المؤلفون: Dorota Ćwiek, Małgorzata Zimny, Katarzyna Szymoniak, Krystyna Czechowska, Olimpia Sipak-Szmigiel

المصدر: Nutrients; Volume 15; Issue 5; Pages: 1110

مصطلحات موضوعية: fatty acids (FA), breast milk, docosahexaenoic acid (DHA), body weight composition

جغرافية الموضوع: agris

الوصف: The total amount of fat in the milk of nursing mothers depends on maternal reserves, as well as food intake and its synthesis in the mammary glands. The aim of this study was to assess the contents of fatty acids in the milk of women from the West Pomeranian region of Poland with regards to supplementation and the amount of adipose tissue. We also wanted to find out whether these women, who have direct access to the sea and potential access to fresh marine fish, have higher levels of DHA. Methods: We analyzed milk samples obtained 6–7 weeks postpartum from 60 women. The content of fatty acid methyl esters (FAME) in lipids was determined by gas chromatography–mass spectrometry (GC/MS) using a Clarus 600 device (PerkinElmer). Results: Women using dietary supplements had significantly higher levels of docosahexaenoic acid (DHA) (C22:6 n-3) (p = 0.000) and eicosapentaenoic acid (EPA) (20:5 n-3) (p = 0.000). The levels of eicosatrienoic acid (ETA) (C20:3 n-3) and γ-linolenic acid (GLA) increased with the amount of body fat, and the level of DHA was lowest in subjects where body fat exceeded 40% (p = 0.036). Conclusions: The contents of fatty acids in the milk of women from the West Pomeranian region of Poland were similar to that reported by other authors. The levels of DHA in women using dietary supplements was also comparable to the values reported worldwide. BMI had an effect on the levels of ETE and GLA acids.

وصف الملف: application/pdf

العلاقة: Lipids; https://dx.doi.org/10.3390/nu15051110Test

الإتاحة: https://doi.org/10.3390/nu15051110Test

المؤلفون: Lingsi Zeng, Honggang Lv, Xubo Wang, Ranran Xue, Cong Zhou, Xia Liu, Hao Yu

المصدر: Frontiers in Nutrition, Vol 9 (2022)

مصطلحات موضوعية: depression, Mendelian randomization, fatty acids (FA), non-polyunsaturated fatty acids (non-PUFA), polyunsaturated fatty acids (PUFA), omega-3 fatty acids, Nutrition. Foods and food supply, TX341-641

الوصف: ObjectivesFatty acids (FA) are widely believed to play a role in the pathophysiology of depression. However, the causal relationships between FA and depression remain elusive and warrant further research. We aimed to investigate the potential causal relationship between FA [saturated fatty acids (SFA), mono-unsaturated fatty acids (MUFA), and polyunsaturated fatty acids (PUFA)] and the risk of depression using Mendelian randomization (MR) analysis.MethodsWe conducted a two-sample MR analysis using large-scale European-based genome-wide association studies (GWASs) summary data related to depression (n = 500,199 individuals) and FA [saturated fatty acids (SFA), mono-unsaturated fatty acids (MUFA), and polyunsaturated fatty acids (PUFA)] levels. MR analysis was performed using the Wald ratio and inverse variance-weighted (IVW) methods, and sensitivity analysis was conducted by the simple mode, weighted mode, weighted median method, and MR-Egger method.ResultsWe found the causal effects for the levels of oleic acid (OA; OR = 1.07, p = 5.72 × 10–4), adrenic acid (OR = 0.74, p = 1.01 × 10–3), α-linolenic acid (ALA; OR = 2.52, p = 1.01 × 10–3), eicosapentaenoic acid (EPA; OR = 0.84, p = 3.11 × 10–3) on depression risk, after Bonferroni correction. The sensitivity analyses indicated similar trends. No causal effect between the levels of SFA and depression risk was observed.ConclusionOur study suggests that adrenic acid and EPA are protective against the risk of depression, while OA and ALA are potential risk factors for depression. Nonetheless, the underlying mechanisms that mediate the association between these FAs and depression risk should be investigated in further experiments.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fnut.2022.1010476/fullTest; https://doaj.org/toc/2296-861XTest

الوصول الحر: https://doaj.org/article/33123a6d6e3448c1863bb10fc0f2e8f7Test

المؤلفون: Ana Montero-Calle, Marta Gómez de Cedrón, Adriana Quijada-Freire, Guillermo Solís-Fernández, Victoria López-Alonso, Isabel Espinosa-Salinas, Alberto Peláez-García, María Jesús Fernández-Aceñero, Ana Ramírez de Molina, Rodrigo Barderas

المصدر: Frontiers in Oncology, Vol 12 (2022)

مصطلحات موضوعية: CRC (colorectal cancer), metabolic reprograming, tropism of metastasis, obesity, fatty acids (FA), organotropism, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: Approximately 25% of colorectal cancer (CRC) patients experience systemic metastases, with the most frequent target organs being the liver and lung. Metabolic reprogramming has been recognized as one of the hallmarks of cancer. Here, metabolic and functional differences between two CRC cells with different metastatic organotropisms (metastatic KM12SM CRC cells to the liver and KM12L4a to the lung when injected in the spleen and in the tail vein of mice) were analysed in comparison to their parental non-metastatic isogenic KM12C cells, for a subsequent investigation of identified metabolic targets in CRC patients. Meta-analysis from proteomic and transcriptomic data deposited in databases, qPCR, WB, in vitro cell-based assays, and in vivo experiments were used to survey for metabolic alterations contributing to their different organotropism and for the subsequent analysis of identified metabolic markers in CRC patients. Although no changes in cell proliferation were observed between metastatic cells, KM12SM cells were highly dependent on oxidative phosphorylation at mitochondria, whereas KM12L4a cells were characterized by being more energetically efficient with lower basal respiration levels and a better redox management. Lipid metabolism-related targets were found altered in both cell lines, including LDLR, CD36, FABP4, SCD, AGPAT1, and FASN, which were also associated with the prognosis of CRC patients. Moreover, CD36 association with lung metastatic tropism of CRC cells was validated in vivo. Altogether, our results suggest that LDLR, CD36, FABP4, SCD, FASN, LPL, and APOA1 metabolic targets are associated with CRC metastatic tropism to the liver or lung. These features exemplify specific metabolic adaptations for invasive cancer cells which stem at the primary tumour.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fonc.2022.903033/fullTest; https://doaj.org/toc/2234-943XTest

الوصول الحر: https://doaj.org/article/050b971bb1f84d0ca089a7952ddb0af1Test

المؤلفون: Ana-Maria Dobri, Elena Codrici, Ionela-Daniela Popescu, Lucian Albulescu, Emanuel Tudor Fertig, Ana-Maria Enciu, Cristiana Tanase, Mihail E. Hinescu

المصدر: Metabolites; Volume 12; Issue 4; Pages: 329

مصطلحات موضوعية: fatty acids (FA), palmitic acid (PA), oleic acid (OA), pro-inflammation cytokines, IL-6, IL-8

الوصف: Fatty acids (FAs) have been shown to exhibit a pro-inflammatory response in various cell types, but astrocytes have been mostly overlooked. FAs, both saturated and unsaturated, have previously been shown to induce pro-inflammatory responses in astrocytes at high concentrations of hundreds of µg/mL. SSO (Sulfo-N-succinimidyl Oleate sodium), an inhibitor of FA translocase CD36, has been shown to prevent inflammation in the mouse brain by acting on local microglia and infiltrating monocytes. Our hypothesis was that SSO treatment would also impact astrocyte pro-inflammatory response to FA. In order to verify our assumption, we evaluated the expression of pro- and anti-inflammatory cytokines in normal human astrocyte cell culture pre-treated (or not) with SSO, and then exposed to low concentrations of both saturated (palmitic acid) and unsaturated (oleic acid) FAs. As a positive control for astrocyte inflammation, we used fibrillary amyloid. Neither Aβ 1–42 nor FAs induced CD36 protein expression in human astrocytes in cell culture At low concentrations, both types of FAs induced IL-8 protein secretion, and this effect was specifically inhibited by SSO pre-treatment. In conclusion, low concentrations of oleic acid are able to induce an early increase in IL-8 expression in normal human astrocytes, which is specifically downregulated by SSO.

وصف الملف: application/pdf

العلاقة: Endocrinology and Clinical Metabolic Research; https://dx.doi.org/10.3390/metabo12040329Test

الإتاحة: https://doi.org/10.3390/metabo12040329Test

المؤلفون: Cristiana Tanase, Ana Maria Enciu, Elena Codrici, Ionela Daniela Popescu, Maria Dudau, Ana Maria Dobri, Sevinci Pop, Simona Mihai, Ancuța-Augustina Gheorghișan-Gălățeanu, Mihail Eugen Hinescu

المصدر: International Journal of Molecular Sciences; Volume 23; Issue 2; Pages: 604

مصطلحات موضوعية: fatty acids (FA), CD36, CD47, thrombospondin-1 (TSP-1), glioblastoma (GBM)

جغرافية الموضوع: agris

الوصف: Glioblastoma (GBM) is one of the most aggressive tumors of the central nervous system, characterized by a wide range of inter- and intratumor heterogeneity. Accumulation of fatty acids (FA) metabolites was associated with a low survival rate in high-grade glioma patients. The diversity of brain lipids, especially polyunsaturated fatty acids (PUFAs), is greater than in all other organs and several classes of proteins, such as FA transport proteins (FATPs), and FA translocases are considered principal candidates for PUFAs transport through BBB and delivery of PUFAs to brain cells. Among these, the CD36 FA translocase promotes long-chain FA uptake as well as oxidated lipoproteins. Moreover, CD36 binds and recognizes thrombospondin-1 (TSP-1), an extracellular matrix protein that was shown to play a multifaceted role in cancer as part of the tumor microenvironment. Effects on tumor cells are mediated by TSP-1 through the interaction with CD36 as well as CD47, a member of the immunoglobulin superfamily. TSP-1/CD47 interactions have an important role in the modulation of glioma cell invasion and angiogenesis in GBM. Separately, FA, the two membrane receptors CD36, CD47, and their joint ligand TSP-1 all play a part in GBM pathogenesis. The last research has put in light their interconnection/interrelationship in order to exert a cumulative effect in the modulation of the GBM molecular network.

وصف الملف: application/pdf

العلاقة: Molecular Oncology; https://dx.doi.org/10.3390/ijms23020604Test

الإتاحة: https://doi.org/10.3390/ijms23020604Test

المؤلفون: Montero-Calle, Ana Maria, Gómez de Cedrón, Marta, Quijada-Freire, Adriana, Solís-Fernández, Guillermo, Lopez-Alonso, Victoria, Espinosa-Salinas, Isabel, Peláez-García, Alberto, Fernández-Aceñero, María Jesús, Ramírez de Molina, Ana, Barderas Manchado, Rodrigo

المساهمون: Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), Instituto de Salud Carlos III, Ministerio de Ciencia (España), Plan Nacional de I+D+i (España), Comunidad de Madrid (España), Fundación Ramón Areces, Ministerio de Educación, Cultura y Deporte (España), Research Foundation - Flanders

مصطلحات موضوعية: CRC (colorectal cancer), Metabolic reprograming, Tropism of metastasis, Obesity, Fatty acids (FA), Organotropism

الوصف: Approximately 25% of colorectal cancer (CRC) patients experience systemic metastases, with the most frequent target organs being the liver and lung. Metabolic reprogramming has been recognized as one of the hallmarks of cancer. Here, metabolic and functional differences between two CRC cells with different metastatic organotropisms (metastatic KM12SM CRC cells to the liver and KM12L4a to the lung when injected in the spleen and in the tail vein of mice) were analysed in comparison to their parental non-metastatic isogenic KM12C cells, for a subsequent investigation of identified metabolic targets in CRC patients. Meta-analysis from proteomic and transcriptomic data deposited in databases, qPCR, WB, in vitro cell-based assays, and in vivo experiments were used to survey for metabolic alterations contributing to their different organotropism and for the subsequent analysis of identified metabolic markers in CRC patients. Although no changes in cell proliferation were observed between metastatic cells, KM12SM cells were highly dependent on oxidative phosphorylation at mitochondria, whereas KM12L4a cells were characterized by being more energetically efficient with lower basal respiration levels and a better redox management. Lipid metabolism-related targets were found altered in both cell lines, including LDLR, CD36, FABP4, SCD, AGPAT1, and FASN, which were also associated with the prognosis of CRC patients. Moreover, CD36 association with lung metastatic tropism of CRC cells was validated in vivo. Altogether, our results suggest that LDLR, CD36, FABP4, SCD, FASN, LPL, and APOA1 metabolic targets are associated with CRC metastatic tropism to the liver or lung. These features exemplify specific metabolic adaptations for invasive cancer cells which stem at the primary tumour. ; This work was supported by grants cofounded by Fondo Europeo de Desarrollo Regional -FEDER- PI17CIII/00045 and PI20CIII/00019 from the AES-ISCIII program to RB from the Instituto de Salud Carlos III (ISCIII) and grants from Spanish Ministry of ...

العلاقة: Publisher's version; https://doi.org/10.3389/fonc.2022.903033Test; info:eu-repo/grantAgreement/ES/PID2019-110183RBC21; info:eu-repo/grantAgreement/ES/PI17CIII/00045; info:eu-repo/grantAgreement/ES/PI20CIII/00019; Front Oncol. 2022 Jul 25;12:903033.; http://hdl.handle.net/20.500.12105/15011Test; Frontiers in oncology

الإتاحة: https://doi.org/20.500.12105/15011Test
https://doi.org/10.3389/fonc.2022.903033Test
https://hdl.handle.net/20.500.12105/15011Test

المؤلفون: Stefano Turolo, Alberto C. Edefonti, William Morello, Marie-Louise Syren, Valentina De Cosmi, Luciana Ghio, Chiara Tamburello, Erika A. Demarco, Alfredo Berrettini, Gianantonio Manzoni, Carlo Agostoni, Giovanni Montini

المصدر: Frontiers in Pediatrics, Vol 8 (2021)

مصطلحات موضوعية: idiopathic nephrotic syndrome (INS), fatty acids (FA), arachidonic acids, stable remission, omega-6 (ω-6) PUFA, Pediatrics, RJ1-570

الوصف: Steroid-sensitive nephrotic syndrome is an immunological disorder mediated by still poorly defined circulating factor(s) that target the podocyte and damage the filtration barrier. Fatty acids (FA) have several biological roles and, in particular, are strictly involved in cell to cell communication, inflammatory processes and regulation of lymphocyte pools. Studies of FAs during INS have been mainly focused on biochemical changes during the phase of proteinuria; while no information is available about FA profile in patients with idiopathic nephrotic syndrome (INS) on stable remission. Aim of this study is to assess differences in blood FA profile between pediatric patients with INS during the phase of stable remission. Blood fatty acid profile of 47 pediatric patients on stable remission and 47 matched healthy controls were evaluated with gas chromatography. Patients with INS on stable remission had significantly higher levels of PUFA and omega-6 than controls (40.17 vs. 37.91% and 36.95 vs. 34.79%), lower levels of SFA and MUFA. Considering the single fatty acids, levels of omega-6 18:2n6 linoleic acid and omega-6 20:4n6 arachidonic acid were significantly higher in patients with INS than in controls (23.01 vs. 21.55%, p-value 0.003 and 10.37 vs. 9.65%, p-value 0.01). Moreover, patients with INS showed lower levels of SFA 14:0 (0.74 vs. 0.92%) and 18:0 (10.74 vs. 11.74%) and MUFA 18:1n9 oleic acid (18.50 vs. 19.83%). To the best of our knowledge this is the first study assessing FAs profile in children with INS in stable remission. In a population of 47 patients, we were able to demonstrate a higher blood level of linoleic and arachidonic acid, and consequently of omega-6 and PUFA, compared to controls. Persistently higher than normal levels of either linoleic or arachidonic acid, could be viewed as candidate biomarker for a state of risk of relapse in children with idiopathic nephrotic syndrome.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fped.2020.633470/fullTest; https://doaj.org/toc/2296-2360Test

الوصول الحر: https://doaj.org/article/a2ce253fe5344c659909cdc7c19739e4Test

المؤلفون: Turolo S., Edefonti A. C., Morello W., Syren M. -L., De Cosmi V., Ghio L., Tamburello C., Demarco E. A., Berrettini A., Manzoni G., Agostoni C., Montini G.

المساهمون: S. Turolo, A.C. Edefonti, W. Morello, M.-. Syren, V. De Cosmi, L. Ghio, C. Tamburello, E.A. Demarco, A. Berrettini, G. Manzoni, C. Agostoni, G. Montini

مصطلحات موضوعية: arachidonic acid, fatty acids (FA), idiopathic nephrotic syndrome (INS), omega-6 (ω-6) PUFA, stable remission, Settore MED/38 - Pediatria Generale e Specialistica

الوصف: Steroid-sensitive nephrotic syndrome is an immunological disorder mediated by still poorly defined circulating factor(s) that target the podocyte and damage the filtration barrier. Fatty acids (FA) have several biological roles and, in particular, are strictly involved in cell to cell communication, inflammatory processes and regulation of lymphocyte pools. Studies of FAs during INS have been mainly focused on biochemical changes during the phase of proteinuria; while no information is available about FA profile in patients with idiopathic nephrotic syndrome (INS) on stable remission. Aim of this study is to assess differences in blood FA profile between pediatric patients with INS during the phase of stable remission. Blood fatty acid profile of 47 pediatric patients on stable remission and 47 matched healthy controls were evaluated with gas chromatography. Patients with INS on stable remission had significantly higher levels of PUFA and omega-6 than controls (40.17 vs. 37.91% and 36.95 vs. 34.79%), lower levels of SFA and MUFA. Considering the single fatty acids, levels of omega-6 18:2n6 linoleic acid and omega-6 20:4n6 arachidonic acid were significantly higher in patients with INS than in controls (23.01 vs. 21.55%, p-value 0.003 and 10.37 vs. 9.65%, p-value 0.01). Moreover, patients with INS showed lower levels of SFA 14:0 (0.74 vs. 0.92%) and 18:0 (10.74 vs. 11.74%) and MUFA 18:1n9 oleic acid (18.50 vs. 19.83%). To the best of our knowledge this is the first study assessing FAs profile in children with INS in stable remission. In a population of 47 patients, we were able to demonstrate a higher blood level of linoleic and arachidonic acid, and consequently of omega-6 and PUFA, compared to controls. Persistently higher than normal levels of either linoleic or arachidonic acid, could be viewed as candidate biomarker for a state of risk of relapse in children with idiopathic nephrotic syndrome.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/33585371; info:eu-repo/semantics/altIdentifier/wos/WOS:000616666800001; volume:8; numberofpages:6; journal:FRONTIERS IN PEDIATRICS; http://hdl.handle.net/2434/823657Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85100759895

الإتاحة: https://doi.org/10.3389/fped.2020.633470Test
http://hdl.handle.net/2434/823657Test

المؤلفون: Bando, Hiroshi, Bando, Masahiro

مصطلحات موضوعية: Atherosclerotic cardiovascular disease (ASCVD), Monounsaturated fatty acid (MUFA), Nonalcoholic fatty liver disease (NAFLD), Polyunstaturated fatty acid (PUFA), ω-3 Fatty acids (FA)

الوصف: Obesity and metabolic syndrome have lipids intake problems including Monounsaturated Fatty Acid (MUFA) and Polyunsaturated Fatty Acid (PUFA). For decreasing the Atherosclerotic Cardiovascular Disease (ASCVD) risk, to replace of Saturated Fatty Acid (SFA) with PUFA and/or MUFA would be adequate. Finn Study including 2200 cases showed that Odd Ratio (OR) for obesity was SFAs: 1.28, MUFAs: 1.38, PUFAs: 0.70, Linoleic Acid (LA): 0.67 and DHA: 0.75. In Norwegian study with 3706 cases, higher LA levels were significantly associated with lower values of LDL-C, triglycerides, blood glucose, body mass index, blood pressure and eGFR. These current data are useful for practice.

العلاقة: http://repo.lib.tokushima-u.ac.jp/files/public/11/116087/20210702170206187481/jobw_2_2_7.pdfTest; http://repo.lib.tokushima-u.ac.jp/116087Test

الإتاحة: http://repo.lib.tokushima-u.ac.jp/116087Test

المؤلفون: Dörthe C. Müller-Navarra, Liliane Ruess

المصدر: Frontiers in Ecology and Evolution, Vol 7 (2019)

مصطلحات موضوعية: essential biomolecules, fatty acids (FA), amino acid (AA), sterol, vitamins, trophic interaction, Evolution, QH359-425, Ecology, QH540-549.5

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/article/10.3389/fevo.2019.00471/fullTest; https://doaj.org/toc/2296-701XTest

الوصول الحر: https://doaj.org/article/8992a345ea964624b24e9e0d79268515Test