المؤلفون: Kevin Qin, Michael Yu, Jiaming Fan, Hongwei Wang, Piao Zhao, Guozhi Zhao, Wei Zeng, Connie Chen, Yonghui Wang, Annie Wang, Zander Schwartz, Jeffrey Hong, Lily Song, William Wagstaff, Rex C. Haydon, Hue H. Luu, Sherwin H. Ho, Jason Strelzow, Russell R. Reid, Tong-Chuan He, Lewis L. Shi

المصدر: Genes and Diseases, Vol 11, Iss 1, Pp 103-134 (2024)

مصطلحات موضوعية: β-catenin, Canonical Wnt, Noncanonical Wnt, Signal transduction, Signaling crosstalk, Medicine (General), R5-920, Genetics, QH426-470

الوصف: Wnt signaling plays a major role in regulating cell proliferation and differentiation. The Wnt ligands are a family of 19 secreted glycoproteins that mediate their signaling effects via binding to Frizzled receptors and LRP5/6 coreceptors and transducing the signal either through β-catenin in the canonical pathway or through a series of other proteins in the noncanonical pathway. Many of the individual components of both canonical and noncanonical Wnt signaling have additional functions throughout the body, establishing the complex interplay between Wnt signaling and other signaling pathways. This crosstalk between Wnt signaling and other pathways gives Wnt signaling a vital role in many cellular and organ processes. Dysregulation of this system has been implicated in many diseases affecting a wide array of organ systems, including cancer and embryological defects, and can even cause embryonic lethality. The complexity of this system and its interacting proteins have made Wnt signaling a target for many therapeutic treatments. However, both stimulatory and inhibitory treatments come with potential risks that need to be addressed. This review synthesized much of the current knowledge on the Wnt signaling pathway, beginning with the history of Wnt signaling. It thoroughly described the different variants of Wnt signaling, including canonical, noncanonical Wnt/PCP, and the noncanonical Wnt/Ca2+ pathway. Further description involved each of its components and their involvement in other cellular processes. Finally, this review explained the various other pathways and processes that crosstalk with Wnt signaling.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2352304223000557Test; https://doaj.org/toc/2352-3042Test

الوصول الحر: https://doaj.org/article/e9c5d2e8d60a4f7bab671fa685bf5817Test

المؤلفون: Junyi Liao, Bowen Chen, Zhenglin Zhu, Chengcheng Du, Shengqiang Gao, Guozhi Zhao, Piao Zhao, Yonghui Wang, Annie Wang, Zander Schwartz, Lily Song, Jeffrey Hong, William Wagstaff, Rex C. Haydon, Hue H. Luu, Jiaming Fan, Russell R. Reid, Tong-Chuan He, Lewis Shi, Ning Hu, Wei Huang

المصدر: Genes and Diseases, Vol 10, Iss 4, Pp 1351-1366 (2023)

مصطلحات موضوعية: Cancer, Epigenetic regulation, H19, LncRNA, Long-noncoding RNA, Metabolic diseases, Medicine (General), R5-920, Genetics, QH426-470

الوصف: Recent advances in deep sequencing technologies have revealed that, while less than 2% of the human genome is transcribed into mRNA for protein synthesis, over 80% of the genome is transcribed, leading to the production of large amounts of noncoding RNAs (ncRNAs). It has been shown that ncRNAs, especially long non-coding RNAs (lncRNAs), may play crucial regulatory roles in gene expression. As one of the first isolated and reported lncRNAs, H19 has gained much attention due to its essential roles in regulating many physiological and/or pathological processes including embryogenesis, development, tumorigenesis, osteogenesis, and metabolism. Mechanistically, H19 mediates diverse regulatory functions by serving as competing endogenous RNAs (CeRNAs), Igf2/H19 imprinted tandem gene, modular scaffold, cooperating with H19 antisense, and acting directly with other mRNAs or lncRNAs. Here, we summarized the current understanding of H19 in embryogenesis and development, cancer development and progression, mesenchymal stem cell lineage-specific differentiation, and metabolic diseases. We discussed the potential regulatory mechanisms underlying H19's functions in those processes although more in-depth studies are warranted to delineate the exact molecular, cellular, epigenetic, and genomic regulatory mechanisms underlying the physiological and pathological roles of H19. Ultimately, these lines of investigation may lead to the development of novel therapeutics for human diseases by exploiting H19 functions.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2352304223000569Test; https://doaj.org/toc/2352-3042Test

الوصول الحر: https://doaj.org/article/578f419536f7488ab664e00e601ede51Test

المؤلفون: Zander Schwartz, Piao Zhao, Annie Wang, Guozhi Zhao, Wei Zeng, Yonghui Wang, Hue H. Luu, Rex C. Haydon, Tong-Chuan He, Russell R. Reid, Jason Strelzow

المصدر: Genes and Diseases, Vol 10, Iss 2, Pp 310-312 (2023)

مصطلحات موضوعية: Medicine (General), R5-920, Genetics, QH426-470

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S235230422200246XTest; https://doaj.org/toc/2352-3042Test

الوصول الحر: https://doaj.org/article/9545394da9f44967afad1814dccc0d38Test

المؤلفون: Kevin Qin, Michael Yu, Jiaming Fan, Hongwei Wang, Piao Zhao, Guozhi Zhao, Wei Zeng, Connie Chen, Yonghui Wang, Annie Wang, Zander Schwartz, Jeffrey Hong, Lily Song, William Wagstaff, Rex C. Haydon, Hue H. Luu, Sherwin H. Ho, Jason Strelzow, Russell R. Reid, Tong-Chuan He, Lewis L. Shi

المصدر: Genes & Diseases.

مصطلحات موضوعية: Cell Biology, Molecular Biology, Biochemistry, Genetics (clinical)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::e4024d94863afd2106615b21538bb2b0Test
https://doi.org/10.1016/j.gendis.2023.01.030Test

المؤلفون: Kevin Qin, Michael Yu, Jiaming Fan, Hongwei Wang, Piao Zhao, Guozhi Zhao, Wei Zeng, Connie Chen, Yonghui Wang, Annie Wang, Zander Schwartz, Jeffrey Hong, Lily Song, William Wagstaff, Rex C. Haydon, Hue H. Luu, Sherwin H. Ho, Jason Strelzow, Russell R. Reid, Tong-Chuan He, Lewis L. Shi

المصدر: Genes and Diseases, Vol 11, Iss 1, Pp 103-134 (2024)

مصطلحات موضوعية: β-catenin, Canonical Wnt, Noncanonical Wnt, Signal transduction, Signaling crosstalk, Medicine (General), R5-920, Genetics, QH426-470

الوصف: Wnt signaling plays a major role in regulating cell proliferation and differentiation. The Wnt ligands are a family of 19 secreted glycoproteins that mediate their signaling effects via binding to Frizzled receptors and LRP5/6 coreceptors and transducing the signal either through β-catenin in the canonical pathway or through a series of other proteins in the noncanonical pathway. Many of the individual components of both canonical and noncanonical Wnt signaling have additional functions throughout the body, establishing the complex interplay between Wnt signaling and other signaling pathways. This crosstalk between Wnt signaling and other pathways gives Wnt signaling a vital role in many cellular and organ processes. Dysregulation of this system has been implicated in many diseases affecting a wide array of organ systems, including cancer and embryological defects, and can even cause embryonic lethality. The complexity of this system and its interacting proteins have made Wnt signaling a target for many therapeutic treatments. However, both stimulatory and inhibitory treatments come with potential risks that need to be addressed. This review synthesized much of the current knowledge on the Wnt signaling pathway, beginning with the history of Wnt signaling. It thoroughly described the different variants of Wnt signaling, including canonical, noncanonical Wnt/PCP, and the noncanonical Wnt/Ca2+ pathway. Further description involved each of its components and their involvement in other cellular processes. Finally, this review explained the various other pathways and processes that crosstalk with Wnt signaling.

العلاقة: http://www.sciencedirect.com/science/article/pii/S2352304223000557Test; https://doaj.org/toc/2352-3042Test; https://doaj.org/article/e9c5d2e8d60a4f7bab671fa685bf5817Test

الإتاحة: https://doi.org/10.1016/j.gendis.2023.01.030Test
https://doaj.org/article/e9c5d2e8d60a4f7bab671fa685bf5817Test