المؤلفون: Yujing Pan, Dan Li, Zhoucang Zhang, Jing Xu, Xinping Sun, Mei Wang, Jiaxiang Ding

المصدر: BMC Nephrology, Vol 25, Iss 1, Pp 1-10 (2024)

مصطلحات موضوعية: Coronavirus disease 2019 (COVID-19), Maintenance hemodialysis (MHD), Omicron variant, Prognosis, Severe acute respiratory syndrome coronavirus-2 (SARS-cov-2), Diseases of the genitourinary system. Urology, RC870-923

الوصف: Abstract Background The clinical manifestations and prognosis of hemodialysis patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) during the Omicron wave of the pandemic infection were still unclear. This study investigated the clinical characteristics of patients undergoing maintenance hemodialysis (MHD) infected with it. Methods This retrospective single-center study included 151 patients undergoing MHD. Healthcare workers were selected as control group were assessed from December 1, 2022 to March 31, 2023. Clinical data, laboratory test results, treatment protocols, and prognoses were collected and analyzed. Results The study population included 146 patients with MHD, 93 (63.7%) of whom were infected with SARS-CoV-2. The number of non-severe, severe, and critical cases was 84 (90.3%), 4 (4.3%), and 5 (5.3%), respectively. Six patients (6.5%) died during the study period. The main symptoms of SARS-CoV-2 infection, including fever, cough, and fatigue, were less common in patients with MHD than the controls. During SARS-CoV-2 infection, the C-reactive protein (2.9 vs. 11.8 mg/dl, p

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1471-2369Test

الوصول الحر: https://doaj.org/article/d76172e1a04e4fe89f7af692c503a16cTest

المؤلفون: Zhoucang Zhang, Jiarui Li, Jiaxiang Ding, Shenglei Zhang, Mei Wang, Jinsheng Xu

المصدر: Renal Failure, Vol 46, Iss 1 (2024)

مصطلحات موضوعية: Hemodialysis, effective blood flow rate, all-cause mortality, major adverse cardiovascular events, arteriovenous fistula, Diseases of the genitourinary system. Urology, RC870-923

الوصف: The association between blood flow rate (BFR) and clinical outcomes in patients undergoing maintenance hemodialysis (MHD) is inconclusive. This retrospective study included 175 patients undergoing MHD treatment between July 2015 and March 2022, divided into two groups based on time-averaged effective blood flow rate (eBFR) median value. We investigated arteriovenous fistula (AVF) outcomes and the association of eBFR with all-cause mortality and new major adverse cardiovascular events (MACE). Mean ± SD and median time-averaged eBFR values were 276 ± 24 and 275 mL/min, respectively. After adjusting for relevant factors including age, sex, vintage, diabetes, CVD, receiving hemodiafiltration (HDF) treatment and spKt/V, Cox models indicated a low time-averaged eBFR (≤ 275 ml/min) was associated with increased risks of all-cause mortality (hazard ratio [HR] 14.18; 95% confidence interval [CI], 3.14–64.1) and new MACE (HR 3.76; 95% CI, 1.91–7.40) in MHD patients. Continuous Cox models demonstrated each 20 ml/min increase in eBFR linked to a 63% decrease in the risk of all-cause mortality (HR: 0.37, 95% CI: 0.23–0.59) and a 38% decrease in the occurrence of new MACE (HR: 0.62, 95% CI: 0.46–0.84). There was no significant difference in AVF outcomes between the two groups. Our study noted higher eBFR (>275 mL/min) is associated with lower risks of both all-cause mortality and new MACE compared with low eBFR (≤275 mL/min). Increased eBFR is not associated with a higher risk of AVF failure.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/0886-022XTest; https://doaj.org/toc/1525-6049Test

الوصول الحر: https://doaj.org/article/7ee508a0180c4fd3b82eb61ed03396adTest

المؤلفون: Zhoucang Zhang, Lei Zheng, Yisheng Pan, Mei Wang

مصطلحات موضوعية: Diagnosis and Management of Hyponatremia, Pulmonary and Respiratory Medicine, Medicine, Health Sciences, Chronic Kidney Disease and Dialysis Treatment, Nephrology, Rhabdomyolysis and Compartment Syndromes, Surgery, Hyponatremia, Dialysis, Mace, Internal medicine, Hemodialysis, Proportional hazards model, Confounding, Intensive care medicine, Percutaneous coronary intervention, Myocardial infarction

الوصف: Chronic pre-dialysis hyponatremia is not rare in maintenance hemodialysis (MHD) patients. However, the association between chronic pre-dialysis hyponatremia and mortality is uncertain due to multiple potential confounders such as hyperglycemia, fluid overload, and malnutrition. This study aimed to more comprehensively evaluate the association between chronic pre-dialysis hyponatremia and clinical outcomes in MHD patients.We analyzed the data of 194 MHD patients with regular real-time measurements of pre-dialysis serum sodium from July 2015 to March 2021. Hyponatremia was defined as SNa ≤ 135 mmol/L and normonatremia as SNa > 135 mmol/L and < 145 mmol/L. We evaluated the association of baseline pre-dialysis serum sodium (SNa) and time-averaged SNa (TASNa) levels with all-cause mortality or new major adverse cardiovascular events (MACE) in MHD patients. Furthermore, the SNa levels were glucose, serum albumin, and fluid overload adjusted. The associations between SNa levels and all-cause mortality or new ... : نقص صوديوم الدم المزمن قبل الغسيل الكلوي ليس نادرًا في مرضى الغسيل الكلوي المستمر. ومع ذلك، فإن الارتباط بين نقص صوديوم الدم المزمن قبل الغسيل الكلوي والوفيات غير مؤكد بسبب العديد من الارتباكات المحتملة مثل ارتفاع السكر في الدم، والحمل الزائد للسوائل، وسوء التغذية. هدفت هذه الدراسة إلى إجراء تقييم أكثر شمولاً للارتباط بين نقص صوديوم الدم المزمن قبل الغسيل الكلوي والنتائج السريرية لدى مرضى نقص صوديوم الدم المزمن. قمنا بتحليل بيانات 194 مريض نقص صوديوم الدم المزمن مع قياسات منتظمة في الوقت الفعلي لصوديوم مصل ما قبل الغسيل الكلوي من يوليو 2015 إلى مارس 2021. تم تعريف نقص صوديوم الدم على أنه SNa ≤ 135 مليمول/لتر و Normonatremia على أنه SNa > 135 مليمول/لتر و < 145 مليمول/لتر. قمنا بتقييم ارتباط خط الأساس لمستويات الصوديوم في مصل ما قبل الغسيل الكلوي (SNa) ومستويات SNa (TASNa) المتوسطة للوقت مع جميع أسباب الوفيات أو الأحداث القلبية الوعائية السلبية الرئيسية الجديدة (MACE) في مرضى نقص صوديوم الغسيل الكلوي. علاوة على ذلك، كانت مستويات SNa هي الجلوكوز وألبومين المصل وتعديل الحمل الزائد للسوائل. تم تحليل ...

العلاقة: https://dx.doi.org/10.60692/1graq-pcp15Test

الإتاحة: https://doi.org/10.60692/4100h-bk45010.60692/1graq-pcp15Test

المؤلفون: Zhoucang, Zhang, Liren, Zheng, Yujing, Pan, Mei, Wang

المصدر: International Urology and Nephrology. 54:3221-3232

مصطلحات موضوعية: Heart Failure, Urology, Malnutrition, Sodium, Water-Electrolyte Imbalance, Glucose, Renal Dialysis, Nephrology, Hyperglycemia, Chronic Disease, Humans, Dialysis, Serum Albumin, Hyponatremia

الوصف: Objective Chronic pre-dialysis hyponatremia is not rare in maintenance hemodialysis (MHD) patients. However, the association between chronic pre-dialysis hyponatremia and mortality is uncertain due to multiple potential confounders such as hyperglycemia, fluid overload, and malnutrition. This study aimed to more comprehensively evaluate the association between chronic pre-dialysis hyponatremia and clinical outcomes in MHD patients. Methods We analyzed the data of 194 MHD patients with regular real-time measurements of pre-dialysis serum sodium from July 2015 to March 2021. Hyponatremia was defined as SNa ≤ 135 mmol/L and normonatremia as SNa > 135 mmol/L and Results Among the total of 194 patients, 24 patients died and 45 new MACE occurred during a mean 35.2-month follow-up period. The baseline pre-dialysis SNa level was 137.1 ± 2.8 mmol/L (127–144 mmol/L). Kaplan–Meier survival analysis showed that there were no significant differences in all-cause mortality or new MACE between hyponatremia and normonatremia groups according to baseline pre-dialysis SNa or glucose-corrected SNa (gcSNa). The mean values of both TASNa and time-averaged glucose-corrected SNa (TAgcSNa) were 136.9 ± 2.4 mmol/L and 138.3 ± 2.0 mmol/L, respectively. Kaplan–Meier survival analysis showed that patients with pre-dialysis hyponatremia had higher all-cause mortality or new MACE compared with normonatremia patients whether grouped on TASNa or TAgcSNa. Cox models showed an increased risk of all‐cause mortality and new MACE in MHD patients with pre-dialysis hyponatremia based on TASNa or TAgcSNa. Even after full adjustment including time-dependent age and dialysis vintage, gender, diabetes, time-averaged weight gain (TAWG), and serum albumin, patients with pre-dialysis hyponatremia based on TASNa (HR 2.89; 95% CI 1.18–7.04; model 3) or TAgcSNa (HR 5.03; 95% CI 1.87–13.57; model 3) had approximately twofold or fourfold greater risk of all-cause mortality, respectively, compared with those with normonatremia. The risk of new MACE was also significantly elevated in patients with pre-dialysis hyponatremia based on TASNa (HR 3.86; 95% CI 2.13–7.01; model 1) or TAgcSNa (HR 2.43; 95% CI 1.14–5.15; model 1). After adjustment for time-dependent age and dialysis vintage, gender, diabetes, TAWG, and serum albumin, patients with pre-dialysis hyponatremia based on TASNa (HR 2.33; 95% CI 1.16–4.68; model 3) had a higher risk of new MACE compared with those with normonatremia. Conclusions Pre-dialysis time-averaged hyponatremia is independently associated with increased risks of all-cause mortality or new MACE in MHD patients. The baseline SNa level is not a predictor of clinical outcomes due to its variation over time. Hyperglycemia, fluid overload, and malnutrition do not have a significant impact on the risk association between chronic hyponatremia and all-cause mortality or new MACE in MHD patients.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a84cff910e126e11428e651f14951cefTest
https://doi.org/10.1007/s11255-022-03241-1Test

المؤلفون: Rui Zhao, Zhoucang Zhang, Dongliang Zhang, Jingjing Chang, Li Wan

المصدر: The journal of vascular access. 21(5)

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, China, Time Factors, medicine.medical_treatment, Veins, Arteriovenous Shunt, Surgical, Postoperative Complications, Predictive Value of Tests, Renal Dialysis, Risk Factors, medicine, Humans, Prospective Studies, Prospective cohort study, Vascular Patency, Aged, Ultrasonography, Blood flow volume, business.industry, Ultrasound, Middle Aged, Surgery, Forearm, Treatment Outcome, Nephrology, Radial Artery, Female, Vascular Resistance, Hemodialysis, business, Blood Flow Velocity

الوصف: Target:To compare the ultrasound characteristics between functional, mature arteriovenous fistulas and functional, non-mature arteriovenous fistulas and to identify the predictors of arteriovenous fistula maturation in the forearm.Methods:Patients with newly set-up functional arteriovenous fistulas were enrolled in this prospective cohort study. Ultrasound examinations were conducted pre-operatively and post-operatively. The inner vessel diameter, blood flow volume, and resistance index were measured and compared between the maturation group (Group M) and non-maturation group (Group N). Baseline parameters were calculated to determine the predictors of non-maturation of arteriovenous fistulas.Results:All 52 patients with functional arteriovenous fistulas, who were categorized into Group M (25 patients, 48.08%) and Group N (27 patients, 51.92%), finished 24 weeks of follow-up after arteriovenous fistula surgery. The arteriovenous fistulas displayed a significant and rapid increase in the vessel diameter (mean increase of 1.34 times in the arteries and 1.92 times in the veins) and blood flow volume (mean increase of 9.29 times of the arteries and 43.66 times of the veins) and a decrease in the resistance index (mean decrease in 48.00% in the arteries) 8 weeks after surgery. Group N had a lesser increase in the vessel diameters (1.78 times vs 2.06 times, t = −3.136, p = 0.003) and blood flow volume (33.98 times vs 54.11 times, t = −2.383, p = 0.021) of the cephalic vein draining segments (a6) than Group M. The baseline diameter of a6 was the only independent predictor (regression coefficient = 26.229, p = 0.008) of maturation of the functional arteriovenous fistulas after correcting for sex, age, diabetes kidney disease, weight, and height.Conclusion:The baseline diameter of the cephalic vein was the only predictor of arteriovenous fistula maturation based on the pre-operative ultrasound measurements in Chinese hemodialysis patients.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5de4a07aa0494856b0ee37255528ecc2Test
https://pubmed.ncbi.nlm.nih.gov/31884877Test

المؤلفون: Zhoucang Zhang, Dongliang Zhang

المصدر: The Journal of Vascular Access. 19:197-198

مصطلحات موضوعية: medicine.medical_specialty, business.industry, medicine.medical_treatment, Treatment outcome, 030232 urology & nephrology, MEDLINE, Atrial Thrombus, Asymptomatic, Surgery, 03 medical and health sciences, Catheter, 0302 clinical medicine, Text mining, Nephrology, medicine, 030212 general & internal medicine, Hemodialysis, medicine.symptom, business, Asymptomatic Diseases

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::c9428822ad889905765c61db6adb8427Test
https://doi.org/10.5301/jva.5000813Test

المؤلفون: Lin, Fan, Wu, Xu, Huidi Zhang, Xiaohan You, Zhoucang Zhang, Rongrong Shao, Chaoxing Huang

الوصف: Sequences of primers used in real-time PCR analysis of miRNA.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53b9e737b6d6c8fbffe92fd317ab6879Test

المؤلفون: Lin, Fan, Wu, Xu, Huidi Zhang, Xiaohan You, Zhoucang Zhang, Rongrong Shao, Chaoxing Huang

الوصف: Sequences of primers used in real-time PCR analysis of mRNA expression.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37ca578233311c7d529f935bce14187fTest

المؤلفون: Chun, Chen, Yang, Wang, Xueding, Cai, Qi, Zhang, Xiaoying, Huang, Honglei, Xu, Fangyou, Yu, Chan, Chen, Yuanyuan, Lu, Weixi, Zhang, Dan, Yao, Zhoucang, Zhang, Lehe, Yang, Cheng, Ding, Liangxing, Wang

المصدر: Life Sciences ; volume 90, issue 19-20, page 721-727 ; ISSN 0024-3205

مصطلحات موضوعية: General Pharmacology, Toxicology and Pharmaceutics, General Biochemistry, Genetics and Molecular Biology, General Medicine

الإتاحة: https://doi.org/10.1016/j.lfs.2012.03.008Test
https://api.elsevier.com/content/article/PII:S0024320512001312?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0024320512001312?httpAccept=text/plainTest

المؤلفون: Fan Lin, Xu Wu, Huidi Zhang, Xiaohan You, Zhoucang Zhang, Rongrong Shao, Chaoxing Huang

المصدر: BMC Nephrology; Aug2015, Vol. 16 Issue 1, p1-9, 9p

مصطلحات موضوعية: MICRORNA, FIBROSIS, PERITONEAL dialysis, HEMODIALYSIS, RNA

مستخلص: Background: Peritoneal fibrosis is a common complication in patients treated with long-term peritoneal dialysis. The aim of this study was to identify the microRNAs (miRNAs) involved in regulation of peritoneal fibrosis in a rat model of peritoneal dialysis. Methods: Twenty-four Sprague-Dawley (SD) rats were randomly allocated into three groups: (i) Control group (Cg, n = 8); (ii) Saline group (Sg, n = 8): daily intraperitoneal injection with 0.9% normal saline; (iii) Hypertonic dialysate group (HDg, n = 8): daily intraperitoneal injection with 4.25% peritoneal dialysis solution. Rats were sacrificed after four weeks for histological evaluation of peritoneal membrane and the expression of α-SMA and COL-1. A miRNA screen was performed using microarray analysis to identify differentially expressed miRNAs, which were then validated by real-time PCR. Results: Compared with the control and the saline groups, hypertonic dialysate group showed impaired peritoneal function accompanied by a spectrum of morphological changes including thicker peritoneal membrane, higher collagen deposition, infiltration of mononuclear cells and neovascularization in the peritoneum. Increased mRNA and protein levels of α-SMA and COL-1 were observed in hypertonic dialysate group, indicating the progression of peritoneal fibrosis. The miRNA screen identified 8 significantly down-regulated miRNAs (miR-31, miR-93, miR-100, miR-152, miR-497, miR-192, miR-194 and miR-200b) and one highly up-regulated miRNA (miR-122) in the hypertonic dialysate group. The results were confirmed by real-time PCR. Conclusions: Altered miRNA expression in peritoneum was found in the rat model of peritoneal fibrosis, indicating that these miRNAs may be associated with pathogenesis of peritoneal fibrosis. [ABSTRACT FROM AUTHOR]

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