المؤلفون: Ping Lin, Jia-Cheng Zeng, Ji-Guang Chen, Xu-Liang Nie, En Yuan, Xiao-Qiang Wang, Da-Yong Peng, Zhong-Ping Yin

المصدر: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1879-1890 (2020)

مصطلحات موضوعية: 1-deoxynojirimycin derivatives, α-glucosidase, inhibitor, structure–activity relationship, docking study, Therapeutics. Pharmacology, RM1-950

الوصف: A series of novel N-alkyl-1-deoxynojirimycin derivatives 25 ∼ 44 were synthesised and evaluated for their in vitro α-glucosidase inhibitory activity to develop α-glucosidase inhibitors with high activity. All twenty compounds exhibited α-glucosidase inhibitory activity with IC50 values ranging from 30.0 ± 0.6 µM to 2000 µM as compared to standard acarbose (IC50 = 822.0 ± 1.5 µM). The most active compound 43 was ∼27-fold more active than acarbose. Kinetic study revealed that compounds 43, 40, and 34 were all competitive inhibitors on α-glucosidase with Ki of 10 µM, 52 µM, and 150 µM, respectively. Molecular docking demonstrated that the high active inhibitors interacted with α-glucosidase by four types of interactions, including hydrogen bonds, π–π stacking interactions, hydrophobic interactions, and electrostatic interaction. Among all the interactions, the π–π stacking interaction and hydrogen bond played a significant role in a various range of activities of the compounds.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1475-6366Test; https://doaj.org/toc/1475-6374Test

الوصول الحر: https://doaj.org/article/3ca7608a036348e0a87d91e7c3d39694Test

المؤلفون: Xiao-Qiang Wang, Kyu-Won Kim, Sang-Ho Chu, Rungnapa Phitaktansakul, Sang-Won Park, Ill-Min Chung, Young-Sang Lee, Yong-Jin Park

المصدر: ACS Omega, Vol 4, Iss 21, Pp 19358-19365 (2019)

مصطلحات موضوعية: Chemistry, QD1-999

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2470-1343Test

الوصول الحر: https://doaj.org/article/fc8c7d0bf3d040bd89d30935fc580975Test

المؤلفون: Jie Luo, Xiao-Fan Rong, Yu-Yuan Ye, Wen-Zhen Li, Xiao-Qiang Wang, Wenjing Wang

المصدر: Molecules, Vol 27, Iss 5, p 1632 (2022)

مصطلحات موضوعية: organic radicals, OLED, room-temperature luminescence, open-shell, doublet state, Organic chemistry, QD241-441

الوصف: Perchlorotrityl radical (PTM), tris (2,4,6-trichlorophenyl) methyl radical (TTM), (3,5-dichloro-4-pyridyl) bis (2,4,6 trichlorophenyl) methyl radical (PyBTM), (N-carbazolyl) bis (2,4,6-trichlorophenyl) methyl radical (CzBTM), and their derivatives are stable organic radicals that exhibit light emissions at room temperature. Since these triarylmethyl radicals have an unpaired electron, their electron spins at the lowest excited state and ground state are both doublets, and the transition from the lowest excited state to the ground state does not pose the problem of a spin-forbidden reaction. When used as OLED layers, these triarylmethyl radicals exhibit unique light-emitting properties, which can increase the theoretical upper limit of the OLED’s internal quantum efficiency (IQE) to 100%. In recent years, research on the luminescent properties of triarylmethyl radicals has attracted increasing attention. In this review, recent developments in these triarylmethyl radicals and their derivatives in OLED devices are introduced.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/1420-3049/27/5/1632Test; https://doaj.org/toc/1420-3049Test

الوصول الحر: https://doaj.org/article/3c6c35dba77e41b892817e7b99b4730aTest

المؤلفون: Dong-Lin Zhao, Xi-Fen Zhang, Rui-Huan Huang, Dan Wang, Xiao-Qiang Wang, Yi-Qiang Li, Cai-Juan Zheng, Peng Zhang, Cheng-Sheng Zhang

المصدر: Frontiers in Microbiology, Vol 11 (2020)

مصطلحات موضوعية: nafuredins, epithiodiketopiperazines, Magnaporthe oryzae, antifungal activity, Trichoderma harzianum, Microbiology, QR1-502

الوصف: A new polyketide derivative, nafuredin C (1), a novel heterocyclic dipeptide, trichodermamide G (3), together with four known biogenetically related compounds nafuredin A (2), trichodermamide A (4), aspergillazin A (5), and peniisocoumarin H (6), were isolated from the mangrove-derived fungus Trichoderma harzianum D13. Their structures, including their absolute configurations, were determined by spectroscopic analysis and time-dependent density functional theory-electronic circular dichroism (ECD) calculations. Trichodermamide G was found to be a novel epithiodiketopiperazine derivative with an unprecedented cyclic system containing a sulfur bridge, and nafuredin C represented the third nafuredin derivative of these homologous compounds. The new compound nafuredin C exhibited obvious antifungal activity against Magnaporthe oryzae with a minimum inhibitory concentration (MIC) of 8.63 μM, which is on the same order of magnitude as the positive control carbendazim (MIC = 3.27 μM).

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/article/10.3389/fmicb.2020.01495/fullTest; https://doaj.org/toc/1664-302XTest

الوصول الحر: https://doaj.org/article/c6d1d72c04914c5c9ac0bde22c08f9f1Test

المؤلفون: Rui-Huan Huang, Wei Lin, Peng Zhang, Jian-Yang Liu, Dan Wang, Yi-Qiang Li, Xiao-Qiang Wang, Cheng-Sheng Zhang, Wei Li, Dong-Lin Zhao

المصدر: Frontiers in Marine Science, Vol 7 (2020)

مصطلحات موضوعية: furanones, penicillic acid, Ralstonia solanacearum, phytopathogenic bacteria, antibacterial activity, Science, General. Including nature conservation, geographical distribution, QH1-199.5

الوصف: In order to search for new lead compounds with anti-phytopathogenic bacterial activity, three pairs of new furanone derivatives, sclerotiorumins D–F (1–3), and eight known compounds (4–11) were isolated from the seaweed-derived fungus, Aspergillus sp. D40, fermented with potato dextrose seawater (PDW) medium. Their structures were determined using comprehensive spectroscopic analyzes including HRESIMS, 1D and 2D NMR data. Compounds 1–4 and 9 existed as inseparable mixtures of a pair of epimers. Penicillic acid (7) exhibited clear antibacterial activity against Ralstonia solanacearum and several other plant pathogenic bacteria with IC50 values ranging from 11.6 to 58.2 μg/mL.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/article/10.3389/fmars.2020.00313/fullTest; https://doaj.org/toc/2296-7745Test

الوصول الحر: https://doaj.org/article/6dafb6aef437480499d0d00aab347b7dTest

المؤلفون: Zheng Gu, Su-Ling Hong, Xia Ke, Yang Shen, Xiao-Qiang Wang, Di Hu, Guo-Hua Hu, Hou-Yong Kang

المصدر: PLoS ONE, Vol 10, Iss 1, p e0116419 (2015)

مصطلحات موضوعية: Medicine, Science

الوصف: BACKGROUND:Heredity and environmental exposures may contribute to a predisposition to allergic rhinitis (AR). Autoimmunity may also involve into this pathologic process. FCRL3 (Fc receptor-like 3 gene), a novel immunoregulatory gene, has recently been reported to play a role in autoimmune diseases. OBJECTIVE:This study was performed to evaluate the potential association of FCRL3 polymorphisms with AR in a Chinese Han population. METHODS:Five single-nucleotide polymorphisms of FCRL3, rs945635, rs3761959, rs7522061, rs10489678 and rs7528684 were genotyped in 540 AR patients and 600 healthy controls using a PCR-restriction fragment length polymorphism assay. Allele, genotype and haplotype frequencies were compared between patients and controls using the χ2 test. The online software platform SHEsis was used to analyze their haplotypes. RESULTS:This study identified three strong risk SNPs rs7528684, rs10489678, rs7522061 and one weak risk SNP rs945635 of FCRL3 in Chinese Han AR patients. For rs7528684, a significantly increased prevalence of the AA genotype and A allele in AR patients was recorded. The frequency of the GG genotype and G allele of rs10489678 was markedly higher in AR patients than those in controls. For rs7522061, a higher frequency of the TT genotype, and a lower frequency of the CT genotype were found in AR patients. Concerning rs945635, a lower frequency of the CC genotype, and a higher frequency of G allele were observed in AR patients. According to the analysis of the three strong positive SNPs, the haplotype of AGT increased significantly in AR cases (AR = 38.8%, Controls = 24.3%, P = 8.29 × 10(-14), OR [95% CI] 1.978 [1.652~2.368]). CONCLUSIONS:This study found a significant association between the SNPs in FCRL3 gene and AR in Chinese Han patients. The results suggest these gene polymorphisms might be the autoimmunity risk for AR.

وصف الملف: electronic resource

العلاقة: http://europepmc.org/articles/PMC4296936?pdf=renderTest; https://doaj.org/toc/1932-6203Test

الوصول الحر: https://doaj.org/article/267f3b12b8a049ad902585b884bbd0baTest

المؤلفون: Xiao-Qiang Wang, Jun-Feng Tong, Wen-Kui Dong, Shang-Sheng Gong, Jian-Chao Wu

المصدر: Acta Crystallographica Section E, Vol 65, Iss 8, Pp o2013-o2013 (2009)

مصطلحات موضوعية: Crystallography, QD901-999

الوصف: The salen-type bis-oxime title compound, C26H36N2O4, lies about a crystallographic inversion centre. Classical intramolecular O—H...N hydrogen bonds generate two S(6) ring motifs. In the crystal structure, pairs of weak intermolecular C—H...O hydrogen bonds link adjacent molecules into an infinite one-dimensional supramolecular structure.

وصف الملف: electronic resource

العلاقة: http://scripts.iucr.org/cgi-bin/paper?S1600536809029341Test; https://doaj.org/toc/1600-5368Test

الوصول الحر: https://doaj.org/article/c401ed26bca1415ebce1f91be878d59fTest

المؤلفون: Wen-Zhen Li¹, Xiao-Qiang Wang¹, Ling-Ran Liu^2,3, Ju Xiao¹, Xin-Qiong Wang⁴ wangxq@wust.edu.cn, Yu-Yuan Ye¹, Zi-Xin Wang¹, Mai-Yong Zhu³, Yao Sun⁵ sunyaogbasp@ccnu.edu.cn, Peter J. Stang⁶ stang@chem.utah.edu, Yan Sun² elaine.sun@henu.edu.cn

المصدر: Proceedings of the National Academy of Sciences of the United States of America. 4/2/2024, Vol. 121 Issue 14, p1-8. 53p.

مصطلحات موضوعية: *SPIDER silk, *HEALING, *PHOTOTHERMAL effect, *WOUND healing, *PLATINUM, *WOUND infections

مستخلص: The exploitation of novel wound healing methods with real-time infection sensing and high spatiotemporal precision is highly important for human health. Pt-based metal-organic cycles/cages (MOCs) have been employed as multifunctional antibacterial agents due to their superior Pt-related therapeutic efficiency, various functional subunits and specific geometries. However, how to rationally apply these nanoscale MOCs on the macroscale with controllable therapeutic output is still challenging. Here, a centimeter-scale Pt MOC film was constructed via multistage assembly and subsequently coated on a N,N'-dimethylated dipyridinium thiazolo[5,4-d]thiazole (MPT)-stained silk fabric to form a smart wound dressing for bacterial sensing and wound healing. The MPT on silk fabric could be used to monitor wound infection in real-time through the bacteria-mediated reduction of MPT to its radical form via a color change. The MPT radical also exhibited an excellent photothermal effect under 660 nm light irradiation, which could not only be applied for photothermal therapy but also induce the disassembly of the Pt MOC film suprastructure. The highly ordered Pt MOC film suprastructure exhibited high biosafety, while it also showed improved antibacterial efficiency after thermally induced disassembly. In vitro and in vivo studies revealed that the combination of the Pt MOC film and MPT-stained silk can provide real-time information on wound infection for timely treatment through noninvasive techniques. This study paves the way for bacterial sensing and wound healing with centimeter-scale metal-organic materials. [ABSTRACT FROM AUTHOR]

المؤلفون: Yi-Ru Ruan, Wen-Zhen Li, Yu-Yuan Ye, Jie Luo, Shi-Yuan Xu, Ju Xiao, Xiao-Wei Lin, Simin Liu, Xiao-Qiang Wang, Wenjing Wang

المصدر: Journal of Colloid and Interface Science. 641:146-154

مصطلحات موضوعية: Biomaterials, Colloid and Surface Chemistry, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::9aef1989e28689045a5cd152e4ab9c7bTest
https://doi.org/10.1016/j.jcis.2023.03.009Test

المؤلفون: Qing-Xin Sun (11254442), He Chen (104732), Shuai Liu (145969), Xiao-Qiang Wang (684194), Xin-Hua Duan (1392880), Li-Na Guo (1490104)

مصطلحات موضوعية: Biophysics, Biochemistry, Microbiology, Biotechnology, Ecology, Inorganic Chemistry, Mental Health, Hematology, Chemical Sciences not elsewhere classified, cycloalkyl hydroperoxides, Selenylation, keto-functionalized thioethers, selenium compounds, iron-catalyzed, Iron-Catalyzed Thiolation, access, transformation, disulfide, Cleavage, Bond, redox-neutral protocol, Remarkably

الوصف: A cheap iron-catalyzed C–C bond cleavage/thiolation and selenylation of cycloalkyl hydroperoxides are presented. This redox-neutral protocol provides efficient access to diverse distal keto-functionalized thioethers and selenium compounds. Remarkably, only some amounts of disulfides are required for this transformation.

العلاقة: https://figshare.com/articles/journal_contribution/Iron-Catalyzed_Thiolation_and_Selenylation_of_Cycloalkyl_Hydroperoxides_via_C_C_Bond_Cleavage/15141560Test

الإتاحة: https://doi.org/10.1021/acs.joc.1c01366.s001Test