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1
المؤلفون: Shinde, Ganesh H., Sundén, Henrik, 1978
المصدر: Chemistry - A European Journal. 29(1016)
مصطلحات موضوعية: BBr 3, aryl-aldehydes, N-heterocycles, Selectfluor, regioselective, ortho C−H halogenation
الوصف: An efficient regioselective functionalization of 2-aryl-heteroarenes and aryl aldehydes via an azaaryl BF2 complex has been developed. Mechanistically the reaction comprises fluoride to bromide ligand exchange on an aryl boron species and consecutive C−B bond cleavage to deliver a broad range of functionalized products. The reaction is high yielding, has a broad substrate scope where several different heteroarenes can be functionalized with chloro, bromo, iodo, hydroxyl, amine and BF2 in a highly regioselective fashion. The method can be applied for late-stage functionalization or for rapid skeleton remodeling with for instance cross-couplings.
وصف الملف: electronic
الوصول الحر: https://research.chalmers.se/publication/533972Test
https://research.chalmers.se/publication/533972/file/533972_Fulltext.pdfTest -
2دورية أكاديمية
المؤلفون: Sudha S, Mohamed Afzal Pasha
المصدر: Green Synthesis and Catalysis, Vol 3, Iss 2, Pp 190-193 (2022)
مصطلحات موضوعية: Bis pyrozolyl-methanes, Ethyl acetoacetate, Aromatic/het (aryl) aldehydes, Hydrazine/phenyl hydrazine, One-pot multi-component synthesis, Ultrasound, Chemical technology, TP1-1185, Biochemistry, QD415-436
الوصف: An efficient, catalyst-free and eco-friendly ultrasound-assisted novel one-pot pseudo-five-component synthesis of aryl-bis-[1H-pyrazol-5-ol-4yl]methanes, het(aryl)-bis-[1H-pyrazol-5-ol-4yl]methanes and their 1-phenyl derivatives in water is reported. The products were obtained in excellent yield in shorter duration with high purity, by simple filtration. This synthetic methodology has been optimized and discussed herein.
وصف الملف: electronic resource
العلاقة: http://www.sciencedirect.com/science/article/pii/S266655492200031XTest; https://doaj.org/toc/2666-5549Test
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3دورية أكاديمية
المؤلفون: Etify A. Bakhite, Suzan Abuelhassan, Mohamed A. Gad, Abdu E. Abdel-Rahman, Omaima F. Ibrahim, Islam S. Marae, Shaaban K. Mohamed, Joel T. Mague, Ayman Nafady
مصطلحات موضوعية: Biochemistry, Neuroscience, Biotechnology, Sociology, Plant Biology, Virology, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, 4 -( thiophen, nicotinate (< b, carboxylate (< b, related heterocyclic derivatives, thio )- 5, refluxing ethanol containing, b . b, f b, b >, 3a b, 2d b, 2a b, >- aryl derivatives, corresponding spiro compounds, yl )- 6, b <, pyridine derivatives, n <, ethyl 5, corresponding tetrahydropyrimidinones, aryl aldehydes, absolute ethanol
الوصف: The reaction of ethyl 5-cyano-2-methyl-4-(thiophen-2-yl)-6-thioxo-1,6-dihydropyridine-3-carboxylate ( 1 ) with 2-chloroacetamide or its N -aryl derivatives gave ethyl 6-((2-amino-2-oxoethyl)thio)-5-cyano-2-methyl-4-(thiophen-2-yl) nicotinate ( 2a ) or its N -aryl derivatives 2b – f , respectively. Cyclization of 2a – f into their isomers 3a – f was carried out by heating in absolute ethanol in the presence of a catalytic amount of sodium ethoxide. The o -aminoamide 3a was reacted with some aryl aldehydes in refluxing ethanol containing a few drops of conc. HCl to afford the corresponding tetrahydropyrimidinones 4a – d . The cyclocondensation reaction of 3a with some cycloalkanones such as cyclopentanone and cyclohexanone gave the corresponding spiro compounds 5a,b. The crystal structures of compounds 2a and 2d were determined by single-crystal X–ray diffraction techniques. All new compounds were evaluated for their insecticidal activity toward nymphs and adults of Aphis gossypi.
الإتاحة: https://doi.org/10.1021/acs.jafc.3c01202.s001Test
https://figshare.com/articles/journal_contribution/Pyridine_Derivatives_as_Insecticides_Part_4_Synthesis_Crystal_Structure_and_Insecticidal_Activity_of_Some_New_Thienylpyridines_Thienylthieno_2_3_i_b_i_pyridines_and_Related_Heterocyclic_Derivatives/24532765Test -
4دورية أكاديمية
المؤلفون: Ashmita Singh, Anudeep Kumar Narula
المصدر: Results in Chemistry, Vol 4, Iss , Pp 100279- (2022)
مصطلحات موضوعية: Aryl aldehydes, Phenyl acetylenes, Amines, TBAI, Propargylamines, Multi-component reaction, Chemistry, QD1-999
الوصف: A new and facile methodology was developed for the synthesis of a wide variety of synthetically important propargylamines via the A3 coupling reaction of aryl aldehydes, phenyl acetylenes, and amines. The reaction was catalyzed by tetra-butyl ammonium iodide (TBAI) in solvent acetonitrile utilizing a multi-component approach. The reaction is unique in the way that it operates smoothly in the air at optimum temperature in shorter reaction duration without any metal catalyst and is high yielding.
وصف الملف: electronic resource
العلاقة: http://www.sciencedirect.com/science/article/pii/S2211715621001843Test; https://doaj.org/toc/2211-7156Test
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5دورية أكاديمية
المؤلفون: Majid Mommahed Heravi (9225485), Ali Ayati (12001177), Mansoureh Daraie (6995462), Bahareh Tanhaei (12001201)
مصطلحات موضوعية: Organic Chemistry, Nuclear Chemistry, Computational Chemistry, Non-metal Chemistry, Nanochemistry and Supramolecular Chemistry, Optical Properties of Materials, Natural Products Chemistry, Organic Green Chemistry, Organic Chemistry not elsewhere classified, Quantum Chemistry, Organometallic Chemistry, Catalysts, Chitin, Chitosan, Energy dispersive spectroscopy, Fourier transform infrared spectroscopy, Scanning, electron microscopy, Aryl aldehydes, Energy dispersive X ray spectroscopy, Facile procedure, Magnetic chitosan, Novel catalysts, Novel nanocomposites, Refluxing condition, Three-components reactions, Silicon compounds
الوصف: A novel nanocomposite, H4SiW12O40 immobilised magnetic chitosan (HSiW-MC) was prepared via a facile procedure in one-pot fashion. This composite was fully characterised using several methods including, Fourier transform infrared spectroscopy, X-ray diffraction, energy-dispersive X-ray spectroscopy and scanning electron microscopy. It was applied as a novel catalyst in two three components reaction involving, dimedone, differently substituted aryl aldehydes and either 3-amino-1,2,4-triazole or 2-amino benzimidazole to afford the corresponding [1,2,4]triazolo/benzimidazolo quinazolinone derivatives. It showed excellent performance in the aforementioned reaction with the high yield of 96%. Also, the effect of HSiW-MC amount, catalysts, solvents and temperatures were studied and the best results were obtained in CH3CN in the presence of HSiW-MC (0.04 g) under refluxing conditions.
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6دورية أكاديمية
المؤلفون: Goodarzi Esmaeil, Mirza Behrooz
المصدر: Journal of the Serbian Chemical Society, Vol 85, Iss 1, Pp 79-87 (2020)
مصطلحات موضوعية: multi-component, electrosynthesis, 4-dihydro-pyridine, nanosized, aryl aldehydes, Chemistry, QD1-999
الوصف: An electrochemical strategy to the synthesis of novel 4-aryl-5-benzoyl- 2-hydroxy-6-(trifluoromethyl)-1,4-dihydropyridine-3-carbonitriles nanoparticles via three-component reaction of aromatic aldehydes, malononitrile and 4,4,4-trifluoro-1-phenylbutane-1,3-dione in water/ethanol in an undivided cell in the presence of sodium bromide as an electrolyte is described. This method has several advantages, such as high to excellent product yields (65–85 %), atom economy, environment friendly, and no need for chromatographic separations.
وصف الملف: electronic resource
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7دورية أكاديمية
المؤلفون: Panigrahi, Naresh1, 2, 1, Ganguly, Swastika2, Panda, Jagadeesh3
المصدر: Research Journal of Pharmacy and Technology 11(12):5611-5622. 2018
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8دورية أكاديمية
المؤلفون: Vetrivelan Murugesan (10073586), Anirban Ganguly (1601971), Ardra Karthika (11027100), Ramesh Rasappan (1363335)
مصطلحات موضوعية: Biochemistry, Genetics, Molecular Biology, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, allylic pyridinium salts, acyl radicals, formyl, availability, bioactive molecules, aryl halides, benzylic, activation, TBADT catalyst, cleavage, bond, Alkylation, handful, alkyl, site-selective functionalization, Merging TBADT Hydrogen Atom Transfer, presence, α- methylene carbonyl, Aldehyde, aryl aldehydes, sterically, Polarity-matched, synthesis, amines, Nickel Catalysis Catalyst
الوصف: Catalyst controlled site-selective C–H functionalization is a challenging but powerful tool in organic synthesis. Polarity-matched and sterically controlled hydrogen atom transfer (HAT) provides an excellent opportunity for site-selective functionalization. As such, the dual Ni/photoredox system was successfully employed to generate acyl radicals from aldehydes via selective formyl C–H activation and subsequently cross-coupled to generate ketones, a ubiquitous structural motif present in the vast majority of natural and bioactive molecules. However, only a handful of examples that are constrained to the use of aryl halides are developed. Given the wide availability of amines, we developed a cross-coupling reaction via C–N bond cleavage using the economic nickel and TBADT catalyst for the first time. A range of alkyl and aryl aldehydes were cross-coupled with benzylic and allylic pyridinium salts to afford ketones with a broad spectrum of functional group tolerance. High regioselectivity toward formyl C–H bonds even in the presence of α-methylene carbonyl or α-amino/oxy methylene was obtained.
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9دورية أكاديمية
المؤلفون: Abdolhamid Alizadeh (10526534), Mohammad Mehdi Khodaei (10573925), Maryam Haghipour (10573926)
مصطلحات موضوعية: Organic Chemistry, Magnetic nanocatalyst, Aryl aldehydes, Anilines, Dimethyl acetylenedicarboxylate, 4-Carboxybenzyl sulfamic acid on magnetic, nanoparticles
الوصف: 4-Carboxybenzyl sulfamic acid functionalized Fe3O4 nanoparticles as a novel catalyst was manufactured. This catalyst was characterized and evaluated in the one-pot synthesis of furan-2(5H)-one derivatives from dimethyl acetylenedicarboxylate, aryl aldehydes, and various anilines in terms of activity and reusability. The catalyst showed high catalytic activity, good recoverability and reusability, thermal stability and provides clean production of fine furan-2(5H)-one derivatives in short reaction times. The heterogeneous catalyst could be used at least five times without significant loss of its activity.
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10دورية أكاديمية
المؤلفون: Kesatebrhan Haile Asressu (10277062), Chieh-Kai Chan (2936862), Cheng-Chung Wang (1735783)
مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Biotechnology, Ecology, Computational Biology, Chemical Sciences not elsewhere classified, nitrogen source, transition-metal-free condition, Claisen, Michael addition reaction, Application, Diketone, Derivative, ammonium acetate, base employment, aryl aldehydes, additive, substrate scope, One-Pot Synthesis, strategy, Pyridine, method, preparation, catalyst-free system, material, X-ray single-crystal diffraction an., reagent, cost-effectiveness
الوصف: We developed a facile and green one-pot synthetic method for substituted 1,3,5-triaryl-1,5-diketones by Claisen–Schmidt condensation following Michael addition reaction of aryl ketones and aryl aldehydes under a transition-metal-free condition. This convenient one-pot synthetic strategy has several advantages, including being transition-metal-free, having no extra additives or reagents, having a broad substrate scope, having a high isolated yield, having a minimum amount of base employment, having a shorter reaction time, use of cheap starting materials, cost-effectiveness, and being environment friendly. Some of the chemical structures of 1,5-diketones were confirmed by X-ray single-crystal diffraction analysis. The application of 1,5-diketones was demonstrated in the preparation of 2,4,6-triaryl pyridine derivatives under a catalyst-free system using ammonium acetate as a nitrogen source.