المؤلفون: Syed Muhammad Asad, Xiaoshuai Zhang, Yao Sun, Rao Naveed Bin Rais, Sajjad Hussain, Qammer H. Abbasi, Muhammad Ali Imran

المصدر: IEEE Access, Vol 12, Pp 66690-66700 (2024)

مصطلحات موضوعية: Blockchain, intelligent transport systems, next generation train networks, Electrical engineering. Electronics. Nuclear engineering, TK1-9971

الوصف: The integration of private mobile networks (PMN) driven by next generation train networks (NGTNs) require a paradigm for a secure spectrum sharing with mobile network operators (MNOs) to provide privacy driven architecture. For such unprecedented performance expectations, a fine-grained spectrum sharing PMN is required to address secure communication with volume, time, and usage area parameters. In this article, we study a novel vision for empowering secure spectrum sharing for NGTNs with MNOs using blockchain technology by using smart contracts. In particular, blockchain key features and its integration along with the anticipated challenges and potential benefits of the proposed architecture are discussed. Finally, we have also highlighted potential NGTN use-cases to address the outlined challenges. This would unlock several practical scenarios and critical applications to meet rising business demands. From the implementation perspective, this article would exploit a conceptual blockchain-driven intelligent network that is ready to satisfy a number of NGTN applications that need privacy preservation.

وصف الملف: electronic resource

العلاقة: https://ieeexplore.ieee.org/document/10526278Test/; https://doaj.org/toc/2169-3536Test

الوصول الحر: https://doaj.org/article/84c6f168100a4010ba62c33b49f24c4fTest

المؤلفون: Chonghua Ren, Yejie Wen, Shaojuan Zheng, Zheng Zhao, Ethan Yihao Li, Chenjing Zhao, Mingtao Liao, Liang Li, Xiaoshuai Zhang, Suning Liu, Dongwei Yuan, Kai Luo, Wei Wang, Jifeng Fei, Sheng Li

المصدر: Cell Reports, Vol 43, Iss 3, Pp 113889- (2024)

مصطلحات موضوعية: CP: Developmental biology, Biology (General), QH301-705.5

الوصف: Summary: The mystery of appendage regeneration has fascinated humans for centuries, while the underlying regulatory mechanisms remain unclear. In this study, we establish a transcriptional landscape of regenerating leg in the American cockroach, Periplaneta americana, an ideal model in appendage regeneration studies showing remarkable regeneration capacity. Through a large-scale in vivo screening, we identify multiple signaling pathways and transcription factors controlling leg regeneration. Specifically, zfh-2 and bowl contribute to blastema cell proliferation and morphogenesis in two transcriptional cascades: bone morphogenetic protein (BMP)/JAK-STAT-zfh-2-B-H2 and Notch-drm/bowl-bab1. Notably, we find zfh-2 is working as a direct target of BMP signaling to promote cell proliferation in the blastema. These mechanisms might be conserved in the appendage regeneration of vertebrates from an evolutionary perspective. Overall, our findings reveal that two crucial transcriptional cascades orchestrate distinct cockroach leg regeneration processes, significantly advancing the comprehension of molecular mechanism in appendage regeneration.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2211124724002171Test; https://doaj.org/toc/2211-1247Test

الوصول الحر: https://doaj.org/article/70763606e15f4fe698fd285b4b2960edTest

المؤلفون: Lirong Zhang, Guangxuan Han, Lifeng Zhou, Xinge Li, Xiaojie Wang, Xiaoshuai Zhang, Leilei Xiao

المصدر: Frontiers in Microbiology, Vol 15 (2024)

مصطلحات موضوعية: precipitation change, saltmarsh, CO2 production potential, carbon quantity and quality, microbial r-/K-strategy, Microbiology, QR1-502

الوصف: Saltmarsh is widely recognized as a blue carbon ecosystem with great carbon storage potential. Yet soil respiration with a major contributor of atmospheric CO2 can offset its carbon sink function. Up to date, mechanisms ruling CO2 emissions from saltmarsh soil remain unclear. In particular, the effect of precipitation on soil CO2 emissions is unclear in coastal wetlands, due the lack of outdoor data in real situations. We conducted a 7-year field manipulation experiment in a saltmarsh in the Yellow River Delta, China. Soil respiration in five treatments (−60%, −40%, +0%, +40%, and + 60% of precipitation) was measured in the field. Topsoils from the last 3 years (2019–2021) were analyzed for CO2 production potential by microcosm experiments. Furthermore, quality and quantity of soil organic carbon and microbial function were tested. Results show that only the moderate precipitation rise of +40% induced a 66.2% increase of CO2 production potential for the microcosm experiments, whereas other data showed a weak impact. Consistently, soil respiration was also found to be strongest at +40%. The CO2 production potential is positively correlated with soil organic carbon, including carbon quantity and quality. But microbial diversity did not show any positive response to precipitation sizes. r-/K-strategy seemed to be a plausible explanation for biological factors. Overall, our finding reveal that a moderate precipitation increase, not decrease or a robust increase, in a saltmarsh is likely to improve soil organic carbon quality and quantity, and bacterial oligotroph:copiotroph ratio, ultimately leading to an enhanced CO2 production.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fmicb.2024.1328965/fullTest; https://doaj.org/toc/1664-302XTest

الوصول الحر: https://doaj.org/article/090e21404de744ea8d94e834c0df6017Test

المؤلفون: Jiru Zhong, Andi Jing, Shaojuan Zheng, Sheng Li, Xiaoshuai Zhang, Chonghua Ren

المصدر: Cell Regeneration, Vol 12, Iss 1, Pp 1-12 (2023)

مصطلحات موضوعية: Appendage regeneration, Physiological condition, Molecular mechanism, Signaling pathways, Epigenetics, Insects, Medicine (General), R5-920, Biology (General), QH301-705.5

الوصف: Abstract Regeneration, as a fascinating scientific field, refers to the ability of animals replacing lost tissue or body parts. Many metazoan organisms have been reported with the regeneration phenomena, but showing evolutionarily variable abilities. As the most diverse metazoan taxon, hundreds of insects show strong appendage regeneration ability. The regeneration process and ability are dependent on many factors, including macroscopic physiological conditions and microscopic molecular mechanisms. This article reviews research progress on the physiological conditions and internal underlying mechanisms controlling appendage regeneration in insects.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2045-9769Test

الوصول الحر: https://doaj.org/article/8bfe0c27a63b41539609fb93471dfa03Test

المؤلفون: Feiyang Qi, Mei Bao, Xiaoshuai Zhang, Shasha Zhao, Wenwen LI, Chenglei Wang, Qian Jiang

المصدر: HemaSphere, Vol 7, p e23831a8 (2023)

مصطلحات موضوعية: Diseases of the blood and blood-forming organs, RC633-647.5

وصف الملف: electronic resource

العلاقة: http://journals.lww.com/10.1097/01.HS9.0000974692.23831.a8Test; https://doaj.org/toc/2572-9241Test

الوصول الحر: https://doaj.org/article/4c0b64924f6b465db645b20e5df39e00Test

المؤلفون: Ziyu LI, Qian Jiang, Xiaoshuai Zhang, Yanli Zhang, Na Xu, Huanling Zhu, Hai Lin, Weiming LI, Xin Du, Rong Liang, Fei LI, Chunyan Chen, Bingcheng Liu, Xiaodong Wang, Lijie Yang, Zhenfang Liu, Liping Pang, Zhuogang Liu, Xiuli Sun, Yanliang Bai, LI Meng, Suning Chen

المصدر: HemaSphere, Vol 7, p e760773c (2023)

مصطلحات موضوعية: Diseases of the blood and blood-forming organs, RC633-647.5

وصف الملف: electronic resource

العلاقة: http://journals.lww.com/10.1097/01.HS9.0000974688.76077.3cTest; https://doaj.org/toc/2572-9241Test

الوصول الحر: https://doaj.org/article/54431d5135454fae801b36267fb6ab75Test

المؤلفون: Jingyi Bai, Xi Li, Jun Zhao, Huifang Zong, Yuan Yuan, Lei Wang, Xiaoshuai Zhang, Yong Ke, Lei Han, Jianrong Xu, Buyong Ma, Baohong Zhang, Jianwei Zhu

المصدر: International Journal of Molecular Sciences, Vol 25, Iss 3, p 1593 (2024)

مصطلحات موضوعية: β-amyloid, amyloid light chain, amyloidosis, mAb, antibody design, Biology (General), QH301-705.5, Chemistry, QD1-999

الوصف: Amyloidosis involves the deposition of misfolded proteins. Even though it is caused by different pathogenic mechanisms, in aggregate, it shares similar features. Here, we tested and confirmed a hypothesis that an amyloid antibody can be engineered by a few mutations to target a different species. Amyloid light chain (AL) and β-amyloid peptide (Aβ) are two therapeutic targets that are implicated in amyloid light chain amyloidosis and Alzheimer’s disease, respectively. Though crenezumab, an anti-Aβ antibody, is currently unsuccessful, we chose it as a model to computationally design and prepare crenezumab variants, aiming to discover a novel antibody with high affinity to AL fibrils and to establish a technology platform for repurposing amyloid monoclonal antibodies. We successfully re-engineered crenezumab to bind both Aβ42 oligomers and AL fibrils with high binding affinities. It is capable of reversing Aβ42-oligomers-induced cytotoxicity, decreasing the formation of AL fibrils, and alleviating AL-fibrils-induced cytotoxicity in vitro. Our research demonstrated that an amyloid antibody could be engineered by a few mutations to bind new amyloid sequences, providing an efficient way to reposition a therapeutic antibody to target different amyloid diseases.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/1422-0067/25/3/1593Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test

الوصول الحر: https://doaj.org/article/bca050be09ea4cb1a19f27d75f3ab83aTest

المؤلفون: Zhen Yan, Xijun Lin, Xiaoshuai Zhang, Jianliang Xu, Haipeng Qu

المصدر: Entropy, Vol 26, Iss 1, p 74 (2024)

مصطلحات موضوعية: matchmaking encryption, equality test, confidentiality, authenticity, anonymity, Science, Astrophysics, QB460-466, Physics, QC1-999

الوصف: The identity-based encryption with equality test (IBEET) has become a hot research topic in cloud computing as it provides an equality test for ciphertexts generated under different identities while preserving the confidentiality. Subsequently, for the sake of the confidentiality and authenticity of the data, the identity-based signcryption with equality test (IBSC-ET) has been put forward. Nevertheless, the existing schemes do not consider the anonymity of the sender and the receiver, which leads to the potential leakage of sensitive personal information. How to ensure confidentiality, authenticity, and anonymity in the IBEET setting remains a significant challenge. In this paper, we put forward the concept of the identity-based matchmaking encryption with equality test (IBME-ET) to address this issue. We formalized the system model, the definition, and the security models of the IBME-ET and, then, put forward a concrete scheme. Furthermore, our scheme was confirmed to be secure and practical by proving its security and evaluating its performance.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/1099-4300/26/1/74Test; https://doaj.org/toc/1099-4300Test

الوصول الحر: https://doaj.org/article/d8eb5c7a78824ecd81aa2c87a4b7fb2cTest

المؤلفون: Yiting Cao, Shuang Ji, Yujiao Chen, Xiaoshuai Zhang, Guoyong Ding, Fang Tang

المصدر: Comprehensive Psychiatry, Vol 122, Iss , Pp 152370- (2023)

مصطلحات موضوعية: autoimmune diseases of the nervous system, schizophrenia, autoimmune disease, meta-analysis, cohort study, Psychiatry, RC435-571

الوصف: Introduction: Numerous studies have found an association between autoimmune diseases of the nervous system (ADNS) and schizophrenia (SCZ), but the findings remain controversial. We conducted the first meta-analysis to summarize the current evidence from cohort studies that evaluated the association between ADNS and SCZ. Methods: PubMed, Web of Science, and Embase were comprehensively searched until May 30, 2022 for articles on the association between ADNS and SCZ. Every included study was reported effect size with 95% CIs for the association between ADNS and SCZ. Meta-regression and subgroup analysis were used to assess the heterogeneity. Results: A total of 8 cohort studies with 12 cohorts were included in the meta-analysis. We observed a significant association between ADNS and SCZ (RR = 1.42; 95%CI, 1.18–1.72). Subgroup analysis showed that the risk of SCZ was significantly increased when ADNS were used as exposure factors (RR = 1.48; 95%CI, 1.15–1.89), whereas with SCZ did not observe an increased risk of subsequent ADNS (RR = 1.33; 95%CI, 0.92–1.92); multiple sclerosis (MS) was positively associated with SCZ (RR = 1.36; 95%CI, 1.12–1.66), but no significant association was found between Guillain-Barre syndrome (GBS) and SCZ (RR = 1.90; 95%CI, 0.87–4.17). Meanwhile, we found location was the source of heterogeneity. Limitations: High heterogeneity was observed (I2 = 92.0%), and only English literature was included in the meta-analysis. Conclusions: We found a positive association between ADNS and SCZ, and the association was different across the different types of ADNS. The results of the study are helpful for clinicians to carry out targeted preventive measures for ADNS and SCZ.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S0010440X2300007XTest; https://doaj.org/toc/0010-440XTest

الوصول الحر: https://doaj.org/article/b05f8587be824e3ab92359f3efac87abTest

المؤلفون: Changhong Tan, Xi Liu, Xiaoshuai Zhang, Wuxue Peng, Hui Wang, Wen Zhou, Jin Jiang, Lijuan Mo, Yangmei Chen, Lifen Chen

المصدر: BMC Molecular and Cell Biology, Vol 22, Iss 1, Pp 1-11 (2021)

مصطلحات موضوعية: High glucose, Dopaminergic neuronal apoptosis, Parkinson’s disease, Fyn, mTOR, Cytology, QH573-671

الوصف: Abstract Background High glucose (HG) is linked to dopaminergic neuron loss and related Parkinson’s disease (PD), but the mechanism is unclear. Results Rats and differentiated SH-SY5Y cells were used to investigate the effect of HG on dopaminergic neuronal apoptotic death. We found that a 40-day HG diet elevated cleaved caspase 3 levels and activated Fyn and mTOR/S6K signaling in the substantia nigra of rats. In vitro, 6 days of HG treatment activated Fyn, enhanced binding between Fyn and mTOR, activated mTOR/S6K signaling, and induced neuronal apoptotic death. The proapoptotic effect of HG was rescued by either the Fyn inhibitor PP1 or the mTOR inhibitor rapamycin. PP1 inhibited mTOR/S6K signaling, but rapamycin was unable to modulate Fyn activation. Conclusions HG induces dopaminergic neuronal apoptotic death via the Fyn/mTOR/S6K pathway.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2661-8850Test

الوصول الحر: https://doaj.org/article/07db3d4d479a4271b34493c9b0bb7ad8Test