نتائج البحث - "physiologically based pharmacokinetics"

المصدر: AAPS Journal, 21(3):Unsp 38. Springer New York
Calvier, E A M, Krekels, E H J, Johnson, T N, Rostami-Hodjegan, A, Tibboel, D & Knibbe, C A J 2019, ' Scaling Drug Clearance from Adults to the Young Children for Drugs Undergoing Hepatic Metabolism : A Simulation Study to Search for the Simplest Scaling Method ', AAPS Journal, vol. 21, no. 3, 38 . https://doi.org/10.1208/s12248-019-0295-0Test
The AAPS Journal
AAPS Journal, 21(3), 38

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::782eb04e5c8043ac66994ce7a8895b53Test
https://pure.eur.nl/en/publications/ccc5df5b-4704-4d8a-b33c-a369c2167e57Test

104

Accounting for inter-correlation between enzyme abundance: a simulation study to assess implications on global sensitivity analysis within physiologically-based pharmacokinetics

المؤلفون: Adam S. Darwich, Nicola Melillo, Paolo Magni, Amin Rostami-Hodjegan

المصدر: Melillo, N, Darwich, A S, Magni, P & Rostami-hodjegan, A 2019, ' Accounting for inter-correlation between enzyme abundance: a simulation study to assess implications on global sensitivity analysis within physiologically-based pharmacokinetics ', Journal of pharmacokinetics and pharmacodynamics . https://doi.org/10.1007/s10928-019-09627-6Test

مصطلحات موضوعية: Physiologically based pharmacokinetic modelling, Population, Biological Availability, Computational biology, Biology, 030226 pharmacology & pharmacy, Models, Biological, Correlation, Cytochrome P-450 CYP2C8, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, Piperidines, medicine, Cytochrome P-450 CYP3A, Humans, Computer Simulation, education, Pharmacology, education.field_of_study, CYP3A4, Liver-Specific Organic Anion Transporter 1, Repaglinide, Confidence interval, Bioavailability, Enzymes, Liver, Pharmaceutical Preparations, Global sensitivity analysis, 030220 oncology & carcinogenesis, Inactivation, Metabolic, Physiologically based pharmacokinetics, Carbamates, Simulation, medicine.drug

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ba236810a2c2e62b4ab33f3506a83caTest
https://doi.org/10.1007/s10928-019-09627-6Test

105

How to scale clearance from adults to children for drugs undergoing hepatic metabolism? Insights from advanced PBPK modelling and simulation

المؤلفون: Calvier, E.A.M.

المساهمون: Knibbe, C.A.J., Tibboel, D., Krekels, E.H.J., Irth, H., Bouwstra, J.A., Graaf, P.H. van der, Guchelaar, H.J., Vermeulen, A., Vinks, A.A., Leiden University

المصدر: None

مصطلحات موضوعية: Optimal design, Hepatic metabolism, Clearance, Paediatrics, Pharmacokinetics, Allometric scaling, Physiologically-based pharmacokinetics

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::78aba20938be21dd1f1499ed0c10752aTest
http://hdl.handle.net/1887/67138Test

106

رسالة جامعية

Mechanistic Physiologically based Pharmacokinetic and Pharmacokinetic/Pharmacodynamic Models to Evaluate the Mutual Relationships between an Acid Pump Antagonist and Intragastric pH in Humans ; 위산 펌프 길항제와 위 내 산도 상호간의 효능 관계를 규명하기 위한 생리학적 약물 동태 모델과 약동/약력학 모델 구축 연구: 칼륨 경쟁적 위산 분비 억제제인 YH4808을 예시로 ; Using YH4808, a novel K+-competitive acid blocker, as an example

المؤلفون: 이현아

المساهمون: 이형기, Hyun A Lee, 융합과학기술대학원 융합과학부, 방사선융합의생명 전공

مصطلحات موضوعية: intragastric pH, physiologically-based pharmacokinetics, pharmacokinetics, pharmacodynamics, modeling, simulation, potassium-competitive acid blocker, 620.5

العلاقة: 000000157239; https://hdl.handle.net/10371/162246Test; http://dcollection.snu.ac.kr/common/orgView/000000157239Test; I804:11032-000000157239; 000000000040▲000000000041▲000000157239▲

الإتاحة: https://hdl.handle.net/10371/162246Test
http://dcollection.snu.ac.kr/common/orgView/000000157239Test

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107

Recent Advances in Development and Application of Physiologically-Based Pharmacokinetic (PBPK) Models: a Transition from Academic Curiosity to Regulatory Acceptance

المؤلفون: Masoud Jamei

المصدر: Current Pharmacology Reports

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9a71d4bbc97e0985da0569e936a07cbTest
https://doi.org/10.1007/s40495-016-0059-9Test

108

دورية أكاديمية

Investigation into pulmonary absorption using a combination of the ex vivo model of isolated perfused rat lungs and a simple PK model

المؤلفون: Schwarz, Katharina, Koch, Wolfgang, Walter, Dorothee

مصطلحات موضوعية: Lung, Pulmonary or respiratory system, Physiologically-based pharmacokinetics, In vitro and alternatives

الوقت: 610, 615, 620

العلاقة: Society of Toxicology (Annual Meeting) 2018; The Toxicologist; https://publica.fraunhofer.de/handle/publica/254286Test

الإتاحة: https://publica.fraunhofer.de/handle/publica/254286Test

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109

دورية أكاديمية

Safety of medicines during breastfeeding - from case report to modeling: a contribution from the ConcePTION project.

المؤلفون: Nauwelaerts, N., Nordeng, H., Teil, M., Allegaert, K., Smits, A., Gandia, P., Edginton, A., Ito, S.

المصدر: Expert opinion on drug metabolism & toxicology, vol. 19, no. 5, pp. 269-283

مصطلحات موضوعية: Infant, Female, Humans, Breast Feeding, Milk, Human, Models, Biological, Breastfed infants, Breastfeeding, Drug exposure, Human milk, Pharmacokinetics, Physiologically based pharmacokinetics

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/37269321; info:eu-repo/semantics/altIdentifier/eissn/1744-7607; https://serval.unil.ch/notice/serval:BIB_FDFE0C5041A6Test; urn:issn:1742-5255

الإتاحة: https://doi.org/10.1080/17425255.2023.2221847Test
https://serval.unil.ch/notice/serval:BIB_FDFE0C5041A6Test

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110

دورية أكاديمية

WinPBPK-A Software for Physiologically-based Pharmacokinetic Model Analysis: Application to Tissue and Organ Distribution Analysis of Tacrolimus

المؤلفون: Hiroko SONE, Hiroshi YOSHIKAWA, Kanji TAKADA, Yukako YOSHIKAWA

المصدر: Drug Metabolism and Pharmacokinetics. 1999, 14(1):22

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