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1دورية أكاديمية
المؤلفون: Warmbrunn, Moritz V., Boulund, Ulrika, Aron-Wisnewsky, Judith, de Goffau, Marcus C., Abeka, Rosamel E., Davids, Mark, Bresser, Lucas R. F., Levin, Evgeni, Clement, Karine, Galenkamp, Henrike, Ferwerda, Bart, van den Born, Bert-Jan J. H., Kurilshikov, Alexander, Fu, Jingyuan, Zwinderman, Aeilko H., Soeters, Maarten R., van Raalte, Daniel H., Herrema, Hilde, Groen, Albert K., Nieuwdorp, Max
المصدر: Warmbrunn , M V , Boulund , U , Aron-Wisnewsky , J , de Goffau , M C , Abeka , R E , Davids , M , Bresser , L R F , Levin , E , Clement , K , Galenkamp , H , Ferwerda , B , van den Born , B-J J H , Kurilshikov , A , Fu , J , Zwinderman , A H , Soeters , M R , van Raalte , D H , Herrema , H , Groen , A K & Nieuwdorp , M 2024 , ' Networks of ....
الوصف: Aims Gut microbiota have been linked to blood lipid levels and cardiovascular diseases (CVDs). The composition and abundance of gut microbiota trophic networks differ between ethnicities. We aim to evaluate the relationship between gut microbiotal trophic networks and CVD phenotypes. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Methods We included cross-sectional data from 3860 individuals without CVD history from 6 ethnicities living in the Amsterdam region and results participating in the prospective Healthy Life in Urban Setting (HELIUS) study. Genetic variants were genotyped, faecal gut microbiota were profiled, and blood and anthropometric parameters were measured. A machine learning approach was used to assess the relationship between CVD risk (Framingham score) and gut microbiota stratified by ethnicity. Potential causal relationships between gut microbiota composition and CVD were inferred by performing two-sample Mendelian randomization with hard CVD events from the Pan-UK Biobank and microbiome genome-wide association studies summary data from a subset of the HELIUS cohort (n = 4117). Microbial taxa identified to be associated with CVD by machine learning and Mendelian randomization were often ethnic-specific, but some concordance across ethnicities was found. The microbes Akkermansia muciniphila and Ruminococcaceae UCG-002 were protective against ischaemic heart disease in African-Surinamese and Moroccans, respectively. We identified a strong inverse association between blood lipids, CVD risk, and the combined abundance of the correlated microbes Christensenellaceae–Methanobrevibacter–Ruminococcaceae (CMR). The CMR cluster was also identified in two ...
الإتاحة: https://doi.org/10.1093/cvr/cvae018Test
https://research.vumc.nl/en/publications/8b522cb7-d7ca-4aaf-bc75-bdbd572679ddTest
http://www.scopus.com/inward/record.url?scp=85189150325&partnerID=8YFLogxKTest -
2دورية أكاديمية
المؤلفون: Bjornstad, Petter, Choi, Ye Ji, Platnick, Carson, Gross, Susan, Narongkiatikhun, Phoom, Melena, Isabella, Remmers, Lauryn, Baca, Madison, Schutte, Grant, Dobbs, Tyler, Vigers, Tim, Pyle, Laura, Driscoll, Lynette, Tommerdahl, Kalie, Kendrick, Jessica, Looker, Helen C., Dart, Allison, Cherney, David, van Raalte, Daniel H., Srivastava, Anand, Li, Luping, Prasad, Pottumarthi
المصدر: Bjornstad , P , Choi , Y J , Platnick , C , Gross , S , Narongkiatikhun , P , Melena , I , Remmers , L , Baca , M , Schutte , G , Dobbs , T , Vigers , T , Pyle , L , Driscoll , L , Tommerdahl , K , Kendrick , J , Looker , H C , Dart , A , Cherney , D , van Raalte , D H , Srivastava , A , Li , L , Prasad , P & Bjornstad Lab 2024 , ' Insulin Secretion, ....
الوصف: OBJECTIVE b-Cell dysfunction and insulin resistance magnify the risk of kidney injury in type 2 diabetes. The relationship between these factors and intraglomerular hemody-namics and kidney oxygen availability in youth with type 2 diabetes remains in-completely explored. RESEARCH DESIGN AND METHODS Fifty youth with type 2 diabetes (mean age ± SD 16 ± 2 years; diabetes duration 2.3 ± 1.8 years; 60% female; median HbA 1c 6.4% [25th, 75th percentiles 5.9, 7.6%]; BMI 36.4 ± 7.4 kg/m 2 ; urine albumin-to-creatinine ratio [UACR] 10.3 [5.9, 58.0] mg/g) 21 control participants with obesity (OCs; age 16 ± 2 years; 29% female; BMI 37.6 ± 7.4 kg/m 2 ), and 20 control participants in the normal weight category (NWCs; age 17 ± 3 years; 70% female; BMI 22.5 ± 3.6 kg/m 2 ) underwent iohexol and p-aminohippurate clearance to assess glomerular filtration rate (GFR) and renal plasma flow, kidney MRI for oxygenation, hyperglycemic clamp for insulin secretion (acute C-peptide response to glucose [ACPRg]) and disposition index (DI; ×10 3 mg/kg lean/min), and DXA for body composition. RESULTS Youth with type 2 diabetes exhibited lower DI (0.6 [0.0, 1.6] vs. 3.8 [2.4, 4.5] × 10 3 mg/kg lean/min; P < 0.0001) and ACPRg (0.6 [0.3, 1.4] vs. 5.3 [4.3, 6.9] nmol/L; P < 0.001) and higher UACR (10.3 [5.9, 58.0] vs. 5.3 [3.4, 14.3] mg/g; P = 0.003) and intraglomerular pressure (77.8 ± 11.5 vs. 64.8 ± 5.0 mmHg; P < 0.001) compared with OCs. Youth with type 2 diabetes and OCs had higher GFR and kidney oxygen availability (relative hyperoxia) than NWCs. DI was associated inversely with intra-glomerular pressure and kidney hyperoxia. CONCLUSIONS Youth with type 2 diabetes demonstrated severe b-cell dysfunction that was associated with intraglomerular hypertension and kidney hyperoxia. Similar but attenuated findings were found in OCs.
الإتاحة: https://doi.org/10.2337/dc23-1818Test
https://research.vumc.nl/en/publications/d0d11020-327b-4be6-9805-f9e09dea31afTest
http://www.scopus.com/inward/record.url?scp=85185840713&partnerID=8YFLogxKTest -
3دورية أكاديمية
المؤلفون: Fuhri Snethlage, Coco M, Meijnikman, Abraham S, Mak, Anne Linde, Rampanelli, Elena, Voermans, Bas, Callender, Cengiz A K, de Groen, Pleun, Roep, Bart O, van Raalte, Daniël H, Knop, Filip K, Holleboom, Adriaan G, Nieuwdorp, Max, Hanssen, Nordin M J
المصدر: European Journal of Endocrinology ; ISSN 0804-4643 1479-683X
الوصف: Aims/hypothesis The prevalence and severity of MASLD in type 1 diabetes remain unclear. Therefore, we investigated the prevalence and severity of MASLD in type 1 diabetes, and assessed which clinical features are most important in predicting MASLD severity. Methods 453 individuals with type 1 diabetes (41.6±15.0 years, 64% female, BMI 25.4±4.2kg/m2, HbA1c 55.6±12mmol/mol) underwent vibration-controlled transient elastography (VCTE), with a controlled attenuation parameter (CAP) score for steatosis (≥ 280.0dB/m) and a liver stiffness measurement (LMS) for fibrosis (≥ 8.0kPa). A machine-learning Extra-Trees classification model was performed to assess the predictive power of the clinical features associated with type 1 diabetes with respect to steatosis and fibrosis. Results The prevalence of hepatic steatosis and fibrosis was 9.5% [95% CI 6.8-12.2] and 3.5% [95% CI 1.8-5.2]. Higher LMS was associated with a longer duration of type 1 diabetes (median 30.5 [IQR 18.0-39.3] years vs. 15.0 [IQR 6.0-27.0] years) and individuals were older and had a higher BMI (mean 27.8 ±5.2 vs. 25.3 ±4.1kg/m2), and a higher CAP score (mean 211.4±51.7 dB/m vs. 241.4±75.6 dB/m). The most important predictive features of fibrosis were duration of type 1 diabetes, age, and systolic blood pressure, with a mean± standard deviation (SD) area under the curve of 0.73±0.03. Conclusion Individuals with type 1 diabetes and high blood pressure, older age, BMI and duration of disease could be considered at high-risk for developing MASLD.
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4كتاب
المؤلفون: van Baar, Michaël J.B., van Bommel, Erik J.M., Touw, Daan J., Nieuwdorp, Max, Joles, Jaap A., Krebber, Merle M., Bjornstad, Petter, van Raalte, Daniël H.
المساهمون: MS Nefrologie, Regenerative Medicine and Stem Cells, Nefro Vasculaire Geneeskunde
مصطلحات موضوعية: diabetic kidney disease, glomerular filtration rate, insulin infusion, kidney hemodynamics, kidney perfusion, renal vascular resistance, Nephrology, Journal Article
وصف الملف: application/pdf
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5دورية أكاديمية
المؤلفون: Smits, Mark M., van Raalte, Daniel H.
المصدر: Smits , M M & van Raalte , D H 2023 , ' GLP-1 Receptor Agonists and the Risk of Thyroid Cancer. Diabetes Care 2023;46 : 384–390 ' , Diabetes Care , vol. 46 , no. 5 , pp. e120 . https://doi.org/10.2337/dc23-0134Test
الإتاحة: https://doi.org/10.2337/dc23-0134Test
https://research.vumc.nl/en/publications/c431ee2b-558a-4545-8862-844b17802345Test
http://www.scopus.com/inward/record.url?scp=85159340030&partnerID=8YFLogxKTest -
6دورية أكاديمية
المؤلفون: Verhaar, Barbara J. H., Mosterd, Charlotte M., Collard, Didier, Galenkamp, Henrike, Muller, Majon, Rampanelli, Elena, van Raalte, Daniël H., Nieuwdorp, Max, van den Born, Bert-Jan H.
المصدر: Verhaar , B J H , Mosterd , C M , Collard , D , Galenkamp , H , Muller , M , Rampanelli , E , van Raalte , D H , Nieuwdorp , M & van den Born , B-J H 2023 , ' Sex differences in associations of plasma metabolites with blood pressure and heart rate variability : The HELIUS study ' , Atherosclerosis , vol. 384 , 117147 . https://doi.org/10.1016/j.atherosclerosis.2023.05.016Test
الوصف: Background and aims: Since plasma metabolites can modulate blood pressure (BP) and vary between men and women, we examined sex differences in plasma metabolite profiles associated with BP and sympathicovagal balance. Our secondary aim was to investigate associations between gut microbiota composition and plasma metabolites predictive of BP and heart rate variability (HRV). Methods: From the HELIUS cohort, we included 196 women and 173 men. Office systolic BP and diastolic BP were recorded, and heart rate variability (HRV) and baroreceptor sensitivity (BRS) were calculated using finger photoplethysmography. Plasma metabolomics was measured using untargeted LC-MS/MS. Gut microbiota composition was determined using 16S sequencing. We used machine learning models to predict BP and HRV from metabolite profiles, and to predict metabolite levels from gut microbiota composition. Results: In women, best predicting metabolites for systolic BP included dihomo-lineoylcarnitine, 4-hydroxyphenylacetateglutamine and vanillactate. In men, top predictors included sphingomyelins, N-formylmethionine and conjugated bile acids. Best predictors for HRV in men included phenylacetate and gentisate, which were associated with lower HRV in men but not in women. Several of these metabolites were associated with gut microbiota composition, including phenylacetate, multiple sphingomyelins and gentisate. Conclusions: Plasma metabolite profiles are associated with BP in a sex-specific manner. Catecholamine derivatives were more important predictors for BP in women, while sphingomyelins were more important in men. Several metabolites were associated with gut microbiota composition, providing potential targets for intervention.
الإتاحة: https://doi.org/10.1016/j.atherosclerosis.2023.05.016Test
https://research.vumc.nl/en/publications/e499db3d-1090-4511-9f8c-caf4e0d524a7Test
http://www.scopus.com/inward/record.url?scp=85161068296&partnerID=8YFLogxKTest -
7دورية أكاديمية
المصدر: Muskiet , M H A , Elders , P J M & van Raalte , D H 2023 , ' Diabetes care in older people : a call for action ' , The Lancet Healthy Longevity , vol. 4 , no. 12 , pp. e657-e659 . https://doi.org/10.1016/S2666-7568Test(23)00234-9
الإتاحة: https://doi.org/10.1016/S2666-7568Test(23)00234-9
https://research.vumc.nl/en/publications/96d5a2b4-aae0-4c52-9a8c-8cb514604656Test
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85178347745&origin=inwardTest
https://www.ncbi.nlm.nih.gov/pubmed/38042157Test -
8دورية أكاديمية
المؤلفون: van der Aart-van der Beek, Annemarie B., Apperloo, Ellen, Jongs, Niels, Rouw, Dennis B., Sjöström, C. David, Friedli, Iris, Johansson, Lars, van Raalte, Daniël H., Hoogenberg, Klaas, Heerspink, Hiddo J. L.
المصدر: van der Aart-van der Beek , A B , Apperloo , E , Jongs , N , Rouw , D B , Sjöström , C D , Friedli , I , Johansson , L , van Raalte , D H , Hoogenberg , K & Heerspink , H J L 2023 , ' Albuminuria-lowering effect of dapagliflozin, exenatide, and their combination in patients with type 2 diabetes : A randomized cross-over clinical study ' , Diabetes, Obesity and Metabolism , vol. 25 , no. 6 , pp. 1758-1768 . https://doi.org/10.1111/dom.15033Test
الوصف: Aim: To evaluate the albuminuria-lowering effect of dapagliflozin, exenatide, and the combination of dapagliflozin and exenatide in patients with type 2 diabetes and microalbuminuria or macroalbuminuria. Methods: Participants with type 2 diabetes, an estimated glomerular filtration rate (eGFR) of more than 30 ml/min/1.73m2 and an urinary albumin: creatinine ratio (UACR) of more than 3.5 mg/mmol and 100 mg/mmol or less completed three 6-week treatment periods, during which dapagliflozin 10 mg/d, exenatide 2 mg/wk and both drugs combined were given in random order. The primary outcome was the percentage change in UACR. Secondary outcomes included blood pressure, HbA1c, body weight, extracellular volume, fractional lithium excretion and renal haemodynamic variables as determined by magnetic resonance imaging. Results: We enrolled 20 patients, who completed 53 treatment periods in total. Mean percentage change in UACR from baseline was –21.9% (95% CI: –34.8% to –6.4%) during dapagliflozin versus –7.7% (95% CI: –23.5% to 11.2%) during exenatide and –26.0% (95% CI: –38.4% to –11.0%) during dapagliflozin-exenatide treatment. No correlation was observed in albuminuria responses between the different treatments. Numerically greater reductions in systolic blood pressure, body weight and eGFR were observed during dapagliflozin-exenatide treatment compared with dapagliflozin or exenatide alone. Renal blood flow and effective renal plasma flow (ERPF) did not significantly change with either treatment regimen. However, all but four and two patients in the dapagliflozin and dapagliflozin-exenatide groups, respectively, showed reductions in ERPF. The filtration fraction did not change during treatment with dapagliflozin or exenatide, and decreased during dapagliflozin-exenatide treatment (–1.6% [95% CI: –3.2% to –0.01%]; P =.048). Conclusions: In participants with type 2 diabetes and albuminuria, treatment with dapagliflozin, exenatide and dapagliflozin-exenatide reduced albuminuria, with a numerically larger reduction in the ...
الإتاحة: https://doi.org/10.1111/dom.15033Test
https://research.vumc.nl/en/publications/8a62b75b-6a03-41ae-839a-e402962332b0Test
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85150613740&origin=inwardTest
https://www.ncbi.nlm.nih.gov/pubmed/36843215Test -
9دورية أكاديمية
المؤلفون: Scholtes, Rosalie A., Mosterd, Charlotte M., Hesp, Anne C., Smits, Mark M., Heerspink, Hiddo J. L., van Raalte, Daniël H.
المصدر: Scholtes , R A , Mosterd , C M , Hesp , A C , Smits , M M , Heerspink , H J L & van Raalte , D H 2023 , ' Mechanisms underlying the blood pressure-lowering effects of empagliflozin, losartan and their combination in people with type 2 diabetes : A secondary analysis of a randomized crossover trial ' , Diabetes, Obesity and Metabolism , vol. 25 , no. 1 , pp. 198-207 . https://doi.org/10.1111/dom.14864Test
الوصف: Aim: To study the effects of the sodium-glucose co-transporter-2 (SGLT2) inhibitor empagliflozin, the angiotensin receptor blocker (ARB) losartan, and their combination on blood pressure, while studying the mechanisms potentially involved. Methods: A total of 24 people with type 2 diabetes (T2D) (age: 66 ± 6 years; body mass index: 31.0 ± 3 kg/m 2 ; estimated glomerular filtration rate: 90 ml/min/1.73m 2 ) received a 1-week treatment with empagliflozin 10 mg once daily, losartan 50 mg once daily, their combination, and placebo, in a randomized double-blind crossover design, with 4-week washout periods in between. Blood pressure, arterial stiffness, autonomic nervous system activity and plasma volume, extracellular fluid and serum albumin were assessed. Results: Versus placebo (139 mmHg), empagliflozin reduced systolic blood pressure (SBP) by 8 mmHg (P =.001), losartan by 12 mmHg (P =.001) and empagliflozin + losartan by 15 mmHg (P <.001). Combination therapy had a larger SBP-lowering effect versus empagliflozin monotherapy (-7 [95% CI -12; -2] mmHg) and numerically larger effects versus losartan monotherapy (-3 [-8; 2] mmHg). Empagliflozin reduced sympathetic nervous system (SNS) activity, arterial stiffness and extracellular fluid, while increasing serum albumin. Losartan reduced SNS activity and arterial stiffness. Combination therapy induced volume contraction variables, together with a reduction in SNS activity and arterial stiffness. Conclusion: In people with T2D, SGLT2 inhibition in combination with an ARB had a larger blood pressure-lowering effect versus placebo than either of the drugs alone. Our data further suggest that the mechanisms underlying these blood pressure reductions at least partially differ between these agents.
الإتاحة: https://doi.org/10.1111/dom.14864Test
https://research.vumc.nl/en/publications/763244f8-e6ff-4212-a7cc-4a3cae76f11dTest
http://www.scopus.com/inward/record.url?scp=85139068077&partnerID=8YFLogxKTest -
10دورية أكاديمية
المؤلفون: de Wit, Maartje, van Raalte, Daniël H., van den Berg, Kirsten, Racca, Catherina, Muijs, Linda T., Lutgers, Helen L., Siegelaar, Sarah E., Serné, Erik, Snoek, Frank J.
المصدر: de Wit , M , van Raalte , D H , van den Berg , K , Racca , C , Muijs , L T , Lutgers , H L , Siegelaar , S E , Serné , E & Snoek , F J 2023 , ' Glucose variability and mood in people with type 1 diabetes using ecological momentary assessment ' , Journal of Psychosomatic Research , vol. 173 , 111477 . https://doi.org/10.1016/j.jpsychores.2023.111477Test
الوصف: Objective: Mood fluctuations related to blood glucose excursions are a commonly reported source of diabetes-distress, but research is scarce. We aimed to assess the relationship between real-time glucose variability and mood in adults with type 1 diabetes (T1D) using ecological momentary assessments. Methods: In this prospective observational study, participants wore a masked continuous glucose monitor and received prompts on their smartphone 6 times a day to answer questions about their current mood (Profile Of Mood States (POMS)-SF (dimensions: Anxiety, Depressive symptoms, Anger, Fatigue, Vigor)) for 14 days. Mixed model analyses examined associations over time between daily Coefficient of Variation (CV) of blood glucose and mean and variability (CV) of POMS scores. Further, within-person differences in sleep and nocturnal hypoglycemia were explored. Results: 18 people with T1D (10 female, mean age 44.3 years) participated. A total of 264 out of 367 days (70.2%) could be included in the analyses. No overall significant associations were found between CV of blood glucose and mean and CV of POMS scores, however, nocturnal hypoglycemia moderated the associations between CV of blood glucose and POMS scales (mean Fatigue Estimate 1.998, p < .006, mean Vigor Estimate −3.308, p < .001; CV Anger Estimate 0.731p = 0.02, CV Vigor Estimate −0.525, p = .006). Conclusion: We found no overall relationship between real-time glycemic variability and mood per day. Further research into within-person differences such as sleep and nocturnal hypoglycemia is warranted.
الإتاحة: https://doi.org/10.1016/j.jpsychores.2023.111477Test
https://research.vumc.nl/en/publications/3e653ce7-6eeb-4580-b463-d1f716699fe9Test
http://www.scopus.com/inward/record.url?scp=85168997796&partnerID=8YFLogxKTest
النص الكامل