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1دورية أكاديمية
المؤلفون: Akari Tanino, Kento Kono, Megumi Hamaguchi, Mika Nakao, Noriaki Kurimoto, Takamasa Hotta, Takeshi Isobe, Yoshihiro Amano, Yukari Tsubata
المصدر: Internal Medicine. 2024, 63(3):443
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2دورية أكاديمية
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3دورية أكاديمية
المؤلفون: Mika Horie, Kazuhisa Nakashima, Yoshihiro Amano, Yohei Shiratsuki, Kotaro Murakami, Takeshi Isobe, Yukari Tsubata
المصدر: Respiratory Medicine Case Reports, Vol 47, Iss , Pp 101976- (2024)
مصطلحات موضوعية: Pulmonary alveolar proteinosis, Lung cancer, Immune checkpoint inhibitor, Atezolizumab, Case report, Diseases of the respiratory system, RC705-779
الوصف: Primary lung cancer with pulmonary alveolar proteinosis (PAP) is a rare condition. We present a case of a patient with primary lung cancer with PAP treated with an immune checkpoint inhibitor (ICI). A 62-year-old man was diagnosed with autoimmune PAP 8 years prior to current admission. Lung adenocarcinoma was found in his right lung, and platinum-based chemotherapy was administered, followed by atezolizumab. He experienced disease progression after atezolizumab treatment, whereas ICI-induced pneumonia or exacerbation of PAP did not occur. This indicates that ICI may be safely used in patients with primary lung cancer with PAP.
وصف الملف: electronic resource
العلاقة: http://www.sciencedirect.com/science/article/pii/S2213007123001715Test; https://doaj.org/toc/2213-0071Test
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4دورية أكاديمية
المؤلفون: Ryosuke Tanino, Yukari Tsubata, Takamasa Hotta, Tamio Okimoto, Yoshihiro Amano, Mayumi Takechi, Tetsuya Tanaka, Tomomi Akita, Mamiko Nagase, Chikamasa Yamashita, Koichiro Wada, Takeshi Isobe
المصدر: Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
الوصف: Abstract Emphysema limits airflow and causes irreversible progression of chronic obstructive pulmonary disease (COPD). Strain differences must be considered when selecting mouse models of COPD, owing to disease complexity. We previously reported that a novel C57BL/6JJcl substrain, the Mayumi-Emphysema (ME) mouse, exhibits spontaneous emphysema; however, the other characteristics remain unknown. We aimed to characterize the lungs of ME mice and determine their experimental availability as a model. ME mice had a lower body weight than the control C57BL/6JJcl mice, with a median survival time of ~80 weeks. ME mice developed diffused emphysema with respiratory dysfunction from 8 to 26 weeks of age, but did not develop bronchial wall thickening. Proteomic analyses revealed five extracellular matrix-related clusters in downregulated lung proteins in ME mice. Moreover, EFEMP2/fibulin-4, an essential extracellular matrix protein, was the most downregulated protein in the lungs of ME mice. Murine and human EFEMP2 were detected in the pulmonary artery. Furthermore, patients with mild COPD showed decreased EFEMP2 levels in the pulmonary artery when compared to those without COPD. The ME mouse is a model of mild, accelerated aging with low-inflammatory emphysema and respiratory dysfunction that progresses with age and pulmonary EFEMP2 decrease, similar to that observed in patients with mild COPD.
وصف الملف: electronic resource
العلاقة: https://doaj.org/toc/2045-2322Test
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5دورية أكاديمية
المؤلفون: Keita Kawakado, Kazuhisa Nakashima, Hiroshi Tobita, Mamiko Nagase, Ken Yoshihara, Mika Horie, Megumi Hamaguchi, Tamio Okimoto, Yukari Tsubata, Takeshi Isobe
المصدر: Thoracic Cancer, Vol 14, Iss 13, Pp 1208-1211 (2023)
مصطلحات موضوعية: azathioprine, hepatitis, immune‐related events, mercaptopurine, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
الوصف: Abstract An 82‐year‐old man was treated with ipilimumab and nivolumab for malignant pleural mesothelioma. Although he was previously treated with prednisolone (1 mg/kg/day) for immune‐related adverse event (irAE) hepatitis by a previous doctor, he still had worsening liver function and was transferred to our hospital. Blood tests and imaging findings were negative for autoimmune and infectious hepatitis, and liver biopsy results were consistent with irAE hepatitis. Steroid pulse therapy improved liver function, but tapering to prednisolone (1 mg/kg/day) again worsened his liver function. Concomitant use of mycophenolate mofetil was initiated, but no improvement in liver function was observed, therefore azathioprine, a thiopurine immunosuppressant, was administered in combination with steroids. During the course of treatment, hepatic dysfunction due to azathioprine was suspected, and the concomitant use of mercaptopurine and prednisolone was started. Afterward, the liver function improved, and the prednisolone dose was gradually reduced to 10 mg/day. This is a rare case in which a thiopurine‐based immunosuppressant was effective against irAE hepatitis, therefore thiopurine‐based immunosuppressants may be effective against steroid‐refractory hepatitis.
وصف الملف: electronic resource
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6دورية أكاديمية
المؤلفون: Takae Okuno, Noriaki Kurimoto, Akari Tanino, Megumi Hamaguchi, Takamasa Hotta, Ryosuke Tanino, Misato Kobayashi, Yohei Shiratsuki, Shunichi Hamaguchi, Takeshi Isobe, Yukari Tsubata
المصدر: Thoracic Cancer, Vol 14, Iss 2, Pp 186-194 (2023)
مصطلحات موضوعية: biopsybronchoscopyendocytoscopy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
الوصف: Abstract Background Endocytoscopy (ECS) provides a magnification of approximately 450× for real‐time observation of lesion nuclei. Using ECS, we aimed to evaluate whether sufficient samples for diagnosis can be obtained during bronchoscopy. We also investigated whether ECS can enable two‐class diagnosis of malignant or non‐malignant transbronchial biopsy specimens in real‐time during bronchoscopy. Methods This was a single‐facility, prospective, observational, ex vivo study. Forty cases with localized peripheral pulmonary lesions underwent transbronchial biopsy with endobronchial ultrasonography using a guide sheath. Each biopsy specimen was immediately observed and evaluated endocytoscopically after the collection by the bronchoscopic procedure. Results Thirty‐seven cases were enrolled. The diagnostic accuracy achieved by ECS was 91.9% (34/37). The agreement rate between the endocytoscopic evaluation and pathological diagnosis of each specimen (170 specimens) was 65.3% (111/170). The median time required for endocytoscopic evaluation per specimen was 70 s. When we judged a specimen to be malignant a second time on ECS evaluations of five specimens in one case, pathologically malignant specimens were collected in 26 of 27 cases (96.3%). Conclusions ECS with methylene blue staining may aid in the two‐class diagnosis of malignant or non‐malignant transbronchial biopsy specimens during bronchoscopy. This may reduce the number of tissue biopsies.
وصف الملف: electronic resource
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7دورية أكاديمية
المؤلفون: Keita Kawakado, Yukari Tsubata, Takamasa Hotta, Masahiro Yamasaki, Nobuhisa Ishikawa, Kazunori Fujitaka, Tetsuya Kubota, Kunihiko Kobayashi, Takeshi Isobe
المصدر: Cancers, Vol 16, Iss 2, p 301 (2024)
مصطلحات موضوعية: lung cancer, venous thrombosis, bleeding, edoxaban, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
الوصف: Despite the occurrence of various hemorrhagic events during advanced lung cancer treatment, few researchers have reported on their risk factors. Moreover, the development of cancer-related thromboembolism indicates anticoagulant use. However, adverse events such as bleeding should be monitored. In this study, we aimed to identify factors that influence the onset of hemorrhagic events in patients with lung cancer. The Rising-VTE/NEJ037 study was a multicenter, prospective, observational study. A total of 1008 patients with lung cancer who were unsuitable for radical resection or radiation were enrolled and followed up for 2 years. Multivariate analysis using a Cox proportional hazard model was performed to compare the outcomes of the time to the onset of hemorrhagic events for 2 years after registration. Hemorrhagic events occurred in 115 patients (11.4%), with 35 (30.4%) experiencing major bleeding. Significant risk factors included venous thromboembolism (VTE) (hazard ratio [HR]: 4.003, p < 0.001) and an Eastern Cooperative Oncology Group Performance Status score of 1 (HR: 2.476, p < 0.001). Factors that significantly reduced hemorrhagic event risk were female sex (HR: 0.454, p = 0.002) and M1a status (HR: 0.542, p = 0.038). VTE is a risk factor for hemorrhagic events in patients with advanced lung cancer, and risks associated with anticoagulant therapy should be considered.
وصف الملف: electronic resource
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8دورية أكاديمية
المؤلفون: Kazuhisa Nakashima, Yuki Mitarai, Seiko Tanaka, Mika Nakao, Takae Okuno, Tamio Okimoto, Ryo Tanabe, Takashi Yanagawa, Yukari Tsubata, Takeshi Isobe
المصدر: Respirology Case Reports, Vol 11, Iss 5, Pp n/a-n/a (2023)
مصطلحات موضوعية: hepatic disorder, lung cancer, old patient, RET fusion, Selpercatinib, Diseases of the respiratory system, RC705-779
الوصف: Abstract An 83‐year‐old woman with RET fusion‐positive advanced lung adenocarcinoma was administered selpercatinib 320 mg/day. Despite the shrinking of the tumour, fever, fatigue, and anorexia developed on day 17. Selpercatinib administration was interrupted. On day 21, elevated blood aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were observed. On day 28, AST and ALT levels increased to demonstrate Grade 4 in CTCAE Ver.5. The patient received a glycyrrhizin‐compounding agent and steroid treatment, and AST and ALT levels gradually decreased. On day 63, selpercatinib 160 mg/day was restarted after improvement of the hepatic disorder. Since then, selpercatinib was continued without any severe adverse events. Selpercatinib is a reasonable treatment option for RET fusion‐positive advanced non‐small cell lung cancer even in older patients. However, old age may be a risk factor for adverse events including hepatic disorders. For safe treatment in such patients, careful follow‐up is required.
وصف الملف: electronic resource
العلاقة: https://doaj.org/toc/2051-3380Test
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9دورية أكاديمية
المؤلفون: Takamasa Hotta, Noriaki Kurimoto, Yohei Shiratsuki, Yoshihiro Amano, Megumi Hamaguchi, Akari Tanino, Yukari Tsubata, Takeshi Isobe
المصدر: Scientific Reports, Vol 12, Iss 1, Pp 1-7 (2022)
الوصف: Abstract Endobronchial ultrasonography with a guide sheath (EBUS-GS) improves the accuracy of bronchoscopy. The possibility of differentiating benign from malignant lesions based on EBUS findings may be useful in making the correct diagnosis. The convolutional neural network (CNN) model investigated whether benign or malignant (lung cancer) lesions could be predicted based on EBUS findings. This was an observational, single-center cohort study. Using medical records, patients were divided into benign and malignant groups. We acquired EBUS data for 213 participants. A total of 2,421,360 images were extracted from the learning dataset. We trained and externally validated a CNN algorithm to predict benign or malignant lung lesions. Test was performed using 26,674 images. The dataset was interpreted by four bronchoscopists. The accuracy, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the CNN model for distinguishing benign and malignant lesions were 83.4%, 95.3%, 53.6%, 83.8%, and 82.0%, respectively. For the four bronchoscopists, the accuracy rate was 68.4%, sensitivity was 80%, specificity was 39.6%, PPV was 76.8%, and NPV was 44.2%. The developed EBUS-computer-aided diagnosis system is expected to read EBUS findings that are difficult for clinicians to judge with precision and help differentiate between benign lesions and lung cancers.
وصف الملف: electronic resource
العلاقة: https://doaj.org/toc/2045-2322Test
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10دورية أكاديمية
المؤلفون: Kazuhisa Nakashima, Kento Kono, Takamasa Hotta, Takeshi Isobe, Teruaki Iwahashi, Yukari Tsubata, 中島 和寿, 堀田 尚誠, 岩橋 輝明, 河野 謙人, 津端 由佳里, 礒部 威
المصدر: 肺癌 / Haigan. 2023, 63(1):52
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