المؤلفون: Arthur Borderie, Anne Caclin, Jean-Philippe Lachaux, Marcela Perrone-Bertollotti, Roxane S. Hoyer, Philippe Kahane, Hélène Catenoix, Barbara Tillmann, Philippe Albouy

مصطلحات موضوعية: Neuroscience, Physiology, Mental Health, Biological Sciences not elsewhere classified, superior temporal sulcus, regions across participants, machine learning analysis, intracranial eeg data, inferior temporal gyrus, inferior frontal gyrus, gamma bursts restricted, successful task performance, manipulated task difficulty, hippocampal networks enables, silent retention period, global neural code, global biological mechanism, consistent phase coupling, incorrect memory trials, sequential auditory information, hippocampal networks supports, term memory performance, term retention, sample task, hippocampal activity, term memory, neural excitability, mechanism acts, information processing, frequency coupling

الوصف: Theta (orange) and gamma (red) magnitude averaged over SEEG contacts located in regions showing increased power relative to baseline during retention presented as a function of task (memory, perception).

العلاقة: https://figshare.com/articles/journal_contribution/Theta_orange_and_gamma_red_magnitude_averaged_over_SEEG_contacts_located_in_regions_showing_increased_power_relative_to_baseline_during_retention_presented_as_a_function_of_task_memory_perception_/25344577Test

الإتاحة: https://doi.org/10.1371/journal.pbio.3002512.s002Test
https://figshare.com/articles/journal_contribution/Theta_orange_and_gamma_red_magnitude_averaged_over_SEEG_contacts_located_in_regions_showing_increased_power_relative_to_baseline_during_retention_presented_as_a_function_of_task_memory_perception_/25344577Test

المؤلفون: Arthur Borderie, Anne Caclin, Jean-Philippe Lachaux, Marcela Perrone-Bertollotti, Roxane S. Hoyer, Philippe Kahane, Hélène Catenoix, Barbara Tillmann, Philippe Albouy

مصطلحات موضوعية: Neuroscience, Physiology, Mental Health, Biological Sciences not elsewhere classified, superior temporal sulcus, regions across participants, machine learning analysis, intracranial eeg data, inferior temporal gyrus, inferior frontal gyrus, gamma bursts restricted, successful task performance, manipulated task difficulty, hippocampal networks enables, silent retention period, global neural code, global biological mechanism, consistent phase coupling, incorrect memory trials, sequential auditory information, hippocampal networks supports, term memory performance, term retention, sample task, hippocampal activity, term memory, neural excitability, mechanism acts, information processing, frequency coupling

الوصف: It has been suggested that cross-frequency coupling in cortico-hippocampal networks enables the maintenance of multiple visuo-spatial items in working memory. However, whether this mechanism acts as a global neural code for memory retention across sensory modalities remains to be demonstrated. Intracranial EEG data were recorded while drug-resistant patients with epilepsy performed a delayed matched-to-sample task with tone sequences. We manipulated task difficulty by varying the memory load and the duration of the silent retention period between the to-be-compared sequences. We show that the strength of theta-gamma phase amplitude coupling in the superior temporal sulcus, the inferior frontal gyrus, the inferior temporal gyrus, and the hippocampus (i) supports the short-term retention of auditory sequences; (ii) decodes correct and incorrect memory trials as revealed by machine learning analysis; and (iii) is positively correlated with individual short-term memory performance. Specifically, we show that successful task performance is associated with consistent phase coupling in these regions across participants, with gamma bursts restricted to specific theta phase ranges corresponding to higher levels of neural excitability. These findings highlight the role of cortico-hippocampal activity in auditory short-term memory and expand our knowledge about the role of cross-frequency coupling as a global biological mechanism for information processing, integration, and memory in the human brain.

العلاقة: https://figshare.com/articles/journal_contribution/Regions_and_coordinates_Fig_1D_Heschl_s_gyrus_/25344586Test

الإتاحة: https://doi.org/10.1371/journal.pbio.3002512.s005Test
https://figshare.com/articles/journal_contribution/Regions_and_coordinates_Fig_1D_Heschl_s_gyrus_/25344586Test

المؤلفون: Arthur Borderie, Anne Caclin, Jean-Philippe Lachaux, Marcela Perrone-Bertollotti, Roxane S. Hoyer, Philippe Kahane, Hélène Catenoix, Barbara Tillmann, Philippe Albouy

مصطلحات موضوعية: Neuroscience, Physiology, Mental Health, Biological Sciences not elsewhere classified, superior temporal sulcus, regions across participants, machine learning analysis, intracranial eeg data, inferior temporal gyrus, inferior frontal gyrus, gamma bursts restricted, successful task performance, manipulated task difficulty, hippocampal networks enables, silent retention period, global neural code, global biological mechanism, consistent phase coupling, incorrect memory trials, sequential auditory information, hippocampal networks supports, term memory performance, term retention, sample task, hippocampal activity, term memory, neural excitability, mechanism acts, information processing, frequency coupling

الوصف: Left panel: SEEG contacts showing a positive (hot colormap) and negative (blue colormap) relationship between theta-gamma PAC and performance using data from conditions performed by all 16 participants (6 tones encoding 2 s retention and 6 tones encoding 8 s retention). Results are displayed on the single subject T1 in the MNI space provided by SPM12. (PDF)

العلاقة: https://figshare.com/articles/journal_contribution/Theta-gamma_PAC_in_the_hippocampus_and_ventral_auditory_stream_correlates_with_behavior_/25344583Test

الإتاحة: https://doi.org/10.1371/journal.pbio.3002512.s004Test
https://figshare.com/articles/journal_contribution/Theta-gamma_PAC_in_the_hippocampus_and_ventral_auditory_stream_correlates_with_behavior_/25344583Test

المؤلفون: Arthur Borderie, Anne Caclin, Jean-Philippe Lachaux, Marcela Perrone-Bertollotti, Roxane S. Hoyer, Philippe Kahane, Hélène Catenoix, Barbara Tillmann, Philippe Albouy

مصطلحات موضوعية: Neuroscience, Physiology, Mental Health, Biological Sciences not elsewhere classified, superior temporal sulcus, regions across participants, machine learning analysis, intracranial eeg data, inferior temporal gyrus, inferior frontal gyrus, gamma bursts restricted, successful task performance, manipulated task difficulty, hippocampal networks enables, silent retention period, global neural code, global biological mechanism, consistent phase coupling, incorrect memory trials, sequential auditory information, hippocampal networks supports, term memory performance, term retention, sample task, hippocampal activity, term memory, neural excitability, mechanism acts, information processing, frequency coupling

الوصف: Memory minus perception (the colormap represents the difference in PAC strength between memory and perception trial—note that the contrast is not significant) for the co-modulogram in SEEG contacts that had previously shown an increase in theta and gamma power identified in Fig 1F , retention period).

العلاقة: https://figshare.com/articles/journal_contribution/Memory_minus_perception_the_colormap_represents_the_difference_in_PAC_strength_between_memory_and_perception_trial_note_that_the_contrast_is_not_significant_for_the_co-modulogram_in_SEEG_contacts_that_had_previously_shown_an_increase_in_the/25344580Test

الإتاحة: https://doi.org/10.1371/journal.pbio.3002512.s003Test
https://figshare.com/articles/journal_contribution/Memory_minus_perception_the_colormap_represents_the_difference_in_PAC_strength_between_memory_and_perception_trial_note_that_the_contrast_is_not_significant_for_the_co-modulogram_in_SEEG_contacts_that_had_previously_shown_an_increase_in_the/25344580Test

المؤلفون: Arthur Borderie, Anne Caclin, Jean-Philippe Lachaux, Marcela Perrone-Bertollotti, Roxane S. Hoyer, Philippe Kahane, Hélène Catenoix, Barbara Tillmann, Philippe Albouy

مصطلحات موضوعية: Neuroscience, Physiology, Mental Health, Biological Sciences not elsewhere classified, superior temporal sulcus, regions across participants, machine learning analysis, intracranial eeg data, inferior temporal gyrus, inferior frontal gyrus, gamma bursts restricted, successful task performance, manipulated task difficulty, hippocampal networks enables, silent retention period, global neural code, global biological mechanism, consistent phase coupling, incorrect memory trials, sequential auditory information, hippocampal networks supports, term memory performance, term retention, sample task, hippocampal activity, term memory, neural excitability, mechanism acts, information processing, frequency coupling

الوصف: It has been suggested that cross-frequency coupling in cortico-hippocampal networks enables the maintenance of multiple visuo-spatial items in working memory. However, whether this mechanism acts as a global neural code for memory retention across sensory modalities remains to be demonstrated. Intracranial EEG data were recorded while drug-resistant patients with epilepsy performed a delayed matched-to-sample task with tone sequences. We manipulated task difficulty by varying the memory load and the duration of the silent retention period between the to-be-compared sequences. We show that the strength of theta-gamma phase amplitude coupling in the superior temporal sulcus, the inferior frontal gyrus, the inferior temporal gyrus, and the hippocampus (i) supports the short-term retention of auditory sequences; (ii) decodes correct and incorrect memory trials as revealed by machine learning analysis; and (iii) is positively correlated with individual short-term memory performance. Specifically, we show that successful task performance is associated with consistent phase coupling in these regions across participants, with gamma bursts restricted to specific theta phase ranges corresponding to higher levels of neural excitability. These findings highlight the role of cortico-hippocampal activity in auditory short-term memory and expand our knowledge about the role of cross-frequency coupling as a global biological mechanism for information processing, integration, and memory in the human brain.

العلاقة: https://figshare.com/articles/journal_contribution/Post_hoc_tests_of_Fig_5C_Right_ITG_/25344613Test

الإتاحة: https://doi.org/10.1371/journal.pbio.3002512.s014Test
https://figshare.com/articles/journal_contribution/Post_hoc_tests_of_Fig_5C_Right_ITG_/25344613Test

المؤلفون: Arthur Borderie, Anne Caclin, Jean-Philippe Lachaux, Marcela Perrone-Bertollotti, Roxane S. Hoyer, Philippe Kahane, Hélène Catenoix, Barbara Tillmann, Philippe Albouy

مصطلحات موضوعية: Neuroscience, Physiology, Mental Health, Biological Sciences not elsewhere classified, superior temporal sulcus, regions across participants, machine learning analysis, intracranial eeg data, inferior temporal gyrus, inferior frontal gyrus, gamma bursts restricted, successful task performance, manipulated task difficulty, hippocampal networks enables, silent retention period, global neural code, global biological mechanism, consistent phase coupling, incorrect memory trials, sequential auditory information, hippocampal networks supports, term memory performance, term retention, sample task, hippocampal activity, term memory, neural excitability, mechanism acts, information processing, frequency coupling

الوصف: ( A ) T-values in the time-frequency domain ( t test relative to baseline −1,000 to 0 before stimulus onset, FDR corrected in time and frequency domains) of SEEG contacts located in the right and left Heschl’s gyrus (displayed on the single subject T1 in the MNI space provided by SPM12) for a trial time window (−1,000 to 6,000 ms) for the condition 6-tone memory load, 2 s retention period ( n = 5). ( B ) T-values in the time-frequency domain ( t test relative to baseline −1,000 to 0 before stimulus onset, FDR corrected in time and frequency domains) of SEEG contacts located in the right and left hippocampus (displayed on the single subject T1 in the MNI space provided by SPM12) for a trial time window (−1,000 to 6,000 ms) for the condition 6-tone memory load, 2 s retention period ( n = 14). (PDF)

العلاقة: https://figshare.com/articles/journal_contribution/Brain_oscillations_displayed_with_a_logarithmic_scale_for_the_frequency_axis_/25344574Test

الإتاحة: https://doi.org/10.1371/journal.pbio.3002512.s001Test
https://figshare.com/articles/journal_contribution/Brain_oscillations_displayed_with_a_logarithmic_scale_for_the_frequency_axis_/25344574Test

المؤلفون: Arthur Borderie, Anne Caclin, Jean-Philippe Lachaux, Marcela Perrone-Bertollotti, Roxane S. Hoyer, Philippe Kahane, Hélène Catenoix, Barbara Tillmann, Philippe Albouy

مصطلحات موضوعية: Neuroscience, Physiology, Mental Health, Biological Sciences not elsewhere classified, superior temporal sulcus, regions across participants, machine learning analysis, intracranial eeg data, inferior temporal gyrus, inferior frontal gyrus, gamma bursts restricted, successful task performance, manipulated task difficulty, hippocampal networks enables, silent retention period, global neural code, global biological mechanism, consistent phase coupling, incorrect memory trials, sequential auditory information, hippocampal networks supports, term memory performance, term retention, sample task, hippocampal activity, term memory, neural excitability, mechanism acts, information processing, frequency coupling

الوصف: Regions and coordinates Fig 1E : Hippocampal regions.

العلاقة: https://figshare.com/articles/journal_contribution/Regions_and_coordinates_Fig_1E_Hippocampal_regions_/25344589Test

الإتاحة: https://doi.org/10.1371/journal.pbio.3002512.s006Test
https://figshare.com/articles/journal_contribution/Regions_and_coordinates_Fig_1E_Hippocampal_regions_/25344589Test

المؤلفون: Arthur Borderie, Anne Caclin, Jean-Philippe Lachaux, Marcela Perrone-Bertollotti, Roxane S. Hoyer, Philippe Kahane, Hélène Catenoix, Barbara Tillmann, Philippe Albouy

مصطلحات موضوعية: Neuroscience, Physiology, Mental Health, Biological Sciences not elsewhere classified, superior temporal sulcus, regions across participants, machine learning analysis, intracranial eeg data, inferior temporal gyrus, inferior frontal gyrus, gamma bursts restricted, successful task performance, manipulated task difficulty, hippocampal networks enables, silent retention period, global neural code, global biological mechanism, consistent phase coupling, incorrect memory trials, sequential auditory information, hippocampal networks supports, term memory performance, term retention, sample task, hippocampal activity, term memory, neural excitability, mechanism acts, information processing, frequency coupling

الوصف: Regions and coordinates Fig 2B : PAC memory vs. perception L, Left; R, Right; Sup, Superior; Mid, Middle; Inf, Inferior.

العلاقة: https://figshare.com/articles/journal_contribution/Regions_and_coordinates_Fig_2B_PAC_memory_vs_perception_L_Left_R_Right_Sup_Superior_Mid_Middle_Inf_Inferior_/25344592Test

الإتاحة: https://doi.org/10.1371/journal.pbio.3002512.s007Test
https://figshare.com/articles/journal_contribution/Regions_and_coordinates_Fig_2B_PAC_memory_vs_perception_L_Left_R_Right_Sup_Superior_Mid_Middle_Inf_Inferior_/25344592Test

المؤلفون: Arthur Borderie, Anne Caclin, Jean-Philippe Lachaux, Marcela Perrone-Bertollotti, Roxane S. Hoyer, Philippe Kahane, Hélène Catenoix, Barbara Tillmann, Philippe Albouy

مصطلحات موضوعية: Neuroscience, Physiology, Mental Health, Biological Sciences not elsewhere classified, superior temporal sulcus, regions across participants, machine learning analysis, intracranial eeg data, inferior temporal gyrus, inferior frontal gyrus, gamma bursts restricted, successful task performance, manipulated task difficulty, hippocampal networks enables, silent retention period, global neural code, global biological mechanism, consistent phase coupling, incorrect memory trials, sequential auditory information, hippocampal networks supports, term memory performance, term retention, sample task, hippocampal activity, term memory, neural excitability, mechanism acts, information processing, frequency coupling

الوصف: It has been suggested that cross-frequency coupling in cortico-hippocampal networks enables the maintenance of multiple visuo-spatial items in working memory. However, whether this mechanism acts as a global neural code for memory retention across sensory modalities remains to be demonstrated. Intracranial EEG data were recorded while drug-resistant patients with epilepsy performed a delayed matched-to-sample task with tone sequences. We manipulated task difficulty by varying the memory load and the duration of the silent retention period between the to-be-compared sequences. We show that the strength of theta-gamma phase amplitude coupling in the superior temporal sulcus, the inferior frontal gyrus, the inferior temporal gyrus, and the hippocampus (i) supports the short-term retention of auditory sequences; (ii) decodes correct and incorrect memory trials as revealed by machine learning analysis; and (iii) is positively correlated with individual short-term memory performance. Specifically, we show that successful task performance is associated with consistent phase coupling in these regions across participants, with gamma bursts restricted to specific theta phase ranges corresponding to higher levels of neural excitability. These findings highlight the role of cortico-hippocampal activity in auditory short-term memory and expand our knowledge about the role of cross-frequency coupling as a global biological mechanism for information processing, integration, and memory in the human brain.

العلاقة: https://figshare.com/articles/journal_contribution/Post_hoc_tests_of_Fig_5C_Left_hippocampus_/25344610Test

الإتاحة: https://doi.org/10.1371/journal.pbio.3002512.s013Test
https://figshare.com/articles/journal_contribution/Post_hoc_tests_of_Fig_5C_Left_hippocampus_/25344610Test

المؤلفون: Arthur Borderie, Anne Caclin, Jean-Philippe Lachaux, Marcela Perrone-Bertollotti, Roxane S. Hoyer, Philippe Kahane, Hélène Catenoix, Barbara Tillmann, Philippe Albouy

مصطلحات موضوعية: Neuroscience, Physiology, Mental Health, Biological Sciences not elsewhere classified, superior temporal sulcus, regions across participants, machine learning analysis, intracranial eeg data, inferior temporal gyrus, inferior frontal gyrus, gamma bursts restricted, successful task performance, manipulated task difficulty, hippocampal networks enables, silent retention period, global neural code, global biological mechanism, consistent phase coupling, incorrect memory trials, sequential auditory information, hippocampal networks supports, term memory performance, term retention, sample task, hippocampal activity, term memory, neural excitability, mechanism acts, information processing, frequency coupling

الوصف: Regions and coordinates Fig 4A : Correlation between PAC and IES, L, Left; R, Right; Sup, Superior; Mid, Middle; Inf, Inferior; Oper, Opercular.

العلاقة: https://figshare.com/articles/journal_contribution/Regions_and_coordinates_Fig_4A_Correlation_between_PAC_and_IES_L_Left_R_Right_Sup_Superior_Mid_Middle_Inf_Inferior_Oper_Opercular_/25344598Test

الإتاحة: https://doi.org/10.1371/journal.pbio.3002512.s009Test
https://figshare.com/articles/journal_contribution/Regions_and_coordinates_Fig_4A_Correlation_between_PAC_and_IES_L_Left_R_Right_Sup_Superior_Mid_Middle_Inf_Inferior_Oper_Opercular_/25344598Test