المؤلفون: Masako To, Yoshihito Arimoto, Natsue Honda, Yusuke Kurosawa, Kosuke Haruki, Yasuo To

المصدر: Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)

مصطلحات موضوعية: Medicine, Science

الوصف: Abstract Obesity-related non-eosinophilic asthma has been identified as a phenotype of asthma. However, mepolizumab and omalizumab improve asthma control in severe asthma with obesity, implying that type-2 cytokines may be involved in the deterioration of control in obese asthma. Despite this, the clinical details of obese asthma with positive type-2 inflammation markers have not yet been reported. The objective of this study was to investigate the clinical characteristics of patients with obese asthma with positive type-2 inflammation markers. Adult obese asthmatic patients were enrolled and were classified into two groups: obese asthma with positive type-2 inflammation markers (T2) and obese asthma with negative type-2 inflammation markers (NT2), then data were compared. In total, 434 patients were enrolled (85% of patients were at GINA therapy step 4–5). The T2 group had a higher proportion of patients with persistent asthma since childhood and with allergic rhinitis. A higher percentage of patients used high-dose inhaled corticosteroids (ICS) and experienced acute exacerbations (annual exacerbation ratio ≥ 1) in the T2 group. Multivariate logistic regression analysis showed that the T2 group was independently associated with younger age, comorbidity of allergic rhinitis, persistent asthma since childhood, use of high-dose ICS, and acute exacerbation rate ≥ 1. Adipocytokine levels were similar between the groups. Collectively, obese asthma with positive type-2 inflammation markers is characterised by a higher percentage of persistent asthma since childhood and more severe asthma.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2045-2322Test

الوصول الحر: https://doaj.org/article/5f7e6bbb624c4072b866c31728602e86Test

المؤلفون: Hiroshi Takano, Kei Torikai, Morimichi Nishihira, Satoru Kobayashi, Yoko Karube, Yoshihito Arimoto, Yuji Matsumura

المصدر: Dokkyo Medical Journal. 2023, 2(3):228

المؤلفون: Hiromichi INOUE, Morimichi NISHIHIRA, Satoru KOBAYASHI, Yoko KARUBE, Yoshihito ARIMOTO, Yuji MATSUMURA, 井上 裕道, 小林 哲, 有本 斉仁, 松村 輔二, 苅部 陽子, 西平 守道

المصدر: 日本臨床外科学会雑誌 / Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association). 2023, 84(7):1026

المؤلفون: Atsushi Sato, Atsuto Mouri, Junko Fujitani, Karbir Nath Yogi, Keisuke Yorimoto, Khem Bahadur Karki, Mitsuhiro Kamimura, Motoaki Tanigawa, Shigeki Hayashi, Shohei Yamashita, Taro Kato, Yoshihito Arimoto

المصدر: Journal of Physical Therapy Science. 2020, 32(12):795

المؤلفون: Fumi Yokote, Keigo Sekihara, Satoshi Nagasaka, Satsuki Kina, Yoshihito Arimoto, 喜納 五月, 有本 斉仁, 横手 芙美, 長阪 智, 関原 圭吾

المصدر: 日本呼吸器外科学会雑誌 / The Journal of the Japanese Association for Chest Surgery. 2018, 32(6):777

المؤلفون: Hiromichi INOUE, Satoru KOBAYASHI, Yoshihito ARIMOTO, Yuji MATSUMURA, 井上 裕道, 小林 哲, 有本 斉仁, 松村 輔二

المصدر: 日本臨床外科学会雑誌 / Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association). 2019, 80(11):1983

المؤلفون: Atsushi Sato, Atsuto Mouri, Kaori Hara, Keisuke Yorimoto, Mitsuhiro Kamimura, Munehisa Fukusumi, Shigeki Hayashi, Shohei Yamashita, Taro Kato, Yoshihito Arimoto, 上村 光弘, 佐藤 敦史, 加藤 太郎, 原 歌芳里, 寄本 恵輔, 山下 祥平, 有本 斉仁, 林 茂樹, 毛利 篤人, 福住 宗久

المصدر: 日本呼吸ケア・リハビリテーション学会誌 / The Journal of the Japan Society for Respiratory Care and Rehabilitation. 2018, 27(2):215

المؤلفون: Fumi Yokote, Keigo Sekihara, Satoshi Nagasaka, Satsuki Kina, Yoshihito Arimoto, 喜納 五月, 有本 斉仁, 横手 芙美, 長阪 智, 関原 圭吾

المصدر: 日本呼吸器外科学会雑誌 / The Journal of the Japanese Association for Chest Surgery. 2018, 32(5):600

المؤلفون: Fumi Yokote, Keigo Sekihara, Satoshi Nagasaka, Satsuki Kina, Yoshihito Arimoto, 喜納 五月, 有本 斉仁, 横手 芙美, 長阪 智, 関原 圭吾

المصدر: 日本呼吸器外科学会雑誌 / The Journal of the Japanese Association for Chest Surgery. 2018, 32(5):606

المؤلفون: Naoko Kimura, Takatomo Morita, Tamo Kunimitsu, Yoshihiro Miyauchi, Yoshihito Arimoto, Yusuke Sugita, 國光 多望, 宮内 善広, 有本 斉仁, 木村 尚子, 杉田 裕介, 森田 敬知

المصدر: 日本呼吸器外科学会雑誌 / The Journal of the Japanese Association for Chest Surgery. 2016, 30(7):893