المؤلفون: Yin, Zixiao, Yu, Huiling, Yuan, Tianshuo, Smyth, Clay, Anjum, Md, Zhu, Guanyu, Ma, Ruoyu, Xu, Yichen, An, Qi, Gan, Yifei, Merk, Timon, Qin, Guofan, Xie, Hutao, Zhang, Ning, Wang, Chunxue, Jiang, Yin, Meng, Fangang, Yang, Anchao, Neumann, Wolf-Julian, Li, Luming, Zhang, Jianguo, Starr, Philip, Little, Simon

المصدر: npj Digital Medicine. 7(1)

الوصف: Sleep disturbances profoundly affect the quality of life in individuals with neurological disorders. Closed-loop deep brain stimulation (DBS) holds promise for alleviating sleep symptoms, however, this technique necessitates automated sleep stage decoding from intracranial signals. We leveraged overnight data from 121 patients with movement disorders (Parkinsons disease, Essential Tremor, Dystonia, Essential Tremor, Huntingtons disease, and Tourettes syndrome) in whom synchronized polysomnograms and basal ganglia local field potentials were recorded, to develop a generalized, multi-class, sleep specific decoder - BGOOSE. This generalized model achieved 85% average accuracy across patients and across disease conditions, even in the presence of recordings from different basal ganglia targets. Furthermore, we also investigated the role of electrocorticography on decoding performances and proposed an optimal decoding map, which was shown to facilitate channel selection for optimal model performances. BGOOSE emerges as a powerful tool for generalized sleep decoding, offering exciting potentials for the precision stimulation delivery of DBS and better management of sleep disturbances in movement disorders.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/9vg09337Test

المؤلفون: Shi, Xueduo, Xu, Chenyang, Wen, Yazhou, Jiang, Ming, Yu, Huiling, Wang, Xian, Yuan, Hongmei, Feng, Shanwu

المساهمون: the National Natural Science Foundation of China

المصدر: BMC Anesthesiology ; volume 24, issue 1 ; ISSN 1471-2253

مصطلحات موضوعية: Anesthesiology and Pain Medicine

الوصف: Objective An emergency cesarean section (CS), which is extremely life-threatening to the mother or fetus, seems to be performed within an adequate time horizon to avoid negative fetal-maternal denouement. An effective and vigilant technique for anesthesia remains vital for emergency cesarean delivery. Therefore, this study aimed to validate the impact of various anesthesia tactics on maternal and neonatal outcomes. Method This was a retrospective cohort study of parturient patients who were selected for emergency CS with the assistance of general or neuraxial anesthesia between January 2015 and July 2021 at our institution. The 5-min Apgar score was documented as the primary outcome. Secondary outcomes, including the 1 min Apgar score, decision-to-delivery interval (DDI), onset of anesthesia to incision interval (OAII), decision to incision interval (DII), duration of operation, length of hospitalization, height and weight of the newborn, use of vasopressors, blood loss, neonatal resuscitation rate, admission to neonatal intensive care unit (NICU), duration of NICU and complications, were also measured. Results Of the 539 patients included in the analysis, 337 CSs were performed under general anesthesia (GA), 137 under epidural anesthesia (EA) and 65 under combined spinal-epidural anesthesia (CSEA). The Apgar scores at 1 min and 5 min in newborns receiving GA were lower than those receiving intraspinal anesthesia, and no difference was found between those receiving EA and those receiving CSEA. The DDI of parturients under GA, EA, and CSE were 7[6,7], 6[6,7], and 14[11.5,20.5], respectively. The DDI and DII of GA and EA were shorter than those of CSE, and the DDI and DII were similar between GA and EA. Compared to that in the GA group, the OAII in the intraspinal anesthesia group was significantly greater. GA administration correlated with more frequent resuscitative interventions, increased admission rates to NICU, and a greater incidence of neonatal respiratory distress syndrome (NRDS). Nevertheless, ...

الإتاحة: https://doi.org/10.1186/s12871-024-02412-0Test

المؤلفون: Li Xisheng, Yu Huiling, Li Fang, He Yaping, Xu Liming, Xiao Jie

المصدر: Open Life Sciences, Vol 18, Iss 1, Pp 1260-7 (2023)

مصطلحات موضوعية: super-resolution reconstruction algorithm, magnetic resonance imaging, small-incision approach treatment, proximal tibia fracture, clinical effects, Biology (General), QH301-705.5

الوصف: In this study, magnetic resonance imaging (MRI) based on a deep learning algorithm was used to evaluate the clinical effect of the small-incision approach in treating proximal tibial fractures. Super-resolution reconstruction (SRR) algorithm was used to reconstruct MRI images for analysis and comparison. The research objects were 40 patients with proximal tibial fractures. According to the random number method, patients were divided into a small-incision approach group (22 cases) and an ordinary approach group (18 cases). The peak signal-to-noise ratio (PSNR) and the structural similarity index (SSIM) of the MRI images before and after the reconstruction of the two groups were analyzed. The operative time, intraoperative blood loss, complete weight-bearing time, complete healing time, knee range of motion, and knee function of the two treatments were compared. The results showed that after SRR, the PSNR and SSIM of MRI images were 35.28 and 0.826 dB, respectively, so the MRI image display effect was better. The operation time in the small-incision approach group was 84.93 min, which was significantly shorter than that in the common approach group, and the intraoperative blood loss was 219.95 mL, which was significantly shorter than that in the common approach group (P < 0.05). The complete weight-bearing time and complete healing time in the small-incision approach group were 14.75 and 16.79 weeks, respectively, which were significantly shorter than those in the ordinary approach group (P < 0.05). The half-year knee range of motion and 1-year knee range of motion in the small-incision approach group were 118.27° and 128.72°, respectively, which were significantly higher than those in the conventional approach group (P < 0.05). After 6 months of treatment, the rate of good treatment was 86.36% in the small-incision approach group and 77.78% in the ordinary approach group. After 1 year of treatment, the rate of excellent and good treatment was 90.91% in the small-incision approach group and 83.33% in the ordinary approach group. The rate of good treatment for half a year and 1 year in the small incision group was significantly higher than that in the common approach group (P < 0.05). In conclusion, MRI image based on deep learning algorithm has a high resolution, good display effect, and high application value. The small-incision approach can be applied to the treatment of proximal tibial fractures, which showed good therapeutic effects and a high positive clinical application value.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2391-5412Test

الوصول الحر: https://doaj.org/article/2e7f95e886834cbb8b9986e2473f409cTest

المؤلفون: Wen, Huwei¹ (AUTHOR), Yu, Huiling¹ (AUTHOR), Lee, Chien-Chiang¹ (AUTHOR) cclee6101@gmail.com

المصدر: Applied Economics. Jul2024, p1-14. 14p. 1 Illustration, 8 Charts.

مستخلص: Economic and social activities in the digital age have changed business forms and spatial relations, and identifying evolution of the urban form in the digital age is the key to sustainable urban governance. Based on data from prefecture-level cities in China from 2010 to 2021, this study explores the impact of the digital economy on urban sprawl and the path to its realization, thus providing policy implications for urban governance in the digital economy era. The empirical results show that the digital economy significantly promotes urban sprawl and that the urban sprawl effect caused by the digital economy has regional and scale heterogeneity. Western and medium-sized cities show greater sprawl trends under the influence of the digital economy. Digital economy development can significantly affect residents’ lifestyles and lead to urban sprawl, such as encouraging green, digital, and suburban lifestyles. In addition, the digital economy significantly affects the demand for urban land space, such as the industrial division of labour patterns, urbanization processes, and industrial virtual agglomeration, which are indirect factors leading to urban sprawl. [ABSTRACT FROM AUTHOR]

: Copyright of Applied Economics is the property of Routledge and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Li, Bingbing, Teng, Chao, Yu, Huiling, Jiang, Xiaohong, Xing, Xuyang, Jiang, Qi, Lin, Chenshi, Zhao, Zongmin, Zhang, Ruifeng, He, Wei

المصدر: Acta Pharmaceutica Sinica B ; volume 13, issue 6, page 2369-2382 ; ISSN 2211-3835

مصطلحات موضوعية: General Pharmacology, Toxicology and Pharmaceutics

الإتاحة: https://doi.org/10.1016/j.apsb.2022.12.002Test
https://api.elsevier.com/content/article/PII:S2211383522004968?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2211383522004968?httpAccept=text/plainTest

المؤلفون: Xiong, Rui, Li, Binrui, Yu, Haitao, Fan, Tianceng, Yu, Huiling, Yang, Ying, Wang, Jian-Zhi, Pi, Guilin, Yang, Xifei

المصدر: Journal of Alzheimer's Disease; 2024, Vol. 99 Issue 4, p1303-1316, 14p

مصطلحات موضوعية: SOCIAL skills, AMYGDALOID body, SOCIAL anxiety, NEURAL circuitry, PROTEOMICS, ALZHEIMER'S patients

مستخلص: Background: Anxiety and social withdrawal are highly prevalent among patients with Alzheimer's disease (AD). However, the neural circuit mechanisms underlying these symptoms remain elusive, and there is a need for effective prevention strategies. Objective: This study aims to elucidate the neural circuitry mechanisms underlying social anxiety in AD. Methods: We utilized 5xFAD mice and conducted a series of experiments including optogenetic manipulation, Tandem Mass Tag-labeled proteome analysis, behavioral assessments, and immunofluorescence staining. Results: In 5xFAD mice, we observed significant amyloid-β (Aβ) accumulation in the anterior part of basolateral amygdala (aBLA). Behaviorally, 6-month-old 5xFAD mice displayed excessive social avoidance during social interaction. Concurrently, the pathway from aBLA to ventral hippocampal CA1 (vCA1) was significantly activated and exhibited a disorganized firing patterns during social interaction. By optogenetically inhibiting the aBLA-vCA1 pathway, we effectively improved the social ability of 5xFAD mice. In the presence of Aβ accumulation, we identified distinct changes in the protein network within the aBLA. Following one month of administration of Urolithin A (UA), we observed significant restoration of the abnormal protein network within the aBLA. UA treatment also attenuated the disorganized firings of the aBLA-vCA1 pathway, leading to an improvement in social ability. Conclusions: The aBLA-vCA1 circuit is a vulnerable pathway in response to Aβ accumulation during the progression of AD and plays a crucial role in Aβ-induced social anxiety. Targeting the aBLA-vCA1 circuit and UA administration are both effective strategies for improving the Aβ-impaired social ability. [ABSTRACT FROM AUTHOR]

: Copyright of Journal of Alzheimer's Disease is the property of IOS Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Li, Luming, Yu, Huiling, Gui, Chengsheng, Hu, Lingling, Zou, Miao, Ren, Suhong, Huan, Weiwei, Yu, Xiaohong, Wang, Xue

المساهمون: Natural Science Foundation of Zhejiang Province, National Natural Science Foundation of China

المصدر: Polymer Composites ; ISSN 0272-8397 1548-0569

الوصف: Natural fiber/resin composites exhibit poor fiber–matrix compatibility and easy combustion. In this study, jute‐fiber‐reinforced epoxy resin was used to prepare composite materials by adding marine shell powder, which is a natural non‐combustible inorganic filler that originates from a variety of sources. The morphology, composition, thermal stability, combustion performance, and mechanical properties of the prepared composites were tested using several characterization methods. The results show that the marine shell powder was evenly distributed in the epoxy resin and did not affect the adhesion between the epoxy resin and the jute fiber. When 20% marine shell powder (SMJF20) was added to the jute‐fiber‐reinforced epoxy resin composite, the pyrolytic residual content was 21.88% (60.2% higher than that without), and the maximum heat release rate was 350.75 kW/m 2 (22.8% lower than that without). The total heat release and total smoke release of SMJF20 were also 13.9% and 30% lower than that of MJF, respectively. The addition of marine shell powder did not significantly affect the tensile strength, whereas the tensile modulus of SMJF20 increased by approximately 13.9%, the fracture strain decreased by approximately 13.4%, and the bending strength and modulus decreased by approximately 12.9% and 13.0%, respectively. Marine shell powder is an ideal biomass filler for jute‐fiber‐reinforced epoxy resins. Highlights Jute‐fiber‐epoxy composites fortified with non‐combustible marine shell powder. Effective filler distribution without compromising epoxy‐jute fiber adhesion. 20% marine shell powder significantly reduces heat release and smoke release. Tensile strength unaffected; tensile modulus and residual content increased. Marine shell powder proves ideal for enhancing epoxy resin with jute fibers.

الإتاحة: https://doi.org/10.1002/pc.28251Test

المؤلفون: Qin, Xiaoya, Yuan, Yuan, Yu, Huiling, Yao, Yi, Li, Luming

المساهمون: Ministry of Science and Technology of the People's Republic of China, National Key Research and Development Program of China, Shenzhen International Cooperation Research Project

المصدر: Neurosurgery Clinics of North America ; volume 35, issue 1, page 105-118 ; ISSN 1042-3680

مصطلحات موضوعية: Neurology (clinical), General Medicine, Surgery

الإتاحة: https://doi.org/10.1016/j.nec.2023.09.005Test
https://api.elsevier.com/content/article/PII:S1042368023001018?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1042368023001018?httpAccept=text/plainTest

المؤلفون: ZHANG Linlin, ZHONG Yumei, LU Wenting, SHANG Yanan, GUO Yanding, LUO Xiaochao, CHEN Yang, LUO Kun, HU Danhui, YU Huiling, ZHOU Haiyan

المصدر: Journal of Traditional Chinese Medicine; Apr2024, Vol. 44 Issue 2, p353-361, 9p

المؤلفون: Yu, Huiling, Chen, Liping, Lei, Huiyang, Pi, Guilin, Xiong, Rui, Jiang, Tao, Wu, Dongqin, Sun, Fei, Gao, Yang, Li, Yuanhao, Peng, Wenju, Huang, Bingyu, Song, Guoda, Wang, Xin, Lv, Jingru, Jin, Zetao, Ke, Dan, Yang, Ying, Wang, Jian-Zhi

المساهمون: National Natural Science Foundation of China

المصدر: Nature Communications ; volume 13, issue 1 ; ISSN 2041-1723

مصطلحات موضوعية: General Physics and Astronomy, General Biochemistry, Genetics and Molecular Biology, General Chemistry, Multidisciplinary

الوصف: Generalization is a fundamental cognitive ability of organisms to deal with the uncertainty in real-world situations. Excessive fear generalization and impaired reward generalization are closely related to many psychiatric disorders. However, the neural circuit mechanism for reward generalization and its role in anxiety-like behaviours remain elusive. Here, we found a robust activation of calbindin 1-neurons (Calb 1) in the posterior basolateral amygdala (pBLA), simultaneous with reward generalization to an ambiguous cue after reward conditioning in mice. We identify the infralimbic medial prefrontal cortex (IL) to the pBLA Calb1 (Calb 1 neurons in the pBLA) pathway as being involved in reward generalization for the ambiguity. Activating IL–pBLA inputs strengthens reward generalization and reduces chronic unpredictable mild stress-induced anxiety- and depression-like behaviours in a manner dependent on pBLA Calb1 neuron activation. These findings suggest that the IL–pBLA Calb1 circuit could be a target to promote stress resilience via reward generalization and consequently ameliorate anxiety- and depression-like behaviours.

الإتاحة: https://doi.org/10.1038/s41467-022-33139-6Test
https://www.nature.com/articles/s41467-022-33139-6.pdfTest
https://www.nature.com/articles/s41467-022-33139-6Test