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1دورية أكاديمية
المؤلفون: Zhaoqiang Cui, Zhaohui Qiu, Wenli Cheng, Wei Hu, Genshan Ma, Xiaojun Cai, Yafei Jin, Yi Zhao, Liqun He, Ying Li, Peili Bu, Xiaoping Chen, Ruxing Wang, Lin Chen, Peng Dong, Liuliu Feng, Xuebin Han, Mei Hong, Yinglong Hou, Minlei Liao, Mingliang Wang, Xiaoyan Wang, Jianhong Xie, Yawei Xu, Zhenxing Wang, Kai Huang, Yongle Li, Dongsheng Li, Xiaojun Ji, Jing Huang, Jun Wang, Danhong Fang, Jian'an Wang, Lijiang Tang, Yingwu Liu, Guosheng Fu, Juan Du, Ling Wang, Mengqi Liu, Junbo Ge
المصدر: The Journal of Clinical Hypertension, Vol 26, Iss 1, Pp 5-16 (2024)
مصطلحات موضوعية: adverse events, blood pressure target, essential hypertension, Olmesartan medoxomil‐amlodipine besylate tablet, satisfaction, Diseases of the circulatory (Cardiovascular) system, RC666-701
الوصف: Abstract There lacks real‐world study with a large sample size assessing olmesartan medoxomil‐amlodipine besylate (OM‐AML) tablet. Therefore, this study aimed to evaluate the efficacy and safety of OM‐AML tablet in patients with essential hypertension. Totally, 1341 patients from 36 medical centers with essential hypertension who took OM‐AML (20/5 mg) tablet were analyzed in the current prospective, single‐arm, multi‐center, real‐world study (SVK study). Seated systolic blood pressure (SeSBP) and seated diastolic blood pressure (SeDBP) at baseline, week (W)4 and W8 were measured. The mean (±SE) change of SeSBP/SeDBP was ‐10.8 ± 0.4/‐6.6 ± 0.3 mmHg at W4 and ‐12.7 ± 0.5/‐7.6 ± 0.3 mmHg at W8, respectively. At W4, 78.8% and 29.0% patients achieved BP target by China and American Heart Association (AHA) criteria; at W8, 84.7% and 36.5% patients reached blood pressure (BP) target by China and AHA criteria, accordingly. Meanwhile, 80.2% and 86.4% patients achieved BP response at W4 and W8, respectively. Home‐measured SeSBP and SeDBP decreased from W1 to W8 (both p
وصف الملف: electronic resource
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2دورية أكاديمية
المؤلفون: Hae Hyuk Jung
مصطلحات موضوعية: Medicine, Biotechnology, Developmental Biology, Marine Biology, Cancer, Science Policy, Mental Health, Biological Sciences not elsewhere classified, per 1000 person, estimated across yearly, blood pressure control, adjusted incidence rates, 154 mm hg, 135 mm hg, 134 mm hg, 125 &# 8211, small positive association, slightly inverted associations, blood pressure target, sbp showed j, sbp showed flat, kidney composite events, additional risk factors, age &# 8805, ci ], 3 ), &# 8805, kidney events, risk factors
الوقت: 2, 1, 0
الوصف: Adjusted hazard ratios and incidence rates of cardio-kidney events across on-treatment systolic blood pressure levels according to age.
الإتاحة: https://doi.org/10.1371/journal.pone.0297103.s004Test
https://figshare.com/articles/journal_contribution/Adjusted_hazard_ratios_and_incidence_rates_of_cardio-kidney_events_across_on-treatment_systolic_blood_pressure_levels_according_to_age_/25129105Test -
3دورية أكاديمية
المؤلفون: Hae Hyuk Jung
مصطلحات موضوعية: Medicine, Biotechnology, Developmental Biology, Marine Biology, Cancer, Science Policy, Mental Health, Biological Sciences not elsewhere classified, per 1000 person, estimated across yearly, blood pressure control, adjusted incidence rates, 154 mm hg, 135 mm hg, 134 mm hg, 125 &# 8211, small positive association, slightly inverted associations, blood pressure target, sbp showed j, sbp showed flat, kidney composite events, additional risk factors, age &# 8805, ci ], 3 ), &# 8805, kidney events, risk factors
الوقت: 2, 1, 0
الوصف: It remains unclear what the blood pressure target is and at which point in life it is appropriate for antihypertensive treatment. This study aimed to determine age-specific systolic blood pressure (SBP) targets. In a nationwide cohort of 296,470 hypertensive patients aged ≥75 years and a representative cohort of 259,028 hypertensives aged 45–74 years, multivariable-adjusted incidence rates of cardio-kidney composite events, overt dementia, and all-cause deaths were estimated across yearly-averaged on-treatment SBP levels according to age and the presence of 4 additional risk factors (diabetes, dyslipidemia, albuminuria, and smoking). For cardio-kidney events, on-treatment SBP showed positive curvilinear associations with higher risks at ≥135 mm Hg in most while an attenuated association in age ≥85 years. For overt dementia, SBP showed flat or slightly inverted associations in elderly while a small positive association in age 45–64 years. For all-cause mortality, SBP showed J-shaped associations having right-shifting tendency with age. For risk categories with ≥2, 1, and no additional risk factors, the respective mortality rate differences between SBP 145–154 mm Hg and 125–134 mm Hg were 4.6 (95% confidence interval [CI], 2.0 to 7.3), 1.2 (95% CI, -0.3 to 2.8), and 0.1 (95% CI, -1.4 to 1.8) per 1000 person-years in age ≥75 years and 2.9 (95% CI, 1.7 to 4.3), 0.7 (95% CI, 0.1 to 1.4), and 0.9 (95% CI, 0.2 to 1.6) per 1000 person-years in age 45–74 years. In conclusion, the BP target can be relaxed in very old patients and in elderly patients with few risk factors. However, strict BP control may be needed in patients with multiple risk factors even in those with advanced age.
الإتاحة: https://doi.org/10.1371/journal.pone.0297103.s002Test
https://figshare.com/articles/journal_contribution/NHIS_codes_for_patient_management_and_diagnosis_/25129099Test -
4دورية أكاديمية
المؤلفون: Hae Hyuk Jung
مصطلحات موضوعية: Medicine, Biotechnology, Developmental Biology, Marine Biology, Cancer, Science Policy, Mental Health, Biological Sciences not elsewhere classified, per 1000 person, estimated across yearly, blood pressure control, adjusted incidence rates, 154 mm hg, 135 mm hg, 134 mm hg, 125 &# 8211, small positive association, slightly inverted associations, blood pressure target, sbp showed j, sbp showed flat, kidney composite events, additional risk factors, age &# 8805, ci ], 3 ), &# 8805, kidney events, risk factors
الوقت: 2, 1, 0
الوصف: Adjusted hazard ratios and incidence rates of overt dementia across on-treatment systolic blood pressure levels according to age and sex.
الإتاحة: https://doi.org/10.1371/journal.pone.0297103.s007Test
https://figshare.com/articles/journal_contribution/Adjusted_hazard_ratios_and_incidence_rates_of_overt_dementia_across_on-treatment_systolic_blood_pressure_levels_according_to_age_and_sex_/25129114Test -
5دورية أكاديمية
المؤلفون: Hae Hyuk Jung
مصطلحات موضوعية: Medicine, Biotechnology, Developmental Biology, Marine Biology, Cancer, Science Policy, Mental Health, Biological Sciences not elsewhere classified, per 1000 person, estimated across yearly, blood pressure control, adjusted incidence rates, 154 mm hg, 135 mm hg, 134 mm hg, 125 &# 8211, small positive association, slightly inverted associations, blood pressure target, sbp showed j, sbp showed flat, kidney composite events, additional risk factors, age &# 8805, ci ], 3 ), &# 8805, kidney events, risk factors
الوقت: 2, 1, 0
الوصف: It remains unclear what the blood pressure target is and at which point in life it is appropriate for antihypertensive treatment. This study aimed to determine age-specific systolic blood pressure (SBP) targets. In a nationwide cohort of 296,470 hypertensive patients aged ≥75 years and a representative cohort of 259,028 hypertensives aged 45–74 years, multivariable-adjusted incidence rates of cardio-kidney composite events, overt dementia, and all-cause deaths were estimated across yearly-averaged on-treatment SBP levels according to age and the presence of 4 additional risk factors (diabetes, dyslipidemia, albuminuria, and smoking). For cardio-kidney events, on-treatment SBP showed positive curvilinear associations with higher risks at ≥135 mm Hg in most while an attenuated association in age ≥85 years. For overt dementia, SBP showed flat or slightly inverted associations in elderly while a small positive association in age 45–64 years. For all-cause mortality, SBP showed J-shaped associations having right-shifting tendency with age. For risk categories with ≥2, 1, and no additional risk factors, the respective mortality rate differences between SBP 145–154 mm Hg and 125–134 mm Hg were 4.6 (95% confidence interval [CI], 2.0 to 7.3), 1.2 (95% CI, -0.3 to 2.8), and 0.1 (95% CI, -1.4 to 1.8) per 1000 person-years in age ≥75 years and 2.9 (95% CI, 1.7 to 4.3), 0.7 (95% CI, 0.1 to 1.4), and 0.9 (95% CI, 0.2 to 1.6) per 1000 person-years in age 45–74 years. In conclusion, the BP target can be relaxed in very old patients and in elderly patients with few risk factors. However, strict BP control may be needed in patients with multiple risk factors even in those with advanced age.
الإتاحة: https://doi.org/10.1371/journal.pone.0297103.s003Test
https://figshare.com/articles/journal_contribution/Time-lagged_covariates_for_subsequent_years_/25129102Test -
6دورية أكاديمية
المؤلفون: Hae Hyuk Jung
مصطلحات موضوعية: Medicine, Biotechnology, Developmental Biology, Marine Biology, Cancer, Science Policy, Mental Health, Biological Sciences not elsewhere classified, per 1000 person, estimated across yearly, blood pressure control, adjusted incidence rates, 154 mm hg, 135 mm hg, 134 mm hg, 125 &# 8211, small positive association, slightly inverted associations, blood pressure target, sbp showed j, sbp showed flat, kidney composite events, additional risk factors, age &# 8805, ci ], 3 ), &# 8805, kidney events, risk factors
الوقت: 2, 1, 0
الوصف: Adjusted hazard ratios and incidence rates of cardio-kidney events across on-treatment systolic blood pressure levels according to age and sex.
الإتاحة: https://doi.org/10.1371/journal.pone.0297103.s005Test
https://figshare.com/articles/journal_contribution/Adjusted_hazard_ratios_and_incidence_rates_of_cardio-kidney_events_across_on-treatment_systolic_blood_pressure_levels_according_to_age_and_sex_/25129108Test -
7دورية أكاديمية
المؤلفون: Hae Hyuk Jung
مصطلحات موضوعية: Medicine, Biotechnology, Developmental Biology, Marine Biology, Cancer, Science Policy, Mental Health, Biological Sciences not elsewhere classified, per 1000 person, estimated across yearly, blood pressure control, adjusted incidence rates, 154 mm hg, 135 mm hg, 134 mm hg, 125 &# 8211, small positive association, slightly inverted associations, blood pressure target, sbp showed j, sbp showed flat, kidney composite events, additional risk factors, age &# 8805, ci ], 3 ), &# 8805, kidney events, risk factors
الوقت: 2, 1, 0
الوصف: It remains unclear what the blood pressure target is and at which point in life it is appropriate for antihypertensive treatment. This study aimed to determine age-specific systolic blood pressure (SBP) targets. In a nationwide cohort of 296,470 hypertensive patients aged ≥75 years and a representative cohort of 259,028 hypertensives aged 45–74 years, multivariable-adjusted incidence rates of cardio-kidney composite events, overt dementia, and all-cause deaths were estimated across yearly-averaged on-treatment SBP levels according to age and the presence of 4 additional risk factors (diabetes, dyslipidemia, albuminuria, and smoking). For cardio-kidney events, on-treatment SBP showed positive curvilinear associations with higher risks at ≥135 mm Hg in most while an attenuated association in age ≥85 years. For overt dementia, SBP showed flat or slightly inverted associations in elderly while a small positive association in age 45–64 years. For all-cause mortality, SBP showed J-shaped associations having right-shifting tendency with age. For risk categories with ≥2, 1, and no additional risk factors, the respective mortality rate differences between SBP 145–154 mm Hg and 125–134 mm Hg were 4.6 (95% confidence interval [CI], 2.0 to 7.3), 1.2 (95% CI, -0.3 to 2.8), and 0.1 (95% CI, -1.4 to 1.8) per 1000 person-years in age ≥75 years and 2.9 (95% CI, 1.7 to 4.3), 0.7 (95% CI, 0.1 to 1.4), and 0.9 (95% CI, 0.2 to 1.6) per 1000 person-years in age 45–74 years. In conclusion, the BP target can be relaxed in very old patients and in elderly patients with few risk factors. However, strict BP control may be needed in patients with multiple risk factors even in those with advanced age.
الإتاحة: https://doi.org/10.1371/journal.pone.0297103.s001Test
https://figshare.com/articles/journal_contribution/Covariates_/25129096Test -
8دورية أكاديمية
المؤلفون: Hae Hyuk Jung
مصطلحات موضوعية: Medicine, Biotechnology, Developmental Biology, Marine Biology, Cancer, Science Policy, Mental Health, Biological Sciences not elsewhere classified, per 1000 person, estimated across yearly, blood pressure control, adjusted incidence rates, 154 mm hg, 135 mm hg, 134 mm hg, 125 &# 8211, small positive association, slightly inverted associations, blood pressure target, sbp showed j, sbp showed flat, kidney composite events, additional risk factors, age &# 8805, ci ], 3 ), &# 8805, kidney events, risk factors
الوقت: 2, 1, 0
الوصف: Adjusted hazard ratios and incidence rates of all-cause death across on-treatment systolic blood pressure levels according to age.
الإتاحة: https://doi.org/10.1371/journal.pone.0297103.s008Test
https://figshare.com/articles/journal_contribution/Adjusted_hazard_ratios_and_incidence_rates_of_all-cause_death_across_on-treatment_systolic_blood_pressure_levels_according_to_age_/25129117Test -
9دورية أكاديمية
المؤلفون: Hae Hyuk Jung
مصطلحات موضوعية: Medicine, Biotechnology, Developmental Biology, Marine Biology, Cancer, Science Policy, Mental Health, Biological Sciences not elsewhere classified, per 1000 person, estimated across yearly, blood pressure control, adjusted incidence rates, 154 mm hg, 135 mm hg, 134 mm hg, 125 &# 8211, small positive association, slightly inverted associations, blood pressure target, sbp showed j, sbp showed flat, kidney composite events, additional risk factors, age &# 8805, ci ], 3 ), &# 8805, kidney events, risk factors
الوقت: 2, 1, 0
الوصف: Adjusted hazard ratios and incidence rates of overt dementia across on-treatment systolic blood pressure levels according to the presence of risk factors.
الإتاحة: https://doi.org/10.1371/journal.pone.0297103.s011Test
https://figshare.com/articles/journal_contribution/Adjusted_hazard_ratios_and_incidence_rates_of_overt_dementia_across_on-treatment_systolic_blood_pressure_levels_according_to_the_presence_of_risk_factors_/25129126Test -
10دورية أكاديمية
المؤلفون: Hae Hyuk Jung
مصطلحات موضوعية: Medicine, Biotechnology, Developmental Biology, Marine Biology, Cancer, Science Policy, Mental Health, Biological Sciences not elsewhere classified, per 1000 person, estimated across yearly, blood pressure control, adjusted incidence rates, 154 mm hg, 135 mm hg, 134 mm hg, 125 &# 8211, small positive association, slightly inverted associations, blood pressure target, sbp showed j, sbp showed flat, kidney composite events, additional risk factors, age &# 8805, ci ], 3 ), &# 8805, kidney events, risk factors
الوقت: 2, 1, 0
الوصف: Adjusted hazard ratios and incidence rates of cardio-kidney events across on-treatment systolic blood pressure levels according to the presence of risk factors.
الإتاحة: https://doi.org/10.1371/journal.pone.0297103.s010Test
https://figshare.com/articles/journal_contribution/Adjusted_hazard_ratios_and_incidence_rates_of_cardio-kidney_events_across_on-treatment_systolic_blood_pressure_levels_according_to_the_presence_of_risk_factors_/25129123Test
النص الكامل