المؤلفون: Maria Valles-Salgado, María José Gil-Moreno, Rosie E. Curiel Cid, Alfonso Delgado-Álvarez, Isabel Ortega-Madueño, Cristina Delgado-Alonso, Marta Palacios-Sarmiento, Juan I. López-Carbonero, María Cruz Cárdenas, Jorge Matías-Guiu, María Díez-Cirarda, David A. Loewenstein, Jordi A. Matias-Guiu

المصدر: Frontiers in Psychology, Vol 15 (2024)

مصطلحات موضوعية: Alzheimer’s disease, semantic interference, memory, mild cognitive impairment, neuropsychological assessment, cerebrospinal fluid biomarkers, Psychology, BF1-990

الوصف: IntroductionTimely and accurate diagnosis of the earliest manifestations of Alzheimer’s disease (AD) is critically important. Cognitive challenge tests such as the Loewenstein Acevedo Scales for Semantic Interference and Learning (LASSI-L) have shown favorable diagnostic properties in a number of previous investigations using amyloid or FDG PET. However, no studies have examined LASSI-L performance against cerebrospinal fluid biomarkers of AD, which can be affected before the distribution of fibrillar amyloid and other changes that can be observed in brain neuroimaging. Therefore, we aimed to evaluate the relationship between LASSI-L scores and CSF biomarkers and the capacity of the cognitive challenge test to detect the presence of amyloid and tau deposition in patients with subjective cognitive decline and amnestic mild cognitive impairment (MCI).MethodsOne hundred and seventy-nine patients consulting for memory loss without functional impairment were enrolled. Patients were examined using comprehensive neuropsychological assessment, the LASSI-L, and cerebrospinal fluid (CSF) biomarkers (Aβ1-42/Aβ1-40 and ptau181). Means comparisons, correlations, effect sizes, and ROC curves were calculated.ResultsLASSI-L scores were significantly associated with CSF biomarkers Aβ1-42/Aβ1-40 in patients diagnosed with MCI and subjective cognitive decline, especially those scores evaluating the capacity to recover from proactive semantic interference effects and delayed recall. A logistic regression model for the entire sample including LASSI-L and age showed an accuracy of 0.749 and an area under the curve of 0.785 to detect abnormal amyloid deposition.ConclusionOur study supports the biological validity of the LASSI-L and its semantic interference paradigm in the context of the early stages of AD. These findings emphasize the utility and the convenience of including sensitive cognitive challenge tests in the assessment of patients with suspicion of early stages of AD.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fpsyg.2024.1373541/fullTest; https://doaj.org/toc/1664-1078Test

الوصول الحر: https://doaj.org/article/a39706c58e2a461e87b6c10f28c85408Test

المؤلفون: Delhaye, Emma, D'Innocenzo, Giorgia, Raposo, Ana, Coco, Moreno I

المصدر: Memory and Cognition (2024-05-06)

مصطلحات موضوعية: Conceptual similarity, Long-term visual memory, Semantic interference, Visual similarity, Neuropsychology and Physiological Psychology, Experimental and Cognitive Psychology, Arts and Humanities (miscellaneous), Social & behavioral sciences, psychology, Neurosciences & behavior, Sciences sociales & comportementales, psychologie, Neurosciences & comportement

الوصف: Although long-term visual memory (LTVM) has a remarkable capacity, the fidelity of its episodic representations can be influenced by at least two intertwined interference mechanisms during the encoding of objects belonging to the same category: the capacity to hold similar episodic traces (e.g., different birds) and the conceptual similarity of the encoded traces (e.g., a sparrow shares more features with a robin than with a penguin). The precision of episodic traces can be tested by having participants discriminate lures (unseen objects) from targets (seen objects) representing different exemplars of the same concept (e.g., two visually similar penguins), which generates interference at retrieval that can be solved if efficient pattern separation happened during encoding. The present study examines the impact of within-category encoding interference on the fidelity of mnemonic object representations, by manipulating an index of cumulative conceptual interference that represents the concurrent impact of capacity and similarity. The precision of mnemonic discrimination was further assessed by measuring the impact of visual similarity between targets and lures in a recognition task. Our results show a significant decrement in the correct identification of targets for increasing interference. Correct rejections of lures were also negatively impacted by cumulative interference as well as by the visual similarity with the target. Most interestingly though, mnemonic discrimination for targets presented with a visually similar lure was more difficult when objects were encoded under lower, not higher, interference. These findings counter a simply additive impact of interference on the fidelity of object representations providing a finer-grained, multi-factorial, understanding of interference in LTVM.

العلاقة: https://link.springer.com/content/pdf/10.3758/s13421-024-01563-2.pdfTest; urn:issn:0090-502X; urn:issn:1532-5946

الوصول الحر: https://orbi.uliege.be/handle/2268/318207Test

المؤلفون: Rosie E. Curiel Cid, Elizabeth A. Crocco, Ranjan Duara, David Vaillancourt, Breton Asken, Melissa J. Armstrong, Malek Adjouadi, Mike Georgiou, Michael Marsiske, Wei-in Wang, Monica Rosselli, William W. Barker, Alexandra Ortega, Diana Hincapie, Liz Gallardo, Feras Alkharboush, Steven DeKosky, Glenn Smith, David A. Loewenstein

المصدر: Frontiers in Aging Neuroscience, Vol 16 (2024)

مصطلحات موضوعية: mild cognitive impairment, Alzheimer’s dementia progression, proactive semantic interference, LASSI-L, amyloid imaging, structural MRI, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

الوصف: IntroductionThis study investigated the role of proactive semantic interference (frPSI) in predicting the progression of amnestic Mild Cognitive Impairment (aMCI) to dementia, taking into account various cognitive and biological factors.MethodsThe research involved 89 older adults with aMCI who underwent baseline assessments, including amyloid PET and MRI scans, and were followed longitudinally over a period ranging from 12 to 55 months (average 26.05 months).ResultsThe findings revealed that more than 30% of the participants diagnosed with aMCI progressed to dementia during the observation period. Using Cox Proportional Hazards modeling and adjusting for demographic factors, global cognitive function, hippocampal volume, and amyloid positivity, two distinct aspects of frPSI were identified as significant predictors of a faster decline to dementia. These aspects were fewer correct responses on a frPSI trial and a higher number of semantic intrusion errors on the same trial, with 29.5% and 31.6 % increases in the likelihood of more rapid progression to dementia, respectively.DiscussionThese findings after adjustment for demographic and biological markers of Alzheimer’s Disease, suggest that assessing frPSI may offer valuable insights into the risk of dementia progression in individuals with aMCI.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fnagi.2024.1336008/fullTest; https://doaj.org/toc/1663-4365Test

الوصول الحر: https://doaj.org/article/8e21f558dc6d4a359cc9503bfae2163aTest

المؤلفون: Arrigoni, Eleonora, Rappo, Eleonora, Papagno, Costanza, Romero Lauro, Leonor J., Pisoni, Alberto

المساهمون: Arrigoni, Eleonora, Rappo, Eleonora, Papagno, Costanza, Romero Lauro, Leonor J., Pisoni, Alberto

مصطلحات موضوعية: Meta-analysi, Phonological facilitation, Picture naming, Semantic interference, fMRI

الوصف: Semantic interference (SI) and phonological facilitation (PF) effects occur when multiple representations are co-activated simultaneously in complex naming paradigms, manipulating the context in which word production is set. Although the behavioral consequences of these psycholinguistic effects are well-known, the involved brain structures are still controversial. This paper aims to provide a systematic review and a coordinate-based meta-analysis of the available functional neuroimaging studies investigating SI and PF in picture naming paradigms. The included studies were fMRI experiments on healthy subjects, employing paradigms in which co-activations of representations were obtained by manipulating the naming context using semantically or phonologically related items. We examined the principal methodological aspects of the included studies, emphasizing the existing commonalities and discrepancies across single investigations. We then performed an exploratory coordinate-based meta-analysis of the reported activation peaks of neural response related to SI and PF. Our results consolidated previous findings regarding the involvement of the left inferior frontal gyrus and the left middle temporal gyrus in SI and brought out the role of bilateral inferior parietal regions in PF.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/38319529; info:eu-repo/semantics/altIdentifier/wos/WOS:001156097800001; volume:2024; numberofpages:19; journal:NEUROPSYCHOLOGY REVIEW; https://hdl.handle.net/11572/404229Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85184226381; https://link.springer.com/article/10.1007/s11065-024-09631-9#citeasTest

الإتاحة: https://doi.org/10.1007/s11065-024-09631-9Test
https://hdl.handle.net/11572/404229Test

المؤلفون: Hoshino, Noriko, Beatty-Martínez, Anne L, Navarro-Torres, Christian A, Kroll, Judith F

مصطلحات موضوعية: Language, Communication and Culture, Linguistics, Behavioral and Social Science, Basic Behavioral and Social Science, Clinical Research, different-script bilinguals, cross-language activation, semantic interference, phono-translation, picture-word interference task, Sociology, Communication and media studies

الوصف: The present study examined the role of script in bilingual speech planning by comparing the performance of same and different-script bilinguals. Spanish-English bilinguals (Experiment 1) and Japanese-English bilinguals (Experiment 2) performed a picture-word interference task in which they were asked to name a picture of an object in English, their second language, while ignoring a visual distractor word in Spanish or Japanese, their first language. Results replicated the general pattern seen in previous bilingual picture-word interference studies for the same-script, Spanish-English bilinguals but not for the different-script, Japanese-English bilinguals. Both groups showed translation facilitation, whereas only Spanish-English bilinguals demonstrated semantic interference, phonological facilitation, and phono-translation facilitation. These results suggest that when the script of the language not in use is present in the task, bilinguals appear to exploit the perceptual difference as a language cue to direct lexical access to the intended language earlier in the process of speech planning.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/97r1h83vTest

المؤلفون: Luis A. Sierra, Shelby B. Hughes, Clementina J. Ullman, Andrew Hall, Sarbesh R. Pandeya, Robin Schubert, Samuel A. Frank, Mark A. Halko, Jody Corey-Bloom, Simon Laganiere

المصدر: Frontiers in Neurology, Vol 14 (2023)

مصطلحات موضوعية: semantic interference, cognitive, Huntington disease, executive function, pre-motor manifest HD, LASSI-L, Neurology. Diseases of the nervous system, RC346-429

الوصف: Background and objectivesCognitive decline is an important early sign in pre-motor manifest Huntington’s disease (preHD) and is characterized by deficits across multiple domains including executive function, psychomotor processing speed, and memory retrieval. Prior work suggested that the Loewenstein-Acevedo Scale for Semantic Interference and Learning (LASSI-L)–a verbal learning task that simultaneously targets these domains - could capture early cognitive changes in preHD. The current study aimed to replicate, validate and further analyze the LASSI-L in preHD using larger datasets.MethodsLASSI-L was administered to 50 participants (25 preHD and 25 Healthy Controls) matched for age, education, and sex in a longitudinal study of disease progression and compared to performance on MMSE, Trail A & B, SCWT, SDMT, Semantic Fluency (Animals), and CVLT-II. Performance was then compared to a separate age-education matched-cohort of 25 preHD participants. Receiver operating curve (ROC) and practice effects (12 month interval) were investigated. Group comparisons were repeated using a preHD subgroup restricted to participants predicted to be far from diagnosis (Far subgroup), based on CAG-Age-Product scaled (CAPs) score. Construct validity was assessed through correlations with previously established measures of subcortical atrophy.ResultsPreHD performance on all sections of the LASSI-L was significantly different from controls. The proactive semantic interference section (PSI) was sensitive (p = 0.0001, d = 1.548), similar across preHD datasets (p = 1.0), reliable on test–retest over 12 months (spearman rho = 0.88; p =

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fneur.2023.1191718/fullTest; https://doaj.org/toc/1664-2295Test

الوصول الحر: https://doaj.org/article/b4034b8b7a0e4e6da169f687a9e855e9Test

المؤلفون: Kelly Rapoeye, Robert J. Hartsuiker, Aurélie Pistono

المصدر: Royal Society Open Science, Vol 10, Iss 6 (2023)

مصطلحات موضوعية: disfluency, connected speech, semantic interference, network task, Science

الوصف: Several studies have shown that different types of disfluency occur depending on the language production stage at which people experience difficulties. The current study combined a network task and a picture–word interference task to analyse whether lexical-semantic difficulty triggers errors and disfluencies in connected-speech production. The participants produced more disfluencies in the presence of a semantically related distractor word than an unrelated distractor word, while few semantic errors were made. These results support the hypothesis that difficulties at distinct stages of language production lead to distinct patterns of disfluency, with lexical-semantic difficulties leading to self-corrections and silent pauses. The results also have implications for the role of the monitoring system in connected-speech production.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2054-5703Test

الوصول الحر: https://doaj.org/article/58887accee6c4300a960b4752f0ca9bfTest

المؤلفون: Pinet, Svetlana, Nozari, Nazbanou

مصطلحات موضوعية: language production, semantic interference, phonological interference, Stroop, inhibitory control, EEG, conflict detection, ERN/CRN

الوصف: Published: August 01 2023 ; Contextual similarity between targets and competitors, whether semantic or phonological, often leads to behavioral interference in language production. It has been assumed that resolving such interference relies on control processes similar to those involved in tasks such as Stroop. This article tests this assumption by comparing the electrophysiological signatures of interference resulting from a contextual similarity versus a Stroop-like manipulation. In blocks containing two items, participants repeatedly named pictures that were semantically related, phonologically related, or unrelated (contextual similarity manipulation). In straight blocks, the pictures were named by their canonical names. In reverse blocks, participants had to reverse the names (Stroop-like manipulation). Both manipulations led to behavioral interference, but with different electrophysiological profiles. Whole-scalp stimulus-locked and response-locked analyses of semantic and phonological similarity pointed to a system with global modularity with some degree of cascading and interactivity, whereas the effect of phase reversal was sustained and of the opposite polarity. More strikingly, a representational similarity analysis showed a biphasic pattern for Stroop-like reversal, with earlier higher similarity scores for the reverse phase flipping into lower scores ~500 msec poststimulus onset. In contrast, contextual similarity induced higher similarity scores up to articulation. Finally, response-locked mediofrontal components indexing performance monitoring differed between manipulations. Correct response negativity's amplitude was lower in the phonological blocks, whereas a pre-correct response negativity component had higher amplitude in reverse versus straight blocks. These results argue against the involvement of Stroop-like control mechanisms in resolving interference from contextual similarity in language production. ; This work was supported in part by the Therapeutic Cognitive Neuroscience Fund at Johns ...

وصف الملف: application/pdf

العلاقة: https://direct.mit.edu/jocnTest; Svetlana Pinet, Nazbanou Nozari; Different Electrophysiological Signatures of Similarity-induced and Stroop-like Interference in Language Production. J Cogn Neurosci 2023; 35 (8): 1329–1349. doi: https://doi.org/10.1162/jocn_a_02014Test; Journal of Cognitive Neuroscience; http://hdl.handle.net/10810/63430Test

الإتاحة: https://doi.org/10.1162/jocn_a_02014Test
http://hdl.handle.net/10810/63430Test

المؤلفون: Rapoeye, Kelly, Hartsuiker, Robert, Pistono, Aurelie

المصدر: ROYAL SOCIETY OPEN SCIENCE ; ISSN: 2054-5703

مصطلحات موضوعية: Social Sciences, disfluency, connected speech, semantic interference, network task, LEXICAL ACCESS, TIME PRESSURE, WORD, FREQUENCY, PAUSES

الوصف: Several studies have shown that different types of disfluency occur depending on the language production stage at which people experience difficulties. The current study combined a network task and a picture-word interference task to analyse whether lexical-semantic difficulty triggers errors and disfluencies in connected-speech production. The participants produced more disfluencies in the presence of a semantically related distractor word than an unrelated distractor word, while few semantic errors were made. These results support the hypothesis that difficulties at distinct stages of language production lead to distinct patterns of disfluency, with lexical-semantic difficulties leading to self-corrections and silent pauses. The results also have implications for the role of the monitoring system in connected-speech production.

وصف الملف: application/pdf

العلاقة: https://biblio.ugent.be/publication/01HBDG662F9G4AQCRD8CZW100WTest; http://hdl.handle.net/1854/LU-01HBDG662F9G4AQCRD8CZW100WTest; http://doi.org/10.1098/rsos.230006Test; https://biblio.ugent.be/publication/01HBDG662F9G4AQCRD8CZW100W/file/01HBDHHK1CC0MTV74B749EJWENTest

الإتاحة: https://doi.org/10.1098/rsos.230006Test
https://biblio.ugent.be/publication/01HBDG662F9G4AQCRD8CZW100WTest
http://hdl.handle.net/1854/LU-01HBDG662F9G4AQCRD8CZW100WTest
https://biblio.ugent.be/publication/01HBDG662F9G4AQCRD8CZW100W/file/01HBDHHK1CC0MTV74B749EJWENTest

المؤلفون: Kelly Rapoeye, Robert J. Hartsuiker, Aurélie Pistono

مصطلحات موضوعية: Psychology and Cognitive Sciences not elsewhere classified, disfluency, connected speech, semantic interference, network task

الوصف: Several studies have shown that different types of disfluency occur depending on the language production stage at which people experience difficulties. The current study combined a network task and a picture–word interference task to analyze whether lexical-semantic difficulty triggers errors and disfluencies in connected-speech production. The participants produced more disfluencies in the presence of a semantically related distractor word than an unrelated distractor word, while few semantic errors were made. These results support the hypothesis that difficulties at distinct stages of language production lead to distinct patterns of disfluency, with lexical-semantic difficulties leading to self-corrections and silent pauses. The results also have implications for the role of the monitoring system in connected-speech production.

العلاقة: https://figshare.com/articles/journal_contribution/Detailed_results_of_linear_mixed_models_from_Semantic_interference_affects_speech_production_by_increasing_disfluencies_not_errors/23554830Test

الإتاحة: https://doi.org/10.6084/m9.figshare.23554830.v1Test
https://figshare.com/articles/journal_contribution/Detailed_results_of_linear_mixed_models_from_Semantic_interference_affects_speech_production_by_increasing_disfluencies_not_errors/23554830Test