المؤلفون: Mateus S. Lopes, Gabriel B. Baptistella, Giovana G. Nunes, Matheus V. Ferreira, Joice Maria Cunha, Kauê Marcel de Oliveira, Alexandra Acco, Maria Luiza C. Lopes, Alexessander Couto Alves, Glaucio Valdameri, Vivian R. Moure, Geraldo Picheth, Graciele C. M. Manica, Fabiane G. M. Rego

المصدر: Pharmaceuticals, Vol 17, Iss 4, p 486 (2024)

مصطلحات موضوعية: oxidovanadium(IV), vanadium, STZ-induced diabetic rats, adjunctive to insulin therapies, treatment efficacy, Medicine, Pharmacy and materia medica, RS1-441

الوصف: Diabetes mellitus (DM) complications are a burden to health care systems due to the associated consequences of poor glycemic control and the side effects of insulin therapy. Recently. adjuvant therapies, such as vanadium compounds, have gained attention due to their potential to improve glucose homeostasis in patients with diabetes. In order to determine the anti-diabetic and antioxidant effects of the oxidovanadium(IV) complex (Et3NH)2[{VO(OH}2)(ox)2(µ–ox)] or Vox2), rats with streptozotocin (STZ)-induced diabetes were treated with 30 and 100 mg/kg of Vox2, orally administered for 12 days. Vox2 at 100 mg/kg in association with insulin caused a 3.4 times decrease in blood glucose in STZ rats (424 mg/dL), reaching concentrations similar to those in the normoglycemic animals (126 mg/dL). Compared to insulin alone, the association with Vox2 caused an additional decrease in blood glucose of 39% and 65% at 30 and 100 mg/kg, respectively, and an increased pancreatic GSH levels 2.5 times. Vox2 alone did not cause gastrointestinal discomfort, diarrhea, and hepatic or renal toxicity and was not associated with changes in blood glucose level, lipid profile, or kidney or liver function. Our results highlight the potential of Vox2 in association with insulin in treating diabetes.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/1424-8247/17/4/486Test; https://doaj.org/toc/1424-8247Test

الوصول الحر: https://doaj.org/article/e83ef2c85677421784bbdc5685a2402eTest

المؤلفون: Restrepo Guerrero, Andrés Gonzalo, Goitía, Helen, Naso, Luciana Gissella, Rey, Marilin, Gonzalez, Pablo Javier, Ferrer, Evelina Gloria, Williams, Patricia Ana María

مصطلحات موضوعية: Ciencias Exactas, Química, glycosylated flavonoid, oxidovanadium(IV) complex, antitumoral, antioxidant

الوصف: The complex of oxidovanadium(IV) with naringin (Narg) [VO(Narg)₂] 8H₂O (VONarg) was prepared according to the literature improving the synthetic procedure and physicochemical characterization. In addition, biological activities (cytotoxic, antioxidant, and BSA interaction) were determined. The metal coordinated through the 5-hydroxy and 4-carbonyl groups of rings A and C of naringin, respectively. The antioxidant activity of VONarg, determined in vitro, was higher than those of the flavonoid against superoxide and peroxyl reactive oxygen species (ROS) and DPPH radical. The cytotoxic properties were determined by a MTT assay on adenocarcinoma human alveolar basal epithelial cells (A549). VONarg exerted a 20% decrease in cancer cells viability at 24 h incubation, while naringin and oxidovanadium(IV) cation did not show cytotoxicity. Measurements with the normal HEK293 cell line showed that the inhibitory action of the complex is selective. VONarg generated intracellular reactive oxygen species (ROS), depletion of reduced glutathione and depolarization of mitochondrial membrane potential, typical for apoptotic pathway, producing cell death by oxidative stress mechanism. Moreover, naringin interacted with bovine serum albumin (BSA) through hydrophobic interactions in a spontaneous process, and VONarg showed greater affinity for the protein but can still be transported and delivered by it (Kₐ 10⁴ L⋅mol⁻¹ order). ; Centro de Química Inorgánica

وصف الملف: application/pdf

العلاقة: http://sedici.unlp.edu.ar/handle/10915/155666Test

الإتاحة: http://sedici.unlp.edu.ar/handle/10915/155666Test

المؤلفون: Cappai R., Fantasia A., Crisponi G., Garribba E., Santos M. A., Nurchi V. M.

المساهمون: Cappai, R., Fantasia, A., Crisponi, G., Garribba, E., Santos, M. A., Nurchi, V. M.

مصطلحات موضوعية: Deferiprone, EPR spectroscopy, Oxidovanadium (IV), Potentiometry, UV spectrophotometry

الوصف: The increasing biomedical interest in high-stability oxidovanadium(IV) complexes with hydroxypyridinone ligands leads us to investigate the complex formation equilibria of VIVO2+ ion with a tetradentate ligand, named KC21, which contains two 3-hydroxy-1,2-dimethylpyridin-4(1H)-one (deferiprone) moieties, and with the simple bidentate ligand that constitutes the basic unit of KC21, for comparison, named L5. These equilibrium studies were conducted with joined potentiometric– spectrophotometric titrations, and the results were substantiated with EPR measurements at variable pH values. This multi-technique study gave evidence of the formation of an extremely stable 1:1 complex between KC21 and oxidovanadium(IV) at a physiological pH, which could find promising pharmacological applications.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/35268654; info:eu-repo/semantics/altIdentifier/wos/WOS:000771437600001; volume:27; issue:5; firstpage:1; lastpage:11; numberofpages:11; journal:MOLECULES; https://hdl.handle.net/11584/329394Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85125191918

الإتاحة: https://doi.org/10.3390/molecules27051555Test
https://hdl.handle.net/11584/329394Test

المؤلفون: Ribeiro, Nádia, Bulut, Ipek, Pósa, Vivien, Sergi, Baris, Sciortino, Giuseppe, Pessoa, João Costa, Maia, Luísa B., Ugone, Valeria, Garribba, Eugenio, Enyedy, Éva A., Acilan, Ceyda, Correia, Isabel

المساهمون: LAQV@REQUIMTE

مصطلحات موضوعية: 8-hydroxyquinoline derivatives, Anticancer, Oxidovanadium(IV) complexes, Schiff bases, Solution stability, Speciation, Biochemistry, Inorganic Chemistry, SDG 3 - Good Health and Well-being

الوصف: Funding Information: This work was supported by Centro de Química Estrutural, which is financed by national funds from Fundação para a Ciência e Tecnologia (FCT), projects UIDB/00100/2020, UIDP/00100/2020 and LA/P/0056/2020, and Programa Operacional Regional de Lisboa 2020. We also thank project PTDC/QUI-QIN/0586/2020 and N. Ribeiro acknowledges FCT for SFRH/BD/135797/2018 grant. The Portuguese NMR and Mass spectrometry IST-UL are acknowledged for the access to the equipment. This work was supported by the Portuguese-Hungarian Scientific & Technological CooperationTÉT-PT-2018-00002, ÚNKP-21-3-SZTE-455 (to V. Pósa) New National Excellence Program Ministry of Human Capacities. The support of the ‘Lendület’ Programme (ELKH, LP2019-6/2019) and the COST ActionCA18202, NECTAR-Network for Equilibria and Chemical Thermodynamics Advanced Research is also acknowledged. This work was also supported by Koç University School of Medicine (KUSOM) and the authors gratefully acknowledge use of the services and facilities of the Koç University Research Center for Translational Medicine (KUTTAM), funded by the Presidency of Turkey, Presidency of Strategy and Budget. The content is solely the responsibility of the authors and does not necessarily represent the official views of the Presidency of Strategy and Budget. G. Sciortino, V. Ugone, E. Garribba thank Fondazione di Sardegna (grant FdSGarribba2017) and Regione Autonoma della Sardegna (grant RASSR79857); G. Sciortino also thanks MICINN’ Juan de la Cierva program, FJC2019-039135-I for the financial support. L. Maia thanks the Associate Laboratory for Green Chemistry - LAQV, which is financed by national funds from Fundação para a Ciência e a Tecnologia, MCTES (FCT/MCTES; UIDB/50006/2020 and UIDP/50006/2020). Funding Information: This work was supported by Centro de Química Estrutural , which is financed by national funds from Fundação para a Ciência e Tecnologia (FCT), projects UIDB/00100/2020 , UIDP/00100/2020 and LA/P/0056/2020 , and Programa Operacional Regional de Lisboa ...

العلاقة: PURE: 46465533; PURE UUID: 612dbd86-4b63-44f5-8fd8-43363190ccc7; Scopus: 85135814611; PubMed: 35940023; WOS: 000848287000001; ORCID: /0000-0002-6901-6591/work/124035673; http://hdl.handle.net/10362/145972Test; https://doi.org/10.1016/j.jinorgbio.2022.111932Test

الإتاحة: https://doi.org/10.1016/j.jinorgbio.2022.111932Test
http://hdl.handle.net/10362/145972Test

المؤلفون: Amal S. Basaleh, Fatimah Y. Alomari, Abeer A. Sharfalddin, Najlaa S. Al-Radadi, Doaa Domyati, Mostafa A. Hussien

المصدر: Molecules; Volume 27; Issue 9; Pages: 2796

مصطلحات موضوعية: oxidovanadium(IV) complexes, imidazole drugs, DFT study, DNA-binding, molecular docking, anticancer activity

جغرافية الموضوع: agris

الوصف: Vanadium compounds have been set in various fields as anticancer, anti-diabetic, anti-parasitic, anti-viral, and anti-bacterial agents. This study reports the synthesis and structural characterization of oxidovanadium(IV)-based imidazole drug complexes by the elemental analyzer, molar conductance, magnetic moment, spectroscopic techniques, as well as thermal analysis. The obtained geometries were studied theoretically using density functional theory (DFT) under the B3LYP level. The DNA-binding nature of the ligands and their synthesized complexes has been studied by the electronic absorption titrations method. The biological studies were carried with in-vivo assays and the molecular docking method. The EPR spectra asserted the geometry around the vanadium center to be a square pyramid for metal complexes. The geometries have been confirmed using DFT under the B3LYP level. Moreover, the quantum parameters proposed promising bioactivity of the oxidovanadium(IV) complexes. The results of the DNA-binding revealed that the investigated complexes bind to DNA via non-covalent mode, and the intrinsic binding constant (Kb) value for the [VO(SO4)(MNZ)2] H2O complex was promising, which was 2.0 × 106 M−1. Additionally, the cytotoxic activity of the synthesized complexes exhibited good inhibition toward both hepatocellular carcinoma (HepG-2) and human breast cancer (HCF-7) cell lines. The results of molecular docking displayed good correlations with experimental cytotoxicity findings. Therefore, these findings suggest that our synthesized complexes can be introduced as effective anticancer agents.

وصف الملف: application/pdf

العلاقة: https://dx.doi.org/10.3390/molecules27092796Test

الإتاحة: https://doi.org/10.3390/molecules27092796Test

المؤلفون: Rosita Cappai, Alessandra Fantasia, Guido Crisponi, Eugenio Garribba, M. Amélia Santos, Valeria Marina Nurchi

المصدر: Molecules; Volume 27; Issue 5; Pages: 1555

مصطلحات موضوعية: oxidovanadium (IV), deferiprone, potentiometry, UV spectrophotometry, EPR spectroscopy

جغرافية الموضوع: agris

الوصف: The increasing biomedical interest in high-stability oxidovanadium(IV) complexes with hydroxypyridinone ligands leads us to investigate the complex formation equilibria of VIVO2+ ion with a tetradentate ligand, named KC21, which contains two 3-hydroxy-1,2-dimethylpyridin-4(1H)-one (deferiprone) moieties, and with the simple bidentate ligand that constitutes the basic unit of KC21, for comparison, named L5. These equilibrium studies were conducted with joined potentiometric–spectrophotometric titrations, and the results were substantiated with EPR measurements at variable pH values. This multi-technique study gave evidence of the formation of an extremely stable 1:1 complex between KC21 and oxidovanadium(IV) at a physiological pH, which could find promising pharmacological applications.

وصف الملف: application/pdf

العلاقة: Medicinal Chemistry; https://dx.doi.org/10.3390/molecules27051555Test

الإتاحة: https://doi.org/10.3390/molecules27051555Test

المؤلفون: Fatimah Y. Alomari, Abeer A. Sharfalddin, Magda H. Abdellattif, Doaa Domyati, Amal S. Basaleh, Mostafa A. Hussien

المصدر: Molecules; Volume 27; Issue 3; Pages: 649

مصطلحات موضوعية: oxidovanadium(IV) complexes, DFT modeling, DNA binding, docking, QSAR study

جغرافية الموضوع: agris

الوصف: Four new drug-based oxidovanadium (IV) complexes were synthesized and characterized by various spectral techniques, including molar conductance, magnetic measurements, and thermogravimetric analysis. Moreover, optimal structures geometry for all syntheses was obtained by the Gaussian09 program via the DFT/B3LYP method and showed that all of the metal complexes adopted a square-pyramidal structure. The essential parameters, electrophilicity (ω) value and expression for the maximum charge that an electrophile molecule may accept (ΔNmax) showed the practical biological potency of [VO(CTZ)2] 2H2O. The complexes were also evaluated for their propensity to bind to DNA through UV–vis absorption titration. The result revealed a high binding ability of the [VO(CTZ)2] 2H2O complex with Kb = 1.40 × 10⁶ M−1. Furthermore, molecular docking was carried out to study the behavior of the VO (II) complexes towards colon cancer cell (3IG7) protein. A quantitative structure–activity relationship (QSAR) study was also implemented for the newly synthesized compounds. The results of validation indicate that the generated QSAR model possessed a high predictive power (R2 = 0.97). Within the investigated series, the [VO(CTZ)2] 2H2O complex showed the greatest potential the most selective compound comparing to the stander chemotherapy drug.

وصف الملف: application/pdf

العلاقة: Applied Chemistry; https://dx.doi.org/10.3390/molecules27030649Test

الإتاحة: https://doi.org/10.3390/molecules27030649Test

المؤلفون: Cappai R., Crisponi G., Sanna D., Ugone V., Melchior A., Garribba E., Peana M., Zoroddu M. A., Nurchi V. M.

المساهمون: Cappai, R., Crisponi, G., Sanna, D., Ugone, V., Melchior, A., Garribba, E., Peana, M., Zoroddu, M. A., Nurchi, V. M.

مصطلحات موضوعية: DFT calculation, EPR spectroscopy, ESI-MS spectrometry, Kojic acid, Oxidovanadium(IV), Potentiometry, UV-visible spectrophotometry

الوصف: The good chelating properties of hydroxypyrone (HPO) derivatives towards oxidovanadium(IV) cation, VIVO2+, constitute the precondition for the development of new insulinmimetic and anticancer compounds. In the present work, we examined the VIVO2+ complex formation equilibria of two kojic acid (KA) derivatives, L4 and L9, structurally constituted by two kojic acid units linked in position 6 through methylene diamine and diethyl-ethylenediamine, respectively. These chemical systems have been characterized in solution by the combined use of various complementary techniques, as UV-vis spectrophotometry, potentiometry, NMR and EPR spectroscopy, ESI-MS spectrometry, and DFT calculations. The thermodynamic approach allowed proposing a chemical coordination model and the calculation of the complex formation constants. Both ligands L4 and L9 form 1:1 binuclear complexes at acidic and physiological pHs, with various protonation degrees in which two KA units coordinate each VIVO2+ ion. The joined use of different techniques allowed reaching a coherent vision of the complexation models of the two ligands toward oxidovanadium(IV) ion in aqueous solution. The high stability of the formed species and the binuclear structure may favor their biological action, and represent a good starting point toward the design of new pharmacologically active vanadium species.

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000716361800001; volume:14; issue:10; firstpage:1037; journal:PHARMACEUTICALS; http://hdl.handle.net/11390/1214032Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85117596126

الإتاحة: https://doi.org/10.3390/ph14101037Test
http://hdl.handle.net/11390/1214032Test

المؤلفون: Shohei Yamamoto (422221), Ryoji Mitsuhashi (1918183), Masahiro Mikuriya (2022271), Masayuki Koikawa (556252), Hiroshi Sakiyama (2106628)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Infectious Diseases, Plant Biology, Computational Biology, Chemical Sciences not elsewhere classified, Oxidovanadium(IV) complex, dimethylformamide ligand, magnetic properties, conformational prediction, density functional theory (DFT)

الوصف: Pentakis(dimethylformamide- κO )oxidovanadium(IV) bis(hexafluoridophosphate), [VO(dmf) 5 ][PF 6 ] 2 (dmf: dimethylformamide), was synthesized, and its crystal structure was revealed by a single-crystal X-ray method. The [VO(dmf) 5 ] 2+ complex cation dimerized in the crystal, and a weak ferromagnetic interaction was attributed to the dimerized structure. In addition, conformational prediction was successfully conducted using the enumeration result on the basis of group theory. As a result, a reasonable monomer structure of the defect- S 6 symmetry was obtained as the most stable structure in dilute solution; in addition, a dimer structure was predicted as the structure in a crystal.

العلاقة: https://figshare.com/articles/journal_contribution/Crystal_structure_magnetic_properties_and_structural_prediction_for_an_oxidovanadium_IV_complex_VO_dmf_sub_5_sub_PF_sub_6_sub_sub_2_sub_/14161853Test

الإتاحة: https://doi.org/10.6084/m9.figshare.14161853.v1Test

المؤلفون: Agustin Actis Dato, Luciana G. Naso, Marilin Rey, Pablo J. Gonzalez, Evelina G. Ferrer, Patricia A. M. Williams

المصدر: Inorganics; Volume 10; Issue 1; Pages: 4

مصطلحات موضوعية: oxidovanadium(IV) phenantrholine chrysin, vanadium cellular uptake, anticancer, albumin interaction

الوصف: Metal complexation in general improves the biological properties of ligands. We have previously measured the anticancer effects of the oxidovanadium(IV) cation with chrysin complex, VO(chrys)2. In the present study, we synthesized and characterized a new complex generated by the replacement of one chrysin ligand by phenanthroline (phen), VO(chrys)phenCl, to confer high planarity for DNA chain intercalation and more lipophilicity, giving rise to a better cellular uptake. In effect, the uptake of vanadium has been increased in the complex with phen and the cytotoxic effect of this complex proved higher in the human lung cancer A549 cell line, being involved in its mechanisms of action, the production of cellular reactive oxygen species (ROS), the decrease of the natural antioxidant compound glutathione (GSH) and the ratio GSH/GSSG (GSSG, oxidized GSH), and mitochondrial membrane damage. Cytotoxic activity studies using the non-tumorigenic HEK293 cell line showed that [VO(chrys)phenCl] exhibits selectivity action towards A549 cells after 24 h incubation. The interaction with bovine serum albumin (BSA) by fluorometric determinations showed that the complex could be carried by the protein and that the binding of the complex to BSA occurs through H-bond and van der Waals interactions.

وصف الملف: application/pdf

العلاقة: Bioinorganic Chemistry; https://dx.doi.org/10.3390/inorganics10010004Test

الإتاحة: https://doi.org/10.3390/inorganics10010004Test