المؤلفون: Garcia-Ruiz, A., Macarro, C., Zacchi, F., Mast, R., de Albert, M., Roche, S., Escobar, M., Morales-Barrera, R., Gonzalez, M., Piulats, J.M., Calvo, N., Garcia Bennett, J., Sanguedolce, F., Carles, J., Mateo, J., Grussu, F., Perez-Lopez, R.

المصدر: European Urology Open Science ; volume 57, page S191-S192 ; ISSN 2666-1683

مصطلحات موضوعية: Urology

الإتاحة: https://doi.org/10.1016/s2666-1683Test(23)01426-x
https://api.elsevier.com/content/article/PII:S266616832301426X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S266616832301426X?httpAccept=text/plainTest

المؤلفون: Riva, S.T., Luchini, C., Zacchi, F., Mafficini, A., Borghesani, M., Mongillo, M., Scaglione, I.M., Manduca, S., Lucin, E., Moscarda, V., Pafumi, S., Leta, L.C., Dodi, A., Reni, A., Messineo, L., Chiamulera, C., Urso, E.D.L., Scarpa, A., Lawlor, R., Milella, M.

المصدر: Annals of Oncology ; volume 33, page S1311 ; ISSN 0923-7534

مصطلحات موضوعية: Oncology, Hematology

الإتاحة: https://doi.org/10.1016/j.annonc.2022.07.1762Test
https://api.elsevier.com/content/article/PII:S0923753422036134?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0923753422036134?httpAccept=text/plainTest

المؤلفون: Daniela, T., Avancini, A., Belluomini, L., Trestini, I., Zuliani, S., Sava, T., Gaiani, C., Caldart, A., Casali, M., Benini, L., Zacchi, F., Trevisani, E., Bianchi, F., Riva, S.T., L. del piccolo, Tfaily, A., Rimondini, M., Verlato, G., Pilotto, S., Milella, M.

المصدر: Annals of Oncology ; volume 33, page S1198 ; ISSN 0923-7534

مصطلحات موضوعية: Oncology, Hematology

الإتاحة: https://doi.org/10.1016/j.annonc.2022.07.1533Test
https://api.elsevier.com/content/article/PII:S0923753422033841?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0923753422033841?httpAccept=text/plainTest

المؤلفون: Zanelli, S., Fiorio, E., Zampiva, I., Zacchi, F., Borghesani, G., Giontella, E., Parolin, V., Biondani, P., Zuliani, S., Dieci, M.V., Mioranza, E., Zorzi, M., Conti, M., Gibellini, D., Verlato, G., Milella, M.

المساهمون: Horizon 2020, Ministero dell'Istruzione dell'Universita e della Ricerca, Fondazione Cariverona

المصدر: Annals of Oncology ; volume 33, issue 6, page 661-663 ; ISSN 0923-7534

مصطلحات موضوعية: Oncology, Hematology

الإتاحة: https://doi.org/10.1016/j.annonc.2022.02.227Test
https://api.elsevier.com/content/article/PII:S0923753422003635?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0923753422003635?httpAccept=text/plainTest

المؤلفون: Ottaviano, M, Curvietto, M, Rescigno, P, Tortora, M, Palmieri, G, Giannarelli, D, Aieta, M, Assalone, P, Attademo, L, Avallone, A, Bloise, F, Bosso, D, Borzillo, V, Buono, G, Calderoni, G, Caputo, F, Cartenì, G, Cavallero, D, Cavo, A, Ciardiello, F, Conca, R, Conteduca, V, De Falco, S, De Felice, M, De Laurentiis, M, De Placido, P, De Placido, S, De Santo, I, De Stefano, A, Della Corte, CM, Di Franco, R, Di Lauro, V, Fabbrocini, A, Federico, P, Festino, L, Giordano, P, Giuliano, M, Gridelli, C, Grimaldi, AM, Lia, M, Marretta, AL, Massa, V, Mennitto, A, Merler, S, Merz, V, Messina, C, Messina, M, Milano, M, Minisini, AM, Montesarchio, V, Morabito, A, Morgillo, F, Mucci, B, Nappi, L, Napolitano, F, Paciolla, I, Pagliuca, M, Parola, S, Pepe, S, Petrillo, A, Piantedosi, F, Piccin, L, Picozzi, F, Pietroluongo, E, Pignata, S, Prati, V, Riccio, V, Rosanova, M, Rossi, A, Russo, A, Salati, M, Santabarbara, G, Sbrana, A, Simeone, E, Silvestri, A, Spada, M, Tarantino, P, Taveggia, P, Tomei, F, Vincenzo, T, Trapani, D, Trojanello, C, Vanella, V, Vari, S, Ventriglia, J, Vitale, MG, Vitiello, F, Vivaldi, C, von Arx, C, Zacchi, F, Zampiva, I, Zivi, A, Daniele, B, Ascierto, PA, SCITO (Società Campana di ImmunoTerapia Oncologica)

المساهمون: Rescigno, Pasquale

مصطلحات موضوعية: SCITO (Società Campana di ImmunoTerapia Oncologica), Humans, Pneumonia, Viral, Coronavirus Infections, Neoplasms, Prevalence, Medical Oncology, Infection Control, Geography, Adult, Italy, Female, Male, Drug Prescriptions, Pandemics, CTLA-4 Antigen, Programmed Cell Death 1 Receptor, Time-to-Treatment, Surveys and Questionnaires, Practice Patterns, Physicians', Oncologists, Betacoronavirus, Antineoplastic Agents, Immunological, B7-H1 Antigen, COVID-19, SARS-CoV-2

الوصف: BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic has overwhelmed the health systems worldwide. Data regarding the impact of COVID-19 on cancer patients (CPs) undergoing or candidate for immune checkpoint inhibitors (ICIs) are lacking. We depicted the practice and adaptations in the management of patients with solid tumors eligible or receiving ICIs during the COVID-19 pandemic, with a special focus on Campania region. METHODS: This survey (25 questions), promoted by the young section of SCITO (Società Campana di ImmunoTerapia Oncologica) Group, was circulated among Italian young oncologists practicing in regions variously affected by the pandemic: high (group 1), medium (group 2) and low (group 3) prevalence of SARS-CoV-2-positive patients. For Campania region, the physician responders were split into those working in cancer centers (CC), university hospitals (UH) and general hospitals (GH). Percentages of agreement, among High (H) versus Medium (M) and versus Low (L) group for Italy and among CC, UH and GH for Campania region, were compared by using Fisher's exact tests for dichotomous answers and χ2 test for trends relative to the questions with 3 or more options. RESULTS: This is the first Italian study to investigate the COVID-19 impact on cancer immunotherapy, unique in its type and very clear in the results. The COVID-19 pandemic seemed not to affect the standard practice in the prescription and delivery of ICIs in Italy. Telemedicine was widely used. There was high consensus to interrupt immunotherapy in SARS-CoV-2-positive patients and to adopt ICIs with longer schedule interval. The majority of the responders tended not to delay the start of ICIs; there were no changes in supportive treatments, but some of the physicians opted for delaying surgeries (if part of patients' planned treatment approach). The results from responders in Campania did not differ significantly from the national ones. CONCLUSION: Our study highlights the efforts of Italian oncologists to maintain high standards of care ...

وصف الملف: Print; application/pdf

العلاقة: Journal for immunotherapy of cancer, 2020, 8 (2); https://repository.icr.ac.uk/handle/internal/4346Test

الإتاحة: https://doi.org/10.1136/jitc-2020-001154Test
https://repository.icr.ac.uk/handle/internal/4346Test

المؤلفون: Tregnago, D., Pilotto, S., Belluomini, L., Menis, J., Fiorio, E., Pavarana, M., Casali, M., Benini, L., Zacchi, F., Caldart, A., Trevisani, E., Trestini, I., Avancini, A., Cafaro, D., Cadorin, C., Rimondini, M., Del Piccolo, L., Zuliani, S., Milella, M.

المصدر: Annals of Oncology ; volume 32, page S1159 ; ISSN 0923-7534

مصطلحات موضوعية: Oncology, Hematology

الإتاحة: https://doi.org/10.1016/j.annonc.2021.08.1633Test
https://api.elsevier.com/content/article/PII:S092375342103862X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S092375342103862X?httpAccept=text/plainTest

المؤلفون: Merler, S., Zuliani, S., Zampiva, I., Tregnago, D., Casali, M., Cavaliere, A., Fumagalli, A., Riva, S.T., Rossi, A., Zacchi, F., Zaninotto, E., Auriemma, A., Pavarana, M., Soldà, C., Benini, L., Borghesani, M., Lo Cascio, G., Tacconelli, E., Pilotto, S., Milella, M.

المصدر: Annals of Oncology ; volume 31, page S1011 ; ISSN 0923-7534

مصطلحات موضوعية: Oncology, Hematology

الإتاحة: https://doi.org/10.1016/j.annonc.2020.08.1787Test
https://api.elsevier.com/content/article/PII:S0923753420417831?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0923753420417831?httpAccept=text/plainTest

المؤلفون: Tregnago, D., Zuliani, S., Zampiva, I., Casali, M., Cavaliere, A., Fumagalli, A., Merler, S., Riva, S.T., Rossi, A., Zacchi, F., Zaninotto, E., Caldart, A., Casalino, S., Gaule, M., Kadrija, D., Mongillo, M., Rimondini, M., Del Piccolo, L., Milella, M., Pilotto, S.

المصدر: Annals of Oncology ; volume 31, page S1003 ; ISSN 0923-7534

مصطلحات موضوعية: Oncology, Hematology

الإتاحة: https://doi.org/10.1016/j.annonc.2020.08.1765Test
https://api.elsevier.com/content/article/PII:S0923753420417612?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0923753420417612?httpAccept=text/plainTest

المؤلفون: Raffetti, E, Postorino, M, Castelli, F, Casari, S, Castelnuovo, F, Maggiolo, F, Di Filippo, E, D'Avino, A, Ladisa, N, Di Pietro, M, Sighinolfi, L, Zacchi, F, Torti, C., GORI, ANDREA

المساهمون: Raffetti, E, Postorino, M, Castelli, F, Casari, S, Castelnuovo, F, Maggiolo, F, Di Filippo, E, D'Avino, A, Gori, A, Ladisa, N, Di Pietro, M, Sighinolfi, L, Zacchi, F, Torti, C

مصطلحات موضوعية: Advanced HIV disease, AIDS, HIV infection, Late diagnosi, Late presentation, Public Health, Environmental and Occupational Health

الوصف: Background: We aimed at evaluating frequency and factors associated with late presentation and advanced HIV disease and excess risk of death due to these conditions from 1985 to 2013 among naïve HIV infected patients enrolled in the Italian MASTER Cohort. Methods: All antiretroviral naive adults with available CD4+ T cell count after diagnosis of HIV infection were included. Multivariable logistic regression analysis investigated factors associated either with late presentation or advanced HIV disease. Probabilities of survival were estimated both at year-1 and at year-5 according to the Kaplan-Meier method. Flexible parametric models were used to evaluate changes in risk of death overtime according to late presentation and advanced HIV disease. The analyses were stratified for calendar periods. Results: 19,391 patients were included (54 % were late presenters and 37.6 % were advanced presenters). At multivariable analysis, the following factors were positively associated with late presentation: male gender (OR = 1.29), older age (≥55 years vs. <25 years; OR = 7.45), migration (OR = 1.54), and heterosexual risk factor for HIV acquisition (OR = 1.52) or IDU (OR = 1.27) compared to homosexual risk. Survival rates at year-5 increased steadily and reached 92.1 % for late presenters vs. 97.4 % for non-late presenters enrolled in the period 2004-2009. Using flexible parametric models we found a sustained reduction of hazard ratios over time for any cause deaths between late and non-late presenters over time. Similar results were found for advanced HIV disease. Conclusion: Screening polices need to be urgently implemented, particularly in most-at-risk categories for late presentation, such as migrants, older patients and those with heterosexual intercourse or IDU as risk factors for HIV acquisition. Although in recent years the impact of late presentation on survival decreased, about 10 % of patients diagnosed in more recent years remains at increased risk of death over a long-term follow-up.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/27557878; info:eu-repo/semantics/altIdentifier/wos/WOS:000381982500005; volume:16; issue:1; journal:BMC PUBLIC HEALTH; http://hdl.handle.net/10281/133731Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84983488869; http://www.biomedcentral.com/bmcpublichealthTest

الإتاحة: https://doi.org/10.1186/s12889-016-3477-zTest
http://hdl.handle.net/10281/133731Test
http://www.biomedcentral.com/bmcpublichealthTest

المؤلفون: Raffetti E., Donato F., Castelnuovo F., Ladisa N., Paraninfo G., Di Filippo E., Segala D., Cologni G., Bandera A., Zacchi F., Digiambenedetto S., Di Pietro M., Castelli F., Quiros-Roldan E.

المساهمون: Raffetti, E., Donato, F., Castelnuovo, F., Ladisa, N., Paraninfo, G., Di Filippo, E., Segala, D., Cologni, G., Bandera, A., Zacchi, F., Digiambenedetto, S., Di Pietro, M., Castelli, F., Quiros-Roldan, E.

مصطلحات موضوعية: HIV, Inflammatory marker, Non-Hodgkin lymphoma, Prognostic score

الوصف: Background: The systemic inflammatory response has been postulated as having prognostic significance in a wide range of different cancer types. We aimed to assess the prognostic role of inflammatory markers on survival in HIV-infected patients with Non-Hodgkin Lymphoma (NHL), and to compute a prognostic score based on inflammatory biomarkers. Methods: We evaluated data on HIV patients with NLH diagnosis between 1998 and 2012 in a HIV Italian Cohort. Using Cox proportional regression model, we assessed the prognostic role of Neutrophil-Lymphocyte Ratio (NLR), Platelet-Lymphocyte Ratio (PLR), Glasgow Prognostic Score (GPS), modified Glasgow Prognostic Score (mGPS), Prognostic Index (PI), and Prognostic Nutritional Index (PNI). We also computed a risk score equation, assigning patients to a derivation and a validation sample. The area under the curve (AUC) was use to evaluate the predictive ability of this score. Results: 215 non-Hodgkin lymphoma cases (80.0% males) with a mean age of 43.2 years were included. Deaths were observed in 98 (45.6%) patients during a median follow up of 5 years. GPS, mGPS, PI and PNI were independently associated with risk of death. We also computed a mortality risk score which included PNI and occurrence of an AIDS event within six months from NHL diagnosis. The AUCs were 0.69 (95% CI 0.58 to 0.81) and 0.69 (95% CI 0.57 to 0.81) at 3 and 5 years of the follow-up, respectively. Conclusions: GPS, mGPS, PI and PNI are independent prognostic factors for survival of HIV patients with NHL.

وصف الملف: ELETTRONICO

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/25886534; info:eu-repo/semantics/altIdentifier/wos/WOS:000363502800001; volume:13; issue:1; firstpage:13:89-1; lastpage:13:89-8; numberofpages:8; journal:JOURNAL OF TRANSLATIONAL MEDICINE; http://hdl.handle.net/11392/2416658Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84940851384; https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-015-0446-8Test

الإتاحة: https://doi.org/10.1186/s12967-015-0446-8Test
http://hdl.handle.net/11392/2416658Test