المؤلفون: Hai-yan Liu, Yi-Jing Zhang, Wen-you Zhang

المصدر: Frontiers in Aging Neuroscience, Vol 16 (2024)

مصطلحات موضوعية: physical activity, cognitive function, older adults, NHANES, Mendelian randomization, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

الوصف: BackgroundCognitive function (CF) deterioration is a pressing concern in geriatric research. This study aimed to explore the relationship between physical activity (PA) and CF in older adults.MethodsThis study adopted a dual approach, employing both observational and genetic approaches through data from the National Health and Nutrition Examination Survey (NHANES) 2011–2014 and Mendelian Randomization (MR) analysis. For the NHANES component, PA levels were evaluated using the Global Physical Activity Questionnaire, and CF was assessed via standardized tests. Multivariate regression, threshold effect analysis, smoothing curve fitting, and subgroup analyses were conducted to examine the association between PA and CF. In parallel, MR methods, using genetic variants as instrumental variables, assessed the causal impact of PA on CF and related conditions such as Alzheimer’s disease and dementia.ResultsObservational findings from NHANES demonstrated a positive correlation between PA and CF, notably among female participants. The detailed analysis identified specific thresholds of PA that correlate with cognitive enhancements. However, MR results did not support a significant causal relationship between PA and CF or dementia-related outcomes, indicating an absence of a direct genetic basis for the observational associations.ConclusionAlthough observational data from NHANES suggest that PA is positively associated with CF in older adults, particularly among women, MR analysis did not confirm these findings as causally related. The discrepancy highlights the complexity of the PA-CF relationship and underscores the need for further research. These results emphasize the potential of PA as a modifiable risk factor for CF, though causal effects remain to be definitively established.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fnagi.2024.1418455/fullTest; https://doaj.org/toc/1663-4365Test

الوصول الحر: https://doaj.org/article/9294bc998a704f51bf258326c7f6b3b3Test

المؤلفون: Ze Yuan, Xiao Lin, Peng Li, Yu-Jun Gao, Kai Yuan, Wei Yan, Yu-Xin Zhang, Lin Liu, Xi-Mei Zhu, Yi-Jing Zhang, Yan-Ping Bao, Su-Hua Chang, Lin Lu, Le Shi

المصدر: Frontiers in Psychiatry, Vol 13 (2023)

مصطلحات موضوعية: depressive symptoms, emotional recognition ability, magnetic resonance imaging, functional connectivity, machine learning, Psychiatry, RC435-571

الوصف: IntroductionNegative bias of emotional face is the core feature of depression, but its underlying neurobiological mechanism is still unclear. The neuroimaging findings of negative emotional recognition and depressive symptoms are inconsistent.MethodsThe neural association between depressive symptoms and negative emotional bias were analyzed by measuring the associations between resting state functional connectivity (FC), brain structures, negative emotional bias, and depressive problems. Then, we performed a mediation analysis to assess the potential overlapping neuroimaging mechanisms.ResultsWe found a negative correlation between depressive symptoms and emotional recognition. Secondly, the structure and function of the inferior and lateral orbitofrontal gyrus are related to depressive symptoms and emotional recognition. Thirdly, the thickness of the inferior orbitofrontal cortex and the FC between the inferior orbitofrontal gyrus and fusiform gyrus, precuneate and cingulate gyrus mediated and even predicted the interaction between emotion recognition and depressive symptoms. Finally, in response to a negative stimulus, the activation of the frontal pole and precuneus lobe associated with the inferior orbitofrontal gyrus was higher in participants with depressive symptoms.ConclusionThe core brain regions centered on the inferior orbitofrontal cortex such as middle temporal gyrus, precuneus lobe, frontal pole, insula and cingulate gyrus are the potential neuroimaging basis for the interaction between depressive symptoms and emotional recognition.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fpsyt.2022.1090369/fullTest; https://doaj.org/toc/1664-0640Test

الوصول الحر: https://doaj.org/article/79e3e35f3a714551b69672bcafee3ffbTest

المؤلفون: Yi-Jing Zhang, Li-Sheng Hu

المصدر: Actuators, Vol 10, Iss 5, p 91 (2021)

مصطلحات موضوعية: graph convolution, link prediction, relationship prediction, score function, steam turbine control valve, Materials of engineering and construction. Mechanics of materials, TA401-492, Production of electric energy or power. Powerplants. Central stations, TK1001-1841

الوصف: The control valve is an important piece of equipment in the steam turbine, which frequently suffers from the fault of the dead zone. The graph model is a promising method for dead zone detection, yet establishing an accurate and completed graph topology is not an easy task due to limited mechanism knowledge. Hence, a graph model is proposed to predict the links in the graph and estimate the relationship between variables of related equipment of the control valve. The graph convolution is conducted on the uncompleted graph to learn the low-level representations of the graph nodes, and the score function is used to evaluate the probability of the existence of links between a pair of graph nodes. Results demonstrate a test accuracy of 99.2% for the link prediction, and follow the principles of thermodynamics in the steam turbine. Consequently, the proposed graph model is capable of estimating the relationships for the steam turbine control valve, and other inter-connected industrial systems.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2076-0825/10/5/91Test; https://doaj.org/toc/2076-0825Test

الوصول الحر: https://doaj.org/article/6dc580aee9d2432d9fd203e8a01916b8Test

المؤلفون: Yi-Jing Zhang, Li-Sheng Hu

المصدر: Energies, Vol 14, Iss 2, p 309 (2021)

مصطلحات موضوعية: fault propagation inference, steam turbine system, graph neural network, link prediction, Technology

الوصف: A fault propagates along physical paths until it reaches the boundary of the equipment or system, which shows as a functional failure. Hence, inferring the fault propagation helps to ensure the normal operation of the industrial system. To infer the fault propagation in the steam turbine system, a graph model is developed. Firstly, a process graph topology is constructed according to the system mechanism, whose nodes and edges represent the equipment and mutual relationships. Meanwhile, a fault graph topology is built, in which nodes indicate potential faults and edges are inferred propagation paths. Then, the representations of fault nodes are realized through a graph neural network. Lastly, link prediction methods based on nodes’ representations are conducted, along with the paths inference results. Consequently, the accuracy of fault propagation inference for the steam turbine system is over 86%.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/1996-1073/14/2/309Test; https://doaj.org/toc/1996-1073Test

الوصول الحر: https://doaj.org/article/d4103a0fb8084e68ae3a89775ad09aa1Test

المؤلفون: Yi-Jing Zhang, 張益精

مرشدي الرسالة: Xian-Wei Huang, 黃玄煒

الوصف: 96
An approach is proposed in this thesis to achieve real-time asynchronous search based on the AJAX( Asynchronous JavaScript + XML) and BNF (Backus…..). Multiple strings, duplicated strings, blank string, and English or Chinese phonetic alphabets can be processed correctly in this approach. Different color is assigned to each key and the corresponding display, user can discriminate the search results easily. Furthermore, the searching work can be prompted immediately when the user change the string based on the characteristics of AJAX.

وصف الملف: 42

الإتاحة: http://ndltd.ncl.edu.tw/handle/46033126017555960550Test

المؤلفون: Yi-Jing, Zhang, Lin, Yin, Jun, Li

المصدر: World Journal of Clinical Cases. 10:12221-12229

مصطلحات موضوعية: General Medicine

الوصف: Increasing reports have demonstrated that recombinant human brain natriuretic peptide (rhBNP) can improve acute myocardial infarction (AMI) and heart failure. However, whether it can improve renal function and decrease the risk of contrast-induced nephropathy (CIN) in elderly AMI patients is still unclear.To explore the effect of rhBNP on CIN in elderly AMI patients after percutaneous coronary intervention (PCI).One hundred and thirty-one elderly AMI patients underwent PCI from January 2017 to July 2021. Patients were either given 1 mL of 0.9% normal saline/(kg/h) for 72 h after PCI (control group,The creatinine clearance rate and eGFR were increased, while the creatinine and cystatin C levels were decreased significantly in the rhBNP treatment group compared to the control group at 48 h and 72 h. The incidence of CIN (Early application of rhBNP could protect renal function and decrease the incidence of CIN after primary PCI and acute heart failure.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ece513c37b65b5ec51ddb7a5316f008bTest
https://doi.org/10.12998/wjcc.v10.i33.12221Test

المؤلفون: Yi-Jing Zhang, Ye Yuan, Li-Sheng Hu

المصدر: International Journal of Control, Automation and Systems. 20:2759-2767

مصطلحات موضوعية: Control and Systems Engineering, Computer Science Applications

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::5ec417c7a4d4287fe0b93ff716433da2Test
https://doi.org/10.1007/s12555-021-0061-9Test

المؤلفون: Ze Yuan, Xiao Lin, Peng Li, Yu-Jun Gao, Kai Yuan, Wei Yan, Yu-Xin Zhang, Lin Liu, Xi-Mei Zhu, Yi-Jing Zhang, Yan-Ping Bao, Su-Hua Chang, Lin Lu, Le Shi

مصطلحات موضوعية: Psychiatry (incl. Psychotherapy), depressive symptoms, emotional recognition ability, magnetic resonance imaging, functional connectivity, machine learning

الوصف: Introduction Negative bias of emotional face is the core feature of depression, but its underlying neurobiological mechanism is still unclear. The neuroimaging findings of negative emotional recognition and depressive symptoms are inconsistent. Methods The neural association between depressive symptoms and negative emotional bias were analyzed by measuring the associations between resting state functional connectivity (FC), brain structures, negative emotional bias, and depressive problems. Then, we performed a mediation analysis to assess the potential overlapping neuroimaging mechanisms. Results We found a negative correlation between depressive symptoms and emotional recognition. Secondly, the structure and function of the inferior and lateral orbitofrontal gyrus are related to depressive symptoms and emotional recognition. Thirdly, the thickness of the inferior orbitofrontal cortex and the FC between the inferior orbitofrontal gyrus and fusiform gyrus, precuneate and cingulate gyrus mediated and even predicted the interaction between emotion recognition and depressive symptoms. Finally, in response to a negative stimulus, the activation of the frontal pole and precuneus lobe associated with the inferior orbitofrontal gyrus was higher in participants with depressive symptoms. Conclusion The core brain regions centered on the inferior orbitofrontal cortex such as middle temporal gyrus, precuneus lobe, frontal pole, insula and cingulate gyrus are the potential neuroimaging basis for the interaction between depressive symptoms and emotional recognition.

العلاقة: https://figshare.com/articles/dataset/Data_Sheet_1_The_neural_correlation_of_emotion_recognition_ability_and_depressive_symptoms_evidence_from_the_HCP_database_docx/21951776Test

الإتاحة: https://doi.org/10.3389/fpsyt.2022.1090369.s001Test
https://figshare.com/articles/dataset/Data_Sheet_1_The_neural_correlation_of_emotion_recognition_ability_and_depressive_symptoms_evidence_from_the_HCP_database_docx/21951776Test

المؤلفون: Yi-hang Huang, Hui-xin Hu, Ling-ling Wang, Yi-jing Zhang, Xuan Wang, Yi Wang, Ya Wang, Yan-yu Wang, Simon S.Y. Lui, Raymond C.K. Chan

المصدر: Asian Journal of Psychiatry. 85:103598

مصطلحات موضوعية: Psychiatry and Mental health, General Medicine, General Psychology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::cd5745402ef9997223f4e8cd9103c845Test
https://doi.org/10.1016/j.ajp.2023.103598Test

المؤلفون: Li-Shuang Xie, Yu-Hua Zhu, Xiao-Hua Wang, Xiao-Jun Wang, Jun-Hua Yuan, Yi-Jing Zhang

المصدر: World Journal of Gastrointestinal Oncology

مصطلحات موضوعية: Neutrophil gelatinase-associated lipocalin, integumentary system, business.industry, Colon, Gastroenterology, Matrix metalloproteinase 9, Matrix metalloproteinase-9, Biomarker, Lipocalin, Matrix (biology), Basic Study, digestive system diseases, Tubular adenocarcinoma, Oncology, Tubular Adenocarcinoma, Cancer research, Biomarker (medicine), Medicine, business

الوصف: BACKGROUND Tubular adenocarcinoma of the colon, which originates from the epithelium of the glands, is a major health concern worldwide. However, it is difficult to detect at an early stage. The lack of biomarkers is a main barrier to the diagnosis and treatment of tubular adenocarcinoma. Neutrophil gelatinase-associated lipocalin (NGAL) is a secreted protein that induces the expression of matrix metalloproteinase-9 (MMP-9) and is involved in various tumors. NGAL and MMP-9 have been reported to be associated with tumorigenesis and development. They may have potential as biomarkers for diagnosis of tubular adenocarcinoma of the colon. AIM To determine whether NGAL and MMP-9 can be used as potential biomarkers to indicate the progression of tubular adenocarcinoma of the colon. METHODS Samples were collected from surgically excised tissue from various patients. The content of pro-gastrin-releasing peptide (pro-GRP) in the serum was measured by an electrochemiluminescence immunoassay. The expression patterns of NGAL and MMP-9 and the relationship between NGAL and MMP-9 were examined by quantitative real-time PCR, Western blotting and immunohistochemical analysis. RESULTS In this study, we found that NGAL and MMP-9 can be used as biomarkers for the detection of tubular adenocarcinoma of the colon and that their combination improved diagnostic accuracy. By analyzing the expression of NGAL in tubular adenocarcinoma at different levels, we found that NGAL expression was significantly upregulated in primary tubular adenocarcinoma tissues compared with normal tissues. The upregulation of NGAL expression was strongly correlated with both the degree of differentiation and the disease stage (I–III), indicating that NGAL could serve as a diagnostic biomarker for tubular adenocarcinoma. When using NGAL as a biomarker for diagnosis, the accuracy was similar to that achieved with the widely used biomarker pro-GRP, suggesting that NGAL is reliable. Moreover, the expression of MMP-9 was also strongly correlated with the differentiation stage, demonstrating that MMP-9 could be used as a biomarker to indicate the progression of tubular adenocarcinoma of the colon. More importantly, the combination of NGAL and MMP-9 produced a more accurate diagnosis of tubular adenocarcinoma, and these results were further confirmed by immunohistochemical analysis of tissue sections. CONCLUSION Our study demonstrated that both NGAL and MMP-9 can be used as biomarkers for the diagnosis of colon tubular adenocarcinoma and that the results could be further improved by combining them.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58f8ab572d58281c1d37b0964a71c2acTest
http://europepmc.org/articles/PMC8529926Test