المؤلفون: Kimitoshi Kato, Maho Iwamoto, Mitsuhiko Moriyama, Shinobu Masuda, Tomohiro Nakayama, Yoshiaki Kusumi

المصدر: Internal Medicine. 2022, 61(3):323

المؤلفون: Eiji Osaka, Enomoto Katsuhisa, Fukumoto Satsuki, Katsuhisa Enomoto, Keiichiro Tada, Kusumi Yoshiaki, Osaka Eiji, Satsuki Fukumoto, Tada Keiichiro, Yoshiaki Kusumi

المصدر: 日大医学雑誌 / Journal of Nihon University Medical Association. 2022, 81(1):49

المؤلفون: Haruna Nishimaki, Hiroko Kobayashi, Okuto Koguchi, Shinobu Masuda, Sumie Ohni, Xiaoyan Tang, Yoko Nakanishi, Yoshiaki Kusumi

المصدر: ACTA HISTOCHEMICA ET CYTOCHEMICA. 2021, 54(2):57

المؤلفون: Atsushi Hirayama, Daisuke Fukamachi, Hiroyuki Hao, Naotaka Akutsu, Suguru Migita, Yasuo Okumura, Yoshiaki Kusumi

المصدر: Circulation Reports. 2019, 1(11):538

المؤلفون: Hisashi Hasegawa, Yoshiaki Kusumi, Takeshi Asakawa, Miyoko Maeda, Toshinori Oinuma, Tohru Furusaka, Takeshi Oshima, Mariko Esumi

المصدر: BMC Cancer, Vol 17, Iss 1, Pp 1-8 (2017)

مصطلحات موضوعية: Tongue cancer, pVHL, Diagnostic marker, Cytokeratin 13, Cytokeratin 17, Dysplasia, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: Abstract Background Patients with tongue cancer frequently show loss of heterozygosity (LOH) of the von Hippel–Lindau (VHL) tumor suppressor gene. However, expression of VHL protein (pVHL) in tongue cancer has rarely been investigated and remains largely unknown. We performed immunohistochemical staining of pVHL in tongue tissues and dysplasia, and examined the association with LOH and its clinical significance. Methods Immunohistochemical staining of pVHL in formalin-fixed, paraffin-embedded sections of cancerous and other tissues from 19 tongue cancer patients showed positivity for LOH of VHL in four samples, negativity in four samples, and was non-informative in 11 samples. The staining pattern of pVHL was also compared with those of cytokeratin (CK) 13 and CK17. Results In normal tongue tissues, pVHL staining was localized to the cytoplasm of cells in the basal layer and the area of the spinous layer adjacent to the basal layer of stratified squamous epithelium. Positive staining for pVHL was observed in the cytoplasm of cancer cells from all 19 tongue cancer patients. No differences as a result of the presence or absence of LOH were found. Notably, cytoplasm of poorly differentiated invasive cancer cells was less intensely stained than that of well and moderately differentiated invasive cancer cells. pVHL staining was also evident in epithelial dysplasia lesions with pVHL-positive cells expanding from the basal layer to the middle of the spinous layer. However, no CK13 staining was noted in regions of the epithelium, which were positive for pVHL. In contrast, regions with positive staining for CK17 closely coincided with those positive for pVHL. Conclusions Positive staining for pVHL was observed in cancerous areas but not in normal tissues. pVHL expression was also detected in lesions of epithelial dysplasia. These findings suggest that pVHL may be a useful marker for proliferative lesions.

وصف الملف: electronic resource

العلاقة: http://link.springer.com/article/10.1186/s12885-017-3364-8Test; https://doaj.org/toc/1471-2407Test

الوصول الحر: https://doaj.org/article/ab282f291f204086a2cf57c9287f9e0cTest

المؤلفون: Hidenori TAMEGAI, Masashi FUJII, Megumu WATABE, Mitsugu KOCHI, Tadatoshi TAKAYAMA, Takashi YAO, Yoritaka MATSUNO, Yoshiaki KUSUMI, 八尾 隆史, 東風 貢, 松野 順敬, 楠美 嘉晃, 渡部 愛, 田部井 英憲, 藤井 雅志, 高山 忠利

المصدر: 日本臨床外科学会雑誌 / Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association). 2019, 80(4):714

المؤلفون: Daisaku Hirano, Toshiyuki Yoshida, Daigo Funakoshi, Fuminori Sakurai, Shou Ohno, Yoshiaki Kusumi

المصدر: Case Reports in Urology, Vol 2018 (2018)

مصطلحات موضوعية: Diseases of the genitourinary system. Urology, RC870-923

الوصف: Carcinosarcomas of the urinary bladder are rare biphasic neoplasms, consisting of both malignant epithelial and malignant mesenchymal components, and the prognosis of this tumor is unfavorable in most patients with even possibility of resection of disease. A 77-year-old male with a history of transurethral resection (TUR) of urothelial carcinoma (UC) of the bladder and adjuvant intravesical chemotherapy with pirarubicin 10 years ago revisited our department with a gross hematuria. Cystoscopy demonstrated an approximately 2.5 cm nonpapillary tumor on the right wall of the bladder. Pelvic MRI showed the tumor without extending the base of the bladder wall. The tumor could be completely removed with TUR. The malignant epithelial elements consisted of high-grade UC and the majority of mesenchymal components were fibrosarcomatous differentiation based on immunohistochemical studies. The tumor could be pathologically also suspected to be an early stage on TUR specimens. Although he has received no additional intervention due to the occurrence of myocardial infarction at three weeks after the TUR, he has been alive with no evidence of recurrence of the disease 27 months after the TUR. Some early stages of bladder carcinosarcoma might have a favorable prognosis without aggressive treatments.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2090-696XTest; https://doaj.org/toc/2090-6978Test

الوصول الحر: https://doaj.org/article/1abe8b14558b41b8930a914db0e9b410Test

المؤلفون: Hiroyuki Hao, Hiroyuki Sakurai, Mie Shimamura, Ryota Higure, Ryusuke Tsujimura, Shinichirou Ishimoto, Shinobu Masuda, Tsugumasa Kamata, Yoshiaki Kusumi, 四万村 三惠, 増田 しのぶ, 日暮 亮太, 楠美 嘉晃, 櫻井 裕幸, 石本 真一郎, 羽尾 裕之, 辻村 隆介, 鎌田 嗣正

المصدر: 日大医学雑誌 / Journal of Nihon University Medical Association. 2018, 77(3):181

المؤلفون: Daisaku Hirano, Mizuho Ohkawa, Ryo Hasegawa, Norimichi Okada, Naoki Ishizuka, Yoshiaki Kusumi

المصدر: Case Reports in Urology, Vol 2015 (2015)

مصطلحات موضوعية: Diseases of the genitourinary system. Urology, RC870-923

الوصف: Metastatic spermatic cord (SC) tumor is extremely rare. Recently, we experienced a case of late-onset metastatic SC tumor from cecal cancer. This case is a 68-year-old man presenting with a painless right SC mass. He had undergone a right hemicolectomy for cecal cancer 6 years ago. Radical orchiectomy and adjuvant chemotherapy with S-1 were performed. No recurrence was found after one year of follow-up. We identified a total of 25 cases, including our case, on a literature search via PubMed from January 2000 to April 2015. The most frequent primary sites of the tumors metastasizing to the SC were the stomach (8 cases, 32%) and the colon (8 cases, 32%), next the liver (2 cases, 8%), and kidney (2 cases, 8%). The majority of the cases underwent radical orchiectomy for the metastatic tumors of the SC. Over half of the cases received adjuvant interventions based on the regimens for the primary tumors. Prognosis in the patients with metastatic tumor of the SC was unfavorable except for late-onset metastasis. In patients with a mass in the SC and a history of neoplasm, especially in gastrointestinal tract, the possibility of metastasis from the primary cancer should be considered.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2090-696XTest; https://doaj.org/toc/2090-6978Test

الوصول الحر: https://doaj.org/article/0e22f34bd4934248b714852600534346Test

المؤلفون: Hiroaki Morooka, Mie Shimamura, Motohiko Furuichi, Motomi Shiono, Ryota Higure, Shinichirou Ishimoto, Shinji Takeshita, Takashi Muramatsu, Yoshiaki Kusumi, 古市 基彦, 四万村 三惠, 塩野 元美, 日暮 亮太, 村松 高, 楠美 嘉晃, 石本 真一郎, 竹下 伸二, 諸岡 宏明

المصدر: 日大医学雑誌 / Journal of Nihon University Medical Association. 2016, 75(1):31