المؤلفون: Karel Allegaert, Pieter De Cock, Anne Smits, An Vermeulen

المساهمون: Pediatrics

المصدر: Expert Opinion on Drug Metabolism & Toxicology, 15(1), 25-34. Taylor & Francis Ltd

مصطلحات موضوعية: Physiologically based pharmacokinetic modelling, Computational biology, Toxicology, Models, Biological, physiologically based pharmacokinetics, 030226 pharmacology & pharmacy, system knowledge, Modeling and simulation, 03 medical and health sciences, Biliary excretion, 0302 clinical medicine, Drug Development, Pharmacokinetics, Humans, Medicine, Computer Simulation, Model development, Pharmacology, business.industry, Age Factors, Infant, Newborn, Proteins, modeling, General Medicine, Newborn, Breast Feeding, Drug development, neonatal drug development, 030220 oncology & carcinogenesis, Expert opinion, System parameters, business

وصف الملف: Print-Electronic

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff6202be6f7d327f5b9fceb46e0fe8ebTest
https://doi.org/10.1080/17425255.2019.1558205Test

المؤلفون: Matthew D Harwood, Sibylle Neuhoff, Brahim Achour, Amin Rostami-Hodjegan

المصدر: Neuhoff, S, Harwood, M, Rostami-Hodjegan, A & Achour, B 2021, ' Application of proteomic data in the translation of in vitro observations to associated clinical outcomes ', Drug Discovery Today: Technologies, vol. 39, pp. 13-22 . https://doi.org/10.1016/j.ddtec.2021.06.002Test

مصطلحات موضوعية: Proteomics, In silico, Quantitative proteomics, Computational biology, Biology, Network Pharmacology, 01 natural sciences, Models, Biological, Physiologically-based pharmacokinetics, 03 medical and health sciences, In vitro-in vivo extrapolation, In vivo, Drug Discovery, Distribution (pharmacology), 030304 developmental biology, 0303 health sciences, 010405 organic chemistry, Proteins, Translation (biology), Translational pharmacology, 0104 chemical sciences, Drug development, Molecular Medicine, Systems pharmacology

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f435338e279a24be850c414b8d8212dTest
https://pubmed.ncbi.nlm.nih.gov/34906322Test

المؤلفون: Leding, Albin

مصطلحات موضوعية: Pharmacokinetics, Pharmacometrics, Pharmacology, population pharmacokinetics, physiologically-based pharmacokinetics, in vitro to in vivo extrapolation, IVIVE, PBPK, PK, popPK, tuberculosis, model informed approach, first in vivo pharmacokinetic experiment, mouse, mice, PKSim, NONMEM, in vitro, in vivo, Pharmacology and Toxicology, Farmakologi och toxikologi

وصف الملف: application/pdf

العلاقة: UPTEC K, 1650-8297 ; 21035

الإتاحة: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-447311Test

المؤلفون: Mark McAllister, Angela Effinger, Caitriona M. O'Driscoll, Nikoletta Fotaki

المصدر: Effinger, A, O'Driscoll, C M, McAllister, M & Fotaki, N 2021, ' Predicting budesonide performance in healthy subjects and patients with Crohn's disease using biorelevant in vitro dissolution testing and PBPK modeling ', European Journal of Pharmaceutical Sciences, vol. 157, 105617 . https://doi.org/10.1016/j.ejps.2020.105617Test

مصطلحات موضوعية: Budesonide, Drug, Physiologically based pharmacokinetic modelling, Bioavailability, media_common.quotation_subject, Population, Pharmaceutical Science, 02 engineering and technology, Pharmacology, 030226 pharmacology & pharmacy, Inflammatory bowel disease, Models, Biological, Absorption, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, SDG 3 - Good Health and Well-being, Crohn Disease, medicine, Humans, Computer Simulation, Pharmacokinetic modeling, education, media_common, education.field_of_study, CYP3A4, business.industry, Inflammatory Bowel Disease, 021001 nanoscience & nanotechnology, medicine.disease, Healthy Volunteers, 3. Good health, Solubility, Physiologically based pharmacokinetics, 0210 nano-technology, business, medicine.drug

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd94a99a39e27b01d703a635a49f54f4Test
https://pubmed.ncbi.nlm.nih.gov/33164838Test

المؤلفون: Kenza Abouir (11618500), Caroline F Samer (11618503), Yvonne Gloor (11618506), Jules A Desmeules (11618509), Youssef Daali (10215089)

مصطلحات موضوعية: Pharmacology, Basic Pharmacology, Clinical Pharmacology and Therapeutics, Clinical Pharmacy and Pharmacy Practice, Pharmaceutical Sciences, Pharmacogenomics, Toxicology (incl. Clinical Toxicology), Pharmacology and Pharmaceutical Sciences not elsewhere classified, physiologically-based pharmacokinetics, drug-drug interaction, clinical setting, metabolism, precision dosing, transporters

العلاقة: https://figshare.com/articles/dataset/DataSheet1_Reviewing_Data_Integrated_for_PBPK_Model_Development_to_Predict_Metabolic_Drug-Drug_Interactions_Shifting_Perspectives_and_Emerging_Trends_PDF/16896271Test

الإتاحة: https://doi.org/10.3389/fphar.2021.708299.s001Test

المؤلفون: N. Melillo, S. Grandoni, N. Cesari, G. Brogin, P. Puccini, P. Magni

المساهمون: Melillo, N., Grandoni, S., Cesari, N., Brogin, G., Puccini, P., Magni, P.

مصطلحات موضوعية: Mathematical modeling, pharmacokinetic models, inhaleted drugs, Global sensitivity analysis, Physiologically based pharmacokinetics models

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/32862303; info:eu-repo/semantics/altIdentifier/wos/WOS:000563747700001; volume:22; issue:5; firstpage:116.1; lastpage:116.11; numberofpages:1; journal:THE AAPS JOURNAL; http://hdl.handle.net/11571/1363034Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85089982048

الإتاحة: https://doi.org/10.1208/s12248-020-00499-0Test
http://hdl.handle.net/11571/1363034Test

المؤلفون: Terence J. O'Brien, Blanca Vazquez, Cindy Dobrinsky, Torbjörn Tomson, Edgar Schuck

المصدر: Epilepsia

مصطلحات موضوعية: 0301 basic medicine, Adult, Pediatrics, medicine.medical_specialty, Pyridones, MedDRA, Abortion, physiologically based pharmacokinetics, Rats, Sprague-Dawley, 03 medical and health sciences, Perampanel, chemistry.chemical_compound, Epilepsy, Young Adult, 0302 clinical medicine, perampanel, Pregnancy, Nitriles, medicine, Animals, Humans, Adverse effect, Full Term, Dose-Response Relationship, Drug, business.industry, Pregnancy Outcome, Middle Aged, medicine.disease, adverse events, Rats, Pregnancy Complications, 030104 developmental biology, Neurology, chemistry, Full‐length Original Research, Apgar score, Anticonvulsants, Female, Neurology (clinical), Rabbits, business, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c72223dfeb332ae65ce370b6cfed140eTest
https://pubmed.ncbi.nlm.nih.gov/33666943Test

المؤلفون: Armin Sepp, Mats Bergström, Marie Davies

المصدر: mAbs
article-version (VoR) Version of Record

مصطلحات موضوعية: PBPK, Physiologically based pharmacokinetic modelling, Immunology, Serum Albumin, Human, domain antibody, physiologically based pharmacokinetics, Models, Biological, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, Report, antibody, Humans, Immunology and Allergy, Tissue Distribution, AlbudAb™, albumin, 030304 developmental biology, Radioisotopes, Volume of distribution, 0303 health sciences, biology, Chemistry, Albumin, Antibodies, Monoclonal, ibalizumab, Blood proteins, Extravasation, 030220 oncology & carcinogenesis, biology.protein, Biophysics, Zirconium, Antibody, immunoPET, Human, Binding domain

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4ea0a293a0c62a606bba709831f7aebTest
https://doi.org/10.1080/19420862.2020.1832861Test

المؤلفون: Kwang-Hee Shin, Soo Hyeon Bae, Yoojeong Jang, Anhye Kim, Hyeon-Cheol Jeong, Jung-Woo Bae, Sooyeun Lee

المصدر: Pharmaceutics, Vol 11, Iss 11, p 618 (2019)
Pharmaceutics
Volume 11
Issue 11

مصطلحات موضوعية: tramadol, CYP2D6, O-desmethyltramadol, Cmax, Pharmaceutical Science, lcsh:RS1-441, Pharmacology, 030226 pharmacology & pharmacy, Article, lcsh:Pharmacy and materia medica, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, medicine, Active metabolite, Chemistry, Area under the curve, O-Desmethyltramadol, o-desmethyltramadol, cyp2d6, physiologically-based pharmacokinetics, 030220 oncology & carcinogenesis, Tramadol, Monoamine reuptake inhibitor, pharmacokinetics, medicine.drug

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebbec662699ac184823546050564619aTest
https://www.mdpi.com/1999-4923/11/11/618Test

المؤلفون: Wan-Su Park, Taegon Hong, Soo Hyeon Bae, Gab-jin Park, Dong-Seok Yim, Sangil Jeon, Jongtae Lee, Seunghoon Han

المصدر: The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology

مصطلحات موضوعية: Drug, Physiologically based pharmacokinetic modelling, Physiology, media_common.quotation_subject, Cmax, Pharmacology, 030226 pharmacology & pharmacy, Physiologically-based pharmacokinetics, Rosuvastatin, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, medicine, polycyclic compounds, Telmisartan, Intestinal BCRP transporter, media_common, business.industry, nutritional and metabolic diseases, 030220 oncology & carcinogenesis, Cyclosporine, Racial differences, Original Article, business, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56f888cfd1828139d2a36705940ae9e3Test
http://europepmc.org/articles/PMC5928345Test