المؤلفون: Xiao, Bing, Zhang, Haichao, Zhao, Shijie, Cao, Lu

مصطلحات موضوعية: Electrical Engineering and Systems Science - Systems and Control

الوصف: This brief gives a set of unified Lyapunov stability conditions to guarantee the predefined-time/finite-time stability of a dynamical systems. The derived Lyapunov theorem for autonomous systems establishes equivalence with existing theorems on predefined-time/finite-time stability. The findings proposed herein develop a nonsingular sliding mode control framework for an Euler-Lagrange system to analyze its stability, and its upper bound for the settling time can be arbitrarily determined a priori through predefined time constant.

الوصول الحر: http://arxiv.org/abs/2404.01164Test

المؤلفون: Xiao, Bing, Wong, Hang, Shum, Kam Man

مصطلحات موضوعية: Electrical Engineering and Systems Science - Signal Processing

الوصف: An isotropic antenna radiates and receives electromagnetic wave uniformly in magnitude in 3D space. A multi-frequency quasi-isotropic antenna can serve as a practically feasible solution to emulate an ideal multi-frequency isotropic radiator. It is also an essential technology for mobile smart devices for massive IoT in the upcoming 6G. However, ever since the quasi-isotropic antenna was proposed and achieved more than half a century ago, at most two discrete narrow frequency bands can be achieved, because of the significantly increased structural complexity from multi-frequency isotropic radiation. This limitation impedes numerous related electromagnetic experiments and the advances in wireless communication. Here, for the first time, a design method for multi-band (>2) quasi-isotropic antennas is proposed. An exemplified quasi-isotropic antenna with the desired four frequency bands is also presented for demonstration. The measured results validate excellent performance on both electromagnetics and wireless communications for this antenna.

الوصول الحر: http://arxiv.org/abs/2401.05383Test

المؤلفون: Li, Nan, Gao, Xinyu, Feng, Xianghui, Wu, Kai, Cheng, Yonghong, Xiao, Bing

مصطلحات موضوعية: Physics - Computational Physics

الوصف: Field emission coupled with molecular dynamics simulation (FEcMD) software package is a computational tool for studying the electron emission characteristics and the atomic structure evolution of micro- and nano-protrusions made of pure metals or multi-component alloys by means of multi-physics and multi-scale methodology. The implementations of molecular dynamics, the electrodynamics, and the heat conduction in FEcMD program are addressed. For molecular dynamics simulation, the Lennard-Jones potentials, embedded atomic method (EAM), and moment tensor potentials (MTP) are fully supported for both alloys and pure metals. In the electrodynamics, the FEcMD program incorporates the space charge fields (space charge potential and exchange-correlation effects) in the Wentzel-Kramers-Brillouin-Jeffreys (WKBJ) approximation to evaluate the field emission current density more reliably for nano-gaps between two metal electrodes. Additionally, the advanced two-temperature heat conduction model is implemented in FEcMD program, and which provides more reliable descriptions for the temperature evolutions of electron and phonon subsystems under the radiofrequency (RF) or pulse electric fields. Comprehensive benchmark tests are performed for each module in FEcMD software to validate the numerical results, and also to access the accuracy and efficiency of the implemented algorithms. Finally, some typical applications of FEcMD program are also demonstrated for understanding the evolution of temperature and electric field coupled with the dynamic changing of atomic structures for metal micro- and nano-protrusions.

الوصول الحر: http://arxiv.org/abs/2310.04751Test

المؤلفون: Li, Nan, Guo, Junming, Li, Sateng, Liu, Haoliang, Li, Qianwu, Shi, Fangjie, Li, Yefei, Xiao, Bing

مصطلحات موضوعية: Condensed Matter - Materials Science, Physics - Computational Physics

الوصف: ScaleLat (Scale Lattice) is a computer program written in C for performing the atomic structure analysis of multi-phase system or high entropy alloys (HEAs). The program implements an atomic cluster extraction algorithm to obtain all independent and symmetry-reduced characteristic chemical structures for the complex atomic configurations which are usually obtained from molecular dynamics or kinetic Monte-Carlo simulations for supercell containing more than 104 atoms. ScaleLat employes an efficient and unique chemical structure matching algorithm to map all extracted atomic clusters from a large supercell (>10^4 atoms) to a representative small one (~ 10^3 or less), providing the possibility to directly use the highly accurate quantum mechanical methods to study the electronic, magnetic, and mechanical properties of multi-component alloys with complex microstructures. We demonstrate the capability of ScaleLat code by conducting both the atomic structure analysis and chemical structure matching procedure for Fe-12.8 at.% Cr binary alloy and equiatomic CrFeCoNiCu high entropy alloy, and by successfully obtaining the representatively supercells containing 10^2~10^3 atoms of the two alloys. Overall, ScaleLat program provides a universal platform to efficiently project all essential chemical structures of large complex atomic structures to a relatively easy-handling small supercell for quantum mechanical calculations of various user interested properties.

الوصول الحر: http://arxiv.org/abs/2310.04754Test

المؤلفون: Liu, Haoliang, Bai, Xue, Ning, Jingliang, Hou, Yuxuan, Song, Zifeng, Ramasamy, Akilan, Zhang, Ruiqi, Li, Yefei, Sun, Jianwei, Xiao, Bing

مصطلحات موضوعية: Physics - Computational Physics, Condensed Matter - Materials Science

الوصف: The recent development of the accurate and efficient semilocal density functionals on the third rung of Jacob's ladder of density functional theory such as the revised regularized strongly constrained and appropriately normed (r2SCAN) density functional could enable the rapid and highly reliable prediction of the elasticity and temperature dependence of thermophysical parameters of refractory elements and their intermetallic compounds using quasi-harmonic approximation (QHA). Here, we present a comparative evaluation of the equilibrium cell volumes, cohesive energy, mechanical moduli, and thermophysical properties (Debye temperature and thermal expansion coefficient) for 22 transition metals using semilocal density functionals, including local density approximation (LDA), the Perdew-Burke-Ernzerhof (PBE) and PBEsol generalized gradient approximations (GGA), and the r2SCAN meta-GGA. PBEsol and r2SCAN deliver the same level of accuracies for structural, mechanical and thermophysical properties. Otherwise, PBE and r2SCAN perform better than LDA and PBEsol for calculating cohesive energies of transition metals. Among the tested density functionals, r2SCAN provides an overall well-balanced performance for reliably computing the cell volumes, cohesive energies, mechanical properties, and thermophysical properties of various 3d, 4d, and 5d transition metals using QHA. Therefore, we recommend that r2SCAN could be employed as a workhorse method to evaluate the thermophysical properties of transition metal compounds and alloys in the high throughput workflows.

الوصول الحر: http://arxiv.org/abs/2309.12554Test

المؤلفون: Liu, Jian-Long, Luo, Xi-Yu, Yu, Yong, Wang, Chao-Yang, Wang, Bin, Hu, Yi, Li, Jun, Zheng, Ming-Yang, Yao, Bo, Yan, Zi, Teng, Da, Jiang, Jin-Wei, Liu, Xiao-Bing, Xie, Xiu-Ping, Zhang, Jun, Mao, Qing-He, Jiang, Xiao, Zhang, Qiang, Bao, Xiao-Hui, Pan, Jian-Wei

مصطلحات موضوعية: Quantum Physics, Physics - Optics

الوصف: Towards realizing the future quantum internet, a pivotal milestone entails the transition from two-node proof-of-principle experiments conducted in laboratories to comprehensive, multi-node setups on large scales. Here, we report on the debut implementation of a multi-node entanglement-based quantum network over a metropolitan area. We equipped three quantum nodes with atomic quantum memories and their telecom interfaces, and combined them into a scalable phase-stabilized architecture through a server node. We demonstrated heralded entanglement generation between two quantum nodes situated 12.5 km apart, and the storage of entanglement exceeding the round-trip communication time. We also showed the concurrent entanglement generation on three links. Our work provides a metropolitan-scale testbed for the evaluation and exploration of multi-node quantum network protocols and starts a new stage of quantum internet research.
Comment: 21 pages in total, 4 figures and 1 table in the main text, 5 figures and 8 tables in the supplementary material

الوصول الحر: http://arxiv.org/abs/2309.00221Test

المؤلفون: Jia-ning Wang, Yue Zhang, Chen-ye Huang, Kang Li, Xiao-bing Yu

المصدر: BMC Ophthalmology, Vol 24, Iss 1, Pp 1-5 (2024)

مصطلحات موضوعية: Immune checkpoint inhibitors (ICIs), Vogt-Koyanagi-Harada disease (VKHD)-like uveitis, Immune-related adverse events (irAEs), Anti-PD-1 (Toripalimab), Ophthalmology, RE1-994

الوصف: Abstract Background Several immune checkpoint inhibitors (ICIs) have been linked to the occurrence of Vogt-Koyanagi-Harada disease (VKHD)-like uveitis. Among the ICIs, there has been no report of immune-related adverse events (irAEs) caused by a new programmed death protein-1(PD-1) monoclonal antibody (Toripalimab). Case presentation This paper presents a case of VKHD-like uveitis that arose following Toripalimab therapy for urothelial cancer of the bladder, and the patient experienced symptoms 10 days after the final dosage of 20 months of medication treatment. This patient with bladder uroepithelial carcinoma had severe binocular acute panuveitis with exudative retinal detachment after receiving Toripalimab therapy. Binocular VKHD-like uveitis was suggested as a diagnosis. Both eyes recovered after discontinuing immune checkpoint inhibitors and local and systemic corticosteroid treatment. Conclusions This report suggests that VKHD-like uveitis can also occur in patients receiving novel PD-1 antibodies and the importance of paying attention to eye complications in patients receiving treatment over a long period.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1471-2415Test

الوصول الحر: https://doaj.org/article/7b3510b0118443cda7c969e77b208cfbTest

المؤلفون: Zhi-Xue Yang, Dong-Hao Deng, Zhu-Ying Gao, Zhi-Kang Zhang, Ya-Wen Fu, Wei Wen, Feng Zhang, Xiang Li, Hua-Yu Li, Jian-Ping Zhang, Xiao-Bing Zhang

المصدر: Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)

مصطلحات موضوعية: Biology (General), QH301-705.5

الوصف: Abstract The potential for off-target mutations is a critical concern for the therapeutic application of CRISPR-Cas9 gene editing. Current detection methodologies, such as GUIDE-seq, exhibit limitations in oligonucleotide integration efficiency and sensitivity, which could hinder their utility in clinical settings. To address these issues, we introduce OliTag-seq, an in-cellulo assay specifically engineered to enhance the detection of off-target events. OliTag-seq employs a stable oligonucleotide for precise break tagging and an innovative triple-priming amplification strategy, significantly improving the scope and accuracy of off-target site identification. This method surpasses traditional assays by providing comprehensive coverage across various sgRNAs and genomic targets. Our research particularly highlights the superior sensitivity of induced pluripotent stem cells (iPSCs) in detecting off-target mutations, advocating for using patient-derived iPSCs for refined off-target analysis in therapeutic gene editing. Furthermore, we provide evidence that prolonged Cas9 expression and transient HDAC inhibitor treatments enhance the assay’s ability to uncover off-target events. OliTag-seq merges the high sensitivity typical of in vitro assays with the practical application of cellular contexts. This approach significantly improves the safety and efficacy profiles of CRISPR-Cas9 interventions in research and clinical environments, positioning it as an essential tool for the precise assessment and refinement of genome editing applications.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2399-3642Test

الوصول الحر: https://doaj.org/article/ca2357b3dbc94140bda92191948be5cdTest

المؤلفون: Lili Zhang, Mei Chen, Zhiqiang Wang, Minjuan Zhong, Hong Chen, Ting Li, Linlin Wang, Zhihui Zhao, Xiao-Bing Zhang, Guoliang Ke, Yanlan Liu, Weihong Tan

المصدر: ACS Central Science, Vol 10, Iss 6, Pp 1201-1210 (2024)

مصطلحات موضوعية: Chemistry, QD1-999

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2374-7951Test

الوصول الحر: https://doaj.org/article/298ab79a3cf545f2948dceabfe3022bcTest

المؤلفون: Qiao-Mei Hong, Hao-Nan Wang, Xi-Hui Liu, Wen-Qi Zhou, Xiao-Bing Luo

المصدر: Trials, Vol 25, Iss 1, Pp 1-12 (2024)

مصطلحات موضوعية: Knee osteoarthritis, Blood flow restriction, Resistance training, Vascular occlusion, Rehabilitation, Medicine (General), R5-920

الوصف: Abstract Background Knee osteoarthritis (KOA) is a chronic musculoskeletal disorder characterized by pain and functional impairment. Blood flow restriction (BFR) with low-load resistance training (LLRT) demonstrates a similar improvement in clinical outcomes to high-load resistance training (HLRT) in treating KOA. It has not been established whether intermittent blood flow restriction (iBFR) with LLRT can lead to clinical outcomes that are comparable to those produced by continuous blood flow restriction (cBFR) with LLRT and HLRT. The aim of the proposed study is to evaluate the efficacy of iBFR with LLRT on pain, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), muscle strength, muscle mass, physical function, perceptions of discomfort and effort, and adherence in KOA patients. Methods This is a three-arm, non-inferiority, randomized controlled trial utilizing blinded assessors. Two hundred thirteen participants will be randomly allocated to one of the following three groups: iBFR group—receiving 4 months of LLRT with iBFR, twice weekly (n = 71); cBFR group—receiving 4 months of LLRT with cBFR, twice weekly (n = 71); or HLRT group—receiving 4 months of HLRT without BFR, twice weekly (n = 71). The primary outcome is pain. The secondary outcomes include the WOMAC, muscle strength, muscle mass, physical function, perceptions of discomfort and effort, and adherence. Pain and WOMAC will be measured at the baseline and 4 and 12 months after randomizations. Muscle strength, muscle mass, and physical function will be measured at the baseline and 4 months after randomizations. The perceptions of discomfort and effort will be measured during the first and final sessions. Discussion BFR with LLRT has a similar improvement in clinical outcomes as HLRT. However, cBFR may cause elevated ratings of perceived exertion and local discomfort, compromising patient tolerability and treatment adherence. If iBFR with LLRT could produce improvement in clinical outcomes analogous to those of HLRT and iBFR with LLRT, it could be considered an alternative approach for treating patients with KOA. Trial registration Chinese Clinical Trial Registry ChiCTR2300072820. Registered on June 26, 2023.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1745-6215Test

الوصول الحر: https://doaj.org/article/6c7cd031792a49d2a04455c174eb2c4bTest