المؤلفون: Li, Tudi, Zhang, Rendan, Liu, Yuhong, Yao, Yusi, Guo, Jiao, Zeng, Zhihuan

المصدر: Biomedicine & Pharmacotherapy ; volume 128, page 110311 ; ISSN 0753-3322

مصطلحات موضوعية: Pharmacology, General Medicine

الإتاحة: https://doi.org/10.1016/j.biopha.2020.110311Test
https://api.elsevier.com/content/article/PII:S0753332220305035?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0753332220305035?httpAccept=text/plainTest

المؤلفون: Zhang, Rendan, Li, Tudi, Guo, Jiao, Zhao, Yanqun, Liu, Yuhong, Yao, Yusi, Zeng, Zhihuan

المصدر: Lipids in Health and Disease ; volume 17, issue 1 ; ISSN 1476-511X

مصطلحات موضوعية: Biochemistry (medical), Clinical Biochemistry, Endocrinology, Endocrinology, Diabetes and Metabolism

الإتاحة: https://doi.org/10.1186/s12944-018-0921-3Test

المؤلفون: Yao, Yusi, Li, Wenhui, Han, Qiuqin, Lv, Guanglei, Li, Chunxia, Sun, Anyang

المساهمون: Natural Science Foundation of Shanghai, National Natural Science Foundation of China

المصدر: Zeitschrift für anorganische und allgemeine Chemie ; volume 648, issue 11 ; ISSN 0044-2313 1521-3749

الوصف: Amyloid‐β (Aβ) fibrils play a pivotal role in driving neuroinflammation and the progression of tau pathology in Alzheimer's disease (AD). In addition, Aβ oligomers are presumed to be closely associated with pathogenesis of AD. Currently, although a few Aβ antibodies are available, fluorescent probes still play an important role in detecting Aβ pathology. Herein, we designed and synthesized a pyridyl zinc chelate KZ and tested its potential specificity to Aβ species. The probe KZ showed a good binding to fibrillar Aβ aggregates and an excellent anti‐interference feature in vitro. Importantly, KZ could display a subset of Aβ deposits recognized by OC antibody in brain sections of AD mouse models. Thus, this probe KZ could be used as a sensitive tracer for detecting Aβ fibrils or/and fibrillar oligomers.

الإتاحة: https://doi.org/10.1002/zaac.202200070Test

المؤلفون: Bao, Xinlu, Yao, Yusi, Xu, Yunze, Shen, Yang, Lv, Guanglei, Zhao, Dian, Li, Chunxia

المساهمون: National Natural Science Foundation of China

المصدر: Zeitschrift für anorganische und allgemeine Chemie ; volume 647, issue 20-21, page 1992-1996 ; ISSN 0044-2313 1521-3749

الوصف: Amyloid‐β (Aβ) aggregates are one of biomarkers of Alzheimer's disease (AD). It is well known that Aβ aggregates display neurotoxicty or cytotoxicity to neurons. Thus, degrading Aβ aggregates is crucial for exploring the treatment of AD. Moreover, the excessive production of HOCl in the AD brain is an important feature of the disease. Herein, a novel compound MB‐O based on methylene blue (MB) skeleton was designed and synthesized. The probe MB‐O can specifically react with HOCl, releasing the fluorophore MB with strong fluorescence intensity increase. More importantly, the released MB is capable of degrading Aβ aggregates under red light irradiation.

الإتاحة: https://doi.org/10.1002/zaac.202100253Test

المؤلفون: Shen, Yang, Zheng, Wubin, Yao, Yusi, Wang, Dongmei, Lv, Guanglei, Li, Chunxia

المساهمون: National Natural Science Foundation of China

المصدر: Chemistry – An Asian Journal ; volume 15, issue 18, page 2864-2867 ; ISSN 1861-4728 1861-471X

الوصف: Abstract : It is well known that copper ions play a critical role in various physiological processes. However, a variety of human diseases are tightly correlated with copper overload. Although there are numerous fluorescent probes capable of detecting copper ions, most of them are “turn‐off” probes owing to copper (II) ions fluorescence quenching effect, resulting in poor sensitivity. Herein, a novel “turn‐on” near‐infrared (NIR) fluorescent probe PZ‐N based on phenoxazine was designed and synthesized for the selective detection of copper (II) ions (Cu 2+ ). Upon the addition of Cu 2+ , the probe could quickly react with Cu 2+ and emit strong fluorescence, along with colour change from colourless to obvious blue. Moreover, the probe PZ‐N showed good water solubility, high selectivity, and excellent sensitivity with low limit of detection (1.93 nM) towards copper (II) ions. More importantly, PZ‐N was capable of effectively detecting Cu 2+ in living cells.

الإتاحة: https://doi.org/10.1002/asia.202000783Test

المؤلفون: Yang, Jiajia, Yao, Yusi, Shen, Yang, Xu, Yunze, Lv, Guanglei, Li, Chunxia

المساهمون: National Natural Science Foundation of China, Natural Science Foundation of Zhejiang Province

المصدر: Zeitschrift für anorganische und allgemeine Chemie ; volume 646, issue 9, page 431-436 ; ISSN 0044-2313 1521-3749

الوصف: Hypochlorous acid (HOCl), one of the reactive oxygen species (ROS), is a key microbicidal agent which is used for natural defense. However, it is also linked to varieties of human diseases owing to the overproduction of HOCl. Much effort has been made to exploit selective fluorescent sensors for the detection of HOCl, but most of them have some disadvantages such as short excitation wavelength, low selectivity, and slow response and so on. These restrict the biological application of the probes. In this work, BR‐O was designed and synthesized on the base of phenoxazine for the detection of HOCl. BR‐O exhibited a violent fluorescence enhancement in the presence of HOCl, showing excellent selectivity and high sensitivity. More importantly, the probe BR‐O was capable of detecting exogenous and endogenous HOCl in living cells.

الإتاحة: https://doi.org/10.1002/zaac.202000127Test

المؤلفون: Zheng, Wubin, Yang, Jiajia, Shen, Yang, Yao, Yusi, Lv, Guanglei, Hao, Shiyou, Li, Chunxia

المساهمون: National Natural Science Foundation of China, Zhejiang Provincial Natural Science Foundation, Zhejiang Provincial Ten Thousands Talents Program, the Key Construction Project, Zhejiang Normal University

المصدر: Dyes and Pigments ; volume 179, page 108404 ; ISSN 0143-7208

مصطلحات موضوعية: Process Chemistry and Technology, General Chemical Engineering

الإتاحة: https://doi.org/10.1016/j.dyepig.2020.108404Test
https://api.elsevier.com/content/article/PII:S0143720819330505?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0143720819330505?httpAccept=text/plainTest

المؤلفون: Yao, Yusi¹ (AUTHOR), Liu, Yuhong¹ (AUTHOR), Zeng, Zhihuan¹ (AUTHOR), Zhao, Yanqun¹ (AUTHOR), Li, Tudi¹ (AUTHOR), Chen, Rong¹ (AUTHOR), Zhang, Rendan¹ (AUTHOR)

المصدر: Cardiovascular Therapeutics. 6/1/2020, p1-6. 6p.

مصطلحات موضوعية: *CHINESE medicine, *MUSCARINIC acetylcholine receptors, *HEART beat, *MUSCARINIC receptors, *VENTRICULAR arrhythmia, *ADRENERGIC receptors, *CORONARY disease

مستخلص: Wenxin Keli (WXKL) is a traditional Chinese medicine drug approved for the treatment of cardiovascular diseases. This study aimed to identify WXKL-targeting genes involved in antiarrhythmic efficacy of WXKL. The Traditional Chinese Medicine Systems Pharmacology (TCMSP) technology platform was used to screen active compounds of WXKL and WXKL-targeting arrhythmia-related genes. A pig model of myocardial ischemia (MI) was established by balloon-expanding the endothelium of the left coronary artery. Pigs were divided into the model group and WXKL group (n = 6). MI, QT interval, heart rate, and arrhythmia were recorded, and the mRNA expression of target genes in myocardial tissues was detected by PCR. Eleven active ingredients of WXKL and eight WXKL-targeting arrhythmia-related genes were screened. Five pathways were enriched, and an "ingredient-gene-path" network was constructed. WXKL markedly decreased the incidence of arrhythmia in the MI pig model (P < 0.05). The QT interval was significantly shortened, and the heart rate was slowed down in the WXKL group compared with the model group (P < 0.05). In addition, the expression of sodium channel protein type 5 subunit alpha (SCN5A) and beta-2 adrenergic receptor (ADRB2) was downregulated, while muscarinic acetylcholine receptor M2 (CHRM2) was upregulated in the WXKL group (P < 0.05). In conclusion, WXKL may shorten the QT interval and slow down the heart rate by downregulating SCN5A and ADRB2 and upregulating CHRM2 during MI. These findings provide novel insight into molecular mechanisms of WXKL in reducing the incidence of ventricular arrhythmia. [ABSTRACT FROM AUTHOR]

المؤلفون: Yuhong Liu, Zhihuan Zeng, Xing Yu, Tudi Li, Yusi Yao, Rong Chen, Jianyi Zheng, Liu, Yuhong, Zeng, Zhihuan, Yu, Xing, Li, Tudi, Yao, Yusi, Chen, Rong, Zheng, Jianyi

المصدر: Reviews in Cardiovascular Medicine; Mar2020, Vol. 21 Issue 1, p147-153, 7p

مصطلحات موضوعية: LIPOPROTEINS, TIME, LDL cholesterol, MEDICAL care, RETROSPECTIVE studies, CARDIOVASCULAR system, TREATMENT effectiveness, CORONARY artery disease, RESEARCH funding

مستخلص: The purpose of this study is to investigate the effect of lipoprotein(a) level on long-range prognosis after Percutaneous Coronary Intervention (PCI) in patients with low-density lipoprotein cholesterol (LDL-C) goal attainment. In this retrospective study, 350 patients in Coronary artery disease (CAD) with LDL-C less than 1.8 mmol/L were enrolled in the Guangdong Institute of Cardiovascular Diseases from January 2011 to December 2013. Follow-up was 1 year after PCI. According to the median value of the study population based on Lp(a), the patients were assigned to the high-level group and low-level group. The clinical data of the 2 groups were collected. We compared the baseline data between the 2 groups and the incidence rate of major cardiovascular events. After statistical analysis, the gender composition, hypertension, diabetes, and age of the patients between the 2 groups were similar, and the distinction was not significant. There was no significant distinction in cardio-vascular death, ischemic stroke, and recurrent myocardial infarction between the 2 groups, but the incidence of revascularization was higher in the high-level group (P < 0.05). High Lp(a) level predicts an increased incidence of revascularization of patients in CAD with LDL-C less than 1.8 mmol/L after PCI. [ABSTRACT FROM AUTHOR]

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