المؤلفون: Chang, R., Zhu, Y., Xu, J., Chen, L., Su, G.N., Kijlstra, A., Yang, P.Z.

المصدر: Chang , R , Zhu , Y , Xu , J , Chen , L , Su , G N , Kijlstra , A & Yang , P Z 2021 , ' Identification of Urine Metabolic Biomarkers for Vogt-Koyanagi-Harada Disease ' , Frontiers in Cell and Developmental Biology , vol. 9 , 637489 . https://doi.org/10.3389/fcell.2021.637489Test

مصطلحات موضوعية: Vogt-Koyanagi-Harada disease, diagnosis, disease activity, metabolomics, urine biomarkers, GLYCINE, UVEITIS

الوصف: The diagnosis of Vogt-Koyanagi-Harada (VKH) disease is mainly based on a complex clinical manifestation while it lacks objective laboratory biomarkers. To explore the potential molecular biomarkers for diagnosis and disease activity in VKH, we performed an untargeted urine metabolomics analysis by ultra-high-performance liquid chromatography equipped with quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF/MS). Through univariate and multivariate statistical analysis, we found 9 differential metabolites when comparing VKH patients with healthy controls, and 26 differential metabolites were identified when comparing active VKH patients with inactive VKH patients. Pathway enrichment analysis showed that glycine, serine and threonine metabolism, and arginine and proline metabolism were significantly altered in VKH versus healthy controls. Lysine degradation and biotin metabolism pathways were significantly altered in active VKH versus inactive VKH. Furthermore, the receiver operating characteristic (ROC) curve analysis revealed that the combination of acetylglycine and gamma-glutamylalanine could differentiate VKH from healthy controls with an area under the curve (AUC) of 0.808. A combination of ureidopropionic acid and 5 '-phosphoribosyl-5-amino-4-imidazolecarboxamide (AICAR) had an excellent AUC of 0.958 for distinguishing active VKH from inactive VKH. In summary, this study identified abnormal metabolites in urine of patients with VKH disease. Further studies are needed to confirm whether these metabolites are specific for this disease.

الإتاحة: https://doi.org/10.3389/fcell.2021.637489Test
https://cris.maastrichtuniversity.nl/en/publications/2096253f-9124-4577-a3cd-d2f47b64a024Test

المؤلفون: Yang, P.Z., Zhang, W.Y., Chen, Z.J., Zhang, H., Su, G.N., Cao, Q.F., Zhu, Y., Zhong, Z.Y., Zhou, C.J., Wang, Y., Kijlstra, A.

المصدر: Yang , P Z , Zhang , W Y , Chen , Z J , Zhang , H , Su , G N , Cao , Q F , Zhu , Y , Zhong , Z Y , Zhou , C J , Wang , Y & Kijlstra , A 2021 , ' Development of revised diagnostic criteria for Fuchs' uveitis syndrome in a Chinese population ' , British Journal of Ophthalmology . https://doi.org/10.1136/bjophthalmol-2021-319343Test

مصطلحات موضوعية: diagnostic tests, investigation, iris, anterior chamber, imaging, HETEROCHROMIC IRIDOCYCLITIS, IRIS NODULES, SPECTRUM

الوصف: Background/aims Fuchs' uveitis syndrome (FUS) is one of the frequently misdiagnosed uveitis entities, which is partly due to the absence of internationally recognised diagnostic criteria. This study was performed to develop and evaluate a set of revised diagnostic criteria for FUS. Methods The clinical data of Chinese patients with FUS and patients with non-FUS were collected and analysed from a tertiary referral centre between April 2008 and December 2020. A total of 593 patients with FUS and 625 patients with non-FUS from northern China were enrolled for the development of diagnostic criteria for FUS. Three hundred and seventy-seven patients with FUS and 503 patients with non-FUS from southern China were used to validate the criteria. Clinical symptoms and ocular signs were collected from all patients with FUS and patients with non-FUS. Multivariate two-step cluster analysis, logistic regression and decision tree algorithms in combination with the clinical judgement of uveitis experts were used to revise diagnostic criteria for FUS. Results Three essential findings including diffuse iris depigmentation, absence of posterior synechiae, mild inflammation in the anterior chamber at presentation and five associated findings including mostly unilateral involvement, cataract, vitreous opacities, absence of acute symptoms and characteristic iris nodules were used in the development of FUS diagnostic criteria. All essential findings were required for the diagnosis of FUS, and the diagnosis was further strengthened by the presence of associated findings. Conclusion Revised diagnostic criteria for FUS were developed and validated by analysing data from Chinese patients and showed a high sensitivity (96.55%) and specificity (97.42%).

الإتاحة: https://doi.org/10.1136/bjophthalmol-2021-319343Test
https://cris.maastrichtuniversity.nl/en/publications/db3f7ca2-fa6e-4170-abaa-cf70ed55642bTest

المؤلفون: Tan, H.D., Lin, M., Gou, Q.Q., Li, A.J., Gu, F.J., Liu, Q., Zhang, Q., Xu, M., Kijlstra, A., Yang, P.Z., Li, H.

المصدر: Tan , H D , Lin , M , Gou , Q Q , Li , A J , Gu , F J , Liu , Q , Zhang , Q , Xu , M , Kijlstra , A , Yang , P Z & Li , H 2021 , ' Trends in Corneal Transplantation and Characteristics of Donors in the Chongqing Eye Bank, China: A Retrospective Study, 1999-2018 ' , Frontiers in medicine , vol. 8 , 750898 . https://doi.org/10.3389/fmed.2021.750898Test

مصطلحات موضوعية: corneal transplantation, eye bank, a retrospective study, donor characteristics, transplantation, SURGICAL TECHNIQUES, VISUAL IMPAIRMENT, KERATOPLASTY, MANAGEMENT, ATTITUDES, DONATION, GERMANY

الوصف: Aim: This study aimed to analyze corneal transplantation trends and voluntary donor characteristics at the Chongqing Eye Bank in China. Methods: We retrospectively reviewed and analyzed data from January 1, 1999, to December 31, 2018, covering 5,397 preregistered voluntary donors, 1,955 actual donors, 3,910 donated tissues, and 2,374 corneal transplantations. Results: The 5,397 preregistered donors included 13 ethnic groups, with an overall mean age of 39.6 years (SD 21.5) and 3,010 were women (55.8%). The most prevalent education level was college and above (2,546, 47.2%), and the most common ethnic group was Han (5,335, 98.85%). Of the 1,955 actual donors, the male-to-female ratio was 3.3, and the mean age was 57.1 (SD 23.0 years). Based on population size in 2018, Jiangbei county was the most active in donation willingness, with ~60 x 10(-6) per capita, and the Yuzhong county was the most active in cornea donations, with ~451 x 0(-6) per capita. Of the 3,910 donated corneas, 2,540 (65.0%) were clinically used. Of those not used, 978 (71.4%) were rejected for poor corneal quality. The 2,374 (93.5%) corneal transplantation procedures were done at the Department of Ophthalmology of the First Affiliated Hospital of Chongqing Medical University and the rest (n = 166, 6.5%) were performed in other centers. Of those 2,374 corneal transplantations, there were 1,671 penetrating keratoplasty (70.39%), 700 anterior lamellar keratoplasty (29.49%), and three corneal endothelial transplantations in our center (0.13%). The number of annual corneal transplantations increased by nearly 10 times, from 35 cases in 1999 to 327 cases in 2018. Among them, cases of penetrating keratoplasty and anterior lamellar keratoplasty increased from 27, and eight cases in 1999 to 230 and 94 cases in 2018, respectively. Infectious keratitis (37.0%) was the leading indication for keratoplasty, followed by corneal scar (19.8%). Over the study period, corneal scars dropped from the first (41.1% in 1999-2003) to the second indication (20.5% in ...

الإتاحة: https://doi.org/10.3389/fmed.2021.750898Test
https://cris.maastrichtuniversity.nl/en/publications/e51be282-3e4a-4035-b832-f8317796cdb1Test

المؤلفون: Wang, Q.F., Yi, S.L., Su, G.N., Du, Z.Y., Pan, S., Huang, X.Y., Cao, Q.F., Yuan, G.X., Kijlstra, A., Yang, P.Z.

المصدر: Wang , Q F , Yi , S L , Su , G N , Du , Z Y , Pan , S , Huang , X Y , Cao , Q F , Yuan , G X , Kijlstra , A & Yang , P Z 2021 , ' Changes in the Gut Microbiome Contribute to the Development of Behcet's Disease via Adjuvant Effects ' , Frontiers in Cell and Developmental Biology , vol. 9 , 716760 . https://doi.org/10.3389/fcell.2021.716760Test

مصطلحات موضوعية: gut microbiome, autoimmune disease, Behcet's disease, fecal transplantation, T cells, neutrophils, REGULATORY T-CELLS, INTESTINAL HOMEOSTASIS, RHEUMATOID-ARTHRITIS, AUTOIMMUNITY, BARRIER, LIPOPOLYSACCHARIDE, DIFFERENTIATION, ACTIVATION, EXPRESSION, RESPONSES

الوصف: Behcet's disease (BD) is associated with considerable gut microbiome changes. However, it still remains unknown how the composition of the gut microbiome exactly affects the development of this disease. In this study, transplantation of stool samples from patients with active ocular BD to mice via oral gavage was performed. This resulted in decreases of three short chain fatty acids (SCFAs) including butyric acid, propionic acid and valeric acid in the feces of the BD-recipient group. Intestinal barrier integrity of mice receiving BD feces was damaged as shown by a decreased expression of tight junction proteins and was associated with the release of Lipopolysaccharides (LPS) in the circulation. The mice also showed a higher frequency of splenic neutrophils as well as an enrichment of genes associated with innate immune responses in the neutrophils and CD4 + T cells as identified by single cell RNA sequencing. Analysis of neutrophils and T cells functions in these mice showed an enhanced mesenteric lymph node and splenic Th1 and Th17 cell differentiation in association with activation of neutrophils. Transplantation of BD feces to mice and subsequent induction of experimental uveitis (EAU) or encephalomyelitis (EAE) led to an exacerbation of disease in both models, suggesting a microbial adjuvant effect. These findings suggest that the gut microbiome may regulate an autoimmune response via adjuvant effects including increased gut permeability and enhancement of innate immunity.

الإتاحة: https://doi.org/10.3389/fcell.2021.716760Test
https://cris.maastrichtuniversity.nl/en/publications/ddbc1c87-924b-4054-a5da-8a8326797736Test

المؤلفون: Pan, S., Tan, H.D., Chang, R., Wang, Q.F., Zhu, Y., Chen, L., Li, H.X., Su, G.N., Zhou, C.J., Cao, Q.F., Kijlstra, A., Yang, P.Z.

المصدر: Pan , S , Tan , H D , Chang , R , Wang , Q F , Zhu , Y , Chen , L , Li , H X , Su , G N , Zhou , C J , Cao , Q F , Kijlstra , A & Yang , P Z 2021 , ' High Ambient Temperature Aggravates Experimental Autoimmune Uveitis Symptoms ' , Frontiers in Cell and Developmental Biology , vol. 9 , 629306 . https://doi.org/10.3389/fcell.2021.629306Test

مصطلحات موضوعية: experimental autoimmune uveitis, inflammation, fumaric acid, succinic acid, ambient temperature

الوصف: Whether ambient temperature influences immune responses leading to uveitis is unknown. We thus tested whether ambient temperature affects the symptoms of experimental autoimmune uveitis (EAU) in mice and investigated possible mechanisms. C57BL/6 mice were kept at a normal (22 degrees C) or high temperature (30 degrees C) housing conditions for 2 weeks and were then immunized with human interphotoreceptor retinoid-binding protein (IRBP651-670) peptide to induce EAU. Histological changes were monitored to evaluate the severity of uveitis. Frequency of Th1 cells and Th17 cells was measured by flow cytometry (FCM). The expression of IFN-gamma and IL-17A mRNA was measured by real-time qPCR. The generation of neutrophil extracellular traps (NETs) was quantified by enzyme-linked immunosorbent assay (ELISA). Differential metabolites in the plasma of the mice kept in the aforementioned two ambient temperatures were measured via ultra-high-performance liquid chromatography triple quadrupole mass spectrometry quadrupole time of flight mass spectrometry (UHPLC-QQQ/MS). The differential metabolites identified were used to evaluate their effects on differentiation of Th1 and Th17 cells and generation of NETs in vitro. The results showed that EAU mice kept at high temperature experienced a more severe histopathological manifestation of uveitis than mice kept at a normal temperature. A significantly increased frequency of Th1 and Th17 cells in association with an upregulated expression of IFN-gamma and IL-17A mRNA was observed in the splenic lymphocytes and retinas of EAU mice in high temperature. The expression of NETs as evidenced by myeloperoxidase (MPO) and neutrophil elastase (NE), was significantly elevated in serum and supernatants of neutrophils from EAU mice kept at high temperature compared to the normal temperature group. The metabolites in the plasma from EAU mice, fumaric acid and succinic acid, were markedly increased in the high temperature group and could induce the generation of NETs via the NADPH ...

الإتاحة: https://doi.org/10.3389/fcell.2021.629306Test
https://cris.maastrichtuniversity.nl/en/publications/a2bc926c-2d3c-48b9-a875-75761c66883cTest

المؤلفون: Xu, J., Su, G.N., Huang, X.Y., Chang, R., Chen, Z.J., Ye, Z., Cao, Q.F., Kijlstra, A., Yang, P.Z.

المصدر: Xu , J , Su , G N , Huang , X Y , Chang , R , Chen , Z J , Ye , Z , Cao , Q F , Kijlstra , A & Yang , P Z 2021 , ' Metabolomic Analysis of Aqueous Humor Identifies Aberrant Amino Acid and Fatty Acid Metabolism in Vogt-Koyanagi-Harada and Behcet's Disease ' , Frontiers in Immunology , vol. 12 , 587393 . https://doi.org/10.3389/fimmu.2021.587393Test

مصطلحات موضوعية: Behcet's disease, Vogt-Koyanagi-Harada disease, amino acids, fatty acids, metabolomics, pathway, PREDICTION

الوصف: To investigate aqueous metabolic profiles in Vogt-Koyanagi-Harada (VKH) and Behcet's disease (BD), we applied ultra-high-performance liquid chromatography equipped with quadrupole time-of flight mass spectrometry in aqueous humor samples collected from these patients and controls. Metabolite levels in these three groups were analyzed by univariate logistic regression. The differential metabolites were subjected to subsequent pathway analysis by MetaboAnalyst. The results showed that both partial-least squares discrimination analysis and hierarchical clustering analysis showed specific aqueous metabolite profiles when comparing VKH, BD, and controls. There were 28 differential metabolites in VKH compared to controls and 29 differential metabolites in BD compared to controls. Amino acids and fatty acids were the two most abundant categories of differential metabolites. Furthermore, pathway enrichment analysis identified several perturbed pathways, including pantothenate and CoA biosynthesis when comparing VKH with the control group, and D-arginine and D-ornithine metabolism and phenylalanine metabolism when comparing BD with the control group. Aminoacyl-tRNA biosynthesis was altered in both VKH and BD when compared to controls. Our findings suggest that amino acids metabolism as well as two fatty acids, palmitic acid and oleic acid, may be involved in the pathogenesis of BD and VKH.

الإتاحة: https://doi.org/10.3389/fimmu.2021.587393Test
https://cris.maastrichtuniversity.nl/en/publications/7ad0c0f3-085c-4137-aa6d-c9fe852cb5f4Test

المؤلفون: Yang, P.Z., Tjen, Vanessa H.

المصدر: EJVES Vascular Forum ; volume 53, page 42-43 ; ISSN 2666-688X

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine, Surgery

الإتاحة: https://doi.org/10.1016/j.ejvsvf.2021.10.004Test
https://api.elsevier.com/content/article/PII:S2666688X21000435?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2666688X21000435?httpAccept=text/plainTest

المؤلفون: Qin, P., Ye, Z., Su, G.N., Kijlstra, A., Yang, P.Z.

المساهمون: RS: MHeNs - R3 - Neuroscience, MUMC+: MA Oogheelkunde (9)

المصدر: Frontiers in Medicine
Frontiers in Medicine, Vol 8 (2022)
Frontiers in medicine, 8:772439. Frontiers Media S.A.

مصطلحات موضوعية: outer-segment junction, inner-segment/outer-segment junction, Medicine (General), macular edema, genetic structures, General Medicine, eye diseases, inner-segment, R5-920, OCT feature, T-CELLS, Medicine, prognostic value, sense organs, Original Research, Vogt-Koyanagi-Harada disease

الوصف: Purpose: To determine optical coherence tomographic (OCT) features of macular edema (ME) and identify potential prognostic values for ME and visual outcomes in Vogt-Koyanagi-Harada disease (VKH).Methods: In the retrospective case series, a total of 1,377 VKH patients who were seen in a tertiary uveitis center between September 2011 and January 2018 were reviewed on their demographics, visual acuity, ocular and extraocular manifestations, modes of treatment, and OCT examinations. Of these patients, 79 (5.7%) having ME were included for analysis of OCT features. Four patients were missed without ME resolution, and the remaining 75 patients who either had ME resolved or were followed up for 2 years were included for analysis of disease outcomes.Results: Of the 115 affected eyes in these 79 patients, 100 (87.0%) had cystoid ME (CME), accounting for the most common OCT feature of VKH-related ME. Disruption of the inner-segment/outer-segment junction (IS/OS) band seen in 33 (28.7%) affected eyes of 24 (30.4%) patients was found as a risk factor for the development of persistent ME [10 of 62 (16.1%) vs. 13 of 13 (100%); P < 0.001] and a poor visual outcome (1.16 ± 0.42 vs. 1.17 ± 0.46 in logMAR unit; P = 0.89). CME patients with a concurrent choroidal neovascular membrane often had a disrupted IS/OS band, thus becoming refractory cases. A 6-month well-controlled intraocular inflammation following standard treatment regimens was found to associate with complete resolution of the refractory edema [4 of 5 (80%) vs. 2 of 13 (15%); P = 0.02].Conclusions: Intraretinal cystoid changes are most commonly seen in the edematous macula of VKH patients. Disruption of the IS/OS band is a useful risk sign for poor ME and visual outcomes in VKH-related ME, and a long-term well-controlled intraocular inflammation may be critical for the resolution of refractory cases.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f07ca708813ea8852fe15952c419beeaTest
http://europepmc.org/articles/PMC8785902Test

المؤلفون: Knight S.R., Shaw C.A., Pius R., Drake T.M., Norman L., Ademuyiwa A.O., Adisa A.O., Aguilera M.L., Al-Saqqa S.W., Al-Slaibi I., Bhangu A., Biccard B.M., Brocklehurst P., Costas-Chavarri A., Chu K., Dare A., Elhadi M., Fairfield C.J., Fitzgerald J.E., Ghosh D., Glasbey J., van Berge Henegouwen M., Ingabire J.C.A., Kingham T.P., Lapitan M.C., Lawani I., Lieske B., Lilford R., Martin J., Mclean K.A., Moore R., Morton D., Nepogodiev D., Ntirenganya F., Pata F., Pinkney T., Qureshi A.U., Ramos-De la Medina A., Riad A., Salem H.K., Simões J., Spence R., Smart N., Tabiri S., Thomas H., Weiser T.G., West M., Whitaker J., Harrison E.M., Gjata A., Modolo M.M., King S., Chan E., Nahar S.N., Waterman A., Vervoort D., Bedada A.G., De Azevedo B., Figueiredo A.G., Sokolov M., Barendegere V., Ekwen G., Agarwal A., Liu Q., Camilo Correa J., Malemo K.L., Bake J., Mihanovic J., Kuncarová K., Orhalmi J., Teras J., Kechagias A., Arnaud A.P., Lindert J., Kalles V., Aguilera-Arevalo M.-L., Recinos G., Baranyai Z., Kumar B., Neelamraju Lakshmi H., Zachariah S.K., Alexander P., Kumar Venkatappa S., Pramesh C., Amandito R., Fleming C., Ansaloni L., Pellino G., Altibi A.M., Nour I., Hamdun I., Ghellai A.M., Venskutonis D., Poskus T., Zilinskas J., Malemia P., Tew Y.Y., Borg E., Ellul S., Wafqui F.Z., Borowski D.W., van Dalen A.S., Wells C., Adamou H., Søreide K., Alser O., Tahboub H., Segovia Lohse H.A., Shu Yip S., Major P., Sampaio Soares A., Bratu M.R., Litvin A., Vardanyan A., Allen Ingabire J.C., Gudal A., Albati N., Juloski J., Rems M., Rayne S., Van Straten S., Moodley Y., Ortega Vázquez I., Ruiz-Tovar J., Senanayake K.J., Thalgaspitiya S.P.B., Omer O.A., Homeida A., Cengiz Y., Clerc D., Alshaar M., Bouaziz H., Altinel Y., Doe M., Freigofer M., Teasdale E., Kabariti R., Clements J.M., Ashfaq A., Azodo I., Wagner G., Trostchansky I., Maimbo M., Linyama D., Nina H., Zeko A., Fermani C.G., Villalobos S., Carballo F., Farina P., Guckenheimer S., Dickfos M., Ajmera A., Chong C., Gourlay R., Hussaini S., Lee Y.J., Majid A., Martin P., Miles R., Morris O.J., Phua J., Ridley W., Saluja T., Tan R.R., Teh J., Wells A., Arora B., Dollie Q., Ho D., Ma Y., Perera O.M., Truong A., Dawson A.C., Lim B., Pahalawatta U., Phan J., Woon-Shoo-Tong X.-M.S., Yeoh A., Charman L., Drane A., Laura S., Lo C.C.W., Mozes A., Poon R., Tan H.H., Wall E., Chopra P., De Giovanni J., Dhital B., Draganic B., Duller A., Gani J., Goh Y.K., Jeong J.Y., McManus B., Nagappan P., Pockney P., Rugendyke A., Sarrami M., Smith S., Wills V., Wong H.V., Ye G., Zhang G., Brooker E., Feng D., Lau B., Ngai C., Birks S., Gyorki D., Otero de Pablos J., Abbosh A., Gillespie C., Mahmoud A., Kwan B., Lawson J., Warwick A., Bingham J., Cockbain A.J., Dudi-Venkata N.N., Ellaby-Hall J., Finlay B., Humphries E., Pisaniello J., Pisaniello M., Salih S., Sammour T., Abd Wahab H.H., De Silva A., Hayward N., Iyer K., Maddern G., Prevost G.A., Annapureddy N., Settipalli K.P., Yeo J., Hempenstall L., Pham L., Purcell S., Talavera C., Vaska A.I., Chaggar G., Chrapko P., Cocco A., Coulter-Nile S.M.C.J., Ctercteko G., French J., Gong H., Gosselink M., Jegathees T., Jin I., Kalachov M., Kiefhaber K., Lee K., Luong J., Phan S., Pleass H., Veale K., Zeng Z., Au A., DeBiasio A., Deng I., Myooran J., Nair A., Stewart P., Stift A., Unger L.W., Wimmer K., Ahmed N., Hasan S., Rahman S., O'Shea M., Padmore G., Peters A., Perduca P., Pulcina G., Tinton N., Buxant F., Dabin E., Garofalo G., Dossou F., Gnangnon F.H.R., Imorou Souaibou Y., Motlaleselelo P., Tlhomelang O., Lima Buarque I., Mendonça Ataíde Gomes G., Vieira Barros A., Batashki I., Damianov N., Stoyanov V., Dardanov D., Maslyankov S., Petkov P., Todorov G., Zhivkov E., Akisheva A., Castilla Moreno M.A., Genov G., Ilieva I., Ivanov T., Karamanliev M., Khan A., Mitkov E., Yotsov T., Atanasov B., Belev N., Slavchev M., Nsengiyumva C., Jones E., Stock S., Kyota S., Brown J., Mabanza K. T., Nigo Samuel L., Otuneme C., Prosper N., Umenze F., Boutros M., Caminsky N., Dumitra S., Garfinkle R., Morency D., Salama E., Banks A., Ferri L., He H., Katz A., Liberman A.S., Meterissian S., Pang A., Parvez E., Hameed U., Osman F., Sequeira S., Coburn N., Jaffer A., Karanicolas P., Mosseler M., Musselman R., Liu X., Yip C.W., Garces-Otero J.S., Guzman C., Sierra S., Uribe Valencia A., Cabrera Rivera P.A., Camelo S., Gonzalez A., González-Orozco A., Mosquera Paz M.S., Perez Rivera C.J., Gonzalez F., Isaza-Restrepo A., Nino- Torres L., Arias Madrid N., Mendoza Arango M.C., Tsandiraki J., Jemendžic D., Kocman B., Šuman O., Canic R., Jurišic D., Karakas I., Krizanovic Rupcic A., Pitlovic V., Samardžic J., Kopljar M., Bacic I., Domini E., Karlo R., Miljanic D., Simic A., Ahmed M., Al Nassrallah M., Altaf R., Amjad T., Eltoum R., Haidar H., Hassan A., Khalil O., Qasem M., Ramesh R., Sajith G., Wisal M., Žatecký J., Bujda M., Jirankova K., Paclik A., Abdallah A., Abdulgawad Almogy M., Ayman El-sawy E., ElFayoumy A.M., Elghareeb N., Esmat N.A., Fadel A., Habater A., Hamdy H., Hefni A., Kamal M., Mohamed Abobakr N., Sayed A., Shaker N., Taha E., Tharwat H., Zakaria O., Abdelmotaleb I., Al-Dhufri A., Al-Himyari H.S., El sheikh E., Eldmaty A., Elkhalawy A., M.Elkhashen A., Magdy K., Mostafa S., Sadia H.D., Saleh M.M., Samir D., Yahia Mohamed Ali M., A. Nassar M., Abdelhady S., Abdelrazek A., Abdelsalam I., El-Sawy A., Essam E., Gadelkarim M., Ghaly K., Hassabalnaby M., Masarani R., Mohamed Shaaban N., Sabry A., Salem M., Soliman N.A., Zahran D., Abou El.soud M.R., Badr E.T., Borham H., Elmeslemany N., Elsayed M., Elsherif F., Eslam S., Gaber G., Ibrahim S., Kamh Y., Mohamed S.G., Morshedy E., Omar C., Salem Soliman F., Abdelkawy S., Abdelmohsen N., Abdelshakour M., Dahy A., Gamal N., Gamal M., Hasan A., Hetta H., Mousa N., Omar M., Rabie S., Saad M., Saleh B., Sayed Mohamed M., Shawqi M., Abdelhady Mousa H., Alnoury M., Elbealawy M., Elshafey A., Essam Ibrahim El Desouki Muhammad Ahmed M., Ghonaim M., Hgag F., Ibrahim M., Morsy M., Reda Loaloa M., Refaat A., Samir H., Shahien F., Sobhy M., Sroor F., Abdellatif E., Adel M., Afifi A.A., Afifi E., Antaky M., Dawoud A., El Zoghby N., El-remaily A., Elzanfaly A.A., Gadallah A., Gamal F.A., Hashem O., Medhat Youssef S., Muhammad Attyah A., Munir M., Shazly O., Wilson K., Adel S., Ali A., Eid E., Elhelow E., Elmahdy M., Elshatby B., Hossam el-din Zakaria A., Hossny A., Ibrahim E., M.Yonis A., Metwalli M., Yousry B., Zid E., A Yacoub M., Abdelhakim A., Abouelsoad N., Alkhatib M., Ashraf A., Elazab Y., Elfanty M., Elkabir O., Elshimy A., Elsobky H., Eskander J., Gad A., Hamsho W., Khaled Abdelwahed N., Magdy M., Moharam D., Osama A., Ramadan S., Roum R., Sayed T., Shehada T., Zidan A.M., Abbas K., Attia M., Balata M., El Nakeeb A., Elewaily M.I.E., Elfallal A., Elfeki H., Elkhadragy A., Emile S., Ezzat H., Hosni H., Mansour I., Omar W., Othman G., Sadek K., Shalaby M., Shehab-Eldeen N., Anas khalifa R., Badr H., Eldeep M., Eldeep A., Eldoseuky mohammed A., Khallaf S., Magdy Hegazy E., Mahmoud R., Mikhail P., Morsi M., Mowafy S., Raafat D., Safy A., Sera M., Sera A.S., AbdAllah M.S.M., Abdelkader M., Abdou A.O., Ahmed A., Gaafar S., Ibrahim negm F., Lapic M., Maher A., Mahmoud H., Mostafa A., Samir M., Samy F., Semeda N., Shalaby H.I., El-taweel A., Galal Elnagar A., 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Akinkuolie A., Mosanya A., Ayandipo O., Elemile P., Lawal T.A., Ali SANI S., Garba S., Hauwa SANI R., Olori S., Onyebuashi H., Umoke I., Adenuga A., Adeyeye A., Habeeb O., Lawal B., Nasir A., Aahlin E.K., Kjønås D., Myrseth E., Abbasy J., Alvi A., Saleem O., Afzal A., Nazir A., Farooq M., Liaqat A., Naqi S.A., Raza A., Sarfraz M., Sarwar M., Banglani M., Munir A., Sehrish R., Ayub B., Sayyed R., Altaf A., Ayub S., Saeed K., Syed B., Akbar S.A., Anwer A.W., Khan R.N., Khan A.I., Khattak S., Mohtasham S., Parvaiz M.A., Syed A.A., Ansari A.B., Shahzad N., Khaliq T., Rashid I., Waqar S.H., Abu Al-saleem H., Abu Alqumboz A., Alqadi M., Amro A., Assa R., Awesat E., Ayyad R., Hammad M., Haymony A., Hijazi B., Hmeidat B., Lahaseh R., Qawasmi A., Rajabi A., Shehada M., Shkokani S., Yaghi Y., Yaghi N., AlZohour M., Farid M., Habes Y.M., Juba W., Nubani Y., Rabee A., Sa'deh M., Abed S., Al basos I., Alswerki M., Ashour D., Awad I., Diab S., El Jamassi A., El-Kahlout S., Elhout S., Hajjaj A.N.K., 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المساهمون: Knight, S. R., Shaw, C. A., Pius, R., Drake, T. M., Norman, L., Ademuyiwa, A. O., Adisa, A. O., Aguilera, M. L., Al-Saqqa, S. W., Al-Slaibi, I., Bhangu, A., Biccard, B. M., Brocklehurst, P., Costas-Chavarri, A., Chu, K., Dare, A., Elhadi, M., Fairfield, C. J., Fitzgerald, J. E., Ghosh, D., Glasbey, J., van Berge Henegouwen, M., Ingabire, J. C. A., Kingham, T. P., Lapitan, M. C., Lawani, I., Lieske, B., Lilford, R., Martin, J., Mclean, K. A., Moore, R., Morton, D., Nepogodiev, D., Ntirenganya, F., Pata, F., Pinkney, T., Qureshi, A. U., Ramos-De la Medina, A., Riad, A., Salem, H. K., Simões, J., Spence, R., Smart, N., Tabiri, S., Thomas, H., Weiser, T. G., West, M., Whitaker, J., Harrison, E. M., Gjata, A., Modolo, M. M., King, S., Chan, E., Nahar, S. N., Waterman, A., Vervoort, D., Bedada, A. G., De Azevedo, B., Figueiredo, A. G., Sokolov, M., Barendegere, V., Ekwen, G., Agarwal, A., Liu, Q., Camilo Correa, J., Malemo, K. L., Bake, J., Mihanovic, J., Kuncarová, K., Orhalmi, J., Teras, J., Kechagias, A., Arnaud, A. P., Lindert, J., Kalles, V., Aguilera-Arevalo, M. -L., Recinos, G., Baranyai, Z., Kumar, B., Neelamraju Lakshmi, H., Zachariah, S. K., Alexander, P., Kumar Venkatappa, S., Pramesh, C., Amandito, R., Fleming, C., Ansaloni, L., Pellino, G., Altibi, A. M., Nour, I., Hamdun, I., Ghellai, A. M., Venskutonis, D., Poskus, T., Zilinskas, J., Malemia, P., Tew, Y. Y., Borg, E., Ellul, S., Wafqui, F. Z.

الوصف: Background: 80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LMICs). We compared postoperative outcomes in breast, colorectal, and gastric cancer surgery in hospitals worldwide, focusing on the effect of disease stage and complications on postoperative mortality. Methods: This was a multicentre, international prospective cohort study of consecutive adult patients undergoing surgery for primary breast, colorectal, or gastric cancer requiring a skin incision done under general or neuraxial anaesthesia. The primary outcome was death or major complication within 30 days of surgery. Multilevel logistic regression determined relationships within three-level nested models of patients within hospitals and countries. Hospital-level infrastructure effects were explored with three-way mediation analyses. This study was registered with ClinicalTrials.gov, NCT03471494. Findings: Between April 1, 2018, and Jan 31, 2019, we enrolled 15 958 patients from 428 hospitals in 82 countries (high income 9106 patients, 31 countries; upper-middle income 2721 patients, 23 countries; or lower-middle income 4131 patients, 28 countries). Patients in LMICs presented with more advanced disease compared with patients in high-income countries. 30-day mortality was higher for gastric cancer in low-income or lower-middle-income countries (adjusted odds ratio 3·72, 95% CI 1·70-8·16) and for colorectal cancer in low-income or lower-middle-income countries (4·59, 2·39-8·80) and upper-middle-income countries (2·06, 1·11-3·83). No difference in 30-day mortality was seen in breast cancer. The proportion of patients who died after a major complication was greatest in low-income or lower-middle-income countries (6·15, 3·26-11·59) and upper-middle-income countries (3·89, 2·08-7·29). Postoperative death after complications was partly explained by patient factors (60%) and partly by hospital or country (40%). The absence of consistently available ...

العلاقة: volume:397; firstpage:387; lastpage:397; numberofpages:11; journal:THE LANCET; https://hdl.handle.net/11587/520769Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85099822352

الإتاحة: https://doi.org/10.1016/S0140-6736Test(21)00001-5
https://hdl.handle.net/11587/520769Test

المؤلفون: Tan, H.D., Su, G.N., Tan, X., Qin, Y., Chen, L., Yuan, G.X., Kijlstra, A., Yang, P.Z.

المصدر: Tan , H D , Su , G N , Tan , X , Qin , Y , Chen , L , Yuan , G X , Kijlstra , A & Yang , P Z 2021 , ' SNP-mediated binding of TBX1 to the enhancer element of IL-10 reduces the risk of Behcet's disease ' , Epigenomics , vol. 13 , no. 19 , pp. 1523-1537 . https://doi.org/10.2217/epi-2021-0215Test

مصطلحات موضوعية: Behcet's disease, IL-10, polymorphisms, super-enhancer, TBX1, GENOME-WIDE ASSOCIATION, EXPRESSION, INTERLEUKIN-10, IDENTIFICATION, IL23R-IL12RB2, CELLS, IL10, DATABASE, CHINESE

الوصف: Aims: The genetic association between Behcet's disease susceptibility and IL-10 has been confirmed in multiple cohorts, but the underlying mechanism of this association remains unclear. Materials & methods: We combined public resources and laboratory experiments (electrophoretic mobility shift assays, chromatin immunoprecipitation, luciferase reporter gene and CRISPR/Cas9 genome editing) to analyze transcription factor binding and enhancer activity controlling IL-10 expression. Results & conclusion: The T allele of noncoding rs3024490 within super-enhancer elements is able to specifically bind TBX1 and, in turn, promotes the enhancer activity and increased expression of IL-10. However, a relative deficiency in TBX1 in Behcet's disease patients leads to the low expression of IL-10 and increased risk of developing Behcet's disease.Lay abstract Behcet's disease is an important cause of blindness. Previous reports show that genetic factors are linked with this disease, although the exact genetic mechanism is unclear. Many of these genetic factors are involved in the control of the immune response, including a large family of proteins known as cytokines. Some of the cytokines are proinflammatory while others can dampen the inflammatory response. An example of the latter is the IL-10 cytokine. We found that individuals carrying a specific site in the noncoding region of the IL-10 gene had a higher risk of Behcet's disease than other noncarriers. This study was designed to further investigate the biological mechanisms explaining the role of the specific site in the development of Behcet's disease. The results show that this specific site affects the binding of an important transcription factor, TBX1, which reduces IL-10 production. The dysregulated control of IL-10 explains why individuals with this genetic trait are more susceptible to developing Behcet's disease.

الإتاحة: https://doi.org/10.2217/epi-2021-0215Test
https://cris.maastrichtuniversity.nl/en/publications/ec8e9d5c-a5d9-4286-a855-ce37d329887cTest