المؤلفون: Sciarroni, Elisabetta¹ (AUTHOR) e.sciarroni@gmail.com, Montanelli, Lucia¹ (AUTHOR), Di Cosmo, Caterina¹ (AUTHOR), Bagattini, Brunella¹ (AUTHOR), Comi, Simone¹ (AUTHOR), Pignata, Luisa¹ (AUTHOR), Brancatella, Alessandro¹ (AUTHOR), De Marco, Giuseppina¹ (AUTHOR), Ferrarini, Eleonora¹ (AUTHOR), Nencetti, Chiara² (AUTHOR), Sessa, Maria Rita² (AUTHOR), Latrofa, Francesco¹ (AUTHOR), Santini, Ferruccio¹ (AUTHOR), Tonacchera, Massimo¹ (AUTHOR), Agretti, Patrizia² (AUTHOR)

المصدر: Italian Journal of Pediatrics. 5/29/2024, Vol. 50 Issue 1, p1-6. 6p.

مصطلحات موضوعية: *HYPOTHYROIDISM diagnosis, *GOITER diagnosis, *GOITER treatment, *THYROID gland physiology, *PHYSICAL diagnosis, *BIOPSY, *THYROXINE, *THYROID gland function tests, *GOITER, *GENOMICS, *GENES, *THYROID gland, *GENETIC mutation, *CONGENITAL hypothyroidism, *RADIONUCLIDE imaging, *GENETIC testing

مستخلص: Background: In this study, we used targeted next-generation sequencing (NGS) to investigate the genetic basis of congenital hypothyroidism (CH) in a 19-year-old Tunisian man who presented with severe hypothyroidism and goiter. Case presentation: The propositus reported the appearance of goiter when he was 18. Importantly, he did not show signs of mental retardation, and his growth was proportionate. A partial organification defect was detected through the perchlorate-induced iodide discharge test. NGS identified a novel homozygous mutation in exon 18 of the SLC26A7 gene (P628Qfs*11), which encodes for a new iodide transporter. This variant is predicted to result in a truncated protein. Notably, the patient's euthyroid brother was heterozygous for the same mutation. No renal acid–base abnormalities were found and the administration of 1 mg of iodine failed to correct hypothyroidism. Conclusions: We described the first case of goitrous CH due to a homozygous mutation of the SLC26A7 gene diagnosed during late adolescence. [ABSTRACT FROM AUTHOR]

المؤلفون: Sorouri, Shahabaddin¹ (AUTHOR), Akbarianrad, Samira² (AUTHOR), Naseri, Maryam³ (AUTHOR) maryamnaseri63@yahoo.com

المصدر: Clinical Case Reports. Jun2024, Vol. 12 Issue 6, p1-4. 4p.

مصطلحات موضوعية: *SYMPTOMS, *GOITER, *DYSPNEA, *NECK, *EDEMA, MEDIASTINAL tumors

مستخلص: Key Clinical Message: Anterior mediastinal mass often is serious and its diagnosis requires a comprehensive evaluation involving imaging studies, pathological analysis and consultation with a multidisciplinary team involving radiologist, thoracic surgeons, and oncologist. [ABSTRACT FROM AUTHOR]

المؤلفون: Angelopoulos, Nicholas¹ (AUTHOR) drangelnick@gmail.com, Iakovou, Ioannis¹ (AUTHOR), Effraimidis, Grigoris^2,3 (AUTHOR) grigoris.effraimidis@gmail.com, Livadas, Sarantis⁴ (AUTHOR) sarntis@gmail.com

المصدر: Diagnostics (2075-4418). May2024, Vol. 14 Issue 9, p946. 9p.

مصطلحات موضوعية: *THYROIDECTOMY, *GOITER, *IODINE isotopes, *THYROID cancer, *SURGERY

مستخلص: (1) Background: After thyroid malignancy is ruled out, treatment options for multinodular goiter patients include surgery, levothyroxine suppressive therapy, and 131-I therapy. Surgery effectively reduces goiter size but carries risks of surgical and anesthetic complications. 131-I therapy is the only nonsurgical alternative, but its effectiveness diminishes with goiter size and depends on iodine sufficiency. This study aimed to assess the efficacy and safety of 0.1 mg rhTSH as an adjuvant to a fixed dose of 131-I therapy in patients with a recurrence of large multinodular goiter, several years after the initial thyroidectomy. (2) Methods: 14 patients (13 females and 1 male), aged 59.14 ± 15.44 (range, 35–78 years) received 11mciu of 131-I, 24 h after the administration of 0.1 mg rhTSH. The primary endpoint was the change in thyroid volume (by ultrasound measurements) as well as in the diameter of the predominant nodule during a follow-up period of 10 years. Secondary endpoints were the alterations in thyroid function and potential adverse effects. (3) Results: A significant decrease in the volume of initial thyroid remnants (32.16 ± 16.66 mL) was observed from the first reevaluation (at 4 months, 23.12 ± 11.59 mL) as well as at the end of the follow-up period (10 years, 12.62 ± 8.76 mL), p < 0.01. A significant reduction in the dominant nodule was also observed (from 31.71 ± 10.46 mm in the beginning to 26.67 ± 11.05 mm). (4) Conclusions: Further investigation is needed since this approach could be attractive in terms of minimizing the potential risks of reoperation in these patients. [ABSTRACT FROM AUTHOR]

المؤلفون: Elshafie, Sally¹ sally.elshafie@nhs.net, Tariq, Abu Taher¹, Leon, Francisco Leyva²

المصدر: Pacing & Clinical Electrophysiology. May2024, Vol. 47 Issue 5, p673-675. 3p.

مصطلحات موضوعية: *GOITER diagnosis, *ENDOCRINOLOGY, *GOITER, *COMPLICATIONS of prosthesis, *BLOOD vessels, *COMPUTED tomography, *CHEST X rays, *NURSING, *ELECTROCARDIOGRAPHY, *VENOGRAPHY, *IMPLANTABLE cardioverter-defibrillators, *CARDIAC pacing, *HEART block, *LEFT ventricular dysfunction

مستخلص: Central venous obstruction in the cardiac implantable electronic devices (CIED) population is commonly due to thrombosis and fibrosis secondary to the passage of pre‐existing leads. However, vein occlusion before CIED implantation is uncommon, and one cause is retrosternal goiters. We report a case where the failure of the initial implantation of a primary CIED led to an unusual implantation route without goiter excision. The patient had an indication for cardiac resynchronization therapy (CRT) given his left ventricular (LV) function was impaired and had second‐degree heart block Mobitz Type II; however, he had occluded bilateral subclavian veins due to a sizeable retrosternal goiter. This obstruction led to the implantation of a single lead pacemaker via the right femoral vein after multiple failed attempts at CRT, dual chamber pacemaker and left bundle branch area pacing (LBBaP). [ABSTRACT FROM AUTHOR]

المؤلفون: Popov, Georgi Stoychev¹ (AUTHOR), Ruzhanova-Gospodinova, Iliana Stefanova² (AUTHOR) iliana_ruzhanova@ltu.bg, Aminkov, Konstantin Bogdanov³ (AUTHOR), Georgiev, Georgi Ivanov² (AUTHOR), Manov, Vasil Kostadinov¹ (AUTHOR)

المصدر: Acta Veterinaria. 2024, Vol. 74 Issue 2, p322-330. 9p.

مصطلحات موضوعية: *BLACK bear, *GOITER, *AUTOPSY, *THYROID gland, *COLLOIDS, *COMPUTED tomography

مصطلحات جغرافية: SOFIA (Bulgaria)

مستخلص: The present case report aims to describe a postmortem finding of a colloid goiter, without obvious clinical signs of endocrine disease in a 30-year-old American black bear (Ursus americanus) from the "Zoo" in the city of Sofia, Bulgaria. A clinical examination due to a bad general condition was performed under anesthesia and a computed tomography was conducted. After the established irreversible spondylarthrosis changes the bear was euthanized. Postmortem, the thyroid gland was pathologically examined and typical findings for a colloid goiter were observed. Hibernating mammals such as the American black bear have been shown to enter a state of physiological hypothyroidism during hibernation. Hormonal signals from the thyroid gland have been suggested to be a key mediator of hibernation. From the presented case could be assumed that the captive life conditions and the prolonged life of the zoo bears may affect the function of their thyroid gland. [ABSTRACT FROM AUTHOR]

المؤلفون: R., Chitra¹, Karthikeyan, S.², Sarvesh, P. Suganth¹, Murugesan, P. R.³, Kumar, S. Pranav⁴, Iniya, S.⁴

المصدر: European Journal of Cardiovascular Medicine. 2024, Vol. 14 Issue 2, p1024-1028. 5p.

مصطلحات موضوعية: *THYROIDECTOMY, *GOITER, *HYPOPARATHYROIDISM, *THYROID cancer, *SURGICAL complications, *COMPARATIVE studies, *OPERATIVE surgery, *MEDICAL records

مستخلص: BACKGROUND A retrosternal goiter is an enlarged thyroid which extends below clavicle and sternum. Retrostemal goitre can be defined as thyroid which extends below manubrium but some include only goitres that extends more than 50% or 3 cm below thoracic inlet. Because they are expansions or extensions of multinodular goitres based on the superior or inferior thyroid vasculature, the majority of intrathoracic or substernal goitres are referred to be secondary." They spread outward into the mediastinum anterior. AIM To find out the differences for the need for cervical approach or if it mandates a median sternotomy based on various factors. MATERIAL AND METHODS The present retrospective comparative study was conducted among 31 patients of Retrosternal goitre admitted in PSGIMSR and Hospital over the past 10 years from period 2013-2023. Patient details, history, relevant investigations, operating procedure, postoperative complications and duration of hospital stay were collected. The following factors were examined in these patients' medical records: clinical symptoms, prior thyroidectomy history, surgical technique (only cervical or cervical with median sternotomy), thyroid histology results, thyroid weight, and complications following surgery. RESULTS Of the thirty-one patients, twenty-six (83.87%) had thyroidectomies by cervical incisions, while five (16.13%) required median sternotomies. Mean operative time (min) and hospital stay (days) among subjects who underwent surgery through cervical and thoracic approach was 214.81, 7.92 and 321.92, 15.83 respectively. Hence mean operative time (min) and hospital stay (days) was significantly more in thoracic as compared to cervical approach as p<0.05. Most common postoperative complications among the study subjects was transient hypocalcemia followed by postoperative bleeding. CONCLUSION Due to the low surgical morbidity, high incidence of compression-related symptoms, lack of effective medicinal treatment, and possibility of cancer, the existence of an RSG is an indication for surgery. Although surgically removing a retrosternal goitre is a difficult procedure, it can usually be done safely using a cervical approach. The rate of complications associated with this procedure is slightly higher than that of a cervical goitre thyroidectomy, particularly in regards to hypoparathyroidism and bleeding after surgery. [ABSTRACT FROM AUTHOR]

المؤلفون: Cohen, Oded^1,2,3 (AUTHOR) odedco@assuta.co.il, Amiad, Noa Dagul¹ (AUTHOR), Shavit, Eitan¹ (AUTHOR), Hod, Keren^2,4 (AUTHOR), Khafif, Avi^1,2 (AUTHOR)

المصدر: European Archives of Oto-Rhino-Laryngology. Mar2024, Vol. 281 Issue 3, p1435-1441. 7p.

مصطلحات موضوعية: *GOITER, *NECK dissection, *THYROID gland, *CASE-control method, *THYROIDECTOMY, *HYPOCALCEMIA

مستخلص: Background: Despite ample of evidence regarding feasibility of simple drainless thyroid surgeries, the evidence of feasibility of such procedures in goiters and central neck dissections remains limited. Methods: Patients undergoing total thyroidectomy (TT) between January 2017 and July 2022 were included. The study included two study groups: drainless TT with central neck dissection (CND) and drainless TT due to goiter, which were compared to two controls: non-goiter drainless TT and drained TT for goiter or with CND. Main outcome was post-operative seroma rate. Results: 156 patients met the inclusion criteria for each of the group. No significant differences between groups were found for permanent hypocalcemia, and other complications. Post-operative seroma was found in nine patients (5.8%), all from study groups. No significant differences between groups were found for local infections, aspirations, post-discharge drain insertion. Conclusions: Complex drainless thyroid surgeries, including goiter and CND, are feasible and do not seem to significantly increase rate of post-operative seromas or infections. [ABSTRACT FROM AUTHOR]

المؤلفون: Akbari, Maryam¹ (AUTHOR) maryamakbari_6699@yahoo.com

المصدر: Indian Journal of Otolaryngology & Head & Neck Surgery. Feb2024, Vol. 76 Issue 1, p1049-1053. 5p.

مصطلحات موضوعية: *GOITER, *THYROID cancer, *COMPUTED tomography, *ECTOPIC tissue, *THYROID gland, *ULTRASONIC imaging

مستخلص: parapharyngeal space can have a mass of thyroid origin following metastasis from the thyroid or ectopic thyroid tissue. The extension of multinodular goiter into the parapharyngeal space is rare. A 54-year-old female presented with a 5-month history of neck mass and dyspnea. On examination, a large mass was seen on the right side of the neck which was bulging into the right parapharngeal. In the sonography, a large 50 × 57 mm cyst seen at the upper end of the right lobe of the thyroid. Computed tomography (CT) identified a 46 × 56 mm lesion medial to the right carotid sheath with a mass effect on the parapharyngeal space from the posterolateral aspect and appeared to be an exophytic cystic nodule arising from the upper pole of the right thyroidal lobe. The patient underwent total thyroidectomy, and the final pathology of multinodular goiter was reported. The spread of masses of the thyroid origin to the parapharyngeal space should be considered one of the differential diagnoses of these space masses. [ABSTRACT FROM AUTHOR]

المؤلفون: Aydin, Yener¹ (AUTHOR) dryeneraydin@hotmail.com, Kartal, Murat² (AUTHOR), Ulas, Ali Bilal¹ (AUTHOR), Akcay, Mufide Nuran² (AUTHOR), Ozmen, Sevilay³ (AUTHOR)

المصدر: Indian Journal of Surgery. Apr2024, Vol. 86 Issue 2, p463-465. 3p.

مصطلحات موضوعية: *GOITER diagnosis, *MEDIASTINUM, *GOITER, *MEDIASTINUM diseases, *THYROID gland, STERNUM surgery

مستخلص: Retrosternal goiter is an enlargement of the thyroid gland and a progressive mass that grows insidiously in the chest cavity over a long time. Unlike typical retrosternal goiters, ectopic mediastinal goiters are extremely rare occurring in less than 1% of all goiters. This image presents a 51-year-old woman with a posterior mediastinal goiter in which the left thyroid lobe extends into the retrosternal mediastinum and ectopic thyroid tissue in the anterior mediastinum. [ABSTRACT FROM AUTHOR]

المؤلفون: Sima, Oana-Claudia^1,2, Şandru, Florica^3,4 florysandru@yahoo.com, Costăchescu, Mihai⁵, Dumitraşcu, Mihai-Cristian^6,7, Petca, Aida^6,7, Petca, Răzvan-Cosmin^2,8, Carsote, Mara^9,10, Nistor, Claudiu^11,12

المصدر: Obstetrică şi Ginecologie. 2024, Vol. 72 Issue 1, p36-40. 5p.

مصطلحات موضوعية: *GOITER, *THYROIDECTOMY, *CARCINOMA, *OVARIAN cancer, *THYROID gland

الملخص (بالإنجليزية): Recent data have shown that ovarian cancer might be associated with thyroid nodular (malignant and benign) conditions, probably based on common genetic background (involving a syndromic presentation or not; for instance, DICER pathogenic variants or Cowden syndrome etc.). We aim to present the case of a lady admitted for a recent surgery concerning a severe form of ovarian malignancy in association with a voluminous multinodular goiter. [ABSTRACT FROM AUTHOR]

Abstract (Romanian): Date recente au arătat că malignitatea de tip ovarian ar putea fi asociată cu patologia nodulară tiroidiană (benignă sau malignă), pe baza unui fond genetic comun (ce implică o prezentare în cadrul unui sindrom sau nu; de exemplu, varianta patogenică DICER sau sindromul Cowden etc.). Ne propunem să prezentăm cazul unei paciente operate recent pentru o formă severă de cancer ovarian, asociat cu prezența unei guşi multinodulare voluminoase. [ABSTRACT FROM AUTHOR]