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1دورية أكاديمية
المؤلفون: Ygland Rödström, E., Soto-Beasley, A., Englund, E., Kafantari, E., Dickson, D.W., Wszolek, Z.K., Puschmann, A., Ross, O.A.
المصدر: Parkinsonism & Related Disorders ; volume 113 ; ISSN 1353-8020
مصطلحات موضوعية: Neurology (clinical), Geriatrics and Gerontology, Neurology
الإتاحة: https://doi.org/10.1016/j.parkreldis.2023.105600Test
https://api.elsevier.com/content/article/PII:S1353802023005679?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1353802023005679?httpAccept=text/plainTest -
2دورية أكاديمية
المؤلفون: Domenighetti C., Douillard V., Sugier P.-E., Sreelatha A.A.K., Schulte C., Grover S., May P., Bobbili D.R., Radivojkov-Blagojevic M., Lichtner P., Singleton A.B., Hernandez D.G., Edsall C., Gourraud P.-A., Mellick G.D., Zimprich A., Pirker W., Rogaeva E., Lang A.E., Koks S., Taba P., Lesage S., Brice A., Corvol J.-C., Chartier-Harlin M.-C., Mutez E., Brockmann K., Deutschländer A.B., Hadjigeorgiou G.M., Dardiotis E., Stefanis L., Simitsi A.M., Valente E.M., Petrucci S., Duga S., Straniero L., Zecchinelli A., Pezzoli G., Brighina L., Ferrarese C., Annesi G., Quattrone A., Gagliardi M., Matsuo H., Nakayama A., Hattori N., Nishioka K., Chung S.J., Kim Y.J., Kolber P., van de Warrenburg B.P.C., Bloem B.R., Aasly J., Toft M., Pihlstrøm L., Correia Guedes L., Ferreira J.J., Bardien S., Carr J., Tolosa E., Ezquerra M., Pastor P., Diez-Fairen M., Wirdefeldt K., Pedersen N.L., Ran C., Belin A.C., Puschmann A., Ygland Rödström E., Clarke C.E., Morrison K.E., Tan M., KraincMD D., Burbulla L.F., Farrer M.J., Krüger R., Gasser T., Sharma M., Vince N., Elbaz A., Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease (Courage-PD) Consortium
المصدر: Movement Disorders ; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85133891525&doi=10.1002%2fmds.29133&partnerID=40&md5=657ff63a76e864f8b7b498d3e529adf4Test
مصطلحات موضوعية: John Wiley and Sons Inc
الوصف: Background: Two studies that examined the interaction between HLA-DRB1 and smoking in Parkinson's disease (PD) yielded findings in opposite directions. Objective: To perform a large-scale independent replication of the HLA-DRB1 × smoking interaction. Methods: We genotyped 182 single nucleotide polymorphism (SNPs) associated with smoking initiation in 12 424 cases and 9480 controls to perform a Mendelian randomization (MR) analysis in strata defined by HLA-DRB1. Results: At the amino acid level, a valine at position 11 (V11) in HLA-DRB1 displayed the strongest association with PD. MR showed an inverse association between genetically predicted smoking initiation and PD only in absence of V11 (odds ratio, 0.74, 95% confidence interval, 0.59–0.93, PInteraction = 0.028). In silico predictions of the influence of V11 and smoking-induced modifications of α-synuclein on binding affinity showed findings consistent with this interaction pattern. Conclusions: Despite being one of the most robust findings in PD research, the mechanisms underlying the inverse association between smoking and PD remain unknown. Our findings may help better understand this association. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
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3دورية أكاديمية
المؤلفون: Domenighetti, C., Douillard, V., Sugier, P‐E, Sreelatha, A.A.K., Schulte, C., Grover, S., May, P., Bobbili, D.R., Radivojkov‐Blagojevic, M., Lichtner, P., Singleton, A.B., Hernandez, D.G., Edsall, C., Gourraud, P‐A, Mellick, G.D., Zimprich, A., Pirker, W., Rogaeva, E., Lang, A.E., Kõks, S., Taba, P., Lesage, S., Brice, A., Corvol, J‐C, Chartier‐Harlin, M‐C, Mutez, E., Brockmann, K., Deutschländer, A.B., Hadjigeorgiou, G.M., Dardiotis, E., Stefanis, L., Simitsi, A.M., Valente, E.M., Petrucci, S., Duga, S., Straniero, L., Zecchinelli, A., Pezzoli, G., Brighina, L., Ferrarese, C., Annesi, G., Quattrone, A., Gagliardi, M., Matsuo, H., Nakayama, A., Hattori, N., Nishioka, K., Chung, S.J., Kim, Y.J., Kolber, P., van de Warrenburg, B.P.C., Bloem, B.R., Aasly, J., Toft, M., Pihlstrøm, L., Correia Guedes, L., Ferreira, J.J., Bardien, S., Carr, J., Tolosa, E., Ezquerra, M., Pastor, P., Diez‐Fairen, M., Wirdefeldt, K., Pedersen, N.L., Ran, C., Belin, A.C., Puschmann, A., Ygland Rödström, E., Clarke, C.E., Morrison, K.E., Tan, M., KraincMD, D., Burbulla, L.F., Farrer, M.J., Krüger, R., Gasser, T., Sharma, M., Vince, N., Elbaz, A.
المصدر: Domenighetti, C., Douillard, V., Sugier, P‐E, Sreelatha, A.A.K., Schulte, C., Grover, S., May, P., Bobbili, D.R., Radivojkov‐Blagojevic, M., Lichtner, P., Singleton, A.B., Hernandez, D.G., Edsall, C., Gourraud, P‐A, Mellick, G.D., Zimprich, A., Pirker, W., Rogaeva, E., Lang, A.E., Kõks, S. , Taba, P., Lesage, S., Brice, A., Corvol, J‐C, Chartier‐Harlin, M‐C, Mutez, E., Brockmann, K., Deutschländer, A.B., Hadjigeorgiou, G.M., Dardiotis, E., Stefanis, L., Simitsi, A.M., Valente, E.M., Petrucci, S., Duga, S., Straniero, L., Zecchinelli, A., Pezzoli, G., Brighina, L., Ferrarese, C., Annesi, G., Quattrone, A., Gagliardi, M., Matsuo, H., Nakayama, A., Hattori, N., Nishioka, K., Chung, S.J., Kim, Y.J., ....
الوصف: Background Two studies that examined the interaction between HLA-DRB1 and smoking in Parkinson's disease (PD) yielded findings in opposite directions. Objective To perform a large-scale independent replication of the HLA-DRB1 × smoking interaction. Methods We genotyped 182 single nucleotide polymorphism (SNPs) associated with smoking initiation in 12 424 cases and 9480 controls to perform a Mendelian randomization (MR) analysis in strata defined by HLA-DRB1. Results At the amino acid level, a valine at position 11 (V11) in HLA-DRB1 displayed the strongest association with PD. MR showed an inverse association between genetically predicted smoking initiation and PD only in absence of V11 (odds ratio, 0.74, 95% confidence interval, 0.59–0.93, PInteraction = 0.028). In silico predictions of the influence of V11 and smoking-induced modifications of α-synuclein on binding affinity showed findings consistent with this interaction pattern. Conclusions Despite being one of the most robust findings in PD research, the mechanisms underlying the inverse association between smoking and PD remain unknown. Our findings may help better understand this association.
العلاقة: https://researchrepository.murdoch.edu.au/id/eprint/65476Test/; full_text_status:public
