يعرض 1 - 10 نتائج من 285 نتيجة بحث عن '"amoxicillin plus clavulanic acid"', وقت الاستعلام: 1.14s تنقيح النتائج
  1. 1
    دورية أكاديمية

    الوصف: Objectives: Septic arthritis (SA) is a serious bacterial infection that must be treated efficiently and timely. The large number of culture-negative cases makes local epidemiological data important. Accordingly, this study aimed to evaluate the etiology, clinical characteristics, and therapeutic approach of SA in children in Turkiye, emphasizing the role of real-time polymerase chain reaction (PCR) techniques in the diagnosis. Methods: In this multi-center, prospective study, children hospitalized due to SA between February 2018 and July 2020 in 23 hospitals in 14 cities in Turkiye were included. Clinical, demographic, laboratory, and radiological findings were assessed, and real-time PCR was performed using synovial fluid samples. Results: Seventy-five children aged between 3 and 204 months diagnosed with acute SA were enrolled. Joint pain was the main complaint at admission, and the most commonly involved joints were the knees in 58 patients (77.4%). The combination of synovial fluid culture and real-time PCR detected causative bacteria in 33 patients (44%). In 14 (18.7%) patients, the etiological agent was demonstrated using only PCR. The most commonly isolated etiologic agent was Staphylococcus aureus, which was detected in 22 (29.3%) patients, while Streptococcus pyogenes was found in 4 (5.3%) patients and Kingella kingae in 3 (4%) patients. Streptococcus pyogenes and Kingella kingae were detected using only PCR. Most patients (81.3%) received combination therapy with multiple agents, and the most commonly used combination was glycopeptides plus third-generation cephalosporin. Conclusions: Staphylococcus aureus is the main pathogen in pediatric SA, and with the use of advanced diagnostic approaches, such as real-time PCR, the chance of diagnosis increases, especially in cases due to Kingella kingae and Streptococcus pyogenes. © 2024 by the authors. ; Eskişehir Osmangazi Üniversitesi, ESOGU: 2019/11052 ; We prospectively analyzed the clinical and laboratory findings of pediatric SA patients between February ...

    العلاقة: Children; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://doi.org/10.3390/children11010134Test; https://hdl.handle.net/20.500.12831/19812Test; 11; 2-s2.0-85183187327

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  3. 3
    دورية أكاديمية

    المصدر: Clinical Microbiology and Infection, 27 (3), 398 - 405 (2021)

    الوصف: peer reviewed ; Objectives: Many transplant physicians screen for and treat asymptomatic bacteriuria (ASB) during post-kidney-transplant surveillance. We investigated whether antibiotics are effective in reducing the occurrence of symptomatic urinary tract infection (UTI) in kidney transplant recipients with ASB. Methods: We performed this multicentre, randomized, open-label trial in kidney transplant recipients who had ASB and were ≥2 months post-transplantation. We randomly assigned participants to receive antibiotics or no therapy. The primary outcome was the incidence of symptomatic UTI over the subsequent 12 months. Results: One hundred and ninety-nine kidney transplant recipients with ASB were randomly assigned to antibiotics (100 participants) or no therapy (99 participants). There was no significant difference in the occurrence of symptomatic UTI between the antibiotic and no-therapy groups (27%, 27/100 versus 31%, 31/99; univariate Cox model: hazard ratio 0.83, 95%CI: 0.50–1.40; log-rank test: p 0.49). Over the 1-year study period, antibiotic use was five times higher in the antibiotic group than in the no-therapy group (30 antibiotic days/participant, interquartile range 20–41, versus 6, interquartile range 0–15, p < 0.001). Overall, 155/199 participants (78%) had at least one further episode of bacteriuria during the follow-up. Compared with the participant's baseline episode of ASB, the second episode of bacteriuria was more frequently caused by bacteria resistant to clinically relevant antibiotics (ciprofloxacin, cotrimoxazole, third-generation cephalosporin) in the antibiotic group than in the no-therapy group (18%, 13/72 versus 4%, 3/83, p 0.003). Conclusions: Applying a screen-and-treat strategy for ASB does not reduce the occurrence of symptomatic UTI in kidney transplant recipients who are more than 2 months post-transplantation. Furthermore, this strategy increases antibiotic use and promotes the emergence of resistant organisms. © 2020 The Authors

    العلاقة: urn:issn:1198-743X; urn:issn:1469-0691; https://orbi.uliege.be/handle/2268/296678Test; info:hdl:2268/296678; https://orbi.uliege.be/bitstream/2268/296678/1/PIIS1198743X20305346.pdfTest; scopus-id:2-s2.0-85092010280; info:pmid:32919076

  4. 4
    دورية أكاديمية

    المؤلفون: Çelik, E., Gönen, Tansu

    الوصف: A 46-year-old female patient, who presented with a black, crusty lesion on the upper eyelid, was diagnosed with cutaneous anthrax after the detection of Bacillus anthracis in the skin culture. It was determined that the symptoms started after she cooked the meat she bought from a butcher. Anthrax is a disease that should be kept in mind in cutaneous infections even in isolated lesions, especially in endemic areas. © 2021

    العلاقة: Case Reports in Ophthalmology; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://doi.org/10.1159/000519051Test; https://hdl.handle.net/20.500.11776/8226Test; 12; 836; 840; 2-s2.0-85117530271

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    دورية أكاديمية

    المصدر: Pediatrics. 130(1)

    الوصف: ObjectiveAntibiotic use rates have declined dramatically since the 1990s. We aimed to determine if, when, and at what level the decline in antibiotic-dispensing rates ended and which diagnoses contributed to the trends.MethodsAntibiotic dispensings and diagnoses were obtained from 2 health insurers for 3- to

    وصف الملف: application/pdf

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    دورية أكاديمية

    الوصف: Background/aim: Rapid antigen test (RAT) is a practical test to detect the presence of Group A beta hemolytic streptococcus antigens in throat swab samples. The aim of this study is to investigate the changes in the empiric antibiotic prescribing behavior of 10 family physicians in Kırıkkale Province after using RAT in 2017. Materials and methods: RAT test practice started in Family Medicine in February 2017. Family Medicine Information System (FMIS) includes clinical and prescription records of 10 family physicians, providing health service to approximately 35,000 residents in Kırıkkale. The numbers of antibiotics prescribed by the physicians according to the ICD-10 codes (including upper respiratory tract infections) in February, March, and April of 2015, 2016, 2017 were determined. The number and group of antibiotics prescribed by the family physicians with the determined diagnosis and time periods were specified in the FMIS and recorded. Results: Antibiotic prescription behaviors of family physicians do not show a significant difference between 2015 and 2016. There was a dramatic and significant decrease in the number of prescribed antibiotics in 2017 compared to 2015 and 2016 (P 0.05). Conclusion: This study shows that there has been a significant decrease in antibiotic prescription in 10 Family Medicine departments in 2017 in comparison to February, March, and April 2015 and 2016. The use of RAT resulted in a decrease in antibiotic prescription rates in 2017. © TÃœBÄ°TAK.

    العلاقة: Turkish Journal of Medical Sciences; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/11499/37509Test; https://doi.org/10.3906/sag-1908-164Test; 50; 731; 737; 2-s2.0-85087038236; WOS:000613005100011

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    دورية أكاديمية

    المصدر: Pediatrics. 114(5)

    الوصف: BackgroundWidespread use of broad-spectrum antibiotics contributes to increasing rates of bacterial resistance to antibiotics. Second-generation macrolides have become popular for use among children because of their broad spectrum and favorable dosing and side-effect profiles, although experts do not generally recommend them for use as initial treatment of infections among younger children.ObjectiveTo assess trends in second-generation macrolide use from 1996 to 2000 among children treated as outpatients in 9 US health plans, including associated diagnoses and use as initial treatment.MethodsWe sampled claims data for 25000 children, 3 months to

    وصف الملف: application/pdf

  8. 8
    دورية أكاديمية

    الوصف: We aimed to determine pathogen microorganisms, their antimicrobial resistance patterns, and the effect of initial treatment on clinical outcomes in patients with diabetic foot infection (DFI). Patients with DFI from 5 centers were included in this multicenter observational prospective study between June 2018 and June 2019. Multivariate analysis was performed for the predictors of reinfection/death and major amputation. A total of 284 patients were recorded. Of whom, 193 (68%) were male and the median age was 59.9 ± 11.3 years. One hundred nineteen (41.9%) patients had amputations, as the minor (n = 83, 29.2%) or major (n = 36, 12.7%). The mortality rate was 1.7% with 4 deaths. A total of 247 microorganisms were isolated from 200 patients. The most common microorganisms were Staphylococcus aureus (n = 36, 14.6%) and Escherichia coli (n = 32, 13.0%). Methicillin resistance rates were 19.4% and 69.6% in S aureus and coagulase-negative Staphylococcus spp., respectively. Multidrug-resistant Pseudomonas aeruginosa was detected in 4 of 22 (18.2%) isolates. Extended-spectrum beta-lactamase-producing Gram-negative bacteria were detected in 20 (38.5%) isolates of E coli (14 of 32) and Klebsiella spp. (6 of 20). When the initial treatment was inappropriate, Klebsiella spp. related reinfection within 1 to 3 months was observed more frequently. Polymicrobial infection (p =.043) and vancomycin treatment (p =.007) were independent predictors of reinfection/death. Multivariate analysis revealed vascular insufficiency (p =.004), hospital readmission (p =.009), C-reactive protein > 130?mg/dL (p =.007), and receiving carbapenems (p =.005) as independent predictors of major amputation. Our results justify the importance of using appropriate narrow-spectrum empirical antimicrobials because higher rates of reinfection and major amputation were found even in the use of broad-spectrum antimicrobials. © The Author(s) 2021.

    العلاقة: International Journal of Lower Extremity Wounds; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://doi.org/10.1177/15347346211004141Test; https://hdl.handle.net/20.500.12831/17898Test; 22; 283; 290; 2-s2.0-85104645892

  9. 9
    دورية أكاديمية

    المصدر: Internal Medicine Meeting Abstracts

    الوصف: CASE: A 44-year-old male without signficant past medical history underwent endobronchial ultrasound- guided transbronchial needle aspiration (EBUS-TBNA) for an incidentally identified subcarinal mass. He later presented with pleuritic chest pain and shortness of breath. CT imaging demonstrated enlargement of the subcarinal mass with a trace pericardial effusion. The patient was planned to undergo repeat EBUS-TBNA, however, he quickly developed hemodynamic instability. Echocardiogram revealed a pericardial effusion with evidence of tamponade. Emergent pericardiocentesis was performed with placement of a pericardial drain, purulent fluid was obtained. Videoassisted thoracoscopic surgery (VATS) was performed with mediastinal washout and pericardial window. Fluid cultures returned positive for S. aureus and Capnocytophaga. IMPACT/DISCUSSION: Bacterial pericarditis is a rare cause of pericarditis; in cases of secondary bacterial pericarditis, Staphylococcus Aureus is the most commonly implicated bacteria. Pericarditis is a known procedural complication of EBUS-TBNA. Given our patient's hemodynamic instability in the setting of cardiac tamponade, emergent pericardiocentesis was indicated. VATS was selected as the treatment modality of choice over subxiphoid pericardotomy, the standard of care, in order to achieve optimal source control by marsupialization of the bronchogenic cyst and completion of a mediastinal washout. Infectious disease was consulted given the atypical growth of Capnocytophaga and S. Aureus for which he was initially treated with Vancomycin and Piperacillin-Tazobactam then transitioned to Amoxicillin- Clavulanate to complete a 6-week treatment course. It was determined that Capnocytophagia was likely introduced to the patient's respiratory system by his dog licking the patient's face. Colchicine was administered for treatment of pericarditis in line with the current guideline recommendations. CONCLUSION: We present an uncommon case of Capnocytophaga bacterial pericarditis leading to cardiac ...

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    دورية أكاديمية

    المؤلفون: Kochhar, Parul, Ng Sueng, Luis F

    المصدر: Internal Medicine Meeting Abstracts

    الوصف: CASE: 39 year old female with a history of left nephrectomy in 2009, end-stage renal disease due to obstructive uropathy from neurogenic bladder, status post kidney transplant in 2016 with subsequent failure in 2020. She started peritoneal dialysis that year. She had residual urine production, for which she used intermittent straight catheterization. She was admitted for severe symptomatic anemia. Vitals were within normal limits. The examination was remarkable for subtle pain in the right lower quadrant. Complete blood count revealed a white count of 14.2 and hemoglobin of 6.0 mg/dL. Incidentally, the nursing staff noted cloudy urine with a very dense consistency during her straight catheterization. Dipstick urinalysis was unable to be fully processed due to the dense consistency of her urine but showed 149 RBCs, 182 WBCs, and many bacteria. Computed Tomography Abdomen showed a 7 cm large gas and fluid collection with no normal identifiable renal parenchyma consistent with necrosis of her kidney allograft. Abscess culture grew Actinomyces species and she was started on Ertapenem. The transplant surgery team was consulted but did not recommend transplantectomy due to poor surgical candidacy. A percutaneous drain was placed to achieve source control. She was eventually discharged with long-term oral antibiotic therapy with Augmentin. IMPACT/DISCUSSION: 1 in 5 patients with renal transplantation will have allografts that fail in 5 years, and more than one in two will have graft failure by 10 years. Potential complications of failed allografts include infections, malignancy, bone disease, and cardiovascular disease. Among these, infections remain the leading cause of complications following a kidney transplant. These can occur early post-transplant, during peak immunosuppression, and late onset. The latter occurs 6-12 months following transplant and includes community-acquired pneumonia, upper respiratory infections, and urinary infections, which are by far the most common. In patients with urinary infections, the ...