المؤلفون: Tiffany Chen, Nicolas S. Poupore, Michael C. Shih, Thomas S. Edwards, Shaun A. Nguyen, Zachary M. Soler, Rodney J. Schlosser

المصدر: World Journal of Otorhinolaryngology-Head and Neck Surgery, Vol 10, Iss 1, Pp 66-69 (2024)

مصطلحات موضوعية: chemosensory, olfaction, trigeminal, TRP receptor, Otorhinolaryngology, RF1-547, Surgery, RD1-811

الوصف: Abstract Trigeminal‐specific stimulants have been shown to activate different receptors preferentially and this likely accounts for variation in sensory perception. It is unclear whether trigeminal sensitivity is similar across different transient receptor potential (TRP) receptors or if dysfunction of different receptors results in differing patient symptoms. Therefore, a prospective cohort study was conducted, consisting of trigeminal lateralization testing with three different stimulants (eucalyptol, isothiocyanate, acetic acid), olfaction testing with Sniffin' Sticks, and measurement of various patient‐reported outcome measures (PROMs). A total of 50 participants were enrolled across the olfactory spectrum. Mean TDI score was 27.1 ± 8.3 (range 7.0–39.5) with 38% normosmic and 62% dysosmic. Mean trigeminal lateralization scores out of 20 in the overall cohort were 16.18 (2.78) for eucalyptol, 14.94 (3.49) for mustard oil, and 15.28 (3.68) for vinegar. Eucalyptol showed a significant correlation with threshold scores of Sniffin' Sticks. A significant correlation was found between acetic acid and various PROMs. None of the lateralization scores of the trigeminal stimulants correlated to each other significantly and there was no correlation to age. The lack of correlation suggests that the measured sensitivity of one type of TRP receptor may not translate to similar sensitivity of the other receptors. Additional investigations with TRPV1 and TRPA1 agonists are needed to corroborate our findings.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2095-8811Test; https://doaj.org/toc/2589-1081Test

الوصول الحر: https://doaj.org/article/60c25a4baba945039b305c16acd63728Test

المؤلفون: Jorge A. Gutierrez III, Jeremy L. Barth, Rodney J. Schlosser, Thomas S. Edwards, Timothy L. Smith, Zachary M. Soler

المصدر: World Journal of Otorhinolaryngology-Head and Neck Surgery, Vol 10, Iss 1, Pp 29-36 (2024)

مصطلحات موضوعية: chronic rhinosinusitis without nasal polyps, olfactory dysfunction, RNA sequencing, Otorhinolaryngology, RF1-547, Surgery, RD1-811

الوصف: Abstract Objectives Prior research on olfactory dysfunction in chronic rhinosinusitis (CRS) has focused on patients with polyps and suggests that direct inflammation of the olfactory cleft mucosa plays a contributory role. The purpose of this study was to evaluate gene expression in superior turbinate mucosal specimens, comparing normosmic and dysosmic CRS patients without polyps (CRSsNP). Methods Tissue samples were obtained from the superior turbinates of patients with CRSsNP at the time of endoscopic sinus surgery. Samples subsequently underwent RNA sequencing and functional analysis to investigate biological pathways associated with differentially expressed genes between dysosmic (n = 7) and normosmic (n = 4) patients. Results Differential gene expression analysis comparing dysosmic and normosmic CRSsNP patients showed upregulation of 563 genes and downregulation of 327 genes. Using stringent criteria for multiple comparisons, one upregulated gene (Immediate Early Response 3 [IER3]) had an false discovery rate (FDR) correction adjusted P value considered statistically significant (P

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2095-8811Test; https://doaj.org/toc/2589-1081Test

الوصول الحر: https://doaj.org/article/b6d499f080314ba4b21890bc78cb78feTest

المؤلفون: Varun Vohra, Sahar Assi, Vidyulata Kamath, Zachary M. Soler, Nicholas R. Rowan

المصدر: Nutrients, Vol 15, Iss 18, p 3890 (2023)

مصطلحات موضوعية: olfaction, diet, cognition, Nutrition. Foods and food supply, TX341-641

الوصف: In the context of a growing body of evidence associating olfactory dysfunction (OD) with cognitive decline, this cross-sectional study used data from the 2013–2014 National Health and Nutrition Examination Survey (NHANES) sample in order to explore the role of dietary intake in this association. Leveraging a nationally representative sample of U.S. adults aged 60 years and older, this study analyzed dietary patterns using exploratory factor analysis. OD was categorized based on the NHANES Pocket Smell Test, and cognitive function was measured with a battery of tests. Survey-weighted multivariable regressions and causal mediation analysis were used to examine the relationship between dietary patterns, OD, and cognitive function. Results indicated that a poor adherence to a diet rich in monounsaturated fats (MUFAs) and polyunsaturated fats (PUFAs) was independently associated with both cognitive and olfactory dysfunctions, after adjusting for sociodemographic and health factors. Moreover, the relationship between OD and cognitive decline was found to be partly mediated by adherence to such a diet. This study proposes a potential link between diet, olfactory function, and cognitive decline, highlighting the role of nutritional interventions in mitigating cognitive decline, particularly in individuals with olfactory impairment.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2072-6643/15/18/3890Test; https://doaj.org/toc/2072-6643Test

الوصول الحر: https://doaj.org/article/0db9dd98929a4520bbd63d6ce39b47d3Test

المؤلفون: Nikita Chapurin, Sofia Khan, Jorge Gutierrez, Zachary M. Soler

المصدر: American Journal of Rhinology & Allergy. 37:227-231

مصطلحات موضوعية: Otorhinolaryngology, Immunology and Allergy, General Medicine

الوصف: Background Chronic rhinosinusitis (CRS) with nasal polyposis (CRSwNP) is a chronic inflammatory condition with significant patient morbidity and associated healthcare costs. While the economic burden of CRS overall has been previously described, the economic impact of CRSwNP has received less attention. Patients with CRSwNP have higher disease burden and healthcare resource utilization than those with CRS without nasal polyposis. Rapid evolution of medical management in recent years with the use of targeted biologics warrants further investigation into the economic burden of CRSwNP. Objective Provide an updated review of the literature on the economic impact of CRSwNP. Methods A literature review. Results Research shows that patients with CRSwNP have higher direct costs and usage of ambulatory services compared to matched non-CRS controls. Patients undergoing functional endoscopic sinus surgery (FESS) incur roughly $13,000 in costs which is particularly relevant given the rate of disease recidivism and need for revision surgery associated with CRSwNP. Disease burden additionally leads to indirect costs through loss of wages and productivity due to work absenteeism and presenteeism, with estimates of up to roughly $10,000 lost in mean annual productivity cost in refractory CRSwNP. Several studies have shown FESS to be more cost-effective in intermediate and long-term management than medical therapy with biologics, despite similar long-term outcomes with respect to quality-of-life metrics. Conclusion CRSwNP is a chronic condition with high recurrence rates making it a challenge to manage over time. Current research suggests that FESS is more cost-effective than medical management, including use of newer biologics. Further investigation into both direct and indirect costs associated with medical management is warranted to perform accurate cost-effectiveness analyses and allow for the best allocation of limited healthcare resources.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::a3481a546375c8da175e023d6c727dc8Test
https://doi.org/10.1177/19458924221147501Test

المؤلفون: Antonio Bognanni, Derek K. Chu, Matthew A. Rank, Jonathan Bernstein, Anne K. Ellis, David Golden, Matthew Greenhawt, John B. Hagan, Caroline C. Horner, Dennis K. Ledford, Jay Lieberman, Amber U. Luong, Lisa A. Marks, Richard R. Orlandi, Shefali A. Samant, Marcus Shaker, Zachary M. Soler, Whitney W. Stevens, David R. Stukus, Julie Wang, Anju T. Peters

المصدر: Journal of Allergy and Clinical Immunology. 150:1447-1459

مصطلحات موضوعية: Nasal Polyps, Adrenal Cortex Hormones, Immunology, Humans, Immunology and Allergy, Sinusitis, Rhinitis

الوصف: Chronic rhinosinusitis with nasal polyposis (CRSwNP) is associated with a significant disease burden. The optimal use of and administration route for intranasal corticosteroids (INCS) when managing CRSwNP are unclear.We systematically synthesized the evidence addressing INCS for CRSwNP.We searched studies archived in Medline, Embase, and Central from database inception until September 1, 2021, for randomized controlled trials comparing INCS using any delivery method to placebo or other INCS administration types. Paired reviewers screened records, abstracted data, and rated risk of bias (CLARITY revision of Cochrane Risk of Bias version 1 tool) independently and in duplicate. We synthesized the evidence for each outcome using random effects network meta-analyses. We critically appraised the evidence following the GRADE (Grades of Recommendation Assessment, Development, and Evaluation) approach.We analyzed 61 randomized controlled trials (7176 participants, 8 interventions). Sinusitis-related quality of life might improve with INCS rinse (mean difference [MD] -6.83, 95% confidence interval [CI] -11.94 to -1.71) and exhalation delivery system (EDS) (MD -7.86, 95% CI -14.64 to -1.08) compared to placebo (both low certainty evidence). Nasal obstruction symptoms are likely improved when receiving INCS via stent/dressing (MD -0.31, 95% CI -0.54 to -0.08), spray (MD -0.51, 95% CI -0.61 to -0.41), and EDS (MD -0.35, 95% CI -0.51 to -0.18) (all moderate to high certainty) compared to placebo. We found no important differences in adverse effects among interventions (moderate certainty for INCS spray, very low to low certainty for others).Multiple delivery forms of INCS are viable therapeutic options for CRSwNP, resulting in improvement of patient-important outcomes. INCS via stent, spray, and EDS appear to be beneficial across the widest range of considered outcomes.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bc7717ab8120ded77415dc7e28e70bfTest
https://doi.org/10.1016/j.jaci.2022.07.023Test

المؤلفون: Taylor Cave, Michael J. Marino, Devyani Lal, Zachary M. Soler, Bernard R. Bendok, Amar Miglani

المصدر: Contemporary Neurosurgery. 44:1-8

مصطلحات موضوعية: General Earth and Planetary Sciences, General Environmental Science

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::855117362dd0333cd34676b4efd21e68Test
https://doi.org/10.1097/01.cne.0000902656.27844.bdTest

المؤلفون: Michael C. Shih, Zachary M. Soler, Matthew Germroth, Jacob Snyder, Shaun A. Nguyen, Rodney J. Schlosser

المصدر: American Journal of Rhinology & Allergy. 37:253-263

مصطلحات موضوعية: Otorhinolaryngology, Immunology and Allergy, General Medicine

الوصف: Introduction Patients often describe the olfactory loss as either the inability to detect unpleasant odors (eg, smoke or spoiled food) or noticeable impairment in enjoying pleasant odors (eg, food and fragrances). This complex relationship between the hedonics of various odors, their perceived magnitude in odor strength, and the impact on patient quality of life is not well understood. Methods Sixty-five subjects underwent testing with the Henkin olfaction test which assesses hedonics and magnitude for odors traditionally deemed unpleasant (pyridine/dead fish and thiophene/gasoline) and pleasant (amyl acetate/banana and nitrobenzene/almond). Subjects also completed Smell Identification Test-40 (SIT-40), Sniffin’ Sticks (Sniffin’ Sticks), and Snap & Sniffin’ Sticks (Snap) Olfactory Tests, as well as the 17-item Questionnaire for Olfactory Disorders Negative Statements (QODNS) and olfactory symptom visual analog scale (VAS). Spearman's rank correlations were conducted between various olfactory domains, QODNS and VAS. Results Mean age was 52.1 years (range: 28-86), with 63.1% females. Magnitude estimation was greatest for pyridine. Most people rated thiophene (75.4%) and pyridine (92.3%) as “unpleasant.” Although most people rated amyl acetate (47.7%) and nitrobenzene (56.9%) as “pleasant,” many rated amyl acetate (52.3%) and nitrobenzene (43.1%) as “neutral” or “unpleasant” scents. Hedonics for unpleasant odors correlated with each other ( rs = 0.60), but not with hedonics for pleasant odors. Hedonics for unpleasant odors also correlated with magnitude estimation and other psychophysical tests. These findings were not seen for hedonics of pleasant odors. Conclusions The use of unpleasant odors in Henkin testing showed unique relationship patterns with patient-reported outcome measures and validated olfactory tests, which may provide utility in characterizing olfactory dysfunction. The incorporation of more unpleasant odors in current psychophysical olfactory testing may provide enhanced information regarding the patient impact of olfactory dysfunction.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f19aae7edd589f22fd9486ed7533c2d4Test
https://doi.org/10.1177/19458924221136649Test

المؤلفون: Sofia Khan, Jorge A. Gutierrez, Nikita Chapurin, Shaun A. Nguyen, Zachary M. Soler, Rodney J. Schlosser

المصدر: International Forum of Allergy & Rhinology.

مصطلحات موضوعية: Otorhinolaryngology, Immunology and Allergy

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::7b286d0759b014a94c9ef7b87dead75cTest
https://doi.org/10.1002/alr.23184Test

المؤلفون: Lillian W. Dattilo, Vinay K. Rathi, Rodney J. Schlosser, Zachary M. Soler, George A. Scangas, Alan D. Workman, Stacey T. Gray

المصدر: International Forum of Allergy & Rhinology.

مصطلحات موضوعية: Otorhinolaryngology, Immunology and Allergy

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::f78f5f1fd37c135ebe7649d74d3fcf27Test
https://doi.org/10.1002/alr.23185Test

المؤلفون: Rodney J. Schlosser, Zachary M. Soler, Jess Mace, Nyssa Farrell, Ryan Rimmer, Jeremiah A. Alt, Vijay R. Ramakrishnan, Thomas S. Edwards, Timothy L. Smith

المصدر: American Journal of Rhinology & Allergy. 37:26-34

مصطلحات موضوعية: Adult, Smell, Olfaction Disorders, Nasal Polyps, Otorhinolaryngology, Odorants, Chronic Disease, Humans, Immunology and Allergy, General Medicine, Sinusitis, Rhinitis

الوصف: Background Olfactory dysfunction (OD) can occur from a variety of etiologies. However, there are few reports examining whether varying etiologies have unique profiles of psychophysical testing that may provide insight into the pathophysiology of OD. Methods Adults with chronic rhinosinusitis with and without nasal polyps (CRSwNP/CRSsNP) and healthy control adults with no sinus complaints underwent olfactory assessment with Sniffin’ Sticks. Profiles of identification and discrimination were compared between CRS and non-CRS subjects across the spectrum of OD. Results Normosmics with or without CRS identified apple, pineapple, and turpentine less frequently than expected (range 52%-68% correct). Hyposmics with CRS correctly identified orange more frequently than control hyposmics (83%-93% vs 68% for controls) with similar findings for rose. Hyposmics of all cohorts were unable to identify apple (26%). Discrimination profiles were similar across the spectrum of OD and between diagnostic groups. Conclusions Identification and discrimination rates of specific odorants may provide unique information regarding the etiology of OD, however psychophysical testing is a complex interplay of olfactory and trigeminal function, the strength of target odorant, distractor choices, and familiarity with odorants.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84268ff1676adb082b57571ae8be11a7Test
https://doi.org/10.1177/19458924221124692Test