المؤلفون: Yüksel, B., Ayan, E., Utlu, Z.

مصطلحات موضوعية: AAO templates, Composite Material, Pumice, Salt-impregnation, Thermal Energy Storage (TES), Alumina, Aluminum oxide, Composite materials, Heat storage, Magnesium compounds, Renewable energy resources, Sorbents, Sorption, Storage (materials), Structure (composition), Anodic aluminum oxide template, Composites material, Composites structures, Heat storage systems, Pumouse, Storage capability, Thermal energy storage, Thermo-chemical heat storages, Chlorine compounds

الوصف: 36th International Conference on Efficiency, Cost, Optimization, Simulation and Environmental Impact of Energy Systems, ECOS 2023 -- 25 June 2023 through 30 June 2023 -- -- 192881 ; In recent years, when the energy demand has increased day by day, the continuity of energy has become an important issue as well as the need to meet the demand from nature-friendly technologies. Thermochemical Heat Storage (THS) systems are among the important approaches that help the continuous and efficient use of renewable energy resources with its high energy storage density and long storage times. Researches on composite structures consisting of sorbent salt and porous matrix couple among storage materials are noteworthy for the development of sorption materials and thus the heat storage system. Composite sorbents were prepared by impregnating sorbent salt (CaCl2 and MgCl2 etc.) as single and mixture into two different matrix materials, anodic Aluminium oxide (AAO) template and pumice (P), is carried out in this study. The cyclical heat storage behaviours of the obtained composite structures were investigated with the laboratory scale thermochemical heat exchanger prototype system. The aim of this study is that the effect of host matrices with different pore diameters one of whose is produced in the laboratory and other is natural on the thermochemical heat storage capability. Moreover, different sorbent salts which are impregnated into these pores on the heat storage capability is also compared with the help of prototype system. © (2023) by ECOS 2023 All rights reserved. ; Türkiye Bilimsel ve Teknolojik Araştırma Kurumu, TÜBİTAK: 119M073 ; Acknowledgments This study was supported by the Scientific and Technological Research Council of Turkey (TUBİTAK) (Project No: 119M073).

العلاقة: 36th International Conference on Efficiency, Cost, Optimization, Simulation and Environmental Impact of Energy Systems, ECOS 2023; Konferans Öğesi - Uluslararası - Kurum Öğretim Elemanı; https://doi.org/10.52202/069564-0209Test; https://hdl.handle.net/20.500.12831/18002Test; 2322; 2329; 2-s2.0-85174484444

الإتاحة: https://doi.org/10.52202/069564-0209Test
https://doi.org/20.500.12831/18002Test
https://hdl.handle.net/20.500.12831/18002Test

المؤلفون: Yüksel, B�?ra, Hızlı Deniz, Ayşen Aslı, Şahin, Fikrettin, Sahin, Kazim, Türkel, Nezaket

المصدر: Frontiers in Pharmacology ; volume 14 ; ISSN 1663-9812

مصطلحات موضوعية: Pharmacology (medical), Pharmacology

الوصف: Currently, use of cannabinoids is limited to improve adverse effects of chemotherapy and their palliative administration during treatment is curiously concomitant with improved prognosis and regressed progression in patients with different tumor types. Although, non-psychoactive cannabidiol (CBD) and cannabigerol (CBG) display antineoplastic effects by repressing tumor growth and angiogenesis both in cell line and animal models, their use as chemotherapeutic agents is awaiting further investigation. Both clinical and epidemiological evidence supported by experimental findings suggest that micronutrients such as curcumin and piperine may present a safer strategy in preventing tumorigenesis and its recurrence. Recent studies demonstrated that piperine potentiates curcumin’s inhibitory effect on tumor progression via enhancing its delivery and therapeutic activity. In this study, we investigated a plausible therapeutic synergism of a triple combination of CBD/CBG, curcumin, and piperine in the colon adenocarcinoma using HCT116 and HT29 cell lines. Potential synergistic effects of various combinations including these compounds were tested by measuring cancer cell proliferation and apoptosis. Our findings revealed that different genetic backgrounds of HCT116 and HT29 cell lines resulted in divergent responses to the combination treatments. Triple treatment showed synergism in terms of exhibiting anti-tumorigenic effects by activating the Hippo YAP signaling pathway in the HCT116 cell line.

الإتاحة: https://doi.org/10.3389/fphar.2023.1145666Test

المؤلفون: Demirhan, O., Yüksel, B., Yilmaz, S., Cetinel, N.

المصدر: Actas Dermo-Sifiliográficas ; volume 114, issue 10, page T918-T920 ; ISSN 0001-7310

مصطلحات موضوعية: Dermatology, Histology, Pathology and Forensic Medicine

الإتاحة: https://doi.org/10.1016/j.ad.2023.09.007Test
https://api.elsevier.com/content/article/PII:S0001731023007366?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0001731023007366?httpAccept=text/plainTest

المؤلفون: Demirhan, O., Yüksel, B., Yilmaz, S., Cetinel, N.

المصدر: Actas Dermo-Sifiliográficas ; volume 114, issue 10, page 918-920 ; ISSN 0001-7310

مصطلحات موضوعية: Dermatology, Histology, Pathology and Forensic Medicine

الإتاحة: https://doi.org/10.1016/j.ad.2022.11.017Test
https://api.elsevier.com/content/article/PII:S0001731023004143?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0001731023004143?httpAccept=text/plainTest

المؤلفون: Yüksel, B, Özveren, N, Yeşil, Ç

المصدر: Nigerian Journal of Clinical Practice ; volume 27, issue 6, page 759-765 ; ISSN 1119-3077 2229-7731

الوصف: Objectives: This study aims to assess the diagnostic accuracy of an artificial intelligence (AI) system employing deep learning for identifying dental plaque, utilizing a dataset comprising photographs of permanent teeth. Materials and Methods: In this study, photographs of 168 teeth belonging to 20 patients aged between 10 and 15 years, who met our criteria, were included. Intraoral photographs were taken of the patients in two stages, before and after the application of the plaque staining agent. To train the AI system to identify plaque on teeth with dental plaque that is not discolored, plaque and teeth were marked on photos with exposed dental plaque. One hundred forty teeth were used to construct the training group, while 28 teeth were used to create the test group. Another dentist reviewed images of teeth with dental plaque that was not discolored, and the effectiveness of AI in detecting plaque was evaluated using pertinent performance indicators. To compare the AI model and the dentist’s evaluation outcomes, the mean intersection over union (IoU) values were evaluated by the Wilcoxon test. Results: The AI system showed higher performance in our study with a precision of 82% accuracy, 84% sensitivity, 83% F1 score, 87% accuracy, and 89% specificity in plaque detection. The area under the curve (AUC) value was found to be 0.922, and the IoU value was 76%. Subsequently, the dentist’s plaque diagnosis performance was also evaluated. The IoU value was 0.71, and the AUC was 0.833. The AI model showed statistically significantly higher performance than the dentist ( P < 0.05). Conclusions: The AI algorithm that we developed has achieved promising results and demonstrated clinically acceptable performance in detecting dental plaque compared to a dentist.

الإتاحة: https://doi.org/10.4103/njcp.njcp_862_23Test

المؤلفون: Yüksel B, Kartı Ö, Kusbeci T

المصدر: Clinical Ophthalmology, Vol Volume 11, Pp 2183-2190 (2017)

مصطلحات موضوعية: Cataract surgery, macular edema, prevention, nepafenac, diabetic patients., Ophthalmology, RE1-994

الوصف: Bora Yüksel, Ömer Karti, Tuncay Kusbeci Department of Ophthalmology, Bozyaka Training and Research Hospital, İzmir, Turkey Abstract: Since its first description, the prevention of pseudophakic cystoid macular edema (PCME) continues to pose challenges for ophthalmologists. Recent evidence suggests that prophylaxis is unnecessary in patients without risk factors. Diabetes mellitus is generally considered as a risk factor for the development of PCME after cataract surgery since it causes breakdown of the blood–retinal barrier. Diabetic retinopathy (DR) increases the risk even further. Therefore, prophylactic nonsteroidal anti-inflammatory drugs (NSAIDs) should be considered in diabetic patients, especially if they have DR. NSAIDs block the cyclooxygenase enzymes responsible for prostaglandin production and reduce the incidence of PCME after cataract surgery. Nepafenac seems superior to other NSAIDs in terms of ocular penetration allowing higher and sustained therapeutic levels in retina and choroid. Topical steroids are less effective and may cause intraocular pressure increase limiting their long-term use. Nepafenac is cost effective, when the burden of PCME prevention is compared with the burden of treatment. Prevention is much cheaper and less harmful than invasive treatments like periocular or intravitreal injections. Overall, both nepafenac 0.1% and nepafenac 0.3% are well tolerated. They should be used carefully in patients with compromised corneas such as those with severe dry eye or penetrating grafts. If otherwise healthy cataract patients have ≥2 risk factors, like PCME in the other eye or posterior capsule rupture during surgery, treatment should be considered. Once-daily nepafenac 0.3% dosing may improve postoperative outcomes through increased patient compliance and may reduce treatment burden further. Every patient should be assessed in terms of risks/benefits of the treatment, in individual basis, before cataract surgery. Keywords: cataract surgery, macular edema, prevention, nepafenac, diabetic patients

وصف الملف: electronic resource

العلاقة: https://www.dovepress.com/topical-nepafenac-for-prevention-of-post-cataract-surgery-macular-edem-peer-reviewed-article-OPTHTest; https://doaj.org/toc/1177-5483Test

الوصول الحر: https://doaj.org/article/b5cb5fae89844692aad580d33487eb70Test

المؤلفون: Topaloğlu, H., Eser, G., Yüksel, B.

المصدر: Neuromuscular Disorders ; volume 33, page S184 ; ISSN 0960-8966

مصطلحات موضوعية: Genetics (clinical), Neurology (clinical), Neurology, Pediatrics, Perinatology and Child Health

الإتاحة: https://doi.org/10.1016/j.nmd.2023.07.462Test
https://api.elsevier.com/content/article/PII:S0960896623006429?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0960896623006429?httpAccept=text/plainTest

المؤلفون: Bozalan M., Türksoy V.A., Yüksel B., Güvendik G., Söylemezoğlu T.

المساهمون: Belirlenecek

مصطلحات موضوعية: Custom security, FAAS, Lead, Soft plastic toys, Toxicology

الوصف: Objective: Lead is a heavy metal that can affect virtually every organ system in the body, particularly the nervous, hematologic and gastrointestinal systems. Children are more sensitive to the health problems as a consequence of lead exposure than adults. Studies have shown that lead contamination on the ground of inexpensive toys, much of them imported from China, is widespread. The goal of this study was to develop a method for determination of the lead levels in plastic toys using flame atomic absorption spectroscopy, and to evaluate whether or not these inexpensive toys are possible sources of toxic lead for children. Methods: This study involved 50 plastic toys. Turkish (n=19) and Chinese brands (n=31) of inexpensive plastic toys were purchased from the different places of Ankara in Turkey. Toys were classified as their color and origin of country. Samples were prepared by use of microwave acid digestion procedure. Flame atomic absorption spectroscopy was utilized for quantification of lead in the samples which were examined. Results: The method showed linearity in the range of 0-4 mg/kg with a detection and quantification limit equal to 0.01 mg/kg and 0.03 mg/kg, respectively. Lead levels in toys ranged between 0.10 mg/kg and 384.40 mg/kg while median and mean (±SD) lead levels were calculated as 50.01 mg/kg and 68.66±59.72 mg/kg, respectively. Mean lead levels of Turkish brands toys and Chinese brand toys were found 41.44±46.33 mg/ kg and 85.35±91.30 mg/kg, respectively. Samples were classified as their origin of country and colors. Hence, Chinese toys had statistically higher lead levels than Turkish brands toys (p=0.01; p < 0.05). In addition, black toys (144.01 ± 121.61 mg/kg) had statistically higher lead levels than other colored ones (54.31± 61.26 mg/ kg) (p < 0.05). Conclusion: Thus, it is suggested that inexpensive plastic toys are the potential health risk in terms of lead toxicity for the children. This study can be considered as a preliminary step to examine the potential lead exposure ...

العلاقة: Turk Hijyen ve Deneysel Biyoloji Dergisi; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://doi.org/10.5505/TurkHijyen.2019.58234Test; https://hdl.handle.net/20.500.12697/1663Test; 76; 243; 254

الإتاحة: https://doi.org/20.500.12697/1663Test
https://doi.org/10.5505/TurkHijyen.2019.58234Test
https://hdl.handle.net/20.500.12697/1663Test

المؤلفون: Gürbüz F., Taştan M., Turan İ., Yüksel B.

المساهمون: Çukurova Üniversitesi

مصطلحات موضوعية: Children, Inappropriate antidiuretic hormone syndrome, Tolvaptan

الوصف: PubMedID: 30257818 ; Inappropriate antidiuretic hormone syndrome (SIADH) may develop after intracranial surgery. SIADH in the pediatric age group is usually encountered in patients with an intracranial mass both before and after surgery. Fluid restriction is the standard therapy in SIADH. However, a resistant, hyponatremic pattern may be encountered in some cases. Vaptans have been recently introduced for treatment of hyponatremia due to SIADH. There is inadequate data concerning tolvaptan treatment in pediatric patients. We present a 13 year-old female with SIADH of triphasic episode who was transferred to our clinic after surgery for craniopharyngioma. Resistant hyponatremia did not resolve despite fluid restriction and hypertonic saline support. The patient responded rapidly to a single dose of tolvaptan, with no adverse effect, which resulted in successful control of her SIADH. © 2019 by Turkish Pediatric Endocrinology and Diabetes Society.

العلاقة: JCRPE Journal of Clinical Research in Pediatric Endocrinology; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://dx.doi.org/10.4274/jcrpe.galenos.2018.2018.0182Test; https://hdl.handle.net/20.500.12605/14404Test; 11; 202; 206

الإتاحة: https://doi.org/20.500.12605/14404Test
https://doi.org/10.4274/jcrpe.galenos.2018.2018.0182Test
https://hdl.handle.net/20.500.12605/14404Test

المؤلفون: Kışla Ekinci R.M., Gürbüz F., Balcı S., Bişgin A., Taştan M., Yüksel B., Yılmaz M.

المساهمون: Çukurova Üniversitesi

مصطلحات موضوعية: GALNT3, Hyperphosphatemia, Tumoral calcinosis

الوصف: PubMedID: 30015621 ; Inactivating autosomal recessive mutations in fibroblast growth factor 23 (FGF23), klotho (KL) and polypeptide N-acetylgalactosaminotransferase 3 (GALNT3) genes lead to a rare disorder, hyperphosphatemic familial tumoral calcinosis (HFTC). Patients with HFTC present with hyperphosphatemia and tumor like soft tissue calcifications. Although 78% of patients develop their first symptoms between the ages of 2-13 years, diagnosis is usually delayed until adulthood. Some individuals with the same genetic defect develop a condition named hyperphosphatemic hyperostosis syndrome. Herein we report two siblings suffering from periarticular, warm, hard and tender subcutaneous masses. Subcutaneous calcifications were present on X-ray and biopsy results were consistent with calcinosis in both patients. Laboratory results showed marked hyperphosphatemia and elevated renal tubular phosphate reabsorption rates, normal renal function tests and normal serum 25-hydroxyvitamin D levels. Thus, we suspected HFTC and performed next generation sequencing for the GALNT3 gene, reported as the most frequent cause. A novel homozygote P85Rfs*6 (c.254_255delCT) mutation in GALNT3 was identified in both siblings. Our report adds two new patients to the literature about this rare genetic disease and suggests that small deletions in the GALNT3 gene may be related with HFTC phenotype. © 2019 by Turkish Pediatric Endocrinology and Diabetes Society.

العلاقة: JCRPE Journal of Clinical Research in Pediatric Endocrinology; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://dx.doi.org/10.4274/jcrpe.galenos.2018.2018.0134Test; https://hdl.handle.net/20.500.12605/16017Test; 11; 94; 99

الإتاحة: https://doi.org/20.500.12605/16017Test
https://doi.org/10.4274/jcrpe.galenos.2018.2018.0134Test
https://hdl.handle.net/20.500.12605/16017Test