المؤلفون: Jae Kyun Park, Dae Hwan Kim, Tae-Yong Jeon, Sang-Ho Jeong, Tae Han Kim, Jae-Seok Min, Rock Bum Kim, Young Joon Lee, Ji Ho Park, Young Gil Son, Ki Young Yoon, Kyung Won Seo, Ki Hyun Kim, Yoonhong Kim, Hyun Dong Chae, Sun Hwi Hwang, Si-Hak Lee, Jae Hun Chung, Hyoung-Il Kim, Dong Jin Park, Kwang Hee Kim, Sang Hyuk Seo, Sung Jin Oh, Woo Yong Lee, Chang In Choi

المصدر: Trials, Vol 25, Iss 1, Pp 1-10 (2024)

مصطلحات موضوعية: Internal hernia, Minimally invasive surgery, Gastrectomy, Gastric neoplasm, Medicine (General), R5-920

الوصف: Abstract Background Petersen’s hernia, which occurs after Billroth-II (B-II) or Roux-en-Y (REY) anastomosis, can be reduced by defect closure. This study aims to compare the incidence of bowel obstruction above Clavien–Dindo classification grade III due to Petersen’s hernia between the mesenteric fixation method and the conventional methods after laparoscopic or robotic gastrectomy. Methods This study was designed as prospective, single-blind, non-inferiority randomized controlled multicenter trial in Korea. Patients with histologically diagnosed gastric cancer of clinical stages I, II, or III who underwent B-II or REY anastomosis after laparoscopic or robotic gastrectomy are enrolled in this study. Participants who meet the inclusion criteria are randomly assigned to two groups: a CLOSURE group that underwent conventional Petersen’s defect closure method and a MEFIX group that underwent the mesenteric fixation method. The primary endpoint is the number of patients who underwent surgery for bowel obstruction caused by Petersen’s hernia within 3 years after laparoscopic or robotic gastrectomy. Discussion This trial is expected to provide high-level evidence showing that the MEFIX method can quickly and easily close Petersen’s defect without increased postoperative complications compared to the conventional method. Trial registration ClinicalTrials.gov NCT05105360. Registered on November 3, 2021.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1745-6215Test

الوصول الحر: https://doaj.org/article/d19a8eceefaf4de7849b1110e02bd68aTest

المؤلفون: Yoonhong Kim, Dooheon Son, Bu Kyung Kim, Ki Hyun Kim, Kyung Won Seo, Kyoungwon Jung, Seun Ja Park, Sanghyun Lim, Jae Hyun Kim

المصدر: Endocrinology and Metabolism, Vol 37, Iss 3, Pp 475-486 (2022)

مصطلحات موضوعية: obesity, bariatric surgery, gastrointestinal microbiome, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

الوصف: Background Current evidence support that the gut microbiota plays a potential role in obesity. Bariatric surgery can reduce excess weight and decrease the risk of life-threatening weight-related health problems and may also influence gut microbiota. In this study, we aimed to investigate the changes in gut microbiota before and after bariatric surgery and evaluate the association of the gut microbial shift and altered body mass index (BMI) after bariatric surgery. Methods Between January 2019 and July 2020, stools from 58 patients scheduled for bariatric surgery were collected. Six months after bariatric surgery, stools from 22 of these patients were re-collected, and the changes in gut microbiota before and after bariatric surgery were evaluated. In addition, the differences in gut microbiota between patients with severe obesity (BMI >35 kg/m2, n=42) and healthy volunteers with normal BMI (18.8 to 22.8 kg/m2, n=41) were investigated. Results The gut microbiota of patients who underwent bariatric surgery showed increased α-diversity and differed β-diversity compared with those before surgery. Interestingly, Blautia was decreased and Bacteriodes was increased at the genus level after bariatric surgery. Further, the Blautia/Bacteroides ratio showed a positive correlation with BMI. To validate these results, we compared the gut microbiota from severely obese patients with high BMI with those from healthy volunteers and demonstrated that the Blautia/Bacteroides ratio correlated positively with BMI. Conclusion In the gut microbial analysis of patients who underwent bariatric surgery, we presented that the Blautia/Bacteroides ratio had changed after bariatric surgery and showed a positive correlation with BMI.

وصف الملف: electronic resource

العلاقة: http://www.e-enm.org/upload/pdf/enm-2022-1481.pdfTest; https://doaj.org/toc/2093-596XTest; https://doaj.org/toc/2093-5978Test

الوصول الحر: https://doaj.org/article/3548dc11780c414d83434aa2486b8efbTest

المؤلفون: Ki Hyun Kim, Soyoung Ock, Dohyung Lee, Yoonhong Kim, Jihoon Jo, Kyungwon Seo, Kiyoung Yoon, Sukyoung Kwon, Youngsik Choi, Bukyung Kim

المصدر: Kosin Medical Journal, Vol 37, Iss 1, Pp 68-74 (2022)

مصطلحات موضوعية: hepatic steatosis, liver disease, stomach neoplasm, Medicine (General), R5-920

الوصف: Background Nonalcoholic fatty liver disease dramatically improves after bariatric surgery, primarily due to improvements in hepatic insulin sensitivity. Since the procedure for gastric cancer surgery is very similar to that for bariatric surgery, we investigated changes in fatty liver following gastrectomy for gastric cancer according to the type of surgery. Methods We evaluated hepatic steatosis in 212 early gastric cancer patients using Hounsfield units (HUs) on non-contrast computed tomography preoperatively and 6, 12, and 24 months after surgery. We compared the preoperative and postoperative liver-to-spleen HU ratio according to the type of surgery: Billroth I, Billroth II, and total gastrectomy with Roux-en-Y reconstruction. Results The initial results (liver/spleen HUs and the liver-to-spleen HU ratio) did not significantly differ according to surgical group. After surgery, only patients who underwent total gastrectomy with Roux-en-Y exhibited significant changes in the liver-to-spleen HU ratio at 6 months. In 26 patients who had higher initial HU levels of the spleen than the liver, the liver-to-spleen HU ratio significantly increased from 0.836 to 1.115 at 6 months, 1.109 at 12 months, and 1.102 at 24 months (p

وصف الملف: electronic resource

العلاقة: http://www.kosinmedj.org/upload/pdf/kmj-22-008.pdfTest; https://doaj.org/toc/2005-9531Test; https://doaj.org/toc/2586-7024Test

الوصول الحر: https://doaj.org/article/9f30a35ae96d4c6e8fbffdf3bbc22cc1Test

المؤلفون: Yoonhong Kim, Dong Il Kim, Jae Ryong Shim, Tae Beom Lee, Kwang Ho Yang, Je Ho Ryu, Hyun Jung Lee, Byung Hyun Choi

المصدر: Korean Journal of Transplantation, Vol 33, Iss 4, Pp 146-152 (2019)

مصطلحات موضوعية: pancreas transplantation, diabetic nephropathies, calcineurin inhibitors, Medical technology, R855-855.5

الوصف: Pancreas transplantation is the only method that can nearly cure insulin-dependent diabetes mellitus. However, the effect of pancreas transplantation on patients with diabetic nephropathy has recently been considered controversial. In this report, we present a case of abrupt aggravation of proteinuria after successful pancreas transplantation alone without evidence of calcineurin inhibitor (CNI) toxicity. A 22-year-old female patient with type I diabetes mellitus underwent pancreas transplantation alone. The patient already had retinopathy and mild proteinuria, which in this case, may mean diabetic nephropathy. Her glucose levels were managed within the normal range after successful pancreas transplantation. However, the amount of proteinuria fluctuated. Kidney needle biopsy was performed owing to severe elevation of proteinuria, 2 years after the transplantation. Electron microscopy revealed diabetic glomerulosclerosis without evidence of CNI toxicity. This case indicates that diabetic nephropathy can be aggravated after pancreas transplantation, despite well-managed glucose levels and absence of CNI toxicity.

وصف الملف: electronic resource

العلاقة: http://journaleditor.inforang.com/journal/view.html?doi=10.4285/jkstn.2019.33.4.146Test; https://doaj.org/toc/2671-8790Test

الوصول الحر: https://doaj.org/article/32d6a11071914963a5d3674d4bd463c8Test

المؤلفون: Jae Kyun Park, Dae Hwan Kim, Tae-Yong Jeon, Sang-Ho Jeong, Tae Han Kim, Jae-Seok Min, Rock Bum Kim, Young Joon Lee, Ji Ho Park, Young Gil Son, Ki Young Yoon, Kyung Won Seo, Ki Hyun Kim, Yoonhong Kim, Hyun Dong Chae, Sun Hwi Hwang, Si-Hak Lee, Jae Hun Chung, Hyoung-Il Kim, Dong Jin Park, Kwang Hee Kim, Sang Hyuk Seo, Sung Jin Oh, Woo Yong Lee, Chang In Choi

مصطلحات موضوعية: Medicine, Microbiology, Cell Biology, Biotechnology, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Internal hernia, Minimally invasive surgery, Gastrectomy, Gastric neoplasm

الوصف: Additional file 1. SPIRIT Checklist for Trials.

العلاقة: https://figshare.com/articles/journal_contribution/Additional_file_1_of_Comparison_between_the_mesenteric_fixation_method_MEFIX_and_conventional_methods_at_preventing_the_occurrence_of_Petersen_s_hernia_a_study_protocol_for_a_multicenter_randomized_controlled_trial/24934495Test

الإتاحة: https://doi.org/10.6084/m9.figshare.24934495.v1Test
https://figshare.com/articles/journal_contribution/Additional_file_1_of_Comparison_between_the_mesenteric_fixation_method_MEFIX_and_conventional_methods_at_preventing_the_occurrence_of_Petersen_s_hernia_a_study_protocol_for_a_multicenter_randomized_controlled_trial/24934495Test

المؤلفون: Ki Hyun Kim, Yoonhong Kim, Kyung Won Seo

المصدر: Annals of Clinical Nutrition and Metabolism. 15:2-7

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::28e02febad76f5c193f50ac66f2e5923Test
https://doi.org/10.15747/acnm.2023.15.1.2Test

المؤلفون: Yoonhong Kim, Dooheon Son, Bu Kyung Kim, Ki Hyun Kim, Kyung Won Seo, Kyoungwon Jung, Seun Ja Park, Sanghyun Lim, Jae Hyun Kim

المصدر: Endocrinology and Metabolism. 37:701-702

مصطلحات موضوعية: Endocrinology, Endocrinology, Diabetes and Metabolism

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::77f3c4d1c2aebeff75e852f209e38f5dTest
https://doi.org/10.3803/enm.2022.401Test

المؤلفون: Yoonhong Kim, Seunghun Lee, Kyung Won Seo, KI HYUN KIM, Gyung mo Son

المصدر: Journal of minimally invasive surgery. 25(1)

الوصف: Incisional hernia is one of the most common complications after abdominal surgery conducted through a midline incision. Considerable debate remains regarding the design, comorbidity, suture material, and method. We investigated the risk factors for incisional hernia after laparoscopic colorectal surgery in the presence of limited surgery-related factors.A retrospective study was designed with 541 patients who underwent laparoscopic colorectal surgery performed by a single operator from January 2015 to December 2017. Due to open conversions, other abdominal operations, or follow-up loss, only 445 patients were included in the study. After propensity score matching, 266 patients were included. The study was based on diagnosis of incisional hernia on computed tomography at 6 and 12 months postoperatively.Of the 266 total patients, 133 underwent abdominal closure using PDS (Ethicon), while the remaining 133 underwent closure with Vicryl (Ethicon). Of these patients, nine were diagnosed with incisional hernia at the 12-month follow-up six (4.5%) in the Vicryl group and three (2.3%) in the PDS group (BMI of25 kg/m

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d05c40e1ca70156c9aa8d827ef42f60cTest
https://pubmed.ncbi.nlm.nih.gov/35603344Test

المؤلفون: Kyung Won Seo, KI HYUN KIM, Kwang Il Seo, Yoonhong Kim

المصدر: Annals of surgical treatment and research. 102(6)

مصطلحات موضوعية: Surgery

الوصف: Obesity is associated with nonalcoholic fatty liver disease, one of the most common causes of chronic liver disease. We aimed to demonstrate the effectiveness of bariatric surgery for hepatic steatosis and fibrosis in Korean patients.A total of 32 consecutive patients were enrolled in this study. Hepatic steatosis and liver fibrosis were assessed before surgery and 6 months after surgery using transient elastography and serologic panels.Thirteen patients (40.6%) were male and 19 (59.4%) were female, with a mean age of 39.3 ± 11.3 years. The body mass index was significant at the 6th month: 39.1 ± 6.7 and 30.3 ± 4.7 kg/mThese results suggest that bariatric surgery is associated with a significant improvement in liver steatosis and fibrosis. Bariatric surgery has a beneficial effect on nonalcoholic fatty liver disease in patients with morbid obesity in Korea.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d449ae88c902d9a12953e75ee5bf2712Test
https://pubmed.ncbi.nlm.nih.gov/35800999Test

المؤلفون: Yoonhong Kim, Dooheon Son, Bu Kyung Kim, Ki Hyun Kim, Kyung Won Seo, Kyoungwon Jung, Seun Ja Park, Sanghyun Lim, Jae Hyun Kim

مصطلحات موضوعية: Endocrinology, Endocrinology, Diabetes and Metabolism, Bacteroides, Bariatric Surgery, Humans, Obesity, digestive system, Body Mass Index, Gastrointestinal Microbiome

الوصف: Current evidence support that the gut microbiota plays a potential role in obesity. Bariatric surgery can reduce excess weight and decrease the risk of life-threatening weight-related health problems and may also influence gut microbiota. In this study, we aimed to investigate the changes in gut microbiota before and after bariatric surgery and evaluate the association of the gut microbial shift and altered body mass index (BMI) after bariatric surgery. Between January 2019 and July 2020, stools from 58 patients scheduled for bariatric surgery were collected. Six months after bariatric surgery, stools from 22 of these patients were re-collected, and the changes in gut microbiota before and after bariatric surgery were evaluated. In addition, the differences in gut microbiota between patients with severe obesity (BMI > 35, n=42) and healthy volunteers with normal BMI (18.8 – 22.8, n=41) were investigated. The gut microbiota of patients who underwent bariatric surgery showed increased α-diversity and differed β-diversity compared with those before surgery. Interestingly, Blautia was decreased and Bacteriodes was increased at the genus level after bariatric surgery. Further, the Blautia/Bacteroides ratio showed a positive correlation with BMI. These results were similar regardless of the surgery type (Roux-en-Y gastric bypass or sleeve gastrectomy). To validate these results, we compared the gut microbiota from severely obese patients with high BMI with those from healthy volunteers and demonstrated that the Blautia/Bacteroides ratio correlated positively with BMI. In the gut microbial analysis of patients who underwent bariatric surgery, we identified that the Blautia/Bacteroides ratio had changed after bariatric surgery and showed a positive correlation with BMI. Based on these results, we suggest that bariatric surgery could change the gut microbiota and specific microbiomes might have a potential role in obese patients.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea61e5c88822a6371f9cd979693a8efaTest
https://doi.org/10.21203/rs.3.rs-1154068/v1Test