المؤلفون: Zongliang Gao, Sujan Ravendran, Nanna S. Mikkelsen, Jakob Haldrup, Huiqiang Cai, Xiangning Ding, Søren R. Paludan, Martin K. Thomsen, Jacob Giehm Mikkelsen, Rasmus O. Bak

المصدر: Gao, Z, Ravendran, S, Mikkelsen, N S, Haldrup, J, Cai, H, Ding, X, Paludan, S R, Thomsen, M K, Mikkelsen, J G & Bak, R O 2022, ' A truncated reverse transcriptase enhances prime editing by split AAV vectors ', Molecular Therapy, vol. 30, no. 9, pp. 2942-2951 . https://doi.org/10.1016/j.ymthe.2022.07.001Test

مصطلحات موضوعية: Gene Editing, Pharmacology, gene editing, in vivo delivery, Genetic Vectors, RNA-Directed DNA Polymerase, Dependovirus, gene therapy, AAV vectors, Mice, prime editing, reverse transcriptase, Drug Discovery, Genetics, Animals, Molecular Medicine, CRISPR-Cas9, CRISPR-Cas Systems, Proprotein Convertase 9, Molecular Biology, PASTE, RNA, Guide, Kinetoplastida

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e482d3b5e2fcbc3c0e1a39faf07598dbTest
https://doi.org/10.1016/j.ymthe.2022.07.001Test

المؤلفون: Mengyun Xu, Xiumei Wu, Zhenghong Liu, Yu Ding, Weian Kong, Peter J. Little, Suowen Xu, Jianping Weng

المصدر: Biochemical and Biophysical Research Communications. 622:163-169

مصطلحات موضوعية: Mice, Knockout, Liver Diseases, Hypercholesterolemia, Biophysics, Cell Biology, Atherosclerosis, Biochemistry, Plaque, Atherosclerotic, Diet, Fatty Liver, Mice, Inbred C57BL, Disease Models, Animal, Mice, Apolipoproteins E, Cholesterol, Diabetes Mellitus, Type 2, Receptors, LDL, Animals, Proprotein Convertase 9, Molecular Biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d53a7475e182846aa2dca9b40812a912Test
https://doi.org/10.1016/j.bbrc.2022.07.031Test

المؤلفون: Jelani K. Grant, Michael Dangl, Margaret Koester, Mickias Tegegn, Leonardo Knijnik, Harjit Singh, Carl E. Orringer

المصدر: Journal of Clinical Lipidology. 16:608-616

مصطلحات موضوعية: Nutrition and Dietetics, Anticholesteremic Agents, Endocrinology, Diabetes and Metabolism, Hypercholesterolemia, Cholesterol, LDL, Ezetimibe, Atherosclerosis, United States, Cardiovascular Diseases, Internal Medicine, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Proprotein Convertase 9, Cardiology and Cardiovascular Medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da1c7ca9786eddacd1b143b15e6bc73cTest
https://doi.org/10.1016/j.jacl.2022.08.005Test

المؤلفون: Forough, Taheri, Eskandar, Taghizadeh, Fatemeh, Baniamerian, Daryoush, Rostami, Ahmad, Rozeian, Seyed, Mohammad Gheibi Hayat, Tannaz, Jamialahmadi, Željko, Reiner, Amirhossein, Sahebkar

المصدر: Endocrine, Metabolic & Immune Disorders - Drug Targets. 22:1018-1028

مصطلحات موضوعية: Hyperlipoproteinemia Type II, Endocrinology, Diabetes and Metabolism, PCSK9 Inhibitors, Humans, Immunology and Allergy, Cholesterol, LDL, Proprotein Convertase 9

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c115b65c7b7d22480124788df24c8747Test
https://doi.org/10.2174/1871530322666220509040844Test

المؤلفون: Ishaan Jindal, Xiao Wang

المصدر: Current Atherosclerosis Reports. 24:861-866

مصطلحات موضوعية: Gene Editing, Cardiovascular Diseases, Adenine, Liposomes, Animals, Humans, Nanoparticles, Cholesterol, LDL, CRISPR-Cas Systems, Proprotein Convertase 9, Atherosclerosis, Cardiology and Cardiovascular Medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::313a8ff477c634fc0198a1a218209f07Test
https://doi.org/10.1007/s11883-022-01063-1Test

المؤلفون: Fagundes, A, Morrow, DA, Oyama, K, Furtado, RHM, Zelniker, TA, Tang, M, Kuder, JF, Murphy, SA, Hamer, A, Keech, AC, Sever, P, Giugliano, RP, Sabatine, MS, Bergmark, BA

المصدر: Journal of the American College of Cardiology. 80:887-897

مصطلحات موضوعية: Percutaneous Coronary Intervention, Treatment Outcome, Risk Factors, Anticholesteremic Agents, Humans, Coronary Artery Disease, Proprotein Convertase 9, Cardiology and Cardiovascular Medicine, Biomarkers

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2171d0c86530c349141f68b8b84ee629Test
https://doi.org/10.1016/j.jacc.2022.05.051Test

المؤلفون: Daniel B. Rosoff, Andrew S. Bell, Jeesun Jung, Josephin Wagner, Lucas A. Mavromatis, Falk W. Lohoff

المصدر: Journal of the American College of Cardiology. 80:653-662

مصطلحات موضوعية: Cognition, Alzheimer Disease, Humans, Acyl Coenzyme A, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Mendelian Randomization Analysis, Proprotein Convertase 9, Cardiology and Cardiovascular Medicine, Genome-Wide Association Study

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc271624a5b99d2076132f38494a7fc6Test
https://doi.org/10.1016/j.jacc.2022.05.041Test

المؤلفون: Santos R. D., Ruzza A., Hovingh G. K., Wiegman A., Mach F., Kurtz C. E., Hamer A., Bridges I., Bartuli A., Bergeron J., Szamosi T., Santra S., Stefanutti C., Descamps O. S., Greber-Platzer S., Luirink I., Kastelein J. J. P., Gaudet D., HAUSER-RCT Investigators, Arca M.

المساهمون: Santos, R. D., Ruzza, A., Hovingh, G. K., Wiegman, A., Mach, F., Kurtz, C. E., Hamer, A., Bridges, I., Bartuli, A., Bergeron, J., Szamosi, T., Santra, S., Stefanutti, C., Descamps, O. S., Greber-Platzer, S., Luirink, I., Kastelein, J. J. P., Gaudet, D., HAUSER-RCT, Investigator, Arca, M.

مصطلحات موضوعية: adolescent, antibodies, monoclonal, humanized, anticholesteremic agent, child, cholesterol, LDL, double-blind method, drug therapy, combination, female, heterozygote, human, hydroxymethylglutaryl-CoA reductase inhibitor, hyperlipoproteinemia type II, lipid, male, proprotein convertase 9, treatment outcome

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/32865373; info:eu-repo/semantics/altIdentifier/wos/WOS:000575616600008; volume:383; issue:14; firstpage:1317; lastpage:1327; numberofpages:11; journal:NEW ENGLAND JOURNAL OF MEDICINE; http://hdl.handle.net/11573/1493896Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85090787975

الإتاحة: https://doi.org/10.1056/NEJMoa2019910Test
http://hdl.handle.net/11573/1493896Test

المؤلفون: Ray K. K., Wright R. S., Kallend D., Koenig W., Leiter L. A., Raal F. J., Bisch J. A., Richardson T., Jaros M., Wijngaard P. L. J., Kastelein J. J. P., N. Sulli

المساهمون: K. K., Ray, R. S., Wright, D., Kallend, W., Koenig, L. A., Leiter, F. J., Raal, J. A., Bisch, T., Richardson, M., Jaro, P. L. J., Wijngaard, J. J. P., Kastelein, Sulli, N.

مصطلحات موضوعية: aged, 80 and over, anticholesteremic agent, cardiovascular disease, cholesterol, LDL, coronary artery disease, double-blind method, drug administration schedule, female, human, hydroxymethylglutaryl-CoA reductase inhibitor, hypercholesterolemia, injections, subcutaneou, liver function test, male, middle aged, proprotein convertase 9, RNA, small interfering, risk factors

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/32187462; info:eu-repo/semantics/altIdentifier/wos/WOS:000527733300009; volume:382; issue:16; firstpage:1507; lastpage:1519; numberofpages:13; journal:NEW ENGLAND JOURNAL OF MEDICINE; http://hdl.handle.net/11573/1466248Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85082743614

الإتاحة: https://doi.org/10.1056/NEJMoa1912387Test
http://hdl.handle.net/11573/1466248Test

المؤلفون: Paquette, Martine, Gauthier, Dany, Chamberland, Ann, Prat, Annik, De Lucia Rolfe, Emanuella, Rasmussen, Jon J, Kaduka, Lydia, Seidah, Nabil G, Bernard, Sophie, Christensen, Dirk L, Baass, Alexis

مصطلحات موضوعية: Hepatic steatosis, Insulin resistance, Liver, Metabolic syndrome, PCSK9, Adult, Biomarkers, Cohort Studies, Fatty Liver, Female, Humans, Kenya, Male, Middle Aged, Proprotein Convertase 9

وصف الملف: Print-Electronic; application/vnd.openxmlformats-officedocument.wordprocessingml.document; application/vnd.openxmlformats-officedocument.presentationml.presentation

العلاقة: https://www.repository.cam.ac.uk/handle/1810/301012Test

الإتاحة: https://doi.org/10.17863/CAM.48088Test
https://www.repository.cam.ac.uk/handle/1810/301012Test