to IVF there were 15 (20.3%) spontaneous pregnancies in the metformin group and eight (10.7%) in the placebo group (95% CI: −1.9 to 21.1; P = 0.1047). According to intention to treat analyses ( n = 149); significantly higher overall CPR were observed in the metformin versus placebo group (50.0 versus 33.3%; 95% CI: −1.1 to 32.3; P = 0.0391). LBR was also significantly higher with use of metformin versus placebo (48.6 versus 32.0; 95% CI: 1.1 to 32.2; P = 0.0383). No major unexpected safety issues or multiple births were reported. More gastrointestinal side effects occurred in the metformin group (41 versus 12%; 95% CI: 0.15 to 0.42; P < 0.001). CONCLUSIONS Metformin treatment for 12 weeks before and during IVF or ICSI in non-obese women with PCOS significantly increases pregnancy and LBRs compared with placebo. However, there was no effect on the outcome of ART per se . Trial registration: ClinicalTrials.gov Identifier: NCT00159575.

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العلاقة: http://humrep.oxfordjournals.org/cgi/content/short/26/8/2045Test; http://dx.doi.org/10.1093/humrep/der154Test

الإتاحة: https://doi.org/10.1093/humrep/der154Test
http://humrep.oxfordjournals.org/cgi/content/short/26/8/2045Test

المؤلفون: Fujii, R., Fujita, S., Waseda, T., Oka, Y., Takagi, H., Tomizawa, H., Sasagawa, T., Makinoda, S., Cavagna, M., Braga, D.P.A.F., Figueira, R.C.S., Aoki, T., Maldonado, L.G.L., Iaconelli, A., Borges, E., Prabhakar, s., Dittrich, R., Beckmann, M.W., Hoffmann, I., Mueller, A., Kjotrod, S., Carlsen, S.M., Rasmussen, P.E., Holst-Larsen, T., Mellembakken, J., Thurin-Kjellberg, A., Haapaniemi Kouru, K., Morin Papunen, L., Humaidan, P., Sunde, A., von Düring, V., Pappalardo, S., Valeri, C., Crescenzi, F., Manna, C., Sallam, H.N., Polec, A., Raki, M., Tanbo, T., Åbyholm, T., Fedorcsak, P., Tabanelli, C., Ferraretti, A.P., Feliciani, E., Magli, M.C., Fasolino, C., Gianaroli, L., Wang, T., Feng, C., Song, Y., Dong, M.Y., Sheng, J.Z., Huang, H.F., Sayyah Melli, M., Kazemi-shishvan, M., Snajderova, M., Zemkova, D., Pechova, M., Teslik, L., Lanska, V., Ketel, I., Serné, E., Stehouwer, C., Korsen, T., Hompes, P., Smulders, Y., Voorstemans, L., Homburg, R., Lambalk, C., Bellver, J., Martinez-Conejero, J.A., Pellicer, A., Labarta, E., Alama, P., Melo, M.A.B., Horcajadas, J.A., Agirregoitia, N., Peralta, L., Mendoza, R., Expósito, A., Matorras, R., Agirregoitia, E., Ajina, M., Chaouache, N., Gaddas, M., Souissi, A., Tabka, Z., Saad, A., Zaouali-Ajina, M., Zbidi, A., Eguchi, N., Jinno, M., Watanabe, A., Hirohama, J., Hatakeyama, N., Choi, Y.M., Kim, J.J., Kim, D.H., Yoon, S.H., Ku, S.Y., Kim, S.H., Kim, J.G., Lee, K.S., Moon, S.Y., Xiong, Y., Liang, X., Li, Y., Yang, X., Wei, L., Utsunomiya, T., Chu, S., Li, P., Akarsu, S., Dirican, E.K., Akin, K.O., Kormaz, C., Goktolga, U., Ceyhan, S.T., Kara, C., Nadamoto, K., Tarui, S., Ida, M., Sugihara, K., Haruki, A., Hukuda, A., Morimoto, Y., Albu, A., Albu, D., Sandu, L., Kong, G., Cheung, L., Lok, I., Pinto, A., Teixeira, L., Figueiredo, H., Pires, I., Silva Carvalho, J.L., Pereira, M.L., Faut, M., de Zúñiga, I., Colaci, D., Barrios, E., Oubiña, A., Terrado Gil, G., Motta, A., Horton, M., Sobral, F., Gómez Peña, M., Gleicher, N., Barad, D.H., Li, Y.P., Zhao, H.C., Spaczynski, R.Z., Guzik, P., Banaszewska, B., Krauze, T., Wykretowicz, A., Wysocki, H., Pawelczyk, L., Sarikaya, E., Gulerman, C., Cicek, N., Mollamahmutoglu, L., Venetis, C.A., Kolibianakis, E.M., Toulis, K., Goulis, D., Loutradi, K., Chatzimeletiou, K., Papadimas, I., Bontis, I., Tarlatzis, B.C., Schultze-Mosgau, A., Griesinger, G., Schoepper, B., Cordes, T., Diedrich, K., Al-Hasani, S., Gomez, R., Jovanovic, V., Sauer, C.M., Shawber, C.J., Sauer, M.V., Kitajewski, J., Zimmermann, R.C., Bungum, L., Jacobsson, A.K., Rosen, F., Becker, C., Andersen, C.Y., Güner, N., Giwercman, A., Kiapekou, E., Zapanti, E., Boukelatou, D., Mavreli, T., Bletsa, R., Stefanidis, K., Drakakis, P., Mastorakos, G., Loutradis, D., Malhotra, N., Sharma, V., Kumar, S., Roy, K.K., Sharma, J.B., Ferraretti, A., Crippa, A., Stanghellini, I., Robles, F., Serdynska-Szuster, M., Kristensen, S.L., Ernst, E., Toft, G., Olsen, S.F., Bonde, J.P., Vested, A., Ramlau-Hansen, C.H., Wang, F.F., Qu, F., Ding, G.L., Gallot, V., Genro, V., Roux, I., Scheffer, J.B., Frydman, R., Fanchin, R., Kanta Goswami, S., Banerjee, S., Chakravarty, B.N., Kabir, S.N., Seeber, B.E., Morandell, E., Kurzthaler, D., Wildt, L., Dieplinger, H., Tütüncü, L., Bodur, S., Dundar, O., Ron - El, R., Seger, R., Komarovsky, D., Kasterstein, E., Komsky, A., Maslansky, B., Strassburger, D., Ben-Ami, I., Zhao, X.M., Ni, R.M., Lin, L., Dong, M., Tu, C.H., He, Z.H., Yang, D.Z., Karamalegos, C., Polidoropoulos, N., Papanikopoulos, C., Stefanis, P., Argyrou, M., Doriza, S., Sisi, V., Moschopoulou, M., Karagianni, T., Mentorou, C., Economou, K., Davies, S., Mastrominas, M., Gougeon, A., De Los Santos, M.J., Garcia-Laez, V., Esteban, F., Crespo, J., Li, H.W.R., Anderson, R.A., Yeung, W.S.B., Ho, P.C., Ng, E.H.Y., Yang, H.I., Lee, K.E., Seo, S.K., Kim, H.Y., Cho, S.H., Choi, Y.S., Lee, B.S., Park, K.H., Cho, D.J., Hart, R., Doherty, D., Mori, T., Hickey, M., Sloboda, D., Norman, R., Huang, R.C., Beilin, L., Freiesleben, N., Løssl, K., Johannsen, T.H., Loft, A., Bangsbøll, S., Hougaard, D., Friis-Hansen, L., Christiansen, M., Nyboe Andersen, A., Thum, M.Y., Abdalla, H., Martínez-Salazar, J., De la Fuente, G., Kohls, G., García Velasco, J.A., Yasmin, E., Kukreja, S., Barth, J., Balen, A.H., Esra, T., Var, T., Citil, A., Dogan, M., Messini, C.I., Dafopoulos, K., Chalvatzas, N., Georgoulias, P., Anifandis, G., Messinis, I.E., Celik, O., Hascalik, S., Celik, N., Sahin, I., Aydin, S., Hanna, C.W., Bretherick, K.L., Liu, C.C., Stephenson, M.D., Robinson, W.P., Louwers, Y.V., Goodarzi, M.O., Taylor, K.D., Jones, M.R., Cui, J., Kwon, S., Chen, Y.D.I., Guo, X., Stolk, L., Uitterlinden, A.G., Laven, J.S.E., Azziz, R., Navaratnarajah, R., Grun, B., Sinclair, J., Dafou, D., Gayther, S., Timms, J.F., Hardiman, P.J., Ye, Y., Wu, R., Ou, J., Kim, S.D., Jee, B.C., Lee, J.Y., Suh, C.S., Jung, J.H., Opmeer, B.C., Broeze, K.A., Coppus, S.F., Collins, J.A., Den Hartog, J.E., Land, J.A., Van der Linden, P.J., Marianowski, P., Ng, E., Van der Steeg, J.W., Steures, P., Strandell, A., Mol, B.W., Tarlatzi, T.B., Kyrou, D., Mertzanidou, A., Fatemi, H.M., Devroey, P., Batenburg, T.E., König, T.E., Overbeek, A., Schats, R., Lambalk, C.B., Carone, D., Vizziello, G., Vitti, A., Chiappetta, R., Topçu, H.O., Yüksel, B., Islimye, M., Karakaya, J., özat, M., Batioglu, S., Kuchenbecker, W.K., Groen, H., Bolster, J.H., van Asselt, S., Wolffenbuettel, B.H., Hoek, A., Wu, Y., Pan, H., Chen, X., Huang, H., Zavos, A., Verikouki, C., Van Os, L., Vink-Ranti, C.Q.J., Rijnders, P.M., Tucker, K.E., Jansen, C.A.M., Lucco, F., Pozzobon, C., Lara, E., Galliano, D., Ballesteros, A., Ghoshdastidar, B., Maity, S.P., Ghoshdastidar, S., Luna, M., Vela, G., Sandler, B., Barritt, J., Flisser, E.D., Copperman, A.B., Nogueira, D., Prat, L., Degoy, J., Bonald, F., Montagut, J., Maity, S., Chen, S., Luo, C., Zhen, H., Shi, X., Wu, F., Ni, Y., Merdassi, G., Chaker, A., Kacem, K., Benmeftah, M., Fourati, S., Wahabi, D., Zhioua, F., Zhioua, A., Saini, P., Saini, A., Sugiyama, R., Nakagawa, K., Nishi, Y., Jyuen, H., Kuribayashi, Y., Inoue, M., Jancar, N., Vrtacnik Bokal, E., Virant-Klun, I., Lee, J.H., Kim, S.G., Cha, E.M., Park, I.H., Lee, K.H., Dahdouh, E.M., Desrosiers, P., St-Michel, P., Villeneuve, M., Fontaine, J.Y., Granger, L., Ramón, O., Burgos, J., Abanto, E., González, M., Múgica, J., Corcóstegui, B., Tal, J., Ziskind, G., Ohel, G., Paltieli, Y., Paz, G., Lewit, N., Sendel, H., Khouri, S., Calderon, I., van Gelder, P., Al-Inany, H.G., Antaki, R., Dean, N., Lapensée, L., Racicot, M., Ménard, S., Kadoch, I., Meylaerts, L.J., Dreesen, L., Vandersteen, M., Neumann, C., Zollner, U., Kato, K., Segawa, T., Kawachiya, S., Okuno, T., Kobayashi, T., Takehara, Y., Kato, O., Jayaprakasan, K., Nardo, L., Hopkisson, J., Campbell, B., Raine-Fenning, N.

مصطلحات موضوعية: Abstracts

الوصف: Introduction: Ovarian function is controlled not only by endocrine system, but also by autocrine/paracrine regulation in the ovarian cells, which may be mediated by a network of cytokines. The aim of this study was to elucidate the involvement of a multifunctional cytokine, interleukin-6 (IL-6), in human ovarian function especially in human luteolysis. Material and Methods: All subjects were women with normal menstrual cycles (28-35 days), which gave their informed consent to participate in this study. The mean age of the subjects was 39.0 ± 8.7 years (range: 22-53 years, n = 37). Ovarian samples were collected at the time of gynecological operation, and follicular or luteal tissue was isolated macroscopically from each sample. Blood serum was also collected at the same time. All subjects were divided into 3 phases of ovarian cycle (follicular, early-mid luteal, and late luteal phase), according to the date of menstrual cycle and serum hormonal values (classified into follicular phase, if progesterone (P) < 2.0 ng/ml, classified into early-mid luteal phase, if progesterone (P) > 2.0 ng/ml, and classified into late luteal phase, if E 2 < 80 pg/ml) at the point of operation. The relative expression levels of IL-6 (n = 37) and its receptors (gp130 and IL-6Rα, n = 21) mRNA in granulosa, theca and luteal cells were analyzed with quantitative RT–PCR using TaqMan technology. The relative values of IL-6 protein in the ovarian tissue were also analyzed with immunoblotting (n = 21). The localization of IL-6 and its receptors, gp130 and IL-6Rα, in the ovarian tissues was examined by immunohistochemical staining (n = 8). All data are presented as the mean ± S.D. Inter-group differences were confirmed with Kruskal-Wallis test, and post-hoc test (Scheffe's F) was used for detecting the significant differences between the groups. Results: The relative level of IL-6 mRNA in late luteal phase (4.46 ± 2.05, n = 8) was significantly higher than those of follicular (1.55 ± 0.94, n = 18: p < 0.00005) and early-mid luteal ...

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العلاقة: http://humrep.oxfordjournals.org/cgi/content/short/25/suppl_1/i285Test; http://dx.doi.org/10.1093/humrep/de.25.s1.438Test

الإتاحة: https://doi.org/10.1093/humrep/de.25.s1.438Test
http://humrep.oxfordjournals.org/cgi/content/short/25/suppl_1/i285Test

المؤلفون: Kjøtrød, S.B., von Düring, V., Carlsen, S.M.

مصطلحات موضوعية: Reproductive endocrinology

الوصف: BACKGROUND: Our aim was to investigate the effect of pre‐treatment with metformin in women with polycystic ovary syndrome (PCOS) scheduled for IVF stimulation. METHODS: Seventy‐three oligo/amenorrhoeic women with polycystic ovaries and at least one of the following criteria: hyperandrogenaemia, elevated LH/FSH ratio, hyperinsulinism, decreased SHBG levels or hirsutism, were studied. Normal weight and overweight patients were randomized separately in a prospective, randomized, double blind study. All patients were treated for at least 16 weeks with metformin (1000 mg bid) or placebo ending on the day of HCG injection. RESULTS: No differences were found in the primary end‐points: duration of FSH stimulation 14.4 (13.1–15.7) versus 14.2 (12.6–15.7) days or estradiol on the day of HCG injection 6.8 (5.3–8.2) versus 7.6 (5.6–9.6) nmol/l in the metformin and placebo groups, respectively. The secondary end‐points number of oocytes, fertilization rates, embryo quality, pregnancy rates and clinical pregnancy rates were equal. However, in the normal weight subgroup (BMI <28 kg/m2, n = 27), pregnancy rates following IVF were 0.71 (0.63–0.79) versus 0.23 (0.15–0.31) in the metformin and placebo groups, respectively ( P = 0.04). Overall clinical pregnancy rates were equal: 0.51 (0.34–0.68) versus 0.44 (0.27–0.62) in the metformin and placebo groups, respectively. However, in the normal weight subgroup, clinical pregnancy rates were 0.67 (0.43–0.91) and 0.33 (0.06–0.60), respectively ( P = 0.06). CONCLUSIONS: Pre‐treatment with metformin prior to conventional IVF/ICSI in women with PCOS does not improve stimulation or clinical outcome. However, among normal weight PCOS women, pre‐treatment with metformin tends to improve pregnancy rates. Further studies in subgroups of PCOS women are required.

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العلاقة: http://humrep.oxfordjournals.org/cgi/content/short/19/6/1315Test; http://dx.doi.org/10.1093/humrep/deh248Test

الإتاحة: https://doi.org/10.1093/humrep/deh248Test
http://humrep.oxfordjournals.org/cgi/content/short/19/6/1315Test

المؤلفون: Kjøtrød, S, von Düring, V, Sunde, A, Carlsen, S.M

المصدر: Fertility and Sterility ; volume 81, page 7-9 ; ISSN 0015-0282

مصطلحات موضوعية: Obstetrics and Gynecology, Reproductive Medicine

الإتاحة: https://doi.org/10.1016/j.fertnstert.2004.02.085Test
https://api.elsevier.com/content/article/PII:S0015028204003759?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0015028204003759?httpAccept=text/plainTest

المؤلفون: Tunón, K., Eik‐Nes, S.H., Grøttum, P., Von Düring, V., Kahn, J.A.

المصدر: Ultrasound in Obstetrics & Gynecology ; volume 15, issue 1, page 41-46 ; ISSN 0960-7692 1469-0705

الوصف: Objective To compare gestational age (GA) and day of delivery estimated from the time of in vitro fertilization (IVF) (oocyte retrieval + 14 days), the ultrasonic measurement of the crown–rump length (CRL) and the biparietal diameter (BPD) in pregnancies conceived in an IVF setting. Design Included were 208 singletons and 72 twin pregnancies conceived after IVF. GA estimated from the time of IVF was compared with the GA estimated from the ultrasonic measurement of the CRL in the first trimester and the BPD in the second trimester. Results In singletons the mean difference in gestational age was 0.9 days between IVF and CRL estimates and 2.1 days between IVF and BPD estimates. The gestational age as estimated from CRL or BPD was shorter than the GA estimated from IVF. There was no systematic variation in the mean differences in GA between the methods. In three pregnancies there was a difference of more than 7 days between the gestational age estimated from IVF and CRL and in 22 pregnancies between gestational age estimated from IVF and BPD. A difference of > 14 days for any of the estimates was not found in any case. In singletons there was a high correlation in the gestational age at birth assessed from the time of IVF and from CRL, from the time of IVF and from BPD. Conclusion Assessment of gestational age from the time of IVF, CRL and BPD in pregnancies conceived after IVF shows equally high agreement between the three methods. This supports the use of ultrasound as a reliable method for estimation of gestational age.

الإتاحة: https://doi.org/10.1046/j.1469-0705.2000.00004.xTest

المؤلفون: Kahn, J.A., von Düring, V., Sunde, A., Sørdal, T., Molne, K.

مصطلحات موضوعية: Articles

الوصف: We have developed an insemination method using a large (4 ml) volume of the inseminate. This method incorporates ovarian stimulation, isolation of an optimal number of motile spermatozoa and, finally, Fallopian tube sperm perfusion (FSP). In a clinical study, 139 couples with various causes of infertility, had a total of 239 treatment cycles. The pregnancy rate per treatment in groups with ednometriosis, ovulation disorders, tubal impairment, combined male and female factors and subnormal sperm quality were low, ranging from 2.7% to 7.7%. In patients with unexplained infertility, the pregnancy rate per treatment was 26.9% and for this group, the pregnancy rate in the first treatment cycle was 37.3%. In the cervical hostility group, two pregnancies occurred after five treatments. FSP seems to be a favourable treatment for couples with cervical hostility or unexplained infertility. About half of the women in these groups conceived after three treatment cycles. FSP is easier to perform and is less expensive than other methods of assisted procreation, such as in vitro fertilization and gamete intra-Fallopian transfer.

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العلاقة: http://humrep.oxfordjournals.org/cgi/content/short/7/suppl_1/19Test; http://dx.doi.org/10.1093/humrep/7.suppl_1.19Test

الإتاحة: https://doi.org/10.1093/humrep/7.suppl_1.19Test
http://humrep.oxfordjournals.org/cgi/content/short/7/suppl_1/19Test

المؤلفون: Romundstad, L. B., Romundstad, P. R., Sunde, A., von Düring, V., Skjaerven, R., Gunnell, D., Vatten, L. J.

المصدر: Obstetric Anesthesia Digest ; volume 29, issue 3, page 122-123 ; ISSN 0275-665X

الإتاحة: https://doi.org/10.1097/01.aoa.0000358387.92885.c4Test
http://journals.lww.com/00132582-200909000-00017Test

المؤلفون: Kahn, J A, Sunde, A, von Düring, V, Sørdal, T, Remen, A, Lippe, B, Siegel, J, Molne, K

المصدر: Human Reproduction; Sep1993, Vol. 8 Issue 9, p1414-1419, 6p

مستخلص: Fallopian tube sperm perfusion (FSP) is a combination of ovarian stimulation and intra-uterine insemination using a large volume (4 ml) of inseminate containing 10(7)-10(8) spermatozoa. The inseminate will flush the Fallopian tubes and some of it will end up in the pouch of Douglas. In the present study, we have investigated whether the FSP method will result in the formation of serum antisperm antibodies in the female. A total of 184 treatment cycles were given to 128 women. The indications for treatment were: unexplained infertility (n = 35), various infertility diagnoses (n = 28) and donor insemination (n = 65). Prior to treatment, 11 (8.6%) women had a positive tray-agglutination test (Friberg) and/or a positive immunobead test. After completing one to four treatment cycles, another six (4.7%) women had developed serum antisperm antibodies. The antibodies induced by the treatment were of isotype IgM and directed against the tail-tip of the spermatozoa. Two of the women, who prior to the treatment had antisperm antibodies, showed an increase in antibody titre during treatment. There was no statistically significant difference in the pregnancy rate between the women with antisperm antibodies and the women without. In our opinion, the small risk of developing antisperm antibodies is no contra-indication for treating infertile couples with FSP. [ABSTRACT FROM AUTHOR]

: Copyright of Human Reproduction is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Kahn, Jarl A., Sunde, Arne, Koskemies, Aarne, von Düring, Vidar, Sørdal, Terje, Christensen, Flemming, Molne, Kåre, Kahn, J A, Sunde, A, Koskemies, A, von Düring, V, Sørdal, T, Christensen, F, Molne, K

المصدر: Human Reproduction; Jun1993, Vol. 8 Issue 6, p890-894, 5p

مستخلص: Prospective randomization of 60 couples with unexplained infertility was performed for treatment either with intrauterine insemination (IUI), using a volume of 0.5 ml of the inseminate, or Fallopian tube sperm perfusion (FSP), using a volume of 4 ml of inseminate. The protocols for ovarian stimulation and induction of ovulation were the same in the two groups. The two groups were similar concerning age of the female at the start of treatment and the number of follicles > 15 mm diameter, the serum oestradiol concentrations and the endometrial thickness on the day of human chorionic gonadotrophin (HCG) administration. The mean (±SD) number of motile spermatozoa inseminated was significantly higher in the FSP group than in the IUI group (52 ± 5 × 10 and 28 ± 3 × 10 respectively). In the FSP group, 30 women were given a total of 52 treatment cycles; 14 clinical pregnancies occurred in this group, giving a pregnancy rate of 26.9% per cycle and 46.7% per woman. In the IUI group, 28 women were given a total of 51 treatment cycles; five clinical pregnancies occurred, giving a pregnancy rate of 9.8% per cycle and 17.9% per woman. The pregnancy rates per cycle and per woman in the FSP group were significantly higher than in the IUI group ( < 0.05, chi-square test). This study indicates that in the treatment of couples with unexplained infertility, Fallopian tube sperm perfusion (FSP) is more successful than intra-uterine insemination (IUI). [ABSTRACT FROM PUBLISHER]

: Copyright of Human Reproduction is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Kahn, Jarl A., von Düring, Vidar, Sunde, Arne, Sørdal, Terje, Molne, Kåre, Kahn, J A, von Düring, V, Sunde, A, Sørdal, T, Molne, K

المصدر: Human Reproduction; Feb1993, Vol. 8 Issue 2, p247-252, 6p

مصطلحات موضوعية: CRYOPRESERVATION of organs, tissues, etc., FERTILIZATION in vitro, LONGITUDINAL method, EVALUATION of medical care, PREGNANCY, EMBRYOS

مستخلص: A cohort of 485 couples starting their first in-vitro fertilization (IVF) attempt between January, 1989 and February, 1991 inclusive, were followed until June 1, 1992. A total of 1086 treatment cycles were initiated (mean 2.2, range 1–6). Of these, 235 (21.8%) cycles were cancelled, giving a total of 851 embryo replacements (mean 1.7, range 1–5). After IVF treatment, 189 women have either delivered or have an ongoing pregnancy in the second or third trimester. This gives a baby take-home rate of 17.4% per started cycle and 22.2% per embryo replacement. For 91 (18.6%) of the couples, the treatment was abandoned prior to completion of the three scheduled IVF attempts and 57 (11.7%) of these had no completed IVF cycles. In the group of couples with reduced sperm quality, the delivery rate was significantly lower than that of the other groups. A total of 193 women had embryos cryopreserved in at least one IVF cycle; 124 of these women started a frozen embryo replacement cycle and 88 had at least one cycle with replacement of frozen/thawed embryos, resulting in 25 deliveries/ongoing pregnancies. Due to the Norwegian law on assisted procreation 65 (33.7%) of the women have had their frozen embryos thawed and discarded after 12 months of storage. The cryopreservation programme, with the limitations of the Norwegian law, gives a 5.2% increase in the baby take-home rate for women entering the IVF programme, an increase of 13.2% in the number of ongoing pregnancies/deliveries and an 11.6% increase in number of children/viable fetuses. A total of 214 women have delivered or have ongoing pregnancies in the second or third trimester. This represents 44.1% of the 485 women accepted for IVF treatment, irrespective of whether they were treated or not, and 50.0% of those couples who completed at least one IVF cycle. [ABSTRACT FROM PUBLISHER]

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