المؤلفون: Pengfei Cui, Xiaoyi Li, Caihua Huang, Donghai Lin

المصدر: Journal of Cachexia, Sarcopenia and Muscle, Vol 15, Iss 3, Pp 781-793 (2024)

مصطلحات موضوعية: Cancer cachexia, Metabolic pathway, Metabolomics, Therapeutic target, Diseases of the musculoskeletal system, RC925-935, Human anatomy, QM1-695

الوصف: Abstract Cancer cachexia (CC) is a devastating metabolic syndrome characterized by skeletal muscle wasting and body weight loss, posing a significant burden on the health and survival of cancer patients. Despite ongoing efforts, effective treatments for CC are still lacking. Metabolomics, an advanced omics technique, offers a comprehensive analysis of small‐molecule metabolites involved in cellular metabolism. In CC research, metabolomics has emerged as a valuable tool for identifying diagnostic biomarkers, unravelling molecular mechanisms and discovering potential therapeutic targets. A comprehensive search strategy was implemented to retrieve relevant articles from primary databases, including Web of Science, Google Scholar, Scopus and PubMed, for CC and metabolomics. Recent advancements in metabolomics have deepened our understanding of CC by uncovering key metabolic signatures and elucidating underlying mechanisms. By targeting crucial metabolic pathways including glucose metabolism, amino acid metabolism, fatty acid metabolism, bile acid metabolism, ketone body metabolism, steroid metabolism and mitochondrial energy metabolism, it becomes possible to restore metabolic balance and alleviate CC symptoms. This review provides a comprehensive summary of metabolomics studies in CC, focusing on the discovery of potential therapeutic targets and the evaluation of modulating specific metabolic pathways for CC treatment. By harnessing the insights derived from metabolomics, novel interventions for CC can be developed, leading to improved patient outcomes and enhanced quality of life.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2190-5991Test; https://doaj.org/toc/2190-6009Test

الوصول الحر: https://doaj.org/article/47f3e69627d340a58031be6152ac5d78Test

المؤلفون: Zhiyuan Mao, Xingyue Li, Zhenhua Li, Liangliang Shen, Xiaoyi Li, Yanyan Yang, Wenda Wang, Tingyun Kuang, Jian-Ren Shen, Guangye Han

المصدر: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

مصطلحات موضوعية: Science

الوصف: Abstract Cryptophyte algae are an evolutionarily distinct and ecologically important group of photosynthetic unicellular eukaryotes. Photosystem II (PSII) of cryptophyte algae associates with alloxanthin chlorophyll a/c-binding proteins (ACPs) to act as the peripheral light-harvesting system, whose supramolecular organization is unknown. Here, we purify the PSII-ACPII supercomplex from a cryptophyte alga Chroomonas placoidea (C. placoidea), and analyze its structure at a resolution of 2.47 Å using cryo-electron microscopy. This structure reveals a dimeric organization of PSII-ACPII containing two PSII core monomers flanked by six symmetrically arranged ACPII subunits. The PSII core is conserved whereas the organization of ACPII subunits exhibits a distinct pattern, different from those observed so far in PSII of other algae and higher plants. Furthermore, we find a Chl a-binding antenna subunit, CCPII-S, which mediates interaction of ACPII with the PSII core. These results provide a structural basis for the assembly of antennas within the supercomplex and possible excitation energy transfer pathways in cryptophyte algal PSII, shedding light on the diversity of supramolecular organization of photosynthetic machinery.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2041-1723Test

الوصول الحر: https://doaj.org/article/caea9707228e4484b9b69bfa5616ff67Test

المؤلفون: Jiang Ji, Luying Gao, Ruifeng Liu, Xinlong Shi, Liyuan Ma, Aonan Pan, Naishi Li, Chunhao Liu, Xiaoyi Li, Meng Yang, Yu Xia, Yuxin Jiang

المصدر: Cancer Imaging, Vol 24, Iss 1, Pp 1-8 (2024)

مصطلحات موضوعية: Primary thyroid lymphoma, Ultrasound, Relapse, Refractory, Treatment outcome, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: Abstract Background Primary thyroid lymphoma (PTL) is a rare malignant disorder, and ultrasound plays an important role in PTL diagnosis and follow-up surveillance. Prediction of refractory/relapse events in PTL patients is an essential issue, yet no ultrasonic PTL features have been discovered to be related to refractory/local relapse events. Methods From January 2008 to September 2022, newly diagnosed PTL patients in our center who underwent standard first-line treatment and received an ultrasound examination before treatment were enrolled. Data regarding patients’ clinical and sonographic features, as well as their therapeutic responses were collected. Subjects with an ideal prognosis were compared to those with refractory/relapse events. Results In total, 37 PTL patients were analyzed, including 26 with diffuse large B-cell lymphoma, 2 with follicular lymphoma and 9 with mucosa-associated lymphoid tissue lymphoma. During the median follow-up of 25 months, 30 patients obtained a complete response, 4 were refractory patients, and 3 experienced local relapse. No significant difference was detected in the baseline clinical characteristics between patients with an ideal prognosis and those with refractory/local relapse events. In terms of sonographic features, however, an event-free survival (EFS) curve comparison revealed that patients with bilobar enlargement (defined as an anterior-posterior diameter > 2.5 cm on both sides of thyroid lobes) had a poorer EFS than those without (P 2.5 cm for both thyroid lobes or PTL patients of the diffuse ultrasound type could be prone to refractory/local relapse events.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1470-7330Test

الوصول الحر: https://doaj.org/article/2fba7a2ff78e4139bbf2a2bed1dc6fdaTest

المؤلفون: Dianyu Li, Rongqian Mo, Xiaoyi Li, Rongrong Cheng, Jingying Xie, Hongshan Li, Yanmei Yang, Shasha Li, Huixia Li, Zhenfang Yan, Suocheng Wei, Adi Idris, Xiangrong Li, Ruofei Feng

المصدر: mSphere, Vol 9, Iss 6 (2024)

مصطلحات موضوعية: mammalian orthoreovirus, σ3 protein, RIG-I-like receptor signaling, mitochondrial antiviral signaling protein, Microbiology, QR1-502

الوصف: ABSTRACT Mammalian orthoreovirus (MRV) outer capsid protein σ3 is a multifunctional protein containing a double-stranded RNA-binding domain, which facilitates viral entry and assembly. We reasoned that σ3 has an innate immune evasion function. Here, we show that σ3 protein localizes in the mitochondria and interacts with mitochondrial antiviral signaling protein (MAVS) to activate the intrinsic mitochondria-mediated apoptotic pathway. Consequently, σ3 protein promotes the degradation of MAVS through the intrinsic caspase-9/caspase-3 apoptotic pathway. Moreover, σ3 protein can also inhibit the expression of the components of the RNA-sensing retinoic acid-inducible gene (RIG)-like receptor (RLR) signaling pathway to block antiviral type I interferon responses. Mechanistically, σ3 inhibits RIG-I and melanoma differentiation-associated gene 5 expression is independent of its inhibitory effect on MAVS. Overall, we demonstrate that the MRV σ3 protein plays a vital role in negatively regulating the RLR signaling pathway to inhibit antiviral responses. This enables MRV to evade host defenses to facilitate its own replication providing a target for the development of effective antiviral drugs against MRV.IMPORTANCEMammalian orthoreovirus (MRV) is an important zoonotic pathogen, but the regulatory role of its viral proteins in retinoic acid-inducible gene-like receptor (RLR)-mediated antiviral responses is still poorly understood. Herein, we show that MRV σ3 protein co-localizes with mitochondrial antiviral signaling protein (MAVS) in the mitochondria and promotes the mitochondria-mediated intrinsic apoptotic pathway to cleave and consequently degrade MAVS. Furthermore, tryptophan at position 133 of σ3 protein plays a key role in the degradation of MAVS. Importantly, we show that MRV outer capsid protein σ3 is a key factor in antagonizing RLR-mediated antiviral responses, providing evidence to better unravel the infection and transmission mechanisms of MRV.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2379-5042Test

الوصول الحر: https://doaj.org/article/18e7e51c893543eebec534368e53054eTest

المؤلفون: Simi Ogunnowo, BA, James Oyeniyi, MD, Ross Milner, MD, Xiaoyi Li, MD

المصدر: Journal of Vascular Surgery Cases and Innovative Techniques, Vol 10, Iss 3, Pp 101450- (2024)

مصطلحات موضوعية: Abdominal aortic aneurysm (AAA), Aortic iliac occlusive disease (AIOD), Endovascular aortic repair (EVAR), Lithotripsy, Surgery, RD1-811, Diseases of the circulatory (Cardiovascular) system, RC666-701

الوصف: As the use of endovascular aneurysm repair (EVAR) increases, anatomic constraints remain a challenge. In this case report, we describe the use of intravascular lithotripsy to facilitate EVAR in a patient with a severely calcified and stenotic aortic bifurcation. Future applications of intravascular lithotripsy could help expand the use of EVAR to patients with severely stenotic vasculature and optimize outcomes in the treatment of infrarenal abdominal aortic aneurysms.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2468428724000340Test; https://doaj.org/toc/2468-4287Test

الوصول الحر: https://doaj.org/article/929c83b3d11945b39fdac4895d906ff5Test

المؤلفون: Hui Li, Mande Xue, Huairen Zhang, Fengyue Zhao, Xiaoyi Li, Shuancang Yu, Danhua Jiang

المصدر: Plant Communications, Vol 5, Iss 5, Pp 100833- (2024)

مصطلحات موضوعية: temperature, thermomorphogenesis, PIF4, GI, TOC1, feedback loop, Botany, QK1-989

الوصف: Plants can sense temperature changes and adjust their growth accordingly. In Arabidopsis, high ambient temperatures stimulate stem elongation by activating a key thermoresponsive regulator, PHYTOCHROME INTERACTING FACTOR 4 (PIF4). Here, we show that warmth promotes the nighttime transcription of GI, which is necessary for the high temperature-induced transcription of TOC1. Genetic analyses suggest that GI prevents excessive thermoresponsive growth by inhibiting PIF4, with this regulatory mechanism being partially reliant on TOC1. GI transcription is repressed by ELF3 and HY5, which concurrently inhibit PIF4 expression and activity. Temperature elevation causes the deactivation or degradation of ELF3 and HY5, leading to PIF4 activation and relief of GI transcriptional repression at high temperatures. This allows PIF4 to further activate GI transcription in response to elevated temperatures. GI, in turn, inhibits PIF4, establishing a negative feedback loop that fine-tunes PIF4 activity. In addition, we demonstrate that ELF3, HY5, and PIF4 regulate GI transcription by modulating the enrichment of histone variant H2A.Z at the GI locus. Together, our findings suggest that thermal release of a negative feedback loop finely adjusts plant thermomorphogenesis.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2590346224000531Test; https://doaj.org/toc/2590-3462Test

الوصول الحر: https://doaj.org/article/e61246f1868d43f58451caf63f4d6844Test

المؤلفون: Hongzhan Liu, Xiaoyi Li, Zehui Yin, Junmin Hu, Liuyong Xie, Huanhuan Wu, Shuying Han, Bing Li, Huifang Zhang, Chaoqiong Li, Lili Li, Fuli Zhang, Guangxuan Tan

المصدر: PeerJ, Vol 12, p e17370 (2024)

مصطلحات موضوعية: Triticum aestivum L, Gene repetition events, Cysteine-rich receptor-like kinases, Collinearity analysis, Gene expression, Medicine, Biology (General), QH301-705.5

الوصف: Cysteine-rich receptor-like kinases (CRKs) play many important roles during plant development, including defense responses under both biotic and abiotic stress, reactive oxygen species (ROS) homeostasis, callose deposition and programmed cell death (PCD). However, there are few studies on the involvement of the CRK family in male sterility due to heat stress in wheat (Triticum aestivum L.). In this study, a genome-wide characterization of the CRK family was performed to investigate the structural and functional attributes of the wheat CRKs in anther sterility caused by heat stress. A total of 95 CRK genes were unevenly distributed on 18 chromosomes, with the most genes distributed on chromosome 2B. Paralogous homologous genes with Ka/Ks ratios less than 1 may have undergone strong purifying selection during evolution and are more functionally conserved. The collinearity analysis results of CRK genes showed that wheat and Arabidopsis (A. thaliana), foxtail millet, Brachypodium distachyon (B. distachyon), and rice have three, 12, 15, and 11 pairs of orthologous genes, respectively. In addition, the results of the network interactions of genes and miRNAs showed that five miRNAs were in the hub of the interactions map, namely tae-miR9657b-5p, tae-miR9780, tae-miR9676-5p, tae-miR164, and tae-miR531. Furthermore, qRT-PCR validation of the six TaCRK genes showed that they play key roles in the development of the mononuclear stage anthers, as all six genes were expressed at highly significant levels in heat-stressed male sterile mononuclear stage anthers compared to normal anthers. We hypothesized that the TaCRK gene is significant in the process of high-temperature-induced sterility in wheat based on the combination of anther phenotypes, paraffin sections, and qRT-PCR data. These results improve our understanding of their relationship.

وصف الملف: electronic resource

العلاقة: https://peerj.com/articles/17370.pdfTest; https://peerj.com/articles/17370Test/; https://doaj.org/toc/2167-8359Test

الوصول الحر: https://doaj.org/article/b327c252c8af4fd289c0dd63ef8fb162Test

المؤلفون: Xiaoyi Li, Ofir Turel, Qinghua He

المصدر: NeuroImage, Vol 291, Iss , Pp 120598- (2024)

مصطلحات موضوعية: Behavioral approach system, Decision-making, Iowa gambling task, Sex difference, Resting-state fMRI, Ventrolateral prefrontal cortex, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

الوصف: It has been observed that one's Behavioral Approach System (BAS) can have an effect on decision-making under uncertainty, although the results have been mixed. To discern the underlying neural substrates, we hypothesize that sex may explain the conflicting results. To test this idea, a large sample of participants was studied using resting state fMRI, utilizing fractional Amplitude of Low Frequency Fluctuations (fALFF) and Resting-State Functional Connectivity (rsFC) techniques. The results of the Iowa Gambling Task (IGT) revealed an interaction between sex and BAS, particularly in the last 60 trials (decision-making under risk). Males with high BAS showed poorer performance than those with low BAS. fALFF analysis showed a significant interaction between BAS group and sex in the left superior occipital gyrus, as well as the functional connectivity between this region and the left ventrolateral prefrontal cortex. Additionally, this functional connectivity was further positively correlated with male performance in the IGT, particularly in the decision-making under risk stage. Furthermore, it was found that the functional connectivity between left ventrolateral prefrontal cortex and left superior occipital gyrus could mediate the relationship between BAS and decision-making in males, particularly in the decision-making under risk stage. These results suggest possible sex-based differences in decision-making, providing an explanation for the inconsistent results found in prior research. Since the research was carried out exclusively with Chinese university students, it is essential to conduct further studies to investigate whether the findings can be generalized.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S1053811924000934Test; https://doaj.org/toc/1095-9572Test

الوصول الحر: https://doaj.org/article/8dbb5472e1f44b00aceda60e9a1f612dTest

المؤلفون: Songhao Zhao, Lili Shen, Xiaoyi Li, Qiushuang Tao, Zhenhua Li, Caizhe Xu, Cuicui Zhou, Yanyan Yang, Min Sang, Guangye Han, Long-Jiang Yu, Tingyun Kuang, Jian-Ren Shen, Wenda Wang

المصدر: Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)

مصطلحات موضوعية: Science

الوصف: Abstract Diatoms are dominant marine algae and contribute around a quarter of global primary productivity, the success of which is largely attributed to their photosynthetic capacity aided by specific fucoxanthin chlorophyll-binding proteins (FCPs) to enhance the blue-green light absorption under water. We purified a photosystem II (PSII)-FCPII supercomplex and a trimeric FCP from Cyclotella meneghiniana (Cm) and solved their structures by cryo-electron microscopy (cryo-EM). The structures reveal detailed organizations of monomeric, dimeric and trimeric FCP antennae, as well as distinct assemblies of Lhcx6_1 and dimeric FCPII-H in PSII core. Each Cm-PSII-FCPII monomer contains an Lhcx6_1, an FCP heterodimer and other three FCP monomers, which form an efficient pigment network for harvesting energy. More diadinoxanthins and diatoxanthins are found in FCPs, which may function to quench excess energy. The trimeric FCP contains more chlorophylls c and fucoxanthins. These diversified FCPs and PSII-FCPII provide a structural basis for efficient light energy harvesting, transfer, and dissipation in C. meneghiniana.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2041-1723Test

الوصول الحر: https://doaj.org/article/1e0ed5bd880b4ef4a028ea6d47d3b535Test

المؤلفون: Xiaoyi Li, Qibo Tian

المصدر: SAGE Open, Vol 14 (2024)

مصطلحات موضوعية: History of scholarship and learning. The humanities, AZ20-999, Social Sciences

الوصف: Haze pollution not only affects the quality of economic growth and the image of the government, but also seriously affects public health. With the improvement of climate risk perception, the public is actively seeking all kinds of risk management measures to combat the hazards of haze pollution. The study of the relationship between haze pollution, climate risk perception and the development of commercial health insurance is of great significance to the formulation of haze control policies and the improvement of social security system. This paper attempts to explore the relationship between haze pollution, climate risk perception and commercial health insurance demand by establishing static and dynamic models based on panel data from 31 provinces in China from 2005 to 2022. Also, the spatial spillover effects of haze pollution in different regions on the development of commercial health insurance in other regions are investigated by establishing a spatial Durbin model. It is found that (1) haze pollution has a lagged positive effect on the demand for commercial health insurance; (2) haze pollution has a significant spatial spillover effect on the development of commercial health insurance; (3) this study used Python technology to construct a climate risk perception index, and found that the moderating effect of the residents’ perception of climate risk existed significantly, and that the residents might take other measures to manage the risk in the short term, but in the long term, the climate risk perception showed a positive correlation with the level of education. This paper provides implications for government departments and social media to strengthen education and publicity, improve residents’ awareness of risk diversification, and deepen the concept of commercial health protection.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2158-2440Test

الوصول الحر: https://doaj.org/article/8b197a4a73af4b46b0afbf25d04fef0fTest