المؤلفون: Esti Charlotte de Graaff, Susannah Hopkins Leisher, Hannah Blencowe, Harriet Lawford, Jillian Cassidy, Paul Richard Cassidy, Elizabeth S. Draper, Alexander E. P. Heazell, Mary Kinney, Paula Quigley, Claudia Ravaldi, Claire Storey, Alfredo Vannacci, the E. P. S. in High-Resource Countries Scorecard Collaboration Group, Vicki Flenady

المصدر: BMC Pregnancy and Childbirth, Vol 23, Iss 1, Pp 1-17 (2023)

مصطلحات موضوعية: Stillbirth, High-income countries, High-resource setting, Scorecard, Equity, Stigma, Gynecology and obstetrics, RG1-991

الوصف: Abstract Background Despite progress, stillbirth rates in many high- and upper-middle income countries remain high, and the majority of these deaths are preventable. We introduce the Ending Preventable Stillbirths (EPS) Scorecard for High- and Upper Middle-Income Countries, a tool to track progress against the Lancet’s 2016 EPS Series Call to Action, fostering transparency, consistency and accountability. Methods The Scorecard for EPS in High- and Upper-Middle Income Countries was adapted from the Scorecard for EPS in Low-Income Countries, which includes 20 indicators to track progress against the eight Call to Action targets. The Scorecard for High- and Upper-Middle Income Countries includes 23 indicators tracking progress against these same Call to Action targets. For this inaugural version of the Scorecard, 13 high- and upper-middle income countries supplied data. Data were collated and compared between and within countries. Results Data were complete for 15 of 23 indicators (65%). Five key issues were identified: (1) there is wide variation in stillbirth rates and related perinatal outcomes, (2) definitions of stillbirth and related perinatal outcomes vary widely across countries, (3) data on key risk factors for stillbirth are often missing and equity is not consistently tracked, (4) most countries lack guidelines and targets for critical areas for stillbirth prevention and care after stillbirth and have not set a national stillbirth rate target, and (5) most countries do not have mechanisms in place for reduction of stigma or guidelines around bereavement care. Conclusions This inaugural version of the Scorecard for High- and Upper-Middle Income Countries highlights important gaps in performance indicators for stillbirth both between and within countries. The Scorecard provides a basis for future assessment of progress and can be used to help hold individual countries accountable, especially for reducing stillbirth inequities in disadvantaged groups.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1471-2393Test

الوصول الحر: https://doaj.org/article/3b160b09d2654b29bdc222977f38b457Test

المؤلفون: Daniel Bühl, Olga Staudacher, Sabine Santibanez, Rainer Rossi, Hermann Girschick, Volker Stephan, Beatrix Schmidt, Patrick Hundsdoerfer, Arpad von Moers, Michael Lange, Michael Barker, Marcus A. Mall, Ulrich Heininger, Dorothea Matysiak-Klose, Annette Mankertz, Horst von Bernuth

المصدر: Frontiers in Pediatrics, Vol 10 (2022)

مصطلحات موضوعية: measles, outbreak, immune amnesia, Europe, high resource setting, Pediatrics, RJ1-570

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fped.2022.1005990/fullTest; https://doaj.org/toc/2296-2360Test

الوصول الحر: https://doaj.org/article/212a88ed671c4bef9a559beba95242aeTest

المؤلفون: Daniel Bühl, Olga Staudacher, Sabine Santibanez, Rainer Rossi, Hermann Girschick, Volker Stephan, Beatrix Schmidt, Patrick Hundsdoerfer, Arpad von Moers, Michael Lange, Michael Barker, Marcus A. Mall, Ulrich Heininger, Dorothea Matysiak-Klose, Annette Mankertz, Horst von Bernuth

المصدر: Frontiers in Pediatrics, Vol 10 (2022)

مصطلحات موضوعية: measles, outbreak, immune amnesia, Europe, high resource setting, Pediatrics, RJ1-570

الوصف: ObjectivesPost-measles increased susceptibility to subsequent infections seems particularly relevant in low-resource settings. We tested the hypothesis that measles causes a specifically increased rate of infections in children, also in a high-resource setting.MethodsWe conducted a retrospective cohort study on a large measles outbreak in Berlin, Germany. All children with measles who presented to hospitals in Berlin were included as cases, children with non-infectious and children with non-measles infectious diseases as controls. Repeat visits within 3 years after the outbreak were recorded.ResultsWe included 250 cases, 502 non-infectious, and 498 infectious disease controls. The relative risk for cases for the diagnosis of an infectious disease upon a repeat visit was 1.6 (95% CI 1.4–2.0, p < 0.001) vs. non-infectious and 1.3 (95% CI 1.1–1.6, p = 0.002) vs. infectious disease controls. 33 cases (27%), 35 non-infectious (12%) and 57 (18%) infectious disease controls presented more than three times due to an infectious disease (p = 0.01, and p = 0.02, respectively). This results in a relative risk of more than three repeat visits due to an infection for measles cases of 1.8 (95% CI 1.3–2.4, p = 0.01), and 1.4 (95% CI 1.0–1.9, p = 0.04), respectively.ConclusionOur study demonstrates for the first time in a high-resource setting, that increased post-measles susceptibility to subsequent infections in children is measles-specific—even compared to controls with previous non-measles infections.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fped.2022.896086/fullTest; https://doaj.org/toc/2296-2360Test

الوصول الحر: https://doaj.org/article/6ea3a5c6eff74891931fcb9da63c52daTest

المؤلفون: Bühl, Daniel

المساهمون: male, N.N.

مصطلحات موضوعية: Measles, Outbreak, Immune Amnesia, High resource setting, Europe, ddc:610

الوصف: Die Masern sind trotz Bemühungen der Weltgesundheitsorganisation (WHO) noch nicht eliminiert. Weltweit erkranken jährlich noch immer zwischen 7,5 und 10 Millionen Menschen. Komplikationen einer Maserninfektion umfassen während der akuten Erkrankung bakterielle Superinfektionen und Enzephalitiden. Im weiteren Verlauf tritt eine Schwächung des adaptiven Immunsystems auf. Dieses Phänomen wird als „Immunamnesie“ bezeichnet. Betroffen sind hauptsächlich Kinder. Als Prophylaxe gegen die Maserninfektion wird seit 1960 mit einer attenuierten Lebendvakzine gegen Masern geimpft. Säuglinge, welche aufgrund ihres Alters noch nicht gegen Masern geimpft werden können, sollen als Postexpostionsprophylaxe (PEP) nach Masernexposition Immunglobuline intravenös (IVIG) erhalten. Zur Beantwortung der Frage, ob Masern auch in einem Land mit qualitativ hoher medizinischer Versorgung zu einer für das Masernvirus spezifischen Immunamnesie führen, wurde der Masernausbruch 2014/2015 in Berlin ausgewertet. Im Rahmen einer retrospektiven Kohortenstudie wurden 250 Kinder, die sich während des Ausbruchs mit Masern in einer Berliner Kinderklinik vorstellten als Fälle, sowie 502 Kinder mit nicht- infektiösem und 498 mit infektiösem Vorstellungsgrund als Kontrollen eingeschlossen und in den Dokumentationssystemen der Kliniken für drei Jahre nachverfolgt. Es konnte gezeigt werden, dass Kinder nach Masern ein erhöhtes relatives Risiko haben, sich erneut mit einer infektiösen Erkrankung vorzustellen (RR 1,6 (95% KI 1,4-2,0; p<0,001) bzw. 1,3 (95% KI 1,1-1,6; p=0,002)). Es zeigte sich auch, dass zweimal gegen Masern geimpfte Kinder seltener erneut aufgrund von Infektionen vorstellig wurden als ungeimpfte Kinder (30% gegen 47%; p<0,001). Eine prospektive Studie soll zur Beantwortung der Frage beitragen, wann nach IVIG- Gabe der bestmögliche Zeitpunkt für eine Masernimpfung ist, um einerseits das schutzlose Intervall möglichst kurz zu halten und andererseits den Impferfolg nicht zu gefährden. Eingeschlossen werden masernexponierte Säuglinge ...

وصف الملف: application/pdf

العلاقة: https://refubium.fu-berlin.de/handle/fub188/42025Test; http://dx.doi.org/10.17169/refubium-41748Test; urn:nbn:de:kobv:188-refubium-42025-8

الإتاحة: https://doi.org/10.17169/refubium-41748Test
https://refubium.fu-berlin.de/handle/fub188/42025Test
https://nbn-resolving.org/urn:nbn:de:kobv:188-refubium-42025-8Test

المؤلفون: Vivek Podder, Binod Dhakal, Gousia Shaik, Kaushik Sundar, Madhava Sivapuram, Vijay Chattu, Rakesh Biswas

المصدر: Healthcare; Volume 6; Issue 3; Pages: 78

مصطلحات موضوعية: overdiagnosis, overtreatment, CBBLE (case-based blended learning ecosystem), case studies, precision medicine, omics driven, low resource setting, high resource setting Healthcare

الوصف: Introduction: Precision medicine aims to focus on meeting patient requirements accurately, optimizing patient outcomes, and reducing under-/overdiagnosis and therapy. We aim to offer a fresh perspective on accuracy driven “age-old precision medicine” and illustrate how newer case-based blended learning ecosystems (CBBLE) can strengthen the bridge between age-old precision approaches with modern technology and omics-driven approaches. Methodology: We present a series of cases and examine the role of precision medicine within a “case-based blended learning ecosystem” (CBBLE) as a practicable tool to reduce overdiagnosis and overtreatment. We illustrated the workflow of our CBBLE through case-based narratives from global students of CBBLE in high and low resource settings as is reflected in global health. Results: Four micro-narratives based on collective past experiences were generated to explain concepts of age-old patient-centered scientific accuracy and precision and four macro-narratives were collected from individual learners in our CBBLE. Insights gathered from a critical appraisal and thematic analysis of the narratives were discussed. Discussion and conclusion: Case-based narratives from the individual learners in our CBBLE amply illustrate their journeys beginning with “age-old precision thinking” in low-resource settings and progressing to “omics-driven” high-resource precision medicine setups to demonstrate how the approaches, used judiciously, might reduce the current pandemic of over-/underdiagnosis and over-/undertreatment.

وصف الملف: application/pdf

العلاقة: https://dx.doi.org/10.3390/healthcare6030078Test

الإتاحة: https://doi.org/10.3390/healthcare6030078Test

المؤلفون: Daniel Bühl, Olga Staudacher, Sabine Santibanez, Rainer Rossi, Hermann Girschick, Volker Stephan, Beatrix Schmidt, Patrick Hundsdoerfer, Arpad von Moers, Michael Lange, Michael Barker, Marcus A. Mall, Ulrich Heininger, Dorothea Matysiak-Klose, Annette Mankertz, Horst von Bernuth

مصطلحات موضوعية: Foetal Development and Medicine, Obstetrics and Gynaecology, Paediatrics, Paediatrics and Reproductive Medicine not elsewhere classified, measles, outbreak, immune amnesia, Europe, high resource setting

الوصف: Objectives Post-measles increased susceptibility to subsequent infections seems particularly relevant in low-resource settings. We tested the hypothesis that measles causes a specifically increased rate of infections in children, also in a high-resource setting. Methods We conducted a retrospective cohort study on a large measles outbreak in Berlin, Germany. All children with measles who presented to hospitals in Berlin were included as cases, children with non-infectious and children with non-measles infectious diseases as controls. Repeat visits within 3 years after the outbreak were recorded. Results We included 250 cases, 502 non-infectious, and 498 infectious disease controls. The relative risk for cases for the diagnosis of an infectious disease upon a repeat visit was 1.6 (95% CI 1.4–2.0, p < 0.001) vs. non-infectious and 1.3 (95% CI 1.1–1.6, p = 0.002) vs. infectious disease controls. 33 cases (27%), 35 non-infectious (12%) and 57 (18%) infectious disease controls presented more than three times due to an infectious disease (p = 0.01, and p = 0.02, respectively). This results in a relative risk of more than three repeat visits due to an infection for measles cases of 1.8 (95% CI 1.3–2.4, p = 0.01), and 1.4 (95% CI 1.0–1.9, p = 0.04), respectively. Conclusion Our study demonstrates for the first time in a high-resource setting, that increased post-measles susceptibility to subsequent infections in children is measles-specific—even compared to controls with previous non-measles infections.

العلاقة: https://figshare.com/articles/dataset/Data_Sheet_1_Specifically_Increased_Rate_of_Infections_in_Children_Post_Measles_in_a_High_Resource_Setting_pdf/20036912Test

الإتاحة: https://doi.org/10.3389/fped.2022.896086.s001Test
https://figshare.com/articles/dataset/Data_Sheet_1_Specifically_Increased_Rate_of_Infections_in_Children_Post_Measles_in_a_High_Resource_Setting_pdf/20036912Test

المؤلفون: Madhava Sai Sivapuram, Binod Dhakal, Kaushik Sundar, Rakesh Biswas, Vivek Podder, Vijay Kumar Chattu, Gousia Ummae Salma Shaik

المصدر: Healthcare
Healthcare, Vol 6, Iss 3, p 78 (2018)
The Road from Nanomedicine to Precision Medicine ISBN: 9781003027058
Volume 6
Issue 3
The Road from Nanomedicine to Precision Medicine ISBN: 9780429295010

مصطلحات موضوعية: Leadership and Management, Computer science, As is, precision medicine, lcsh:Medicine, Health Informatics, CBBLE (case-based blended learning ecosystem), overdiagnosis, Bridge (nautical), high resource setting Healthcare, Article, case studies, 03 medical and health sciences, 0302 clinical medicine, Health Information Management, CBBLE (case-based-based blended learning ecosystem), 030212 general & internal medicine, Overdiagnosis, overtreatment, Health Policy, lcsh:R, omics driven, low resource setting, Precision medicine, Data science, Blended learning, Critical appraisal, Workflow, high resource setting, 030220 oncology & carcinogenesis, Thematic analysis

الوصف: Introduction: Precision medicine aims to focus on meeting patient requirements accurately, optimizing patient outcomes, and reducing under-/overdiagnosis and therapy. We aim to offer a fresh perspective on accuracy driven &ldquo
age-old precision medicine&rdquo
and illustrate how newer case-based blended learning ecosystems (CBBLE) can strengthen the bridge between age-old precision approaches with modern technology and omics-driven approaches. Methodology: We present a series of cases and examine the role of precision medicine within a &ldquo
case-based blended learning ecosystem&rdquo
(CBBLE) as a practicable tool to reduce overdiagnosis and overtreatment. We illustrated the workflow of our CBBLE through case-based narratives from global students of CBBLE in high and low resource settings as is reflected in global health. Results: Four micro-narratives based on collective past experiences were generated to explain concepts of age-old patient-centered scientific accuracy and precision and four macro-narratives were collected from individual learners in our CBBLE. Insights gathered from a critical appraisal and thematic analysis of the narratives were discussed. Discussion and conclusion: Case-based narratives from the individual learners in our CBBLE amply illustrate their journeys beginning with &ldquo
age-old precision thinking&rdquo
in low-resource settings and progressing to &ldquo
omics-driven&rdquo
high-resource precision medicine setups to demonstrate how the approaches, used judiciously, might reduce the current pandemic of over-/underdiagnosis and over-/undertreatment.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::857b82ac952caee068300d3edb264939Test
http://europepmc.org/articles/PMC6163835Test