المؤلفون: Meng-Xia Su, Hsiang-Wen Lin, Hanh T. H. Nguyen, Tien-Chao Lin, Chih-Jung Chen, Hwei-Chung Wang, Chen-Teng Wu, Yao-Chung Wu, Geng-Yan He, Liang-Chih Liu, Chih-Hao Huang

المصدر: BMC Cancer, Vol 24, Iss 1, Pp 1-11 (2024)

مصطلحات موضوعية: Breast cancer, Eribulin, Absolute lymphocyte count, Neutrophil-to-lymphocyte count, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: Abstract Background Studies have shown that the absolute lymphocyte count (ALC) and the neutrophil-to-lymphocyte ratio (NLR) are related to the outcomes in patients with breast cancer receiving specific chemotherapies. However, the reports have focussed on the initial blood test and there is a lack of evidence or data to support that dynamic changes of ALC or NLR are associated with the patients’ survival outcomes. Methods We retrospectively reviewed electronic medical records from patients with breast cancer treated with eribulin from 2015 to 2019 at our institution. Blood test data were available prior to starting eribulin (baseline), and at 1, 3 and 6 months after initiating eribulin. We classified the patients into ALC and NLR high and low groups using the following cut-offs: 1000/µl for ALC and 3 for NLR. We defined ALC and NLR trends as increasing or decreasing compared with the initial data. We assessed the associations between the ALC and NLR with progression-free survival and overall survival. Results There were 136 patients with breast cancer treated with eribulin. Of these patients, 60 had complete blood tests and follow-up data. Neither a high ALC nor a low baseline NLR was associated with the survival outcome. One month after initiating eribulin treatment, a high ALC and a low NLR were significantly associated with longer progression-free survival (p = 0.044 for each). Three months after initiating eribulin, a high ALC was significantly associated with better overall survival (p = 0.006). A high NLR at 3 or 6 months after initiating eribulin was associated with worse overall survival (p = 0.017 and p = 0.001, respectively). The ALC and NLR trends across times were not associated with survivals. Conclusion We showed that 1, 3 and 6 months after initiating eribulin, a high ALC and a low NLR may be related to the patients’ survival outcomes. The ALC and NLR trends were not associated with survival. Accordingly, we believe patients who maintain a high ALC and a low NLR may have better clinical outcomes after initiating eribulin.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1471-2407Test

الوصول الحر: https://doaj.org/article/f97469a6d895400aa394684af461c007Test

المؤلفون: Meng-Xia Su, Hsiang-Wen Lin, Hanh T. H. Nguyen, Tien-Chao Lin, Chih-Jung Chen, Hwei-Chung Wang, Chen-Teng Wu, Yao-Chung Wu, Geng-Yan He, Liang-Chih Liu, Chih-Hao Huang

مصطلحات موضوعية: Medicine, Cell Biology, Genetics, Molecular Biology, Immunology, Cancer, Science Policy, Breast cancer, Eribulin, Absolute lymphocyte count, Neutrophil-to-lymphocyte count

الوصف: Additional file 1: Supplementary Figure 1. Overall survival (OS) among patients with increased or decreased trends of ALC, NLR (0: decreasing, 1: non-decreasing). Supplementary Figure 2. Comparing PFS and OS among different groups of patients stratified by ALC trends according to the baseline level. Supplementary Figure 3. Comparing PFS and OS among different groups of patients stratified by NLR baseline and trends. Supplementary Figure 4. Analysis on the association of high(1)/low(0) NLR/ALC with OS stratified by on(1)/off(0) treatment with eribulin.

العلاقة: https://figshare.com/articles/journal_contribution/Additional_file_1_of_Monitoring_trends_in_the_absolute_lymphocyte_count_and_the_neutrophil-to-lymphocyte_ratio_in_patients_with_breast_cancer_receiving_eribulin/25210508Test

الإتاحة: https://doi.org/10.6084/m9.figshare.25210508.v1Test
https://figshare.com/articles/journal_contribution/Additional_file_1_of_Monitoring_trends_in_the_absolute_lymphocyte_count_and_the_neutrophil-to-lymphocyte_ratio_in_patients_with_breast_cancer_receiving_eribulin/25210508Test

المؤلفون: Riyadi, Nathasya Rizkyana, Carmelita, Austin Bertilova, Sasmithae, Lia, Kahanjak, Donna Novina, Putra S, Ravenalla Abdurrahman Al Hakim Sampurna

المصدر: The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy; Vol 24, No 3 (2023): VOLUME 24, NUMBER 2, December, 2023; 195 ; 2302-8181 ; 1411-4801

مصطلحات موضوعية: Hepatology, absolute lymphocyte count, ascites, liver cirrhosis

الوصف: Background: Cirrhosis is the final stage of liver disease characterized by fibrosis and irreversible nodule formation due to chronic inflammation. The most common liver cirrhosis complication is ascites, where pathological fluid accumulates in the peritoneal cavity. In cirrhosis, lymphocytes infiltrate the liver and contribute to stellate cell activation, differentiation, and the fibrogenic response. Many recent studies have not studied a relationship between the absolute lymphocyte count and ascites in liver cirrhosis. Therefore, it is important to investigate the relationship between lymphocytes and ascites in liver cirrhosis.Method: This is an observational study with a cross-sectional design study. Held in August–October 2022 at Dr. Doris Sylvanus Hospital's Medical Record Installation. 64 samples were selected based on inclusion and exclusion criteria. Meanwhile, absolute lymphocyte count were measured from the patient's blood tests or by calculation. Ascites were diagnosed by physical examination and radiology. The relationship between absolute lymphocyte count and ascites was analyzed using the chi-square test, with the results considered statistically significant when the p-value 0.05.Result: The medical records from April 2019 to April 2022, there were 64 samples, of which 15 and 49 were without and with ascites. Based on the chi-square test results, there was a significant relationship between absolute lymphocyte count and the incidence of ascites, with p = 0.02.Conclusion: This study concluded that there is a relationship between absolute lymphocyte count and ascites in patients with liver cirrhosis, where absolute lymphocyte count tends to decrease.

وصف الملف: application/pdf

العلاقة: http://www.ina-jghe.com/index.php/jghe/article/view/891/771Test; http://www.ina-jghe.com/index.php/jghe/article/downloadSuppFile/891/15Test; http://www.ina-jghe.com/index.php/jghe/article/view/891Test

الإتاحة: https://doi.org/10.24871/2432023195Test
http://www.ina-jghe.com/index.php/jghe/article/view/891Test

المؤلفون: Young, Richard Benjamin, Panchal, Hemali, Ma, Weijie, Chen, Shuai, Steele, Aaron, Iannucci, Andrea, Li, Tianhong

مصطلحات موضوعية: Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Clinical Research, Clinical Trials and Supportive Activities, Cancer, Prevention, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Good Health and Well Being, immune checkpoint inhibitor, inpatient, survival outcome, comorbidities, absolute lymphocyte count, derived neutrophil to lymphocyte ratio, hospitalized adult patients, Clinical sciences, Oncology and carcinogenesis

الوصف: BackgroundImmune checkpoint inhibitor (ICI) therapy has improved survivals with a favorable toxicity profile in a variety of cancer patients. We hypothesized that hospitalized cancer patients who have acute or chronic comorbidities may have suppressed immune systems and poor clinical outcomes to ICIs. The objective of this study was to explore clinical outcomes and predictive factors of hospitalized cancer patients who received ICI therapy at an NCI-designated Comprehensive Cancer Center.MethodsA retrospective review of electronic medical records was conducted for adult cancer patients who received an FDA-approved ICI during admission from 08/2016 to 01/2022. For each patient we extracted demographics, cancer histology, comorbidities, reasons for hospitalization, ICI administered, time from treatment to discharge, time from treatment to progression or death, and complete blood counts. Progression-free survival (PFS) and overall survival (OS) were estimated using the Kaplan-Meier method and compared using the log-rank test. The 95% confidence interval for survival was calculated using the exact binomial distribution. Statistical significance was defined as 2-sided p4 in hospitalized patients was associated with poor survival outcomes.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/7wb7d5prTest

المؤلفون: Wan-Ju Lee, Yi-Lun Wang, Hsiu-Huei Peng, Cheng-Tao Lin

المصدر: Taiwanese Journal of Obstetrics & Gynecology, Vol 62, Iss 4, Pp 506-509 (2023)

مصطلحات موضوعية: Gynecologic malignancies, Immune checkpoint inhibitor, Absolute lymphocyte count, Absolute neutrophil count, Platelet to lymphocyte ratio, Gynecology and obstetrics, RG1-991

الوصف: Objective: Immune checkpoint inhibitors are rapidly being used in solid and hematologic malignancies, including gynecologic cancers. The high mortality and relapsing rates of advanced gynecologic malignancies remain a challenging issue. This study aimed to identify the predicting factors associated with survival prognosis and disease control in patients with refractory/relapsing (R/R) gynecologic malignancies receiving anti PD-1 therapy. Materials and methods: We retrospectively reviewed the medical records of 49 patients diagnosed with R/R gynecologic malignancies between July 2012 and June 2019 in Chang Gung Memorial Hospital, Taiwan. Among the 49 patients, 6 were excluded due to incomplete medical records or not receiving anti PD-1 therapy. The remaining 43 patients were further divided into responsive and non-responsive groups according to disease control for predicting prognostic factor analysis. Results: For the 43 cases, the median age at diagnosis and disease follow-up length were 54 years and 29 months, respectively. Among them, 23 (53%) were categorized into the responsive group, and the remaining 20 (47%) were categorized into the non-responsive group. The mortality rates were 17% and 25% in the responsive and non-responsive groups, respectively. The responsive group had significantly higher absolute lymphocyte count (ALC), higher absolute neutrophil count (ANC) and low platelet to lymphocyte ratio (PLR) than the non-responsive group. A superior long-term survival trend was also observed in the responsive group, but the difference was not statistically significant. Conclusions: This study reinforced the hypothesis that high ALC, high ANC and low PLR are associated with superior disease control in patients with R/R gynecologic malignancies receiving anti PD-1 therapy.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S1028455923001213Test; https://doaj.org/toc/1028-4559Test

الوصول الحر: https://doaj.org/article/2c2adc59355e44ac8792e85eb06a94abTest

المؤلفون: Wei‐Xiang Qi, Xiaoyan Wang, Chengqiang Li, Shuyan Li, Huan Li, Feifei Xu, Jiayi Chen, Shengguang Zhao, Hecheng Li

المصدر: Thoracic Cancer, Vol 14, Iss 17, Pp 1556-1566 (2023)

مصطلحات موضوعية: absolute lymphocyte count, esophageal squamous cell carcinoma, neoadjuvant chemoradiotherapy, pathological complete response, pembrolizumab, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: Abstract Background The aim of the study was to analyze the relationship between pretreatment inflammatory biomarkers (IBs) and survival outcomes for patients with esophageal squamous cell carcinoma (ESCC) treated with neoadjuvant chemoradiotherapy (neo‐CRT) and pembrolizumab. Methods Clinical variables and IBs (absolute monocyte count [AMC], absolute lymphocyte count [ALC], platelet count [PLT], neutrophil‐to‐lymphocyte ratio [NLR], platelet‐to‐lymphocyte ratio [PLR], lymphocyte‐to‐monocyte ratio [LMR], pan‐immune inflammation value [PIV], systemic immunoinflammatory index [SII], systemic immunoreactivity index [SIRI] and prognostic nutritional index [PNI]) were collected. Univariate and multivariate analysis were performed to identify the independent factors for outcomes of ESCC. Results A total of 51 patients were included. Of these, 35 patients achieved pathological complete response (pCR) after neo‐CRT and pembrolizumab (pCR: 68.6%). With a median follow‐up of 20 months, the two‐year PFS and OS of the cohort was 64% and 91%, respectively. Multivariate logistic regression analysis indicated that ALC (overall response [OR] 4.4, p = 0.051) and PLT (OR 6.7, p = 0.023) were two independent predictors for achieving pCR among ESCC treated with neo‐CRT and pembrolizumab. Multivariate Cox regression analysis showed that ALC (HR 0.27, p = 0.028) and SIRI (HR 3.13, p = 0.048) were two independent predictors associated with PFS. Kaplan Meier analysis demonstrated that the PFS of ESCC with high baseline ALC was significantly better than those with low ALC (2‐year PFS: 77% vs. 47%, p = 0.027), but not for overall survival (2‐year OS: 96% vs. 87%, p = 0.46). Conclusions This retrospective analysis based on a prospective cohort for the first time demonstrates that pretreatment ALC is an independent predictor for achieving pCR and favorable outcomes of ESCC treated with neo‐CRT and pembrolizumab.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1759-7706Test; https://doaj.org/toc/1759-7714Test

الوصول الحر: https://doaj.org/article/0bbd9df068ba46e4b632d2e1c1bf1908Test

المؤلفون: Jiale Yang, Xiaojian Zhu, Jun Feng

المصدر: International Journal of Molecular Sciences, Vol 25, Iss 3, p 1902 (2024)

مصطلحات موضوعية: sepsis, lymphocyte depletion, revive, absolute lymphocyte count, innate lymphocyte subgroups, effector T lymphocytes, Biology (General), QH301-705.5, Chemistry, QD1-999

الوصف: Sepsis remains a global challenge, especially in low- and middle-income countries, where there is an urgent need for easily accessible and cost-effective biomarkers to predict the occurrence and prognosis of sepsis. Lymphocyte counts are easy to measure clinically, and a large body of animal and clinical research has shown that lymphocyte counts are closely related to the incidence and prognosis of sepsis. This review extensively collected experimental articles related to lymphocyte counts since the unification of the definition of sepsis. The article categorizes and discusses the relationship between absolute lymphocyte counts, intrinsic lymphocyte subsets, effector T-lymphocytes, B-lymphocytes, dendritic cells, and the incidence and prognosis of sepsis. The results indicate that comparisons of absolute lymphocyte counts alone are meaningless. However, in addition to absolute lymphocyte counts, innate lymphocyte subsets, effector T-cells, B-lymphocytes, and dendritic cells have shown certain research value in related studies.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/1422-0067/25/3/1902Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test

الوصول الحر: https://doaj.org/article/69c85635bbd54a90aefc5a69d7647db2Test

المؤلفون: Lv Y, Liu Y, Li K, Liu Z, Zhang T, Duan M, Chen Y, Ma T, Huang G, Huang Z

المصدر: Journal of Inflammation Research, Vol Volume 16, Pp 1761-1770 (2023)

مصطلحات موضوعية: non-small cell lung cancer. microwave ablation. nomogram. preoperative absolute lymphocyte count, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950

الوصف: Yonghui Lv,1 Yuanwei Liu,1 Kaiguo Li,1 Zhiling Liu,1 Tong Zhang,1 Mingguang Duan,1 Yunchao Chen,1 Teng Ma,1 Guanghui Huang,2,* Zhaoqin Huang1,* 1Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250000, People’s Republic of China; 2Department of Oncology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Guanghui Huang, Department of Oncology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 9677 Jingshi Road, Lixia District, Jinan, Shandong, 250012, People’s Republic of China, Email hgh3612@163.com Zhaoqin Huang, Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324, Jingwu Road, Huaiyin District, Jinan, Shandong, 250012, People’s Republic of China, Email devin813@163.comPurpose: This study aims to investigate the prognostic value of preoperative absolute lymphocyte count (preALC) for non-small cell lung cancer (NSCLC) after microwave ablation (MWA) and build a combined nomograph with clinical features to predict the local recurrence.Patients and Methods: A total of 118 NSCLC patients who underwent microwave ablation were enrolled in this study. The median local recurrence-free survival (LRFS) was 35.5 months. Independent prognostic factors obtained by multivariate analysis were included in the prediction model. The prognostic value of the model was assessed by the area under the time-dependent receiver operating characteristic curve (T-AUC).Results: Histological subtype and preALC were independent risk factors for local relapse-free survival. According to the time-dependent receiver operating characteristic curve (T-ROC), the optimal cut-off value of preALC was 1.965× 109/L, the sensitivity was 0.837, and the specificity was 0.594. The area under the T-ROC curve (AUC) of preALC was 0.703. To establish a nomogram to predict the local recurrence rate of NSCLC after MWA based on the prognostic factors revealed by Cox regression.Conclusion: Preoperative lymphocyte count reduction is associated with poor prognosis of NSCLC. The nomogram model combined with preALC can provide a good individualized prediction of local recurrence after microwave ablation.Keywords: non-small cell lung cancer, microwave ablation, nomogram, preoperative absolute lymphocyte count

وصف الملف: electronic resource

العلاقة: https://www.dovepress.com/nomogram-based-on-preoperativeTest-absolute-lymphocyte-count-to-predict-lo-peer-reviewed-fulltext-article-JIR; https://doaj.org/toc/1178-7031Test

الوصول الحر: https://doaj.org/article/7fc39c666f73452b923c9bfde33b6d32Test

المؤلفون: McManus, Nicholas M., Offman, Ryan, Oetman, Jason D.

المصدر: Western Journal of Emergency Medicine: Integrating Emergency Care with Population Health. 21(6)

مصطلحات موضوعية: COVID-19, Emergency Department, Coronavirus, SARS-CoV-2, Absolute Lymphocyte Count, Neutrophil to Lymphocyte Ratio, D-dimer, phenotype theory, High-flow Nasal Cannula, Non-invasive Ventilation

الوصف: The novel coronavirus, SARs-CoV-2, causes a clinical disease known as COVID-19. Since being declared a global pandemic, a significant amount of literature has been produced and guidelines are rapidly changing as more light is shed on this subject. Decisions regarding disposition must be made with attention to comorbidities. Multiple comorbidities portend a worse prognosis. Many clinical decision tools have been postulated; however, as of now, none have been validated. Laboratory testing available to the emergency physician is nonspecific but does show promise in helping prognosticate and risk stratify. Radiographic testing can also aid in the process. Escalating oxygen therapy seems to be a safe and effective therapy; delaying intubation for only the most severe cases in which respiratory muscle fatigue or mental status demands this. Despite thrombotic concerns in COVID-19, the benefit of anticoagulation in the emergency department (ED) seems to be minimal. Data regarding adjunctive therapies such as steroids and nonsteroidal anti-inflammatories are variable with no concrete recommendations, although steroids may decrease mortality in those patients developing acute respiratory distress syndrome. With current guidelines in mind, we propose a succinct flow sheet for both the escalation of oxygen therapy as well as ED management and disposition of these patients.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/4f96w6xgTest

المؤلفون: Antholi Keloth Kavya, Chandran K Nair, Maya Padmanabhan, Edakkadath Raghavan Sindhu

المصدر: Asian Pacific Journal of Cancer Care, Vol 7, Iss 4, Pp 607-613 (2022)

مصطلحات موضوعية: non-hodgkin's lymphoma, diffuse large b-cell lymphoma, international prognostic index, absolute lymphocyte count, lymphocyte-to-monocyte ratio, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: Background: The present study is a retrospective observational analysis of patients diagnosed with DLBCL and T cell lymphoma during the period of January 2011 to December 2015 at Malabar Cancer Centre, Thalassery. Several studies have shown that ALC and LMR can be used as prognostic indicators for diagnosis, treatment and survival in DLBCL. But there were very few studies done on the correlation of these parameters with T cell lymphoma. So we analysed the influence of haematological parameters in both DLBCL and T cell lymphomas. The primary objective of the present study was to correlate haematological parameters and LMR as predictors of DLBCL and T cell lymphomas. Methods: We analysed total cases of 108 with DLBCL and 25 with T cell lymphomas. The study was done to determine the changes in haematological parameters including WBC count, Platelet count, Hb, HCT, lymphocyte count, monocyte count, ALC, AMC and lymphocyte monocyte ratio in diffuse large B cell lymphoma and T cell lymphomas before and after chemotherapy. Results: The results showed a significant decrease (p˂ 0.05) in the blood platelet counts after chemotherapy in DLBCL. AMC in female patients with DLBCL were decreased (0.69 ± 0.36 to 0.53 ± 0.31; p-value = 0.023) and this was highly significant. LMR was also increased (3.47 ± 3.05 to 5.22 ± 4.34; p-value = 0.048) in female patients with DLBCL. Conclusion: Haematological parameters can be used as a prognostic marker in predicting the extent of disease progression and the effectiveness of the treatment adopted.

وصف الملف: electronic resource

العلاقة: http://www.waocp.com/journal/index.php/apjcc/article/view/909Test; https://doaj.org/toc/2588-3682Test

الوصول الحر: https://doaj.org/article/6400f89393bf4c068014d9ad0b7cad23Test