المؤلفون: Alessandro Consales, Jesse Skoch, Zulma Tovar-Spinoza

المصدر: Frontiers in Neurology, Vol 15 (2024)

مصطلحات موضوعية: MR-gLiTT, epilepsy surgery, brain tumor surgery, stereoelectroencephalography (SEEG), minimally invasive neurosurgery, Neurology. Diseases of the nervous system, RC346-429

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fneur.2024.1378585/fullTest; https://doaj.org/toc/1664-2295Test

الوصول الحر: https://doaj.org/article/556872a100884b64b73891a9c51669d4Test

المؤلفون: Juan I. Guerrero, Luis A. Barragán, Juan D. Martínez, Juan P. Montoya, Alejandra Peña, Fidel E. Sobrino, Zulma Tovar-Spinoza, Kemel A. Ghotme

المصدر: BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-15 (2021)

مصطلحات موضوعية: Central and peripheral nervous system, SARS-CoV-2, COVID-19, Pathophysiology, Clinical manifestations, Neuropathology, Infectious and parasitic diseases, RC109-216

الوصف: Abstract Background SARS-CoV-2 can affect the human brain and other neurological structures. An increasing number of publications report neurological manifestations in patients with COVID-19. However, no studies have comprehensively reviewed the clinical and paraclinical characteristics of the central and peripheral nervous system’s involvement in these patients. This study aimed to describe the features of the central and peripheral nervous system involvement by COVID-19 in terms of pathophysiology, clinical manifestations, neuropathology, neuroimaging, electrophysiology, and cerebrospinal fluid findings. Methods We conducted a comprehensive systematic review of all the original studies reporting patients with neurological involvement by COVID-19, from December 2019 to June 2020, without language restriction. We excluded studies with animal subjects, studies not related to the nervous system, and opinion articles. Data analysis combined descriptive measures, frequency measures, central tendency measures, and dispersion measures for all studies reporting neurological conditions and abnormal ancillary tests in patients with confirmed COVID-19. Results A total of 143 observational and descriptive studies reported central and peripheral nervous system involvement by COVID-19 in 10,723 patients. Fifty-one studies described pathophysiologic mechanisms of neurological involvement by COVID-19, 119 focused on clinical manifestations, 4 described neuropathology findings, 62 described neuroimaging findings, 28 electrophysiology findings, and 60 studies reported cerebrospinal fluid results. The reviewed studies reflect a significant prevalence of the nervous system’s involvement in patients with COVID-19, ranging from 22.5 to 36.4% among different studies, without mortality rates explicitly associated with neurological involvement by SARS-CoV-2. We thoroughly describe the clinical and paraclinical characteristics of neurological involvement in these patients. Conclusions Our evidence synthesis led to a categorical analysis of the central and peripheral neurological involvement by COVID-19 and provided a comprehensive explanation of the reported pathophysiological mechanisms by which SARS-CoV-2 infection may cause neurological impairment. International collaborative efforts and exhaustive neurological registries will enhance the translational knowledge of COVID-19’s central and peripheral neurological involvement and generate therapeutic decision-making strategies. Registration This review was registered in PROSPERO 2020 CRD42020193140 Available from: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020193140Test

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1471-2334Test

الوصول الحر: https://doaj.org/article/df29d4b8d769492baa8d17803a576e20Test

المؤلفون: Santiago Pedroza Gómez, Viviana Gómez Ortega, Zulma Tovar-Spinoza, Kemel A. Ghotme

المصدر: European Journal of Plastic Surgery. 46:315-325

مصطلحات موضوعية: Surgery

الوصف: Background Scalp complications in craniofacial surgeries can increase morbidity and mortality. Given the inelastic characteristics of the scalp, these surgeries can be challenging, and multiple complications can arise. The literature on craniofacial surgery is extensive. However, few articles address scalp complications, associated factors, and prevention. This study aims to identify and classify scalp complications in craniofacial surgery and describe associated risk factors, general preventive measures, and an initial therapeutic approach. Methods We conducted a literature search in PubMed, Scopus, Cochrane Library, and LILACS to review the scalp complications in craniofacial surgery. The studies selected included retrospective case series, narrative reviews, systematic reviews, and cadaveric anatomic studies. We completed the search with book chapters and specific topic reviews. Results We screened a total of 124 sources and selected 35 items for inclusion in this review. Based on the updated review, we categorized scalp complications into wound defects, soft tissue contour irregularities, neurovascular defects, and infection. We discuss the main characteristics, risk factors, preventive measures, and initial management of these complications. Conclusions For craniofacial surgery, understanding the surgical anatomy, identifying risk factors, adequate surgical planning, and interdisciplinary cooperation between neurosurgeons, plastic surgeons, and the interdisciplinary team are essential to prevent and treat scalp complications. Level of evidence: Not ratable

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::74d67ab40a0870681ddea855b0e81c75Test
https://doi.org/10.1007/s00238-022-02008-2Test

المؤلفون: Elsa V. Arocho-Quinones, Sean M. Lew, Michael H. Handler, Zulma Tovar-Spinoza, Matthew D. Smyth, Robert J. Bollo, David Donahue, M. Scott Perry, Michael Levy, David Gonda, Francesco T. Mangano, Benjamin C. Kennedy, Phillip B. Storm, Angela V. Price, Daniel E. Couture, Chima Oluigbo, Ann-Christine Duhaime, Gene H. Barnett, Carrie R. Muh, Michael D. Sather, Aria Fallah, Anthony C. Wang, Sanjiv Bhatia, Daniel Eastwood, Sergey Tarima, Sarah Graber, Sean Huckins, Daniel Hafez, Kavelin Rumalla, Laurie Bailey, Sabrina Shandley, Ashton Roach, Erin Alexander, Wendy Jenkins, Deki Tsering, George Price, Antonio Meola, Wendi Evanoff, Eric M. Thompson, Nicholas Brandmeir

المصدر: J Neurosurg Pediatr

مصطلحات موضوعية: Clinical Article, General Medicine

الوصف: OBJECTIVE The authors of this study evaluated the safety and efficacy of stereotactic laser ablation (SLA) for the treatment of drug-resistant epilepsy (DRE) in children. METHODS Seventeen North American centers were enrolled in the study. Data for pediatric patients with DRE who had been treated with SLA between 2008 and 2018 were retrospectively reviewed. RESULTS A total of 225 patients, mean age 12.8 ± 5.8 years, were identified. Target-of-interest (TOI) locations included extratemporal (44.4%), temporal neocortical (8.4%), mesiotemporal (23.1%), hypothalamic (14.2%), and callosal (9.8%). Visualase and NeuroBlate SLA systems were used in 199 and 26 cases, respectively. Procedure goals included ablation (149 cases), disconnection (63), or both (13). The mean follow-up was 27 ± 20.4 months. Improvement in targeted seizure type (TST) was seen in 179 (84.0%) patients. Engel classification was reported for 167 (74.2%) patients; excluding the palliative cases, 74 (49.7%), 35 (23.5%), 10 (6.7%), and 30 (20.1%) patients had Engel class I, II, III, and IV outcomes, respectively. For patients with a follow-up ≥ 12 months, 25 (51.0%), 18 (36.7%), 3 (6.1%), and 3 (6.1%) had Engel class I, II, III, and IV outcomes, respectively. Patients with a history of pre-SLA surgery related to the TOI, a pathology of malformation of cortical development, and 2+ trajectories per TOI were more likely to experience no improvement in seizure frequency and/or to have an unfavorable outcome. A greater number of smaller thermal lesions was associated with greater improvement in TST. Thirty (13.3%) patients experienced 51 short-term complications including malpositioned catheter (3 cases), intracranial hemorrhage (2), transient neurological deficit (19), permanent neurological deficit (3), symptomatic perilesional edema (6), hydrocephalus (1), CSF leakage (1), wound infection (2), unplanned ICU stay (5), and unplanned 30-day readmission (9). The relative incidence of complications was higher in the hypothalamic target location. Target volume, number of laser trajectories, number or size of thermal lesions, or use of perioperative steroids did not have a significant effect on short-term complications. CONCLUSIONS SLA appears to be an effective and well-tolerated treatment option for children with DRE. Large-volume prospective studies are needed to better understand the indications for treatment and demonstrate the long-term efficacy of SLA in this population.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a507cb734310e4a4de33f34da94cfdd4Test
https://europepmc.org/articles/PMC10193482Test/

المؤلفون: George W. Koutsouras, Maham Ahmed, Zulma Tovar-Spinoza

المصدر: Arachnoid Cysts ISBN: 9783031227004

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::e5d3196ded4d849c2492587b9c744189Test
https://doi.org/10.1007/978-3-031-22701-1_28Test

المؤلفون: Timothy Beutler, Zulma Tovar-Spinoza, Satish Krishnamurthy

المصدر: Child's Nervous System. 38:1047-1050

مصطلحات موضوعية: Male, medicine.medical_specialty, Brain Neoplasms, business.industry, Treatment options, General Medicine, Resection, Pediatric patient, Epithelioid Glioblastoma, Tumor progression, Child, Preschool, hemic and lymphatic diseases, Pediatrics, Perinatology and Child Health, medicine, Humans, Neurology (clinical), Neurosurgery, Radiology, Child, Glioblastoma, business, Craniospinal, Pediatric population

الوصف: Epithelioid glioblastoma is a rare tumor in the pediatric population. We present a case report of a 5-year-old boy found to have a large right frontotemporal epithelioid glioblastoma. The patient was treated with maximal safe resection followed by craniospinal radiation. He has now reached 5-year survival and does not have tumor progression. Given the rarity of epithelioid glioblastoma in the pediatric population, the literature surrounding the diagnosis and treatment options for these tumors is reviewed.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d6e3294c202bd2c97aea95ed91fb99dTest
https://doi.org/10.1007/s00381-021-05304-7Test

المؤلفون: John de Groot, Albert Kim, Sujit Prabhu, Ganesh Rao, Adrian Laxton, Peter Fecci, Barbara O'Brien, Andrew Sloan, Veronica Chiang, Stephen Tatter, Alireza Mohammadi, Dimitris Placantonakis, Roy Strowd, Clark Chen, Constantinos Hadjipanayis, Mustafa Khasraw, David Sun, David Piccioni, Kaylyn Sinicrope, Jian Campian, Sylvia Kurz, Brian Williams, Kris Smith, Zulma Tovar-Spinoza, Eric Leuthardt

المصدر: Neuro-Oncology. 24:vii256-vii257

مصطلحات موضوعية: Cancer Research, Oncology, Neurology (clinical)

الوصف: Treatment options for glioblastoma remain limited, particularly for those who are not eligible for traditional resection, whether due to lesion location or inability to tolerate open craniotomy. Maximal-safe resection followed by radiation with concurrent and adjuvant temozolomide offers the best outcomes for patients. Unfortunately, not all tumors are amenable to conventional surgical resection at the time of diagnosis with only about 1/3 of patients able to receive a gross-total resection and 15-25% of patients receiving biopsy only, thus reducing their projected overall survival to 9 months. Laser interstitial thermal therapy (LITT) is a minimally invasive, cytoreductive tool, that has demonstrated safety as a surgical approach to treat primary brain tumors. METHODS Data from LAANTERN prospective multicenter registry (NCT02392078) was analyzed to determine clinical outcomes for patients with new and recurrent IDH wild-type glioblastoma (N=89). Demographics, intraprocedural data, adverse events, KPS, health-economics, and survival data were prospectively collected then analyzed separately for newly diagnosed GBM (N=29) and recurrent GBM (N=60). RESULTS Median overall-survival was 9.73 months (95% CI: 5.16, 15.91) for newly diagnosed patients and median post-procedure survival was 8.97 (6.94, 12.36) months for recurrent patients. Median overall-survival for newly diagnosed patients receiving post-LITT chemoradiotherapy was 16.14 months (6.11, not reached). The median length of hospital stay was 50 hours and 80% of patients were discharged to home. CONCLUSIONS LITT offers an effective cytoreductive approach for patients with newly diagnosed and recurrent IDH wild-type glioblastoma. Importantly, its use in newly diagnosed patients who receive post-LITT chemoradiotherapy leads to a median OS similar to that of patients treated with conventional surgical resection. LITT remains an important alternative for patients with inoperable tumors or those not amenable to resection. Enrollment in LAANTERN is ongoing and these cohorts will be revisited as data continues to mature. Benefits beyond cytoreduction are also being actively explored.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::029d4c714feb777b90aa55ea220cbcdeTest
https://doi.org/10.1093/neuonc/noac209.989Test

المؤلفون: John F, de Groot, Albert H, Kim, Sujit, Prabhu, Ganesh, Rao, Adrian W, Laxton, Peter E, Fecci, Barbara J, O'Brien, Andrew, Sloan, Veronica, Chiang, Stephen B, Tatter, Alireza M, Mohammadi, Dimitris G, Placantonakis, Roy E, Strowd, Clark, Chen, Constantinos, Hadjipanayis, Mustafa, Khasraw, David, Sun, David, Piccioni, Kaylyn D, Sinicrope, Jian L, Campian, Sylvia C, Kurz, Brian, Williams, Kris, Smith, Zulma, Tovar-Spinoza, Eric C, Leuthardt

المصدر: Neuro-oncology advances. 4(1)

الوصف: Treatment options for unresectable new and recurrent glioblastoma remain limited. Laser ablation has demonstrated safety as a surgical approach to treating primary brain tumors. The LAANTERN prospective multicenter registry (NCT02392078) data were analyzed to determine clinical outcomes for patients with new and recurrentDemographics, intraprocedural data, adverse events, KPS, health economics, and survival data were prospectively collected and then analyzed onA total of 29 new and 60 recurrentLaser ablation is a viable option for patients with new and recurrent glioblastoma. Median OS for

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::bc6be978384d99160071dd0b4a95b489Test
https://pubmed.ncbi.nlm.nih.gov/35611270Test

المؤلفون: George W. Koutsouras, Lu Zhang, Nelci Zanon, Sandi Lam, Frederick A. Boop, Zulma Tovar-Spinoza

المصدر: Journal of neurosurgery.

مصطلحات موضوعية: General Medicine

الوصف: OBJECTIVE The global neurosurgery workforce does not have a defined stance on gender equity. The authors sought to study and characterize the demographic features of the international women neurosurgery community and to better understand the perceptions and reflections of their neurosurgical careers. The objective was to define and characterize the workplace inequities faced by the global women neurosurgeon community. METHODS A 58-item cross-sectional survey was distributed to the global women neurosurgery community. The survey was distributed via an online and mobile platform between October 2018 and December 2020. Responses were anonymized. The authors utilized chi-square analysis to differentiate variables (e.g., career satisfaction) between various groups (e.g., those based on academic position). The authors calculated 95% CIs to establish significance. RESULTS Among 237 respondents, approximately 40% were between the ages of 26 and 35 years. Within their respective departments, 45% identified themselves as the only woman neurosurgeon in their practice. Forty-three percent stated that their department supported women neurosurgeons for leadership roles. Seventy-five percent of respondents were members of organized neurosurgery professional societies; of these, 38% had been involved in leadership roles. Almost 60% of respondents postponed their decision to get pregnant because of resident or work-related influences. CONCLUSIONS This survey provides international feedback for characterizing and understanding the experiences of women neurosurgeons worldwide. Future research should aim to understand all neurosurgeons’ experiences throughout the pipeline and career life cycle of neurosurgery in order to improve the field of neurosurgery.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6402c4650d05f768771992a682f383a3Test
https://pubmed.ncbi.nlm.nih.gov/35907187Test

المؤلفون: Michelle Elizabeth De Witt, Monserrat Almaguer-Ascencio, Kalliopi Petropoulou, Zulma Tovar-Spinoza

المصدر: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery.

مصطلحات موضوعية: Pediatrics, Perinatology and Child Health, Neurology (clinical), General Medicine

الوصف: Cavernous malformations (CM) are central nervous system lesions characterized by interlaced vascular sinusoids coated with endothelial cells without intervening parenchyma. Magnetic resonance imaging-guided laser interstitial thermal therapy (MRIgLITT) is a minimally invasive treatment modality that can precisely treat pathologic cerebral tissue, making it an effective alternative for the management of cavernomas. We describe the outcomes of a series of pediatric patients with cavernous brain malformations treated with MRIgLITT between 2014 and 2018 at our institution.We retrospectively analyzed 11 cavernomas in 6 pediatric patients treated with MRIgLITT. Both the Visualase SystemA total of 11 cavernomas in 6 patients were treated with MRIgLITT. Median age was 15 years (12 to 17 years); 75% were males. Presenting symptoms were headache (75%) and seizures (25%). Two patients presented with multiple CMs. All lesions in this study were supratentorial (cerebral hemispheres 81.8%, corpus callosum 9.1%, basal ganglia 9.1%). Our surgical technique was well-tolerated, with no significant adverse events observed. Hospital stay for all patients was less than 48 hours.MRIgLITT is an effective minimally invasive technique for the treatment of pediatric CMs. It represents a useful and safe tool, when other therapeutic alternatives may represent a greater risk of surgical morbidity.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8305075383c9feb8540911061e4b865dTest
https://pubmed.ncbi.nlm.nih.gov/36416952Test