المؤلفون: Shaoxia Pu, Yaowen Liu, Wenjun Wu, Fei Sun, Hongsheng Lu, Xiaocui Xu, Yanhua Su, Wenming Cheng, Haizhen Wang

المصدر: Heliyon, Vol 10, Iss 7, Pp e28549- (2024)

مصطلحات موضوعية: Rhesus monkeys, Obesity, Type 2 diabetes, Aging, Muscle proteome, Science (General), Q1-390, Social sciences (General), H1-99

الوصف: Age-related functional deterioration in skeletal muscle raises the risk for falls, disability, and mortality in the elderly, particularly in obese people or those with type 2 diabetes mellitus (T2D). However, the response of the skeletal muscle to transitioning from obesity to diabetes remains poorly defined, despite that obesity is classified as a stage of pre-diabetes. We screened and selected spontaneously obese and diabetic rhesus monkeys and examined altered protein expression in skeletal muscle of healthy aging (CON), obesity aging (OB), and type 2 diabetes mellitus aging (T2D) rhesus monkeys using Tandem Mass Tags (TMT)-based quantitative proteomic analysis. In total, we identified 142 differentially expressed proteins. Muscle-nerve communication proteins were firstly suppressed at obese-stage. With the disintegration of skeletal muscle, mitochondrial complex I and other energy homeostasis relate proteins were significantly disordered at T2D stage. Indicating that aging related obesity suppressed muscle-nerve communication and contribute to T2D related functional deterioration of skeletal muscles in elderly rhesus monkeys. Some alterations of muscular functional regulator are detected in both obesity and T2D samples, suggesting some T2D related skeletal muscular hypofunctions are occurring at obesity or pre-obesity stage. Muscle-nerve communication proteins and muscular function related proteins could be potential therapy target or early diagnose marker of for skeletal muscular hypofunctions in aging obesity populations.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2405844024045808Test; https://doaj.org/toc/2405-8440Test

الوصول الحر: https://doaj.org/article/0584281239ce4853913f82c73197b57bTest

المؤلفون: Chan Liu, Jianhua Lu, Peihua Li, Siyang Feng, Yichao Guo, Kangguo Li, Benhua Zhao, Yanhua Su, Tianmu Chen, Xuan Zou

المصدر: International Journal of Infectious Diseases, Vol 134, Iss , Pp 78-87 (2023)

مصطلحات موضوعية: Delta, Omicron BA.1, Omicron BA.2, COVID-19, Transmissibility, Pathogenicity, Infectious and parasitic diseases, RC109-216

الوصف: Objectives: The Omicron BA.2 variant is probably the main epidemic strain worldwide at present. Comparing the epidemiological characteristics, transmissibility, and influencing factors of SARS-CoV-2, the results obtained in this paper will help to provide theoretical support for disease control. Methods: This study was a historical information analysis, using the R programming language and SPSS 24.0 for statistical analysis. The Geoda and Arc GIS were used for spatial autocorrelation analysis. Results: Local spatial autocorrelations of the incidence rate were observed in Delta and Omicron BA.1 outbreaks, whereas Omicron BA.2 outbreaks showed a random distribution in incidence rate. The time-dependent reproduction number of Delta, Omicron BA.1, and Omicron BA.2 were 3.21, 4.29, and 2.96, respectively, and correspondingly, the mean serial interval were 4.29 days (95% confidence interval [CI]: 0.37-8.21), 3.84 days (95% CI: 0-8.37), and 2.77 days (95% CI: 0-5.83). The asymptomatic infection rate of cases in Delta, Omicron BA.1, and Omicron BA.2 outbreaks were 21.71%, 6.25%, and 4.35%, respectively. Conclusion: The Omicron BA.2 variant had the greatest serial interval, transmissibility, and transmission speed, followed by BA.1, and then Delta. Compared with Delta and Omicron BA.1 variants, the Omicron BA.2 variant may be less pathogenic and more difficult to control than Omicron BA.1 and Delta.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S1201971223000395Test; https://doaj.org/toc/1201-9712Test

الوصول الحر: https://doaj.org/article/8af3cd86572a495ebb77372e55fb85aaTest

المؤلفون: Jing Wang, Jia Rui, Yuanzhao Zhu, Xiaohao Guo, Buasiyamu Abudunaibi, Benhua Zhao, Yanhua Su, Tianmu Chen, Jianli Hu

المصدر: Annals of Medicine, Vol 55, Iss 2 (2023)

مصطلحات موضوعية: Norovirus, transmissibility, total attack rate, peak incidence, Medicine

الوصف: AbstractObjective This study aims to estimate the transmissibility of norovirus outbreaks in schools by different transmission routes, and to evaluate the effects of isolation, school-closure and disinfection measures under different intervention intensities, finally, scientific prevention and control suggestions are proposed.Method 23 outbreaks of norovirus infectious diarrhea occurring in Jiangsu Province’s school from 2012-2018 were selected and fitted to the model. The data includes various types of school places and pathogen genotype. A ‘SEIAQRW’ model with two transmission routes was established. The transmissibility of each outbreak was assessed using effective reproduction number, the efficacy of different intervention measures and intensities were evaluated by calculating the total attack rate and peak incidence.Results The mean effective reproduction number of noroviruses was estimated to be 8.92 for the human-to-human route of transmission and 2.19 for the water or food-to-human route of transmission. When all symptomatic cases were isolated, the median peak incidence for both transmission routes both being less than 1.8%. There was a smaller reduction in total attack rate compared to peak incidence, the median total attack rate for the two transmission routes decreased by 17.59% and 42.09%, respectively. When the effect of school-closure or disinfection is more than 90%, the total attack rate and peak incidence in the human-to-human route are reduced by more than 90% compared to no intervention, and the peak incidence in the water or food-to-human routes can be reduced to less than 1.4%, but the reduction in the total attack rate is only 50% or so.Conclusion Norovirus outbreaks have a high rate of transmission in schools. In the case of norovirus outbreaks, isolation should be complemented by other interventions, and the implementation of high-intensity school closures or disinfection of the external environment can be effective in reducing the spread of the virus.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/0785-3890Test; https://doaj.org/toc/1365-2060Test

الوصول الحر: https://doaj.org/article/facfa8fe773e481e9a5daae3c47485c5Test

المؤلفون: Yichao Guo, Wenjing Ye, Zeyu Zhao, Xiaohao Guo, Wentao Song, Yanhua Su, Benhua Zhao, Jianming Ou, Yanqin Deng, Tianmu Chen

المصدر: Infectious Disease Modelling, Vol 8, Iss 1, Pp 270-281 (2023)

مصطلحات موضوعية: Contact tracing, Vaccine effectiveness, Variant of concern, Mathematical model, COVID-19, Infectious and parasitic diseases, RC109-216

الوصف: Although studies have compared the relative severity of Omicron and Delta variants by assessing the relative risks, there are still gaps in the knowledge of the potential COVID-19 burden these variations may cause. And the contact patterns in Fujian Province, China, have not been described. We identified 8969 transmission pairs in Fujian, China, by analyzing a contact-tracing database that recorded a SARS-CoV-2 outbreak in September 2021. We estimated the waning vaccine effectiveness against Delta variant infection, contact patterns, and epidemiology distributions, then simulated potential outbreaks of Delta and Omicron variants using a multi-group mathematical model. For instance, in the contact setting without stringent lockdowns, we estimated that in a potential Omicron wave, only 4.7% of infections would occur in Fujian Province among individuals aged >60 years. In comparison, 58.75% of the death toll would occur in unvaccinated individuals aged >60 years. Compared with no strict lockdowns, combining school or factory closure alone reduced cumulative deaths of Delta and Omicron by 28.5% and 6.1%, respectively. In conclusion, this study validates the need for continuous mass immunization, especially among elderly aged over 60 years old. And it confirms that the effect of lockdowns alone in reducing infections or deaths is minimal. However, these measurements will still contribute to lowering peak daily incidence and delaying the epidemic, easing the healthcare system's burden.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S246804272300009XTest; https://doaj.org/toc/2468-0427Test

الوصول الحر: https://doaj.org/article/d12046e9f26046dc90241e5887090ce4Test

المؤلفون: Tianlong Yang, Yao Wang, Laishun Yao, Xiaohao Guo, Mikah Ngwanguong Hannah, Chan Liu, Jia Rui, Zeyu Zhao, Jiefeng Huang, Weikang Liu, Bin Deng, Li Luo, Zhuoyang Li, Peihua Li, Yuanzhao Zhu, Xingchun Liu, Jingwen Xu, Meng Yang, Qinglong Zhao, Yanhua Su, Tianmu Chen

المصدر: BMC Public Health, Vol 22, Iss 1, Pp 1-12 (2022)

مصطلحات موضوعية: Logistic differential equation model, Generalized logistic differential equation model, Mathematical model, Infectious diseases, Early warning, Jilin province, Public aspects of medicine, RA1-1270

الوصف: Abstract Background There is still a relatively serious disease burden of infectious diseases and the warning time for different infectious diseases before implementation of interventions is important. The logistic differential equation models can be used for predicting early warning of infectious diseases. The aim of this study is to compare the disease fitting effects of the logistic differential equation (LDE) model and the generalized logistic differential equation (GLDE) model for the first time using data on multiple infectious diseases in Jilin Province and to calculate the early warning signals for different types of infectious diseases using these two models in Jilin Province to solve the disease early warning schedule for Jilin Province throughout the year. Methods Collecting the incidence of 22 infectious diseases in Jilin Province, China. The LDE and GLDE models were used to calculate the recommended warning week (RWW), the epidemic acceleration week (EAW) and warning removed week (WRW) for acute infectious diseases with seasonality, respectively. Results Five diseases were selected for analysis based on screening principles: hemorrhagic fever with renal syndrome (HFRS), shigellosis, mumps, Hand, foot and mouth disease (HFMD), and scarlet fever. The GLDE model fitted the above diseases better (0.80 ≤ R 2 ≤ 0.94, P

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1471-2458Test

الوصول الحر: https://doaj.org/article/b63a38a9a8a04c08a659241a274b87cbTest

المؤلفون: Xiaohao Guo, Yichao Guo, Zeyu Zhao, Shiting Yang, Yanhua Su, Benhua Zhao, Tianmu Chen

المصدر: Infectious Disease Modelling, Vol 7, Iss 2, Pp 196-210 (2022)

مصطلحات موضوعية: Definition-based method, Dynamics model, Basic reproduction number, Next-generation method, Infectious and parasitic diseases, RC109-216

الوصف: Objectives: Computing the basic reproduction number (R0) in deterministic dynamical models is a hot topic and is frequently demanded by researchers in public health. The next-generation methods (NGM) are widely used for such computation, however, the results of NGM are usually not to be the true R0 but only a threshold quantity with little interpretation. In this paper, a definition-based method (DBM) is proposed to solve such a problem. Methods: Start with the definition of R0, consider different states that one infected individual may develop into, and take expectations. A comparison with NGM has proceeded. Numerical verification is performed using parameters fitted by data of COVID-19 in Hunan Province. Results: DBM and NGM give identical expressions for single-host models with single-group and interactive Rij of single-host models with multi-groups, while difference arises for models partitioned into subgroups. Numerical verification showed the consistencies and differences between DBM and NGM, which supports the conclusion that R0 derived by DBM with true epidemiological interpretations are better. Conclusions: DBM is more suitable for single-host models, especially for models partitioned into subgroups. However, for multi-host dynamic models where the true R0 is failed to define, we may turn to the NGM for the threshold R0.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2468042722000288Test; https://doaj.org/toc/2468-0427Test

الوصول الحر: https://doaj.org/article/148a34e0c01746d6884931435b589beaTest

المؤلفون: Zeyu Zhao, Meng Yang, Jinlong Lv, Qingqing Hu, Qiuping Chen, Zhao Lei, Mingzhai Wang, Hao Zhang, Xiongjie Zhai, Benhua Zhao, Yanhua Su, Yong Chen, Xu-Sheng Zhang, Jing-An Cui, Roger Frutos, Tianmu Chen

المصدر: Infectious Disease Modelling, Vol 7, Iss 2, Pp 161-178 (2022)

مصطلحات موضوعية: Shigellosis, Seasonality, Transmissibility, Early warning, Infectious and parasitic diseases, RC109-216

الوصف: Objective: In China, the burden of shigellosis is unevenly distributed, notably across various ages and geographical areas. Shigellosis temporal trends appear to be seasonal. We should clarify seasonal warnings and regional transmission patterns. Method: This study adopted a Logistic model to assess the seasonality and a dynamics model to compare the transmission in different areas. The next-generation matrix was used to calculate the effective reproduction number (Reff) to quantify the transmissibility. Results: In China, the rate of shigellosis fell from 35.12 cases per 100,000 people in 2005 to 7.85 cases per 100,000 people in 2017, peaking in June and August. After simulation by the Logistic model, the ‘peak time’ is mainly concentrated from mid-June to mid-July. China's ‘early warning time’ is primarily focused on from April to May. We predict the ‘peak time’ of shigellosis is the 6.30th month and the ‘early warning time’ is 3.87th month in 2021. According to the dynamics model results, the water/food transfer pathway has been mostly blocked off. The transmissibility of different regions varies greatly, such as the mean Reff of Longde County (3.76) is higher than Xiamen City (3.15), higher than Chuxiong City (2.52), and higher than Yichang City (1.70). Conclusion: The ‘early warning time’ for shigellosis in China is from April to May every year, and it may continue to advance in the future, such as the early warning time in 2021 is in mid-March. Furthermore, we should focus on preventing and controlling the person-to-person route of shigellosis and stratified deploy prevention and control measures according to the regional transmission.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2468042722000276Test; https://doaj.org/toc/2468-0427Test

الوصول الحر: https://doaj.org/article/18b19903cf9d4b8d8f2ccc122ad158b5Test

المؤلفون: Chen Tang, Hanxiang Jiang, Bin Zhao, Yi Lin, Shengnan Lin, Tianmu Chen, Yanhua Su, Yiqin Zhang, Lina Zhou, Lianmeng Li, Jincheng Lin, Zhonghua Lu, Yao Wang, Zeyu Zhao, Longjian Liu, Yuxin Wang, Jie Zhang, Heqing Shen

المصدر: Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-16 (2022)

مصطلحات موضوعية: Ageing, Bilirubin, Cohort study, Hypertension, Medicine

الوصف: Abstract Background Hypertension is highly prevalent and associated with the elevated risks of cardiovascular diseases, dementia, and physical disabilities among adults. Although the correlation between bilirubin and hypertension has been reported, the observation in quinquagenarian population is scarce. We aimed to examine bilirubin-hypertension association in Guankou Ageing Cohort Study. Methods Participants ≥ 55 years were recruited and their questionnaires and physical examination data were collected. Kaplan–Meier survival analysis and Cox proportional hazards regression were implemented to assess the hypertension risk. The non-liner dose–response relationships of bilirubin-hypertension were determined by restricted cubic spline (RCS) models. Receiver operating characteristic (ROC) curves and multiple factors analysis (MFA) were performed to evaluate the predictive abilities. Results 1881 eligible participants (male 43.75%, female 56.25%) with the median age of 61.00 (59.00–66.00) were included. The hazard ratio (HR, 95% CI) of serum total bilirubin (STB) and unconjugated bilirubin (UCB) were 1.03 (1.01–1.05) and 1.05 (1.03–1.07), while conjugated bilirubin (CB) showed a weak protective effect with the HR of 0.96 (0.92–0.99), and the associations remained significant in all models. RCS analyses further indicated the similar bidirectional effects of STB and UCB with the cut-off of 12.17 μmol/L and 8.59 μmol/L, while CB exhibited inverse bidirectional dose–response relationship with a cut-off of 3.47 μmol/L. ROC curves and MFA showed baseline STB combined with age, BMI, and waist circumference could well discriminate the low and high of hypertension risk. Conclusions Our findings suggested the higher levels of total and unconjugated bilirubin were hazardous factors of hypertension, while an inverse effect presented when more bilirubin was conjugated.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1479-5876Test

الوصول الحر: https://doaj.org/article/aa02167d15c64acf9fcad3c1f4ce95dbTest

المؤلفون: Wei Zhang, Jia Rui, Xiaoqing Cheng, Bin Deng, Hesong Zhang, Lijing Huang, Lexin Zhang, Simiao Zuo, Junru Li, XingCheng Huang, Yanhua Su, Benhua Zhao, Yan Niu, Hongwei Li, Jian-li Hu, Tianmu Chen

المصدر: Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)

مصطلحات موضوعية: Medicine, Science

الوصف: Abstract Hand, foot, and mouth disease (HFMD) is a serious disease burden in the Asia–Pacific region, including China. This study calculated the transmissibility of HFMD at county levels in Jiangsu Province, China, analyzed the differences of transmissibility and explored the possible influencing factors of its transmissibility. We built a mathematical model for seasonal characteristics of HFMD, estimated the effective reproduction number (R eff ), and compared the incidence rate and transmissibility in different counties using non-parametric tests, rapid cluster analysis and rank-sum ratio in 97 counties in Jiangsu Province from 2015 to 2020. The average daily incidence rate was between 0 and 4 per 100,000 people in Jiangsu Province from 2015–2020. The Quartile of R eff in Jiangsu Province from 2015 to 2020 was 1.54 (0.49, 2.50). Rugao District and Jianhu District had the highest transmissibility according to the rank-sum ratio. R eff generally decreased in 2017 and increased in 2018 in most counties, and the median level of R eff was the lowest in 2017 (P

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2045-2322Test

الوصول الحر: https://doaj.org/article/3b292e453de94cb7899a7a71aacb0aa4Test

المؤلفون: Hui Tang, Gengyao Chen, Zhijun Liu, Ran Zhao, Cheng Lu, Yanhua Su

المصدر: Frontiers in Psychology, Vol 13 (2022)

مصطلحات موضوعية: Chinese, cosmopolitanism, voluntary settlement, independence, relational mobility, residential mobility, Psychology, BF1-990

الوصف: Cosmopolitan cities share similarities with historical frontiers, including potential opportunities for economic success, high social mobility, weakened traditional conventions, and adventure and novel experiences. Individuals with high independence typically prefer to settle in cosmopolitan cities. However, previous research testing this cosmopolitan settlement hypothesis did not consider the influence of relational mobility and residential mobility. Moreover, the mechanisms that drive people to prefer cosmopolitan cities remain unclear. This study examines the relationships among independence, relational mobility, residential mobility, and preference for cosmopolitan cities among 296 Chinese senior undergraduates. The results indicate that: (1) independence remains a positive predictor of the preference for cosmopolitan cities above and beyond relational mobility, residential mobility (i.e., history, state, and intention), and other covariates; (2) intention of residential mobility also positively predicts preference for cosmopolitan cities when controlling for related covariates; and (3) relational mobility indirectly predicts perceived preference for cosmopolitan cities through dependence. This research underscores the importance of identifying the factors and mechanisms affecting cosmopolitan settlement.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fpsyg.2022.1057974/fullTest; https://doaj.org/toc/1664-1078Test

الوصول الحر: https://doaj.org/article/59e21ef9a7a04d1fa66d5fd439159dc8Test