المؤلفون: Peters, Michael C, Schiebler, Mark L, Cardet, Juan Carlos, Johansson, Mats W, Sorkness, Ronald, DeBoer, Mark D, Bleecker, Eugene R, Meyers, Deborah A, Castro, Mario, Sumino, Kaharu, Erzurum, Serpil C, Tattersall, Matthew C, Zein, Joe G, Hastie, Annette T, Moore, Wendy, Levy, Bruce D, Israel, Elliot, Duvall, Melody G, Phillips, Brenda R, Mauger, David T, Wenzel, Sally E, Fajt, Merritt L, Koliwad, Suneil K, Denlinger, Loren C, Woodruff, Prescott G, Jarjour, Nizar N, Fahy, John V, Schiebler, Mark, Carlos Cardet, Juan, Duvall, Melody

المصدر: American Journal of Respiratory and Critical Care Medicine. 206(9)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Clinical Trials and Supportive Activities, Clinical Research, Lung, Asthma, Obesity, Respiratory, Humans, Insulin Resistance, Cross-Sectional Studies, Bronchodilator Agents, Adrenal Cortex Hormones, Forced Expiratory Volume, asthma, obesity, insulin resistance, lung function, National Heart, Lung, and Blood Institute Severe Asthma Research Program-3, Medical and Health Sciences, Respiratory System, Cardiovascular medicine and haematology, Clinical sciences

الوصف: Rationale: The role of obesity-associated insulin resistance (IR) in airflow limitation in asthma is uncertain. Objectives: Using data in the Severe Asthma Research Program 3 (SARP-3), we evaluated relationships between homeostatic measure of IR (HOMA-IR), lung function (cross-sectional and longitudinal analyses), and treatment responses to bronchodilators and corticosteroids. Methods: HOMA-IR values were categorized as without (5.0). Lung function included FEV1 and FVC measured before and after treatment with inhaled albuterol and intramuscular triamcinolone acetonide and yearly for 5 years. Measurements and Main Results: Among 307 participants in SARP-3, 170 (55%) were obese and 140 (46%) had IR. Compared with patients without IR, those with IR had significantly lower values for FEV1 and FVC, and these lower values were not attributable to obesity effects. Compared with patients without IR, those with IR had lower FEV1 responses to β-adrenergic agonists and systemic corticosteroids. The annualized decline in FEV1 was significantly greater in patients with moderate IR (-41 ml/year) and severe IR (-32 ml/year,) than in patients without IR (-13 ml/year, P

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/6h28g1dvTest

المؤلفون: Chedraoui, Celine, Fakhry, Battoul, Sleiman, Joelle, Hu, Bo, Attaway, Amy, Bazeley, Peter, Jo Kim, Hyun, Zhang, Peng, Zein, Joe G.

المساهمون: NHLBI

المصدر: CHEST Pulmonary ; page 100047 ; ISSN 2949-7892

الإتاحة: https://doi.org/10.1016/j.chpulm.2024.100047Test
https://api.elsevier.com/content/article/PII:S2949789224000138?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2949789224000138?httpAccept=text/plainTest

المؤلفون: Zein, Joe G, McManus, Jeffrey M, Sharifi, Nima, Erzurum, Serpil C, Marozkina, Nadzeya, Lahm, Timothy, Giddings, Olivia, Davis, Michael D, DeBoer, Mark D, Comhair, Suzy A, Bazeley, Peter, Kim, Hyun Jo, Busse, William, Calhoun, William, Castro, Mario, Chung, Kian Fan, Fahy, John V, Israel, Elliot, Jarjour, Nizar N, Levy, Bruce D, Mauger, David T, Moore, Wendy C, Ortega, Victor E, Peters, Michael, Bleecker, Eugene R, Meyers, Deborah A, Zhao, Yi, Wenzel, Sally E, Gaston, Benjamin

المصدر: American Journal of Respiratory and Critical Care Medicine. 204(3)

مصطلحات موضوعية: Lung, Asthma, Respiratory, Good Health and Well Being, Adolescent, Adult, Aged, Aged, 80 and over, Breath Tests, Bronchoscopy, Dehydroepiandrosterone Sulfate, Female, Forced Expiratory Volume, Gene Expression, Humans, Male, Middle Aged, Nitric Oxide, Nitric Oxide Synthase Type II, Quality of Life, RNA, Messenger, Receptors, Androgen, Respiratory Mucosa, Sex Factors, Vital Capacity, Young Adult, asthma, androgens, airflow obstruction, airway inflammation, Medical and Health Sciences, Respiratory System

الوصف: Rationale: Androgens are potentially beneficial in asthma, but AR (androgen receptor) has not been studied in human airways.Objectives: To measure whether AR and its ligands are associated with human asthma outcomes.Methods: We compared the effects of AR expression on lung function, symptom scores, and fractional exhaled nitric oxide (FeNO) in adults enrolled in SARP (Severe Asthma Research Program). The impact of sex and of androgens on asthma outcomes was also evaluated in the SARP with validation studies in the Cleveland Clinic Health System and the NHANES (U.S. National Health and Nutrition Examination Survey).Measurements and Main Results: In SARP (n = 128), AR gene expression from bronchoscopic epithelial brushings was positively associated with both FEV1/FVC ratio (R2 = 0.135, P = 0.0002) and the total Asthma Quality of Life Questionnaire score (R2 = 0.056, P = 0.016) and was negatively associated with FeNO (R2 = 0.178, P = 9.8 × 10-6) and NOS2 (nitric oxide synthase gene) expression (R2 = 0.281, P = 1.2 × 10-10). In SARP (n = 1,659), the Cleveland Clinic Health System (n = 32,527), and the NHANES (n = 2,629), women had more asthma exacerbations and emergency department visits than men. The levels of the AR ligand precursor dehydroepiandrosterone sulfate correlated positively with the FEV1 in both women and men.Conclusions: Higher bronchial AR expression and higher androgen levels are associated with better lung function, fewer symptoms, and a lower FeNO in human asthma. The role of androgens should be considered in asthma management.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/0175678rTest

المؤلفون: Zein, Joe G., Strauss, Ronald, Attaway, Amy H., Hu, Bo, Milinovich, Alex, Jawhari, Nesreen, Chamat, Soulaima S., Ortega, Victor E.

المساهمون: National Heart, Lung, and Blood Institute, National Institutes of Health

المصدر: The Journal of Allergy and Clinical Immunology: In Practice ; volume 10, issue 3, page 742-750.e14 ; ISSN 2213-2198

الإتاحة: https://doi.org/10.1016/j.jaip.2021.12.034Test
https://api.elsevier.com/content/article/PII:S2213219822000095?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2213219822000095?httpAccept=text/plainTest

المؤلفون: Strauss, Ronald, Attaway, Amy H., Zein, Joe G.

المصدر: The Journal of Allergy and Clinical Immunology: In Practice ; volume 10, issue 1, page 355-356 ; ISSN 2213-2198

مصطلحات موضوعية: Immunology and Allergy

الإتاحة: https://doi.org/10.1016/j.jaip.2021.10.062Test
https://api.elsevier.com/content/article/PII:S2213219821012526?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2213219821012526?httpAccept=text/plainTest

المؤلفون: Zein, Joe G., Mitri, Jad, Bell, Jordan M., Lopez, Diana, Strauss, Ronald, Attaway, Amy H.

المساهمون: National Heart, Lung, and Blood Institute, National Institutes of Health

المصدر: The Journal of Allergy and Clinical Immunology: In Practice ; volume 10, issue 1, page 318-321.e2 ; ISSN 2213-2198

مصطلحات موضوعية: Immunology and Allergy

الإتاحة: https://doi.org/10.1016/j.jaip.2021.10.041Test
https://api.elsevier.com/content/article/PII:S2213219821011946?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2213219821011946?httpAccept=text/plainTest

المؤلفون: Strauss, Ronald, Jawhari, Nesreen, Attaway, Amy H., Hu, Bo, Jehi, Lara, Milinovich, Alex, Ortega, Victor E., Zein, Joe G.

المساهمون: National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Neurological Disorders and Stroke

المصدر: The Journal of Allergy and Clinical Immunology: In Practice ; volume 9, issue 11, page 3934-3940.e9 ; ISSN 2213-2198

مصطلحات موضوعية: Immunology and Allergy

الإتاحة: https://doi.org/10.1016/j.jaip.2021.08.007Test
https://api.elsevier.com/content/article/PII:S2213219821009065?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2213219821009065?httpAccept=text/plainTest

المؤلفون: Davis, Michael D, Zein, Joe G, Carraro, Silvia, Gaston, Benjamin

المساهمون: Davis, Michael D, Zein, Joe G, Carraro, Silvia, Gaston, Benjamin

الوصف: Children with inherited and/or acquired respiratory disorders often arrive in adolescence and adulthood with diminished lung function that might have been detected and prevented had better mechanisms been available to identify and to assess progression of disease. Fortunately, advances in genetic assessments, low-cost diagnostics, and minimally- invasive novel biomarkers are being developed to detect and to treat respiratory diseases before they give rise to loss of life or lung function. This paper summarizes the Developing Biomarkers for Pulmonary Health sessions of the National Heart, Lung, and Blood Institute- sponsored 2021 Defining and Promoting Pediatric Pulmonary Health workshop. These sessions discussed genetic testing, pulse oximetry, exhaled nitric oxide, and novel biomarkers related to childhood lung diseases.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/37656025; info:eu-repo/semantics/altIdentifier/wos/WOS:001159232100006; volume:152; issue:Suppl 2; journal:PEDIATRICS; https://hdl.handle.net/11577/3492860Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85169393190

الإتاحة: https://doi.org/10.1542/peds.2023-062292CTest
https://hdl.handle.net/11577/3492860Test

المؤلفون: Merhej, Tamara, Zein, Joe G.

المصدر: Precision Approaches to Heterogeneity in Asthma ; Advances in Experimental Medicine and Biology ; page 3-23 ; ISSN 0065-2598 2214-8019 ; ISBN 9783031322587 9783031322594

الإتاحة: https://doi.org/10.1007/978-3-031-32259-4_1Test

المؤلفون: Zein, Joe G., Whelan, Georgina, Erzurum, Serpil C.

المصدر: Journal of Clinical and Translational Science ; volume 5, issue 1 ; ISSN 2059-8661

مصطلحات موضوعية: General Medicine

الإتاحة: https://doi.org/10.1017/cts.2020.543Test
https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S2059866120005439Test