المؤلفون: Xu, Sa, Wang, Wei, Meng, Tao, Wang, Fuyan, Wang, Guoxing, Huang, Fan, Wang, Guobin, Yu, Xiaojun, Wu, Ruolin, Hou, Liujin, Ye, Zhenghui, Zhang, Xinghua, Zhao, Hongchuan, Shen, Yuxian

المصدر: Medicine ; volume 102, issue 42, page e35268 ; ISSN 0025-7974 1536-5964

الوصف: A member of the short-chain dehydrogenase/reductase superfamily (DHRS1, SDR19C1) is a member of the short-chain dehydrogenase/reductase superfamily and a potential predictor of hepatocellular carcinoma (HCC). However, the role of DHRS1 in HCC immunity remains unclear. We systematically analyzed the association between DHRS1 and HCC immunity with transcriptional and clinical data from the Tumor Immune Estimation Resource, an integrated repository portal for tumor immune system interactions, and cBioPortal databases. Six DHRS1-associated immunomodulators strongly correlated with survival and were uncovered by exploiting univariate and multivariate Cox analyses. We created a risk score for each patient by adding the points from each immunomodulator and then classified them into high and low risk categories. Survival analysis were used to compare the overall survival between the 2 groups, and the receiver operating characteristic curve was applied to assess the accuracy of the risk score. Data from our center were adopted as the external validation set, the risk score was calculated using the risk coefficient of the 6 genes in the training cohort, and survival analysis were executed to verify the experimental group results. A nomogram was ultimately constructed with the R package. Our data revealed a correlation between the levels of immune cell infiltration and either the DHRS1 gene copy numbers or mRNA levels in HCC. Second, we generated a signature based on the 6 DHRS1-related immunomodulators (KDR, TNFRSF4, CD276, TNFSF4, SLAMF6, and SIGLEC9). We postulate that the generated risk scores would serve as an independent indicator of HCC prognosis, with an area under the receiver operating characteristic curve for the risk score of 0.743. We further established external validation sets to reconfirm the predictive validity of the risk score. Finally, a prognostic nomogram and calibration curve were created. The DHRS1 gene may exert an impact on HCC immunity. We posit that the nominated immune signature based on ...

الإتاحة: https://doi.org/10.1097/md.0000000000035268Test

المؤلفون: Chen, Wanjin, Wang, Shouwen, Zhao, Hongchuan, Wang, Guobin, Qin, Rong, Huang, Fan, Geng, Wei, Liu, Zimei, Wang, Wei, Wu, Ruolin, Hou, Liujin, Ye, Zhenghui, Zhang, Xinghua, Geng, Xiaoping, Yu, Xiaojun

المساهمون: National Natural Science Foundation of China

المصدر: Scandinavian Journal of Gastroenterology ; volume 58, issue 6, page 643-648 ; ISSN 0036-5521 1502-7708

الإتاحة: https://doi.org/10.1080/00365521.2022.2163184Test

المؤلفون: Chen, Wanjin, Wang, Haibo, Shen, Yuanlong, Wang, Shouwen, Liu, Deng, Zhao, Hongchuan, Wang, Guobin, Huang, Fan, Wang, Wei, Wu, Ruolin, Hou, Liujin, Ye, Zhenghui, Zhang, Xinghua, Geng, Xiaoping, Yu, Xiaojun

المساهمون: National Natural Science Foundation of China

المصدر: Functional & Integrative Genomics ; volume 23, issue 1 ; ISSN 1438-793X 1438-7948

مصطلحات موضوعية: Genetics, General Medicine

الإتاحة: https://doi.org/10.1007/s10142-023-00974-9Test

المؤلفون: Fang Yitian, Wu Ruolin, Huang Fan, Wang Guobin, Feng Lijuan, Yu Xiaojun, Hou Liujin, Ye Zhenghui, Geng Xiaoping, Zhao Hongchuan

المصدر: Qiguan Yizhi, Vol 12, Iss 2, Pp 197-202 (2021)

مصطلحات موضوعية: sepsis, liver transplantation, gram-positive bacteria, continuous renal replacement therapy, lcsh:R, lcsh:Medicine, multi-drug resistant organism, gram-negative bacteria, infection, carbapenem-resistant klebsiella pneumoniae

الوصف: Objective To analyze the risk factors of multi-drug resistant organism (MDRO) infection after liver transplantation. Methods The clinical data of 77 recipients undergoing liver transplantation were retrospectively analyzed. According to the incidence of MDRO infection, all recipients were divided into the non-MDRO infection group (n=51) and MDRO infection group (n=26). The infection rate and strain distribution of MDRO in liver transplant recipients were summarized. The risk factors of MDRO infection in liver transplant recipients were identified. Clinical prognosis of all recipients was statistically compared between two groups. Results The infection rate of MDRO after liver transplantation was 34% (26/77), mainly carbapenem-resistant MDRO infection. The main sites of infection included lung, abdominal cavity and incision. Univariate analysis showed that postoperative tracheal intubation ≥48 h, length of intensive care unit (ICU) stay ≥72 h, length of hospital stay ≥30 d, re-operation, continuous renal replacement therapy (CRRT) and tacrolimus (Tac) blood concentration ≥15 ng/mL were the risk factors for MDRO infection after liver transplantation. Cox regression analysis indicated that postoperative tracheal intubation≥48 h, re-operation, CRRT and Tac blood concentration ≥15 ng/mL were the independent risk factors for MDRO infection after liver transplantation. The fatality in the MDRO infection group was significantly higher than that in the non-MDRO infection group [31%(8/26) vs. 10%(5/51), P=0.01]. Conclusions Postoperative tracheal intubation ≥48 h, re-operation, CRRT and Tac blood concentration ≥15 ng/mL may increase the risk of MDRO infection after liver transplantation and affect clinical prognosis of the recipients.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doajarticles::9311c5201e4ceece275f1120429d6180Test
http://www.organtranspl.com/cn/article/doi/10.3969/j.issn.1674-7445.2021.02.010Test

المؤلفون: Ye Zhenghui, Zhao Hongchuan, Geng Xiaoping, Huang Fan, Wang Guobin, Yu Xiaojun, Wu Ruolin, Hou Liujin

المصدر: Qiguan Yizhi, Vol 10, Iss 5, Pp 589-593, 611 (2019)

مصطلحات موضوعية: reconstruction of hepatic artery, hepatic artery bypass, surgical complication, liver transplantation, hepatic artery, anatomical variation, lcsh:R, hepatic artery thrombosis, lcsh:Medicine

الوصف: Objective To summarize the experience of complex hepatic artery reconstruction in orthotopic liver transplantation. Methods Clinical data of 7 liver transplantation recipients who underwent complex hepatic artery reconstruction from January 2015 to March 2019 were retrospectively analyzed. Among them, 4 recipients received classical liver transplantation and 3 cases underwent piggyback liver transplantation. Intraoperative general conditions including anhepatic phase, intraoperative blood loss, hepatic artery anastomosis time and operation time of the recipients were recorded. The clinical prognosis and complications were observed. Results In two donors, variant right hepatic artery was used for vascular reconstruction. The celiac trunk or the common hepatic artery of the donors was anastomosed with the common hepatic artery of the recipients. Iliac artery bypass was employed in 2 cases, and then the hepatic artery of the donors was anastomosed with the abdominal aorta of the recipients. The superior mesenteric artery of 1 donor was end-to-end anastomosed with the common hepatic artery of the recipient. The celiac trunk of 1 donor was anastomosed with the splenic artery of the recipient. Only 1 case was required to undergo secondary liver transplantation due to acute hepatic artery thrombosis after hepatic artery anastomosis. All the 6 recipients successfully completed the liver transplantation. No perioperative death was observed. The anhepatic phase endured from 49 to 77 min. The intraoperative blood loss was ranged from 300 to 1 500 mL. The anastomosis time of hepatic artery was 23-56 min. The operation time was ranged from 5.3 to 11.1 h. The length of postoperative hospital stay was 23-56 d. Neither hepatic artery thrombosis nor stenosis occurred. The liver function of all recipients was basically restored to normal within postoperative 2 weeks. No severe surgical complications occurred. The liver graft achieved excellent function. Conclusions Appropriate identification of the hepatic artery variation, proper management of liver artery of the donors and recipients and reconstructing the blood supply of liver graft are the crucial procedures of liver transplantation.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doajarticles::bdf1c9698f74c103cf21fa5d3d2958bdTest
http://www.organtranspl.com/browse/detail/qkid/32/id/954.htmlTest

المؤلفون: Yu, Xiaojun, Ye, Zhenghui, Hou, Liujin, Zhang, Xinghua, Liu, Zimei, Wu, Ruolin, Huang, Fan, Wang, Guobin, Geng, Xiaoping, Zhao, Hongchuan

المساهمون: Youth Program of National Natural Science Foundation of China

المصدر: Journal of Cell Communication and Signaling ; volume 16, issue 2, page 179-190 ; ISSN 1873-9601 1873-961X

الإتاحة: https://doi.org/10.1007/s12079-021-00645-zTest

المؤلفون: Yu, Xiaojun, Ye, Zhenghui, Hou, Liujin, Zhang, Xinghua, Liu, Zimei, Wu, Ruolin, Huang, Fan, Wang, Guobin, Geng, Xiaoping, Zhao, Hongchuan

المصدر: Journal of Cell Communication & Signaling; Jun2022, Vol. 16 Issue 2, p179-190, 12p

مستخلص: The long noncoding RNA growth-arrest specific 5 (GAS5) is a suppressor of many cancers. However, the role and mechanism of action of GAS5 in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) remain unclear. Here, the expression of hepatitis B virus x gene (HBx) mRNA and GAS5 was assessed by qRT–PCR, and western blot analysis was performed to determine the protein expression levels. In addition, the cell viability and invasion of cells were confirmed using MTT assay and Transwell assay, respectively. The DNA methylation level of GAS5 was measured by methylation-specific PCR. Moreover, RIP assay and RNA pull down assay were carried out to examine the combination of Y-box-binding protein 1 (YBX1) and GAS5. First, our data proved that HBx is increased, while GAS5 is decreased in HCC cell lines. Subsequently, we found that HBx facilitates HCC cell viability and invasion by inhibiting GAS5 expression. Then, we further clarified that HBx induces the DNA methylation of GAS5 by promoting methyltransferase expression, thereby suppressing GAS5 expression. Furthermore, GAS5 binds YBX1 and promotes YBX1 and p21 expression. Finally, the functional analysis revealed that the upregulation of GAS5 could attenuate cell viability and invasion by boosting p21 expression via binding YBX1. Overall, our results demonstrated that HBx promotes HCC progression by inducing GAS5 methylation to reduce its expression. The upregulation of GAS5 suppressed HBV-related HCC by activating YBX1/p21 signaling. Our data provide novel evidence supporting the potential of GAS5 as a treatment target in HBV-related HCC. [ABSTRACT FROM AUTHOR]

: Copyright of Journal of Cell Communication & Signaling is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Wang, Xinyi, Wang, Haiyun, Ye, Zhenghui, Ding, Guofei, Li, Fengli, Ma, Ji, Hua, Wei

مصطلحات موضوعية: Research Paper, psy, socio

الوصف: Our goal was to examine whether multicomponent exercise performed by older adults with mild cognitive impairment or dementia as group-based exercise in community have beneficial effects on cognition and brain-derived neurotrophic factor. Eight studies were identified through Emabase, Medline, PubMed. Searches combined terms for neurocognitive and biochemical changes with those for MCI and dementia. Data were extracted and checked by a second reviewer, systematically reviewed, and meta analyzed where appropriate. There was significant difference in favor of multicomponent exercise in cognition (WMD:0.18; 95%CI:0.02-0.34), attention (SMD=2.16; 95%CI:1.2to3.12) and executive function (SMD =0.80; 95%CI: 0.28to1.31), but not in memory. However, there was limited reporting of the effects of multicomponent exercise on depression and brain-derived neurotrophic factor for this group of people. In conclusion, this meta-analysis indicated that group exercises improve cognition, attention and executive function in community-dwelling older adults with mild cognitive impairment or Alzheimer's disease.

العلاقة: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138588Test/

الإتاحة: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138588Test/

مستخلص: A charging method for group main line, GML, service is disclosed. For an outgoing call from an extension of the GML, the initiated call is identified by adding a prefix for group service before the called number. When an intelligent network, IN, finds that there is the prefix for group service before the called number, the call is processed as collectively paid by the GML. A service control point, SCP, generates a call record for the call and places a special identification code in the call record. An incoming call redirected through the GML is also processed as collectively paid by the GML. The SCP generates a call record for the call and places a special identification code in the call record. The present invention also discloses a service control device.

المؤلفون: Ye Zhenghui, Zhao Hongchuan, Huang Fan, Wang Guobin, Yu Xiaojun, Hou Liujin

المصدر: Qiguan Yizhi, Vol 9, Iss 3, Pp 227-231 (2018)

مصطلحات موضوعية: graft-to-recipient weight ratio, liver transplantation, pleural effusion, small-for-size liver syndrome, fungal infection, lcsh:R, abdominal infection, lcsh:Medicine, pulmonary infection, acute liver failure, small-for-size, pediatric donor liver, liver regeneration

الوصف: Objective To summarize the clinical experience of small-for-size graft of pediatric donor liver transplantation in the treatment of acute liver failure in an adult recipient. Methods Clinical data of application of small-for-size graft of pediatric donor liver transplantation in an adult recipient was retrospectively analyzed and literature review was performed. Results The pediatric donor was aged 4.5 years old and the weight of donor liver from donation after brain death was 544.6 g. The body mass of recipient was 52 kg. The graft-to-recipient weight ratio was 1.05%. The classic orthotopic liver transplantation was performed. Postoperative recovery was not satisfying. The recipient suffered from brain edema, stress gastrointestinal bleeding, acute kidney injury, small-for-size liver syndrome, atelectasis, lung infection, fungal infection, abdominal infection, pleural effusion and other postoperative complications. After symptomatic and comprehensive treatment, the function of liver graft was gradually restored and regenerated to the normal size of adult liver at postoperative 2 to 3 weeks. The patient was discharged after 102 d hospitalization. During the follow-up at postoperative 10 months, the liver function was evaluated normal and the quality of life was favorable. Conclusions Pediatric small-for-size donor livers can be successfully transplanted to the adult recipients. Nevertheless, it is necessary to select the appropriate recipients, surgical methods and fine perioperative management according to the conditions of the donor livers.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doajarticles::d4ac0f4a76aeb1f7b4e428b51128d5dfTest
http://www.organtranspl.com/browse/detail/qkid/32/id/806.htmlTest