المؤلفون: Yi‐Bo Wang, Zong‐Jin Gan, Jun‐Yan Zhang, Somjit Wanchana, Xi‐Liang Guo

المصدر: Ibrain, Vol 9, Iss 1, Pp 3-12 (2023)

مصطلحات موضوعية: SAM domain, SH3 domain and nuclear localization signal 1, cell viability, neonatal hypoxic–ischemic encephalopathy, neurological injury, neuroprotective effect, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

الوصف: Abstract This article aims to detect the effect of SAM domain, SH3 domain, and nuclear localization signal 1 (SAMSN1) in neonatal rats with neurological dysfunction induced by hypoxia and ischemia (HI). The HI model was created using 7‐day postnatal rats. Zea‐longa score was utilized to validate the neurological injury after HI. Then, the differentially expressed genes (DEGs) were detected by gene sequencing and bioinformatics analysis methods. The oxygen and glucose deprivation (OGD) models were established in the SY5Y cells and fetal human cortical neurons. In addition, SAMSN1‐small interfering RNA, methyl thiazolyl tetrazolium assay, and cell growth curve were employed to evaluate the cell viability variation. Obviously, Zea‐longa scores increased in rats with HI insult. Subsequently, SAMSN1 was screened out, and it was found that SAMSN1 was strikingly upregulated in SY5Y cells and fetal neurons post‐OGD. Interestingly, we found that SAMSN1 silencing could markedly enhance cell viability and cell growth after OGD. These data suggested that downregulation of SAMSN1 may exert a neuroprotective effect on damaged neurons after HI by improving cell viability and cell survival, which provides a potential theoretical basis for clinical trials in the future to treat neonatal hypoxic–ischemic encephalopathy.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2769-2795Test

الوصول الحر: https://doaj.org/article/1d9f29365aa24fdc992335a40b180140Test

المؤلفون: Hao Yuan, Quan-Yuan Chang, Jie Chen, Ya-Ting Wang, Zong-Jin Gan, Song Wen, Ting-Ting Li, Liu-Lin Xiong

المصدر: Journal of Orthopaedic Surgery and Research, Vol 16, Iss 1, Pp 1-10 (2021)

مصطلحات موضوعية: Traumatic thoracolumbar fracture, Acetaminophen dihydrocodeine, Celecoxib, Etoricoxib, Pain degree, Orthopedic surgery, RD701-811, Diseases of the musculoskeletal system, RC925-935

الوصف: Abstract Objective To analyze and compare the effects of peri-treatment analgesics on acute and chronic pain and postoperative functional recovery of patients with thoracolumbar fractures, so as to guide the clinical drug use. Methods Seven hundred nineteen patients with thoracolumbar fractures were collected and divided into acetaminophen dihydrocodeine, celecoxib, and etoricoxib groups. The main indicators were the degree of postoperative pain (visual analog scale (VAS)), the incidence of chronic pain and postoperative functional recovery (Oswestry dysfunction index (ODI) and Japanese Orthopedics Association score (JOA)), which were continuously tracked through long-term telephone follow-up. The correlation analysis of ODI-pain score, peri-treatment VAS score, and ODI index was performed, and bivariate regression analysis was conducted to understand the risk factors for chronic pain. Results Regression analysis showed that severe spinal cord injury and peri-treatment use of acetaminophen dihydrocodeine were both one of the risk factors for postoperative chronic pain. But there were no statistically conspicuous differences in basic characteristics, preoperative injury, and intraoperative conditions. Compared with the other two groups, patients in the acetaminophen dihydrocodeine group had longer peri-therapeutic analgesic use, higher pain-related scores (VAS 1 day preoperatively, VAS 1 month postoperatively, and ODI-pain 1 year postoperatively), higher VAS variation, higher incidence of chronic pain 1 year after surgery, and higher ODI index. And other ODI items and JOA assessments showed no statistically significant differences. In addition, the correlation analysis showed that the peri-treatment pain score was correlated with the severity of postoperative chronic pain. Conclusion Although the peri-treatment analgesic effect of acetaminophen dihydrocodeine is good, it is still necessary to combine analgesics with different mechanisms of action for patients with severe preoperative pain of thoracolumbar fracture, so as to inhibit the incidence of postoperative chronic pain and improve the quality of postoperative rehabilitation.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1749-799XTest

الوصول الحر: https://doaj.org/article/2ee5d39bdd5e4a0ea06bdef7f486b8f8Test

المؤلفون: Zong‐Jin Gan, Ping‐Rong Yao, Kui Shen, Min Sai, Mei Yang, Ya Deng, Min Shi, Cao Fang, Rui Wang, Song Wen, Liu‐Lin Xiong, Min‐Fu You

المصدر: Ibrain, Vol 6, Iss 4, Pp 47-53 (2020)

مصطلحات موضوعية: Lncraniocerebral chronic vascular diseases, Cervical spondylosis, Herpes zoster, Knee osteoarthritis, Lumbar disc disease, Seasonal variations, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

الوصف: Background The distribution characteristics of gender, age, and season and the influence of season on the length of hospitalization stay (LOS) were analyzed based on the information of inpatients about various diseases. Methods A total of 5575 patients’ basic information (gender, age, hospitalization time, season of onset) of five diseases was classified according to spring, summer, autumn, winter. Their distribution characteristics were analysed using T‐test, one‐way ANOVA, Chi‐square test. Then the data were incorporated into SPSS 21.0 for statistical analysis. Results Most cases of cranial chronic vascular disease (CCVD) were found in summer (53% of cases), less in spring, and no cases in winter. The LOS was longer for middle‐aged men, elderly men, and elderly women in the fall group than in the spring group (p < 0.05). The LOS was longer in the fall group than in the summer group for older men and older women (p < 0.05). Herpes zoster cases were more frequent in summer (43%) and autumn (56.30%), less frequent in spring (1.20%), and no cases in winter. Middle‐aged and elderly men in the summer group had longer LOS than the autumn group (p < 0.05). The most cases of cervical spondylosis were found in the spring (42.00%), the fewest were found in the fall (0.10%). Cases of knee osteoarthritis were the most in winter (53.40%) and fewer in summer (7%) and autumn (9.80%). Conclusion CCVD, herpes zoster, cervical spondylosis, and knee osteoarthritis have an obvious seasonal distribution, and seasons have a certain impact on the hospitalization time of patients with CCVD or herpes zoster, especially in older men.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2769-2795Test

الوصول الحر: https://doaj.org/article/346123a8d48e481686557e6091fece91Test

المؤلفون: Yi‐Bo Wang, Zong‐Jin Gan, Jun‐Yan Zhang, Somjit Wanchana, Xi‐Liang Guo

المصدر: Ibrain. 9:3-12

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::8746baecb99f7563270a7d03ea77c2ebTest
https://doi.org/10.1002/ibra.12078Test

المؤلفون: Ting-Ting Li, Song Wen, Ya-Ting Wang, Zong-Jin Gan, Liu-Lin Xiong, Quan-Yuan Chang, Hao Yuan, Jie Chen

المصدر: Journal of Orthopaedic Surgery and Research, Vol 16, Iss 1, Pp 1-10 (2021)
Journal of Orthopaedic Surgery and Research

مصطلحات موضوعية: Male, Time Factors, Diseases of the musculoskeletal system, Pain degree, Etoricoxib, 0302 clinical medicine, Risk Factors, Orthopedics and Sports Medicine, 030212 general & internal medicine, Spinal cord injury, Aged, 80 and over, Orthopedic surgery, Analgesics, Pain, Postoperative, Lumbar Vertebrae, Chronic pain, Middle Aged, Acute Pain, Dihydrocodeine, Drug Combinations, Acetaminophen dihydrocodeine, Anesthesia, Spinal Fractures, Female, Traumatic thoracolumbar fracture, Chronic Pain, Research Article, medicine.drug, Adult, musculoskeletal diseases, Adolescent, Visual analogue scale, Analgesic, Thoracic Vertebrae, Young Adult, 03 medical and health sciences, medicine, Humans, Spinal Cord Injuries, Acetaminophen, Aged, Retrospective Studies, Codeine, business.industry, Recovery of Function, medicine.disease, RC925-935, Celecoxib, Surgery, business, RD701-811, 030217 neurology & neurosurgery, Follow-Up Studies

الوصف: Objective To analyze and compare the effects of peri-treatment analgesics on acute and chronic pain and postoperative functional recovery of patients with thoracolumbar fractures, so as to guide the clinical drug use. Methods Seven hundred nineteen patients with thoracolumbar fractures were collected and divided into acetaminophen dihydrocodeine, celecoxib, and etoricoxib groups. The main indicators were the degree of postoperative pain (visual analog scale (VAS)), the incidence of chronic pain and postoperative functional recovery (Oswestry dysfunction index (ODI) and Japanese Orthopedics Association score (JOA)), which were continuously tracked through long-term telephone follow-up. The correlation analysis of ODI-pain score, peri-treatment VAS score, and ODI index was performed, and bivariate regression analysis was conducted to understand the risk factors for chronic pain. Results Regression analysis showed that severe spinal cord injury and peri-treatment use of acetaminophen dihydrocodeine were both one of the risk factors for postoperative chronic pain. But there were no statistically conspicuous differences in basic characteristics, preoperative injury, and intraoperative conditions. Compared with the other two groups, patients in the acetaminophen dihydrocodeine group had longer peri-therapeutic analgesic use, higher pain-related scores (VAS 1 day preoperatively, VAS 1 month postoperatively, and ODI-pain 1 year postoperatively), higher VAS variation, higher incidence of chronic pain 1 year after surgery, and higher ODI index. And other ODI items and JOA assessments showed no statistically significant differences. In addition, the correlation analysis showed that the peri-treatment pain score was correlated with the severity of postoperative chronic pain. Conclusion Although the peri-treatment analgesic effect of acetaminophen dihydrocodeine is good, it is still necessary to combine analgesics with different mechanisms of action for patients with severe preoperative pain of thoracolumbar fracture, so as to inhibit the incidence of postoperative chronic pain and improve the quality of postoperative rehabilitation.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92251243969964a5afdb739dccc43864Test
https://doi.org/10.1186/s13018-021-02401-wTest