المؤلفون: de Jong E, Genders R, Harwood CA, Green AC, Plasmeijer EI, Proby C, Geissler E, Ferrándiz-Pulido C, Ducroux E, Euvrard S, Geusau A, Jahn-Bassler K, Borik-Heil L, Rácz E, Nägeli M, Hofbauer GF, Piaserico S, Russo I, Mackintosh L, Borges-Costa J, Angeliki-Gkini M, Zavattaro E, Savoia P, Imko-Walszuk B, Dębska-Slizień A, Garmyn M, van Kelst S, Ricar J, Cetkovska P, Matin R, Güleç AT, Seçkin D, Anene CA, Oliveira WRP, Rademaker M, Goeman J, van Geloven N, Ruiz E, Murad F, Karn E, Schmults CD, Bouwes Bavinck JN.

المساهمون: de Jong, E, Genders, R, Harwood, Ca, Green, Ac, Plasmeijer, Ei, Proby, C, Geissler, E, Ferrándiz-Pulido, C, Ducroux, E, Euvrard, S, Geusau, A, Jahn-Bassler, K, Borik-Heil, L, Rácz, E, Nägeli, M, Hofbauer, Gf, Piaserico, S, Russo, I, Mackintosh, L, Borges-Costa, J, Angeliki-Gkini, M, Zavattaro, E, Savoia, P, Imko-Walszuk, B, Dębska-Slizień, A, Garmyn, M, van Kelst, S, Ricar, J, Cetkovska, P, Matin, R, Güleç, At, Seçkin, D, Anene, Ca, Oliveira, Wrp, Rademaker, M, Goeman, J, van Geloven, N, Ruiz, E, Murad, F, Karn, E, Schmults, Cd, Bouwes Bavinck, Jn.

وصف الملف: ELETTRONICO

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/38301923; journal:JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY; https://hdl.handle.net/11579/171262Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85186178551

الإتاحة: https://doi.org/10.1016/j.jaad.2024.01.040Test
https://hdl.handle.net/11579/171262Test

المؤلفون: Nazzaro, G, Carugno, A, Bortoluzzi, P, Buffon, S, Astrua, C, Zappia, E, Trovato, E, Caccavale, S, Pellegrino, V, Paolino, G, Balestri, R, Lacava, R, Ciccarese, G, Verdelli, A, Barruscotti, S, Valenti, M, Toni, G, Giacalone, S, Zavattaro, E, Gironi, LC, Mercuri, SR, Ribero, S, Gisondi, P, Sena, P, Marzano, AV

المساهمون: Nazzaro, G, Carugno, A, Bortoluzzi, P, Buffon, S, Astrua, C, Zappia, E, Trovato, E, Caccavale, S, Pellegrino, V, Paolino, G, Balestri, R, Lacava, R, Ciccarese, G, Verdelli, A, Barruscotti, S, Valenti, M, Toni, G, Giacalone, S, Zavattaro, E, Gironi, L, Mercuri, S, Ribero, S, Gisondi, P, Sena, P, Marzano, A

مصطلحات موضوعية: actinic keratosi, cancerization field, efficacy, real‐life, tirbanibulin, tolerability

الوصف: Background: Tirbanibulin 1% ointment is approved for the field treatment of Olsen grade I actinic keratoses (AKs) of the face and scalp. Methods: We performed a multicenter retrospective study involving 15 dermatologic units in Italy to investigate the efficacy and tolerability of tirbanibulin in a real-life setting. 250 patients were enrolled. Tirbanibulin, 1% ointment, was applied daily for five consecutive days. The efficacy of treatment was measured with modifications of the Actinic Keratosis Area and Severity Index (AKASI). A satisfactory response was defined by complete (100% reduction in the number of lesions) or partial clearance (75-99%) of treated AKs. Results: Overall, the AKASI score was significantly reduced in the studied population (mean, from 4.1 ± 2.7 to 1.4 ± 1.5; P < 0.001). A satisfactory response was observed in 222 (88.8%) cases. The proportion of satisfactory responses was higher when follow-up was performed after 8 weeks (34/35, 97.1%). The reduction in AKASI was significant in patients with Olsen grade II or III lesions (from 5.3 ± 2.8 to 1.6 ± 1.6; P < 0.001). A satisfactory response was observed in 91/104 (87.5%) cases. AKASI reduction was also significant in patients with trunk or limb AKs (from 7.0 ± 1.3 to 2.0 ± 1.6; P = 0.018) since a satisfactory response was observed in 7/8 (87.5%) cases. Tirbanibulin was well tolerated; all adverse events (AEs) included transient local reactions at the site of treatment. Overall, 231 patients had at least one AE. Only 7 (2.8%) grade 4 AEs were recorded. Conclusion: Our retrospective study confirmed that tirbanibulin 1% ointment is effective and well tolerated in a real-life setting and is also promising for Olsen grade II and grade III AKs and AKs localized on difficult-to-treat areas.

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/38605473; info:eu-repo/semantics/altIdentifier/wos/WOS:001200666500001; journal:INTERNATIONAL JOURNAL OF DERMATOLOGY; https://hdl.handle.net/10281/472099Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85190757563

الإتاحة: https://doi.org/10.1111/ijd.17168Test
https://hdl.handle.net/10281/472099Test

المؤلفون: Gironi LC, Guala A, Zottarelli F, Graziola F, Zavattaro E, Esposto E, Damiani G, Savoia P

المساهمون: Gironi, Lc, Guala, A, Zottarelli, F, Graziola, F, Zavattaro, E, Esposto, E, Damiani, G, Savoia, P

وصف الملف: ELETTRONICO

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000975481200017; volume:13; issue:1; journal:DERMATOLOGY PRACTICAL & CONCEPTUAL; https://hdl.handle.net/11579/151240Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85160561196

الإتاحة: https://doi.org/10.5826/dpc.1301a52Test
https://hdl.handle.net/11579/151240Test

المؤلفون: Veronese F, Esposto E, Airoldi C, Gramaglia C, Bestagini L, Zavattaro E, Zeppegno P, Savoia P.

المساهمون: Veronese, F, Esposto, E, Airoldi, C, Gramaglia, C, Bestagini, L, Zavattaro, E, Zeppegno, P, Savoia, P.

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:001044742400001; volume:34; issue:1; numberofpages:8; journal:JOURNAL OF DERMATOLOGICAL TREATMENT; https://hdl.handle.net/11579/161124Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85167353437

الإتاحة: https://doi.org/10.1080/09546634.2023.2245080Test
https://hdl.handle.net/11579/161124Test

المؤلفون: Apostolo D, D'Onghia D, Tonello S, Minisini R, Baricich A, Gramaglia C, Patrucco F, Zeppegno P, Acquaviva A, Balbo PE, Castello LM, Cappellano G, Chiocchetti A, Gerevini C, Giordano Mara, Laaguid F, Manfredi M, Raineri D, Rigamonti C, Rolla R, Romano V, Confalonieri M, Savoia P, Zavattaro E, Pirisi M, Ruaro B, Sainaghi PP, Bellan M.

المساهمون: Apostolo, D, D'Onghia, D, Tonello, S, Minisini, R, Baricich, A, Gramaglia, C, Patrucco, F, Zeppegno, P, Acquaviva, A, Balbo, Pe, Castello, Lm, Cappellano, G, Chiocchetti, A, Gerevini, C, Giordano, Mara, Laaguid, F, Manfredi, M, Raineri, D, Rigamonti, C, Rolla, R, Romano, V, Confalonieri, M, Savoia, P, Zavattaro, E, Pirisi, M, Ruaro, B, Sainaghi, Pp, Bellan, M.

مصطلحات موضوعية: Gas6, TAM receptor, hair lo, inflammation, post-acute COVID-19

الوصف: Post-acute conditions after coronavirus disease 2019 (COVID-19) are quite common, although the underlying pathogenetic mechanisms leading to these conditions are not yet completely understood. In this prospective observational study, we aimed to test the hypothesis that Growth Arrest-Specific 6 (Gas6) and its soluble receptors, Axl (sAxl) and MerTK (sMer), might be implicated. A total of 263 subjects underwent a structured clinical evaluation one year after their hospital discharge for COVID-19, and they consented to donate a blood sample to measure their circulating Gas6, sAxl, and sMer levels. A total of 98 (37.3%) post-COVID-19 subjects complained of at least one residual physical symptom one year after their hospital discharge. Univariate analysis revealed that sAxl was marginally associated with residual symptoms, but at the level of logistic regression analysis, only the diffusing capacity of the lungs for carbon monoxide (DLCO) (OR 0.98, CI 95%: 0.96-0.99; p = 0.007) and the female sex (OR 2.49, CI 95%: 1.45-4.28; p = 0.001) were independently associated with long-lasting symptoms. A total of 69 (26.2%) subjects had hair loss. At the level of univariate analysis, Gas6, sAxl, DLCO, and the female gender were associated with its development. In a logistic regression analysis model, Gas6 (OR 0.96, CI 95%: 0.92-0.99; p = 0.015) and sAxl (OR 0.98, CI 95%; 0.97-1.0; p = 0.014), along with the female sex (OR 6.58, CI 95%: 3.39-12.78; p = 0.0001), were independent predictors of hair loss. Decreased levels of Gas6 and sAxl were associated with a history of hair loss following COVID-19. This was resolved spontaneously in most patients, although 23.7% complained of persistent hair loss one year after hospital discharge.

وصف الملف: ELETTRONICO

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/37047229; info:eu-repo/semantics/altIdentifier/wos/WOS:000969830400001; volume:24; issue:7; firstpage:6257; journal:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; https://hdl.handle.net/11579/153020Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85152314721; https://www.mdpi.com/1422-0067/24/7/6257Test

الإتاحة: https://doi.org/10.3390/ijms24076257Test
https://hdl.handle.net/11579/153020Test
https://www.mdpi.com/1422-0067/24/7/6257Test

المؤلفون: Camillo L., Gironi L. C., Esposto E., Zavattaro E., Savoia P.

المساهمون: Camillo, L., Gironi, L. C., Esposto, E., Zavattaro, E., Savoia, P.

الوصف: Background: Photoaging is mainly caused by ultraviolet radiations inasmuch they can damage the DNA, trigger ROS production, and activate p53/p21 pathway, which cause cell cycle arrest and senescence. The accumulationof senescent cells within the dermis contributes to tissue deregulation and skin carcinogenesis. However, the use of photoprotector molecules could reduce UV-induced damages and prevent photoaging. Therefore, the aim of this study is to evaluate whether the active forms of vitamin B3 (nicotinamide) and the analog of vitamin D3 (calcipotriol) might protect primary human dermal fibroblasts (HDFs) from UVB-induced photoaging. Methods: HDFs were isolated from a healthy adult donor and stimulated with nicotinamide (25 μM) and calcipotriol (100 nM) for 24h before UVB exposure, and then, cultured for further 24h on vitamin-supplemented media. Then, cell viability, ROS production, DNA damages, senescence markers, protein and gene expression were evaluated. Results: HDFs treated with nicotinamide and calcipotriol showed better proliferation properties and lower DNA damages due to a reduced UVB-induced ROS production. Consequently, p53/p21 pathway was less active which enhanced cell cycle progression and reduced senescence and cell death. Conclusions: Overall, our results suggest that nicotinamide and calcipotriol can counteract UVB-induced effects responsible for the onset of skin photoaging.

وصف الملف: ELETTRONICO

العلاقة: volume:12; firstpage:100158; journal:JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY; https://hdl.handle.net/11579/152861Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85142698825; https://reader.elsevier.com/reader/sd/pii/S2666469022000513?token=E6A6CFCA6D1B3BB870BD88DFAAF6F5AF1D27D83651128F552538D897B1C86DD43041F3045613143BA8086FA933341546&originRegion=eu-west-1&originCreation=20230428105807Test

الإتاحة: https://doi.org/10.1016/j.jpap.2022.100158Test
https://hdl.handle.net/11579/152861Test
https://reader.elsevier.com/reader/sd/pii/S2666469022000513?token=E6A6CFCA6D1B3BB870BD88DFAAF6F5AF1D27D83651128F552538D897B1C86DD43041F3045613143BA8086FA933341546&originRegion=eu-west-1&originCreation=20230428105807Test

المؤلفون: Camillo, L., Gironi, L.C., Zavattaro, E., Savoia, P.

المصدر: Journal of Investigative Dermatology ; volume 142, issue 12, page S262 ; ISSN 0022-202X

مصطلحات موضوعية: Cell Biology, Dermatology, Molecular Biology, Biochemistry

الإتاحة: https://doi.org/10.1016/j.jid.2022.09.486Test
https://api.elsevier.com/content/article/PII:S0022202X22024204?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0022202X22024204?httpAccept=text/plainTest

المؤلفون: Meiburger K. M., Veronese F., Tarantino V., Salvi M., Fadda M., Seoni S., Zavattaro E., Santi B. D., Michielli N., Savoia P., Molinari F.

المساهمون: Meiburger, K. M., Veronese, F., Tarantino, V., Salvi, M., Fadda, M., Seoni, S., Zavattaro, E., Santi, B. D., Michielli, N., Savoia, P., Molinari, F.

مصطلحات موضوعية: Dermoscopy, Human, Nevu, Skin Disease, Smartphone

الوصف: The evolution of smartphone technology has made their use more common in dermatological applications. Here we studied the feasibility of using an inexpensive smartphone microscope for the extraction of dermatological parameters and compared the results obtained with a portable dermoscope, commonly used in clinical practice. Forty-two skin lesions were imaged with both devices and visually analyzed by an expert dermatologist. The presence of a reticular pattern was observed in 22 dermoscopic images, but only in 10 smartphone images. The proposed paradigm segments the image and extracts texture features which are used to train and validate a neural network to classify the presence of a reticular pattern. Using 5-fold cross-validation, an accuracy of 100% and 95% was obtained with the dermoscopic and smartphone images, respectively. This approach can be useful for general practitioners and as a triage tool for skin lesion analysis.

وصف الملف: ELETTRONICO

العلاقة: info:eu-repo/semantics/altIdentifier/isbn/978-1-5386-1311-5; info:eu-repo/semantics/altIdentifier/wos/WOS:000557295300092; ispartofbook:Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019; volume:2019; firstpage:399; lastpage:402; numberofpages:4; serie:IEEE ENGINEERING IN MEDICINE AND BIOLOGY . ANNUAL CONFERENCE PROCEEDINGS; http://hdl.handle.net/11583/2931563Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85077860218; https://ieeexplore.ieee.org/abstract/document/8856720Test

الإتاحة: https://doi.org/10.1109/EMBC.2019.8856720Test
http://hdl.handle.net/11583/2931563Test
https://ieeexplore.ieee.org/abstract/document/8856720Test

المؤلفون: Seoni S., Veronese F., Tarantino V., Zavattaro E., Salvi M., Michielli N., De Santi B., Molinari F., Savoia P., Meiburger K. M.

المساهمون: Seoni, S., Veronese, F., Tarantino, V., Zavattaro, E., Salvi, M., Michielli, N., De Santi, B., Molinari, F., Savoia, P., Meiburger, K. M.

مصطلحات موضوعية: Human, Skin, Skin Neoplasm, Spectroscopy, Near-Infrared, Carcinoma, Squamous Cell, Keratosis, Actinic

الوصف: Non-melanoma skin cancers are the most common tumor in the Caucasian population, and include actinic keratosis (AK), which is considered an early form of in-situ squamous cell carcinoma (SCC). Currently the only way to monitor lesion progression (i.e., from AK to invasive SCC) is through an invasive bioptic procedure. Near-infrared spectroscopy (NIRS) is a non-invasive technique that studies haemoglobin (oxygenated haemoglobin, O2Hb, and deoxygenated haemoglobin, HHb) relative concentration variations. The objective of this study is to evaluate if AKs present a different vascular response when compared to healthy skin using time and frequency parameters extracted from the NIRS signals. The NIRS signals were acquired on the AKs and a healthy skin area of patients (n=53), with the same acquisition protocol: baseline signals (1.5 min), application of ice pack near lesion (1.5 min), removal of ice pack and acquisition of vascular recovery (1.5 min). We calculated 18 features to evaluate if the vascular response was different in the two cases (i.e., healthy skin and AK lesions). By applying the multivariate analysis of variance (MANOVA), a statistically significant difference is found in the O2Hb and HHb after the stimulus application. This shows how the NIRS technique can give important vascular information that could help the diagnosis of a lesion and the evaluation of its progression. Overall, the obtained results encourage us to look further into the study of the skin lesions and their progression with NIRS signals.

وصف الملف: ELETTRONICO

العلاقة: info:eu-repo/semantics/altIdentifier/isbn/978-1-5386-1311-5; info:eu-repo/semantics/altIdentifier/wos/WOS:000557295300108; ispartofbook:Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019; volume:2019; firstpage:467; lastpage:470; numberofpages:4; serie:IEEE ENGINEERING IN MEDICINE AND BIOLOGY . ANNUAL CONFERENCE PROCEEDINGS; http://hdl.handle.net/11583/2931565Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85077901854; https://ieeexplore.ieee.org/document/8857279Test

الإتاحة: https://doi.org/10.1109/EMBC.2019.8857279Test
http://hdl.handle.net/11583/2931565Test
https://ieeexplore.ieee.org/document/8857279Test

المؤلفون: Squarzanti DF, Zavattaro E, Pizzimenti S, Amoruso A, Savoia P, Azzimonti B.

المساهمون: Squarzanti, Df, Zavattaro, E, Pizzimenti, S, Amoruso, A, Savoia, P, Azzimonti, B.

مصطلحات موضوعية: in vitro 3D reconstructed skin, Microbiota, Non-Melanoma Skin Cancer (NMSC), animal model, anti-/pro-biotics

الوصف: Recently, research has been deeply focusing on the role of the microbiota in numerous diseases, either affecting the skin or other organs. What it is well established is that its dysregulation promotes several cutaneous disorders (i.e. psoriasis and atopic dermatitis). To date, little is known about its composition, mediators and role in the genesis, progression and response to therapy of Non-Melanoma Skin Cancer (NMSC). Starting from a bibliographic study, we classified the selected articles into four sections: i) normal skin microbiota; ii) in vitro study models; iii) microbiota and NMSC and iv) probiotics, antibiotics and NMSC. What has emerged is how skin microflora changes, mainly represented by increases of Staphylococcus aureus, Streptococcus pyogenes and Pseudomonas aeruginosa strains, modifications in the mutual quantity of β-Human papillomavirus genotypes, of Epstein Barr Virus and Malassezia or candidiasis, may contribute to the induction of a state of chronic self-maintaining inflammation, leading to cancer. In this context, the role of S. aureus and that of specific antimicrobial peptides look to be prominent. Moreover, although antibiotics may contribute to carcinogenesis, due to their ability to influence the microbiota balance, specific probiotics, such as Lacticaseibacillus rhamnosus GG, Lactobacillus johnsonii NCC 533 and Bifidobacteria spp., may be protective.

وصف الملف: ELETTRONICO

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/32692305; info:eu-repo/semantics/altIdentifier/wos/WOS:000550688300001; volume:46; issue:4; firstpage:433; lastpage:449; numberofpages:17; journal:CRITICAL REVIEWS IN MICROBIOLOGY; http://hdl.handle.net/11579/117893Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85088378304

الإتاحة: https://doi.org/10.1080/1040841X.2020.1794792Test
http://hdl.handle.net/11579/117893Test