المؤلفون: Salah Laaraj, Ashiq Hussain, Aziz Mouhaddach, Younes Noutfia, Faiza Iftikhar Gorsi, Shazia Yaqub, Imtiaz Hussain, Rizwan Nisar, Souad Salmaoui, Kaoutar Elfazazi

المصدر: Ecological Engineering & Environmental Technology, Vol 25, Iss 3, Pp 124-132 (2024)

مصطلحات موضوعية: ceratonia siliqua l, antihyperglycemic potential, pharmacological applications, nutriotional profil, natural bioactive compounds, Ecology, QH540-549.5

الوصف: Carob (Ceratonia siliqua L.), a plant native to the Mediterranean, is a member of the legume family and its fruit is called a pod. The flesh of the pod (pulp) is very rich in sugar, while the seeds are high in fat. The pod is also a good source of minerals such as potassium, calcium and phosphorus. It is rich in polyphenols and antioxidants. Due to its nutritional composition, it is suitable for improving human well-being. This article reviews the chemical composition of locust bean fruit and its biological effects on human health. Understanding the traditional uses of locust bean fruit in relation to its potential as an anti-diabetic agent is important in view of the numerous recent scientific studies on its pharmacological properties. The study focuses on in vivo and in vitro antihyperglycemic research, as well as the nutritional profile and potential food applications of this natural product for food formulation and fortification. Based on its chemical and pharmacological properties, this species is believed to have beneficial preventive and therapeutic effects, particularly in hyperglycemia. Researchers can further extract and isolate bioactive compounds from different carob fractions to develop pharmaceutical products and functional foods for the food and pharmaceutical industries.

وصف الملف: electronic resource

العلاقة: http://www.ecoeet.com/Nutritional-Benefits-and-Antihyperglycemic-Potential-of-Carob-Fruit-Ceratonia-siliqua,178456,0,2.htmlTest; https://doaj.org/toc/2719-7050Test

الوصول الحر: https://doaj.org/article/2eb0f08049e44e4c94afc3201f35ede4Test

المؤلفون: Adarsh Kattil, Hamid, Kshirod Kumar Dash, Rafeeya Shams, Shakshi Sharma

المصدر: Future Foods, Vol 9, Iss , Pp 100295- (2024)

مصطلحات موضوعية: Mulberry species, Nutritional composition, Phytochemicals, Extraction techniques: Biological activities, Functional food, Pharmacological applications, Nutrition. Foods and food supply, TX341-641, Food processing and manufacture, TP368-456

الوصف: Mulberry is one of the underutilised fruit with high perishability. The various species of mulberry fruit are characterized by their natural colours as black, white, and red. These fruits are rich sources of the natural pigment anthocyanin, as well as containing substantial quantities of vitamins and minerals. Black mulberry contains a large amount of phytochemicals, particularly flavonoids (anthocyanin) and phenolics (gallic acid, chlorogenic acid, caffeic acid, quercetin, and rutin). These compounds are responsible for its superior pharmacological effects, including antioxidant activity, hyperglycemia, and anti-inflammatory properties. Numerous research were conducted on different extraction techniques to separate bioactive compounds from mulberry. Various components of Morus species also possess potent nutraceutical capabilities, leading to a wide range of clinical trials for identifying its beneficial properties. The present review concentrates on the most recent literature concerning nutritional composition and phytochemical profiling of three distinct species of mulberries, including their fruit, seeds, and leaves. Furthermore, it investigates the process of extracting bioactive compounds from mulberries and investigates their potential uses in pharmacology as well as in the development of functional food or nutraceutical products. This research thoroughly analyzes innovative approaches for utilizing an underutilized perishable crop to generate economically viable functional products.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2666833524000017Test; https://doaj.org/toc/2666-8335Test

الوصول الحر: https://doaj.org/article/3b8bb6db9aaa49ff9fa9ba26118a6d6dTest

المؤلفون: Abdeljalil Hamdi, Walid Daoudi, Mohamed Aaddouz, Mohamed Azzouzi, Hassan Amhamdi, Abdellah Elyoussfi, Abdelmalik El Aatiaoui, Dakeshwar Kumar Verma, Mohamed Abboud, M'hamed Ahari

المصدر: Heliyon, Vol 10, Iss 10, Pp e31253- (2024)

مصطلحات موضوعية: Tri-tetra-substituted imidazole, Radziszewski reaction, Preclinical approaches, Pharmacological applications, Science (General), Q1-390, Social sciences (General), H1-99

الوصف: The imidazole nucleus represents a significant group of heterocyclic molecules with diverse significance in the modern world due to its exploration potential and various pharmacological applications. The relevance of imidazole and its derivatives has gained popularity in recent years, especially in the production of commercial drugs and the treatment of various conditions. The imidazole nucleus is present in many natural compounds and widely distributed in essential amino acids, such as l-histidine, whose derivatives exhibit powerful pharmacological properties. In this review, we delve into the historical timeline and development of synthetic pathways for tri- and tetra-substituted imidazoles used in the renowned Radziszewski reaction. Furthermore, we explore various bacteriological applications documented in the literature, as well as current advances in preclinical approaches to imidazole-based drug discovery. Tri- or tetra-substituted imidazole derivatives show strong potential for new synthesis methods, such as reflux or microwave, as well as various biological activities.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2405844024072840Test; https://doaj.org/toc/2405-8440Test

الوصول الحر: https://doaj.org/article/a698d222c39a493ab1dc0ae3a612c430Test

المؤلفون: Yamila Lebeque-Pérez, Gabriel Llauradó Maury, Manuel de Jesús Serrat Díaz, Paul Cos, Guillermo Antonio Barreto Argilagos

مصطلحات موضوعية: Medicinal Mushrooms Antitumor and Immunomodulating Properties, Pharmacology, Medicine, Health Sciences, Phyllanthus Research and Pharmacological Applications, Pharmacology, Toxicology and Pharmaceutics, Life Sciences, Pleurotus ostreatus, Biology, Botany, Mushroom

الوصف: Base de datos sobre investigación de ensayo donde se evaluó la citotoxicidad de los bioproductos de Pleurotus ostreatus, por el ensayo de reducción del colorante resazurina, en tres líneas celulares. Se utilizaron células no adherentes THP-1 (pre-monocitos de leucemia humana), células adherentes Caco-2 (epitelio de adenocarcinoma de colon humano) y células adherentes RAW 264.7 (macrófagos murinos). ... : قاعدة بيانات عن أبحاث الفحص حيث تم تقييم السمية الخلوية للمنتجات الحيوية للجنب أوستريتوس، من خلال اختبار اختزال صبغة الريسازورين، في ثلاثة خطوط خلوية. تم استخدام الخلايا غير الملتصقة THP -1 (خلايا اللوكيميا الأولية البشرية)، والخلايا الملتصقة Caco -2 (ظهارة سرطان القولون الغدي البشري)، والخلايا الملتصقة الخام 264.7 (الضامة الفئران). ...

العلاقة: https://dx.doi.org/10.60692/begfd-ftd70Test

الإتاحة: https://doi.org/10.60692/ynaba-6pe6810.60692/begfd-ftd70Test

المؤلفون: Yuliana Mahmuddin, Tahir Muhammad, Rosnah Shamsudin, Olly Sanny Hutabarat, Sudarma Dita Wijayanti

مصطلحات موضوعية: Research on Moringa Oleifera, Plant Science, Agricultural and Biological Sciences, Life Sciences, Phyllanthus Research and Pharmacological Applications, Pharmacology, Pharmacology, Toxicology and Pharmaceutics, Bioactive Limonoids in Medicinal Plants, Molecular Biology, Biochemistry, Genetics and Molecular Biology, Ascorbic acid, Browning, Shelf life, Food science, Horticulture, Chemistry, Biology

الوصف: Langsat (Lansium domesticum) is a tropical fruit classified as a climacteric fruit that can only last 4-6 days after harvesting. Skin colour is easier to brown and black after 4 days of harvesting. This condition does not affect the fruit flesh, but visually, it becomes unappealing. Ascorbic acid and polyethylene plastic packaging could be applied to extend shelf life and slow browning. This study aims to investigate the effect of different concentrations of ascorbic acid treatment and polyethylene plastic (PE) packaging on the browning index and shelf life of lan and to determine the best concentration of ascorbic acid during storage at 15 °C. The treatments used in this study involved immersing langsat fruit in different ascorbic acid concentrations: 1.5%, 2%, and 2.5%, respectively. The langsat fruit was then packaged using polyethylene plastic and stored at 15 °C. The results showed that using ascorbic acid could delay browning by up to 14 days, with the lowest browning index found in langsat fruit ... : Langsat (Lansium domesticum) هي فاكهة استوائية مصنفة على أنها فاكهة مناخية لا يمكن أن تستمر إلا بعد 4-6 أيام من الحصاد. يصبح لون البشرة أسهل للون البني والأسود بعد 4 أيام من الحصاد. لا تؤثر هذه الحالة على لحم الثمرة، ولكن بصريًا، تصبح غير جذابة. يمكن استخدام عبوات حمض الأسكوربيك والبولي إيثيلين البلاستيكية لإطالة العمر الافتراضي وإبطاء اللون البني. تهدف هذه الدراسة إلى التحقيق في تأثير التركيزات المختلفة لمعالجة حمض الأسكوربيك وتغليف البولي إيثيلين (PE) على مؤشر التحمير والعمر الافتراضي للشبكة المحلية وتحديد أفضل تركيز لحمض الأسكوربيك أثناء التخزين عند 15 درجة مئوية. تضمنت العلاجات المستخدمة في هذه الدراسة غمر فاكهة لانغسات بتركيزات مختلفة من حمض الأسكوربيك: 1.5 ٪ و 2 ٪ و 2.5 ٪ على التوالي. ثم تم تغليف ثمرة لانغسات باستخدام بلاستيك البولي إيثيلين وتخزينها عند 15 درجة مئوية. وأظهرت النتائج أن استخدام حمض الأسكوربيك يمكن أن يؤخر اللون البني لمدة تصل إلى 14 يومًا، مع وجود أدنى مؤشر للبني في فاكهة لانغسات مغمورة في تركيز حمض الأسكوربيك بنسبة 2.5 ٪ ومعبأة في بلاستيك البولي إيثيلين. أثرت العبوات البلاستيكية ...

العلاقة: https://dx.doi.org/10.60692/7kxe7-f3104Test

الإتاحة: https://doi.org/10.60692/bzacv-vty7610.60692/7kxe7-f3104Test

المؤلفون: Ahmed Zaghlol, Zeinab A. Kandil, Miriam F. Yousif, Riham Salah El-Dine, Wafaa M. Elkady

مصطلحات موضوعية: Biological Activities of Diterpenoids from Medicinal Plants, Molecular Biology, Biochemistry, Genetics and Molecular Biology, Life Sciences, Phyllanthus Research and Pharmacological Applications, Pharmacology, Pharmacology, Toxicology and Pharmaceutics, Biosynthesis and Pharmacological Activities of Medicinal Natural Products, Medicine, Health Sciences, Phytochemistry, Cytotoxicity, Identification biology, Cancer, Chemistry, Traditional medicine, Biology, Botany, Biochemistry, In vitro, Genetics, FOS Biological sciences

الوصف: Background Different herbal phytochemicals have potential in cancer treatment, Euphorbia genus has valuable secondary metabolites and is used in traditional medicine to treat various ailments. However, the specific constituents and biological activity of Euphorbia greenwayi remain largely unexplored. Results Euphorbia greenwayi aerial parts were extracted using methanol. Consequently, the methanol extract was then fractionated with solvents of different polarities viz., n -hexane, chloroform, and ethyl acetate. All were screened for their cytotoxic activity against different cell lines; MCF-7, HepG-2, and SW620. The n -hexane (HF) and chloroform (CF) fractions showed considerable activity against all tested cell lines especially MCF-7 with IC 50 values at 18.6 ± 0.2 and 17.5 ± 0.6 μg/ml respectively. Therefore, a cell migration assay on the MCF-7 cell line was applied to both fractions as well as investigation and isolation of the main active constituents. Lupeol, β- sitosterol, and cycloartenol ... : نبذة مختصرة المواد الكيميائية النباتية العشبية المختلفة لها إمكانات في علاج السرطان، وجنس Euphorbia يحتوي على مستقلبات ثانوية قيمة ويستخدم في الطب التقليدي لعلاج الأمراض المختلفة. ومع ذلك، فإن المكونات المحددة والنشاط البيولوجي لـ Euphorbia greenwayi لا تزال غير مستكشفة إلى حد كبير. النتائج تم استخراج الأجزاء الهوائية Euphorbia greenwayi باستخدام الميثانول. وبالتالي، تم تجزئة مستخلص الميثانول بعد ذلك بمذيبات ذات أقطاب مختلفة، أي ن - هكسان وكلوروفورم وأسيتات الإيثيل. تم فحص جميعهم لنشاطهم السام للخلايا ضد سلالات الخلايا المختلفة ؛ MCF -7 و HepG -2 و SW620. أظهر كسور n - hexane (HF) والكلوروفورم (CF) نشاطًا كبيرًا ضد جميع خطوط الخلايا التي تم اختبارها وخاصة MCF -7 بقيم IC 50 عند 18.6 ± 0.2 و 17.5 ± 0.6 ميكروغرام/مل على التوالي. لذلك، تم تطبيق اختبار هجرة الخلايا على خط خلية MCF -7 على كلا الجزأين بالإضافة إلى فحص وعزل المكونات النشطة الرئيسية. تم عزل اللوبول وبيتا سيتوستيرول وسيكلوارتينول من الأجزاء غير القطبية من E. greenwayi لأول مرة. الاستنتاجات تُظهر الأجزاء الهوائية Euphorbia greenwayi تأثيرات كبيرة مضادة ...

العلاقة: https://dx.doi.org/10.60692/4tam6-khc15Test

الإتاحة: https://doi.org/10.60692/51gjf-bqy6110.60692/4tam6-khc15Test

المؤلفون: Hamdan Alanzi, Hamoud Alenezi, Oladayo Adeyi, Abiola J. Adeyi, Emmanuel Olusola, Chee‐Yuen Gan, Olusegun Abayomi Olalere

مصطلحات موضوعية: Phyllanthus Research and Pharmacological Applications, Pharmacology, Pharmacology, Toxicology and Pharmaceutics, Life Sciences, Counter-Current Chromatography Techniques, Analytical Chemistry, FOS Chemical sciences, Chemistry, Physical Sciences, Biological Properties of Aloe Vera and Related Compounds, Plant Science, Agricultural and Biological Sciences, Plant Analysis, Reliability semiconductor, Genetic programming, Computer science, Process computing, Reliability engineering, Computational biology, Biology, Engineering, Artificial intelligence, Operating system, Power physics, Physics, Quantum mechanics

الوصف: This study investigates the feasibility of extracting bioactive antioxidants from Phyllantus emblica leaves using a combination of ethanol-water mixture (0-100%) and heat-assisted extraction technology (HAE-T). Operating temperature (30-50°C), solid-to-liquid ratio (1:20-1:60 g/mL), and extraction time (45-180 min) were varied to determine their effects on extract total phenolic content (TPC), yield (EY), and antioxidant activity (AA). The Box-Behnken experimental design (BBD) within response surface methodology (RSM) was employed, with multi-objective process optimization using the desirability function algorithm to find the optimal process variables for maximizing TPC, EY, and AA simultaneously. The extraction process was modeled using BBD-RSM and multi-gene genetic programming (MGGP) algorithm, with model reliability assessed via Monte Carlo simulation. HPLC characterization identified betulinic acid, gallic acid, chlorogenic acid, caffeic acid, ellagic acid, and ferulic acid as bioactive constituents in ... : تبحث هذه الدراسة في جدوى استخلاص مضادات الأكسدة النشطة بيولوجيًا من أوراق الصمة Phyllantus باستخدام مزيج من خليط الإيثانول والماء (0-100 ٪) وتكنولوجيا الاستخلاص بمساعدة الحرارة (HAE - T). تباينت درجة حرارة التشغيل (30-50 درجة مئوية)، ونسبة المادة الصلبة إلى السائل (1:20-1:60 جم/مل)، ووقت الاستخلاص (45-180 دقيقة) لتحديد آثارها على إجمالي محتوى الفينول المستخلص (TPC)، والغلة (EY)، والنشاط المضاد للأكسدة (AA). تم استخدام التصميم التجريبي Box - Behnken (BBD) ضمن منهجية سطح الاستجابة (RSM)، مع تحسين العملية متعددة الأهداف باستخدام خوارزمية وظيفة الرغبة للعثور على متغيرات العملية المثلى لتعظيم TPC و EY و AA في وقت واحد. تمت نمذجة عملية الاستخراج باستخدام خوارزمية BBD - RSM والبرمجة الوراثية متعددة الجينات (MGGP)، مع تقييم موثوقية النموذج عبر محاكاة مونت كارلو. حدد توصيف HPLC حمض البيتولينيك وحمض الغاليك وحمض الكلوروجينيك وحمض الكافيين وحمض الإيلاجيك وحمض الفيروليك كمكونات نشطة بيولوجيًا في المستخلص. وجدت الدراسة أن محلول الإيثانول بنسبة 50 ٪ حقق أفضل كفاءة في الاستخراج. تم تحديد معلمات العملية المثلى للحد الأقصى ...

العلاقة: https://dx.doi.org/10.60692/k11zt-kn167Test

الإتاحة: https://doi.org/10.60692/m4hwk-g0m8010.60692/k11zt-kn167Test

المؤلفون: Alexandra Gaspar-Pintiliescu, Laura M. Stefan, Elena Mihai, Catalina Sanda, Vasile S. Manoiu, Daniela Berger, Oana Craciunescu

مصطلحات موضوعية: Biochemistry, Pharmacology, Biotechnology, Ecology, Cancer, Inorganic Chemistry, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, novel bioactive compound, inhibit cell proliferation, important pharmacological applications, free radical scavenging, fourier transform infrared, div >< p, dead assays showed, agarose gel electrophoresis, 2 cell cultures, tumoral cell migration, heparinase iii indicated, rapana venosa <, bovine heparan sulfate, high antioxidant activity, venosa <, heparan sulfate, spectra indicated, antioxidant activity, vitro <, sulfate content, r <

الوصف: Standards of bovine condroitin sulfate (CS) and heparan sulfate (HS) migrated in similar conditions. 1 –CS; 2 –HS; 3 –GAG; 4—no sample; 5 –CS; 6 –HS; 7,8,9,10—no sample. (DOCX)

العلاقة: https://figshare.com/articles/journal_contribution/Agarose_gel_electrophoresis_of_GAG_extract_from_marine_snail_i_Rapana_venosa_i_before_incubation_with_heparinase_III_Hep_III_and_chondroitinase_ABC_Chase_ABC_/25229236Test

الإتاحة: https://doi.org/10.1371/journal.pone.0297803.s001Test
https://figshare.com/articles/journal_contribution/Agarose_gel_electrophoresis_of_GAG_extract_from_marine_snail_i_Rapana_venosa_i_before_incubation_with_heparinase_III_Hep_III_and_chondroitinase_ABC_Chase_ABC_/25229236Test

المؤلفون: Alexandra Gaspar-Pintiliescu, Laura M. Stefan, Elena Mihai, Catalina Sanda, Vasile S. Manoiu, Daniela Berger, Oana Craciunescu

مصطلحات موضوعية: Biochemistry, Pharmacology, Biotechnology, Ecology, Cancer, Inorganic Chemistry, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, novel bioactive compound, inhibit cell proliferation, important pharmacological applications, free radical scavenging, fourier transform infrared, div >< p, dead assays showed, agarose gel electrophoresis, 2 cell cultures, tumoral cell migration, heparinase iii indicated, rapana venosa <, bovine heparan sulfate, high antioxidant activity, venosa <, heparan sulfate, spectra indicated, antioxidant activity, vitro <, sulfate content, r <

الوصف: 1—plant polysaccharides; 2 - plant polysaccharides; 3 –CS; 4 –HS; 5—no sample; 6—GAG+HepIII; 7—GAG+ChaseABC; 8, 9, 10—no sample. (DOCX)

العلاقة: https://figshare.com/articles/journal_contribution/Agarose_gel_electrophoresis_of_GAG_extract_from_marine_snail_i_Rapana_venosa_i_after_incubation_with_heparinase_III_Hep_III_and_chondroitinase_ABC_Chase_ABC_/25229239Test

الإتاحة: https://doi.org/10.1371/journal.pone.0297803.s002Test
https://figshare.com/articles/journal_contribution/Agarose_gel_electrophoresis_of_GAG_extract_from_marine_snail_i_Rapana_venosa_i_after_incubation_with_heparinase_III_Hep_III_and_chondroitinase_ABC_Chase_ABC_/25229239Test

المؤلفون: Radhia Aitfella Lahlou, Filomena Carvalho, Maria João Pereira, João Lopes, Luís R. Silva

المصدر: Pharmaceutics, Vol 16, Iss 4, p 454 (2024)

مصطلحات موضوعية: Natural Park of Serra da Estrela, botanical diversity, medicinal plants, diabetes prevention, pharmacological applications, chemical composition, Pharmacy and materia medica, RS1-441

الوصف: The Serra da Estrela Natural Park (NPSE) in Portugal stands out as a well-preserved region abundant in medicinal plants, particularly known for their pharmaceutical applications in diabetes prevention and treatment. This comprehensive review explores these plants’ botanical diversity, traditional uses, pharmacological applications, and chemical composition. The NPSE boast a rich diversity with 138 medicinal plants across 55 families identified as traditionally and pharmacologically used against diabetes globally. Notably, the Asteraceae and Lamiaceae families are prevalent in antidiabetic applications. In vitro studies have revealed their significant inhibition of carbohydrate-metabolizing enzymes, and certain plant co-products regulate genes involved in carbohydrate metabolism and insulin secretion. In vivo trials have demonstrated antidiabetic effects, including glycaemia regulation, insulin secretion, antioxidant activity, and lipid profile modulation. Medicinal plants in NPSE exhibit various activities beyond antidiabetic, such as antioxidant, anti-inflammatory, antibacterial, anti-cancer, and more. Chemical analyses have identified over fifty compounds like phenolic acids, flavonoids, terpenoids, and polysaccharides responsible for their efficacy against diabetes. These findings underscore the potential of NPSE medicinal plants as antidiabetic candidates, urging further research to develop effective plant-based antidiabetic drugs, beverages, and supplements.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/1999-4923/16/4/454Test; https://doaj.org/toc/1999-4923Test

الوصول الحر: https://doaj.org/article/aed0e07c4301486fac9434019d9cd074Test