المؤلفون: Shimasaki, Yasumasa, Miyoshi, Hiroaki, Kawamoto, Keisuke, Yoshida, Noriaki, Mishina, Tatsuzo, Nakashima, Kazutaka, Imamoto, Teppei, Sugio, Takeshi, Yanagida, Eriko, Kato, Takeharu, Yamada, Kyohei, Takeuchi, Mai, Suzuki, Takaharu, Moritsubo, Mayuko, Furuta, Takuya, Imaizumi, Yoshitaka, Takizawa, Jun, Kato, Koji, Suzumiya, Junji, Suzuki, Ritsuro, Ohshima, Koichi

المصدر: Cancer Medicine ; volume 13, issue 3 ; ISSN 2045-7634 2045-7634

الوصف: Aim Peripheral T‐cell lymphoma not otherwise specified (PTCL‐NOS) is a heterogeneous disease that can be classified into the PTCL‐TBX21 and PTCL‐GATA3 subtypes. Methods In this study, we compared the clinicopathological features of PTCL‐NOS in a Japanese cohort, classified using an IHC algorithm. Results One hundred patients with PTCL‐NOS were categorized as having PTCL‐TBX21 ( n = 55), PTCL‐GATA3 ( n = 24), or PTCL‐unclassified ( n = 21). When comparing PTCL‐TBX21 and PTCL‐GATA3, PTCL‐TBX21 showed significantly lower CD4 positivity ( p = 0.047), lower counts of high endothelial venules ( p = 0.032), and a tendency for a better response to initial treatment ( p = 0.088). Gene expression analysis using the nCounter system showed higher expression of tumor immunity‐related genes, such as PD‐L1, LAG3, and IDO1, in PTCL‐TBX21 than in PTCL‐GATA3. PTCL‐GATA3 had significantly worse overall survival (OS) than those with PTCL‐TBX21 ( p = 0.047), although a similar tendency was observed for progression‐free survival (PFS) ( p = 0.064). PTCL‐GATA3 was a prognostic factor for OS in univariate analysis (HR 2.02; 95% CI, 1.09–3.77; p = 0.027), although multivariate analysis did not show significance (HR 2.07; 95% CI, 0.93–4.61; p = 0.074). In the PFS analysis, PTCL‐GATA3 was an independent prognostic factor by univariate analysis (HR 1.96; 95% CI, 1.08–3.56; p = 0.027) and multivariate analysis (HR 2.34; 95% CI, 1.07–5.11; p = 0.032). Conclusion The classification of PTCL‐NOS into PTCL‐TBX21 and PTCL‐GATA3 is useful for predicting the prognosis of Japanese patients and stratifying the administration of tumor immune checkpoint inhibitors in clinical practice.

الإتاحة: https://doi.org/10.1002/cam4.6793Test

المؤلفون: Hsu, Jo-Yun, Cheng, Johnson Hsin-Chung, Feng, Sheng-Wei, Lai, Pin-Chuang, Yoshida, Noriaki, Chiang, Pao-Chang

المصدر: Journal of Dental Sciences ; ISSN 1991-7902

مصطلحات موضوعية: General Dentistry

الإتاحة: https://doi.org/10.1016/j.jds.2024.04.001Test
https://api.elsevier.com/content/article/PII:S1991790224001168?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1991790224001168?httpAccept=text/plainTest

المؤلفون: Kawano, Noriaki, Kyohei, Yamada, Miyoshi, Hiroaki, Yoshida, Noriaki, Ohshima, Kouichi, Arakawa, Fumiko, Nakashima, Kazutaka, Kameda, Takuro, Kogure, Yasunori, Ito, Yuta, Yoshida, Shuro, Kuriyama, Takuro, Nakaike, Takashi, Tochigi, Taro, Takigawa, Ken, Yamashita, Kiyoshi, Toyofuku, Atsushi, Manabe, Tatsuya, Doi, Atsushi, Terasaka, Soushi, Marutsuka, Kouske, Ochiai, Hidenobu, Kikuchi, Ikuo, Mori, Yasuo, Kataoka, Keisuke, Yoshizumi, Tomoharu, Yamauchi, Junji, Yamano, Yoshihisa, Shimoda, Kazuya

المصدر: Renal Replacement Therapy ; volume 9, issue 1 ; ISSN 2059-1381

مصطلحات موضوعية: Transplantation, Urology, Nephrology

الوصف: Backgrounds Therefore, reports on the risk of HTLV-1-related diseases in organ transplantation have increased in recent years, and the management of HTLV in renal transplantation remains a challenge. Patients and methods We retrospectively analyzed four HTLV-1-positive recipients or donors among 89 renal transplantation cases from 2006 to 2021. Results Among the four HTLV-1-positive recipients, two patients developed adult T cell leukemia/lymphoma (ATL) derived from recipients at approximately 3 years (1016 days and 1195 days) after renal transplantation. Case 1 developed lymphoma-type ATL (an extranodal primary cutaneous variant), including skin and pulmonary lesions. The patient achieved CR with FK tapering and CHOP therapy following cord blood stem cell transplantation. However, the patient died 101 days after ATL development because of a severe fungal infection. Case 2 developed acute-type ATL with an unusual phenotype of CD4+8+30+. The patient was treated with FK tapering and palliative therapy because of poor PS. Notably, in case 1, histopathological findings showed high numbers of PD-1-positive TIL cells in ATL, suggesting exhausted T cells and a correlation with the early onset of ATL. Furthermore, in Case 2, histopathological findings revealed CD 30 expression in ATL cells, suggesting the importance of CD 30 in ATL development. Importantly, case 2 showed typical driver mutations, including CCR4 truncation mutations of the C-terminal, TBL1XR1 mutation, and TP53 mutation in the splice site. Notably, our present study and our previous study on renal transplantation strongly indicated that two out of two and one out of 59 “recipient” positive cases developed ATL, respectively. Furthermore, our previous nationwide study 4 out of 10 “donor” positive cases developed HAM. These findings showed that ATL may be derived from HTLV-I+ recipient cells and HAM may be derived from HTLV-1+ donor cells, although the precise mechanism remains unknown. Conclusions Thus, early onset and rapid progression of ATL ...

الإتاحة: https://doi.org/10.1186/s41100-023-00480-5Test

المؤلفون: Jinnai, Sachio, Hamanaka, Ryo, Komaki, Hiroya, Kuga, Daiki, Yamaguchi, Runa, Tominaga, Jun-ya, Koga, Yoshiyuki, Yoshida, Noriaki

المصدر: American Journal of Orthodontics and Dentofacial Orthopedics ; volume 163, issue 5, page 645-655 ; ISSN 0889-5406

مصطلحات موضوعية: Orthodontics

الإتاحة: https://doi.org/10.1016/j.ajodo.2022.04.018Test
https://api.elsevier.com/content/article/PII:S0889540622007764?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0889540622007764?httpAccept=text/plainTest

المؤلفون: Kuga, Daiki, Hamanaka, Ryo, Komaki, Hiroya, Tominaga, Jun-ya, Yamaguchi, Runa, Emori, Toshiro, Horiguchi, Yui, Yoshida, Noriaki

المصدر: American Journal of Orthodontics & Dentofacial Orthopedics; Jul2024, Vol. 166 Issue 1, p26-35, 10p

مستخلص: This study aimed to determine and compare the effectiveness of the use of the dual-dimensional archwire and conventional rectangular archwire on tooth movement patterns when combined with various lengths of power arms. Displacements of the maxillary central incisor and the deformation of the wire section were calculated when applying retraction forces from different lengths of power arms using the finite element method. Torque control of the incisor could be carried out more effectively when using the dual-dimensional archwire combined with long power arms than with the rectangular archwire. The use of the dual-dimensional archwire produced bodily movement of the central incisor at height levels of the power arm between 8 and 10 mm and lingual root tipping at the level of 10 mm. The use of the dual-dimensional archwire provided better-controlled movement of the incisor, including bodily movement or root movement, than the rectangular archwire. • Biomechanical features of dual-dimensional and rectangular archwire were compared. • The dual-dimensional archwire provided better torque control of the incisor. • The dual-dimensional archwire showed greater mesiolingual molar rotation. • The dual-dimensional archwire produced less frictional resistance. • The use of the dual-dimensional archwire could shorten the treatment time. [ABSTRACT FROM AUTHOR]

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المؤلفون: Terawatpothong, Anutta, Sessirisombat, Chidchanok, Banhiran, Wish, Hotokezaka, Hitoshi, Yoshida, Noriaki, Sirisoontorn, Irin

المصدر: Journal of Clinical Medicine; Jun2024, Vol. 13 Issue 12, p3540, 19p

مستخلص: Background/Objectives: Polysomnography and cephalometry have been used for studying obstructive sleep apnea (OSA) etiology. The association between craniofacial skeleton and OSA severity remains controversial. To study OSA's etiology, cephalometry, fiberoptic pharyngoscopy, polysomnography, and sleep endoscopy have been used; however, airway obstructions cannot be located. Recent research suggested ultrasonography for OSA screening and upper airway obstruction localization. Thus, this study aims to investigate the relationship between specific craniofacial cephalometric and ultrasonic airway parameters in adults at high risk of OSA. Methods: To assess craniofacial structure, lateral cephalograms were taken from thirty-three adults over 18 with a STOP-Bang questionnaire score of three or higher and a waist-to-height ratio (WHtR) of 0.5 or higher. Airway parameters were assessed through submental ultrasound. Results: NSBA correlated with tongue base airspace width, while MP-H correlated with oropharynx, tongue base, and epiglottis airspace width. SNA, SNB, and NSBA correlated with tongue width at the oropharynx. At tongue base, ANB and MP-H correlated with tongue width. SNB and NSBA were associated with deep tissue thickness at the oropharynx, while MP-H correlated with superficial tissue thickness at velum and oropharynx. Conclusions: Cephalometric parameters (SNA, SNB, ANB, NSBA, and MP-H) were correlated with ultrasonic parameters in the velum, oropharynx, tongue base, and epiglottis. [ABSTRACT FROM AUTHOR]

: Copyright of Journal of Clinical Medicine is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Shido, Rena, Ohba, Seigo, Moriuchi, Emi, Yasuda, Gou, Hara, Masahito, Narahara, Shun, Ogata, Kinuko, Yoshida, Noriaki, Yamada, Tomohiro

المصدر: Journal of Craniofacial Surgery; July-August 2024, Vol. 35 Issue: 5 p1513-1516, 4p

مستخلص: The titanium osteosynthesis system used for fixing bone segments after maxillary osteotomy provides reliable outcomes owing to its biocompatibility and adequate strength. In addition, several studies have evaluated the skeletal stability after maxillary osteotomy with fixation using a biodegradable system. However, the indications for applying a biodegradable system after maxillary osteotomy remain controversial. Therefore, this study aimed to compare the long-term skeletal stability of bone segments after maxillary osteotomy with bone fixation using biodegradable and titanium osteosynthesis systems and to assess the usefulness of a biodegradable osteosynthesis system. Patients who underwent Le Fort I osteotomy of the maxilla to correct jaw deformities between April 2008 and March 2021 were included in this study. A total of 45 patients were included, with 28 in the biodegradable osteosynthesis system group and 17 in the titanium group. Cephalometric and computed tomography analyses were performed to evaluate the skeletal stability of the bone segments after maxillary osteotomy with bone fixation using biodegradable or titanium osteosynthesis systems. The maxillary segment was repositioned anteriorly with a clockwise rotation. Skeletal stability was similar between the biodegradable and titanium osteosynthesis systems. Segmental changes occurred mainly in the first 6 months after surgery, and the segment was completely stable between 6 and 12 months after surgery. This study revealed no significant differences in skeletal stability after maxillary osteotomy between the biodegradable and titanium osteosynthesis systems. However, the findings in this study should be interpreted with caution owing to the small sample size and small amount of maxillary-segment movement.

المؤلفون: Narahara, Shun, Morita, Yukiko, Shido, Rena, Yoshida, Noriaki, Ohba, Seigo

المصدر: Odontology; Apr2024, Vol. 112 Issue 2, p640-646, 7p

مصطلحات موضوعية: ORTHOGNATHIC surgery, OPERATIVE surgery, SNAKEBITES, ROTATIONAL motion

مستخلص: The treatment of mandibular deformities with an anterior open bite is challenging. In this study, skeletal stability after mandibular osteotomies was evaluated to determine the best treatment for mandibular prognathism with an anterior open bite in three procedures: intraoral vertical ramus osteotomy (IVRO), conventional sagittal split ramus osteotomy (conv-SSRO), and SSRO without bone fixation (nonfix-SSRO). Patients who underwent mandibular osteotomy to correct skeletal mandibular protrusion were included. Changes in skeletal and soft tissues were assessed using lateral cephalograms taken before (T1), 3 ± 2 days (T2), and 12 ± 3 months (T3) after surgery. Thirty-nine patients were included: nine in the IVRO group and 11 and 19 in the conv- and nonfix-SSRO groups, respectively. The mandibular plane angles (MPAs) of the T2–T1 were − 2.7 ± 2.0 (p = 0.0040), − 3.7 ± 1.7 (p < 0.0001), and − 2.3 ± 0.7 (p < 0.0001) in the IVRO, conv-SSRO, and nonfix-SSRO groups, respectively. The skeletal relapse of the MPAs was not related to the MPA at T2–T1, and it was approximately 1.3° in the conv-SSRO group. The skeletal relapse of the MAPs was significantly correlated with the MPA of T2–T1 in the IVRO (p = 0.0402) and non-fix-SSRO (p = 0.0173) groups. When the relapse of the MPAs was less than 1.3°, the MPA of T2–T1 was calculated as 2.5° in the nonfix-SSRO group. When the MPA of T2–T1 is less than 2.5°, non-fix SSRO may produce a reliable outcome, and when it is more than 2.5°, conv-SSRO may produce better outcomes. [ABSTRACT FROM AUTHOR]

: Copyright of Odontology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Nakamura, Takuya, Hotokezaka, Yuka, Karadeniz, Carmen, Hotokezaka, Hitoshi, Ueda-Ichinose, Yuika, Nishioka-Sakamoto, Kie, Yoshida, Noriaki

المصدر: Angle Orthodontist; Mar2024, Vol. 94 Issue 2, p240-246, 7p

مصطلحات موضوعية: CORRECTIVE orthodontics, ROOT resorption (Teeth), PERIODONTAL ligament, TOOTH replantation, MOLARS, MEDICAL sciences, RATS

مستخلص: The article focuses on determining the correlation between orthodontically induced root resorption (OIRR) and periodontal ligament (PDL) compression in rats. Topics include assessing PDL compression and OIRR in response to orthodontic force application, investigating the correlation between the extent of PDL compression and OIRR induction at different stages, and comparing the effects of bodily versus tipping tooth movement on OIRR and PDL compression.

المؤلفون: Arizono-Shimada, Keira, Hotokezaka, Hitoshi, Morita, Yukiko, Ino-Kondo, Airi, Ueda-Ichinose, Yuika, Nashiro, Yukako, Hotokezaka, Yuka, Yoshimi, Keiko, Kiliaridis, Stavros, Yoshida, Noriaki

المصدر: Arizono-Shimada, Keira; Hotokezaka, Hitoshi; Morita, Yukiko; Ino-Kondo, Airi; Ueda-Ichinose, Yuika; Nashiro, Yukako; Hotokezaka, Yuka; Yoshimi, Keiko; Kiliaridis, Stavros; Yoshida, Noriaki (2022). The effect of masseter muscle mass on the rate of experimental tooth movement in rats. Journal of oral rehabilitation, 49(10), pp. 1012-1019. Wiley 10.1111/joor.13357

مصطلحات موضوعية: 610 Medicine & health

الوصف: BACKGROUND Previous clinical observational studies have suggested that orthodontic tooth movement (OTM) is related, at least partly, to the mass and/or capabilities of the masticatory muscles. OBJECTIVES Our study aimed to examine the influence of masticatory muscle mass on the OTM in an animal experimental model in which the masseter muscle was modulated by botulinum neurotoxin type A (BTX) injection. METHODS Eighteen Wistar rats were equally divided into two groups: BTX injection and control. BTX was injected bilaterally into the masseter muscles. Three days after the injection, the maxillary left first molars were orthodontically moved for 14 days. At the end of the experiment, micro-computed tomography was performed to evaluate the rate of OTM and bone morphometry. The masseter muscles were weighed and prepared for histological analyses. RESULTS The masseter muscle mass in the BTX group was less than that in the control group, and histological findings showed atrophy of muscle fibers. The rate of OTM was significantly higher in the BTX group than in the control group. Furthermore, a negative correlation was detected between masseter muscle mass and OTM in the BTX group. Bone morphometry showed no difference between the control and BTX groups. CONCLUSION Decreased masseter muscle mass was found to be closely related to an increase in the rate of OTM in rats using BTX injection to modify the masseter muscle mass. Masseter muscle mass could be a predictive factor for OTM in rats injected with BTX.

وصف الملف: application/pdf

العلاقة: https://boris.unibe.ch/171356Test/

الإتاحة: https://doi.org/10.1111/joor.13357Test
https://boris.unibe.ch/171356/1/J_of_Oral_Rehabilitation_-_2022_-_Arizono_Shimada_-_The_effect_of_masseter_muscle_mass_on_the_rate_of_experimental_tooth.pdfTest
https://boris.unibe.ch/171356Test/