المؤلفون: Zhang, Peng, Duan, Yunyun, Gu, Guocan, Qu, Liying, Xiao, Dan, Xi, Tianshu, Pan, Changcun, Liu, Ya’ou, Zhang, Liwei

المساهمون: National Natural Science Foundation of China, Beijing Municipal Natural Science Foundation, Beijing Municipal Health Commission

المصدر: Frontiers in Oncology ; volume 13 ; ISSN 2234-943X

مصطلحات موضوعية: Cancer Research, Oncology

الوصف: Objective Diffuse intrinsic pontine gliomas (DIPGs) are rare but devastating diseases. This retrospective cross-sectional study aimed to investigate the clinical, radiological, and pathological features of DIPGs. Materials and methods The clinical data of 80 pediatric DIPGs under clinical treatment in Beijing Tiantan Hospital from July 2013 to July 2019 were retrospectively collected and studied. A follow-up evaluation was performed. Results This study included 48 men and 32 women. The most common symptoms were cranial nerve palsy (50.0%, 40/80 patients) and limb weakness (41.2%, 33/80 patients). Among the 80 patients, 24 cases were clinically diagnosed, 56 cases were pathologically verified, and 45 cases were tested for H3K27 alteration status, with 34 H3K27 alteration cases confirmed. Radiological results indicated that enhancement was common (65.0%, 52/80 patients). Cho/Cr was of predictive value for H3K27 alteration status ( P = 0.012, cutoff value = 2.38, AUC = 0.801). Open cranial surgery followed by further chemotherapy and radiotherapy was beneficial for patients’ overall survival. Cox regression analysis indicated H3K27 alteration to be the independent prognostic influencing factor for DIPGs in this series ( P = 0.002). Conclusion DIPGs displayed a wide spectrum of clinical and imaging features. Surgery-suitable patients could benefit from postoperative comprehensive therapy for a better overall survival. H3K27 alteration was the independent prognostic influencing factor for DIPGs.

الإتاحة: https://doi.org/10.3389/fonc.2023.1007393Test

المؤلفون: Xiao, Dan, Yan, Changxiang, Li, Deling, Xi, Tianshu, Liu, Xianzhi, Zhu, Dan, Huang, Guodong, Xu, Jianguo, He, Zhengwen, Wu, Anhua, Ma, Chiyuan, Long, Jiang, Shu, Kai, Ji, Hongming, Wang, Ning, Chen, Gang, Yang, Jiankai, Ma, Hui, Li, Zhiyong, Sun, Xiaochuan, Qu, Yan, Liu, Zhixiong, Jiang, Xiaofan, Tian, Chunlei, Ni, Shilei, Zhan, Renya, Chen, Liwen, Ge, Ming, Wang, Maode, Jiang, Xiaobing, Guo, Geng, Han, Zhenmin, Zhang, Chuan, Zhang, Tingrong, Dou, Changwu, Chu, Liangzhao, Wang, Pengcheng, Shao, Junfei, Wu, Xiyue, Yu, Ju, Wang, Yu, Wu, Nan, Zhang, Rui, Zhang, Mingming, Hong, Yong, Gao, Jianzhong, Li, Yunqian, Pan, Yawen, Zhao, Bing, Ji, Nan

المصدر: The Lancet Regional Health - Western Pacific ; volume 34, page 100715 ; ISSN 2666-6065

مصطلحات موضوعية: Infectious Diseases, Psychiatry and Mental health, Geriatrics and Gerontology, Public Health, Environmental and Occupational Health, Obstetrics and Gynecology, Health Policy, Pediatrics, Perinatology and Child Health, Internal Medicine

الإتاحة: https://doi.org/10.1016/j.lanwpc.2023.100715Test
https://api.elsevier.com/content/article/PII:S2666606523000330?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2666606523000330?httpAccept=text/plainTest

المؤلفون: Chen, Changqi, Xi, Tianshu, Zhang, Yanan

المصدر: Journal of Physics: Conference Series ; volume 2083, issue 2, page 022052 ; ISSN 1742-6588 1742-6596

الوصف: The Final Optic Assembly (FOA) is one of the key components of the inertial confinement nuclear fusion device. The temperature change in the FOA is related to the laser frequency conversion efficiency of the frequency doubling crystal. In order to research the temperature control of FOA, this paper considers the internal atmosphere and internal structure of FOA, designed and fabricated a vacuum temperature control experiment box, and set up heat sources inside the box to simulate the internal heating of the FOA. This article uses different radiation heat transfer models to analysis the temperature field of the vacuum experiment box. Compare the thermal simulation results of the S2S model and the DO model, and compare them with the actual temperature of the vacuum experiment box under the same boundary conditions. The results show that the S2S model fits well with the experimental results and is more suitable for thermal analysis of FOA, which is of great significance to the follow-up FOA temperature control research.

الإتاحة: https://doi.org/10.1088/1742-6596/2083/2/022052Test

المؤلفون: Zhao, Xiaobin, Li, Deling, Qiao, Zhen, Wang, Kai, Chen, Qian, Pan, Changcun, Wu, Yuliang, Xiao, Dan, Xi, Tianshu, Zhang, Liwei, Ai, Lin

المساهمون: The National Natural Science Foundation of China, The Beijing Natural Science Foundation

المصدر: European Journal of Nuclear Medicine and Molecular Imaging ; volume 50, issue 6, page 1709-1719 ; ISSN 1619-7070 1619-7089

مصطلحات موضوعية: Radiology, Nuclear Medicine and imaging, General Medicine

الإتاحة: https://doi.org/10.1007/s00259-022-06105-zTest

المؤلفون: Zhao, Xiaobin, Li, Deling, Qiao, Zhen, Wang, Kai, Chen, Qian, Pan, Changcun, Wu, Yuliang, Xiao, Dan, Xi, Tianshu, Zhang, Liwei, Ai, Lin

المصدر: European Journal of Nuclear Medicine & Molecular Imaging; May2023, Vol. 50 Issue 6, p1709-1719, 11p, 2 Color Photographs, 4 Charts, 2 Graphs

مصطلحات موضوعية: GLIOMAS, CHILD patients, PROGNOSIS, PROGRESSION-free survival, OPTICAL tomography, UNIVARIATE analysis, OVERALL survival, POSITRON emission tomography

مستخلص: Purpose: This study aimed to describe ¹¹C-methionine (¹¹C-MET) PET imaging characteristics in patients with paediatric diffuse intrinsic pontine glioma (DIPG) and correlate them with survival and H3 K27M mutation status. Methods: We retrospectively analysed 98 children newly diagnosed with DIPG who underwent ¹¹C-MET PET. PET imaging characteristics evaluated included uptake intensity, uniformity, metabolic tumour volume (MTV), and total lesion methionine uptake (TLMU). The maximum, mean, and peak of the tumour-to-background ratio (TBR), calculated as the corresponding standardised uptake values (SUV) divided by the mean reference value, were also recorded. The associations between the PET imaging characteristics and clinical outcomes in terms of progression-free survival (PFS) and overall survival (OS) and H3 K27M mutation status were assessed, respectively. Results: In univariate analysis, imaging characteristics significantly associated with shorter PFS and OS included a higher uniformity grade, higher TBRs, larger MTV, and higher TLMU. In multivariate analysis, larger MTV at diagnosis, shorter symptom duration, and no treatment were significantly correlated with shorter PFS and OS. The PET imaging features were not correlated with H3 K27M mutation status. Conclusion: Although several imaging features were significantly associated with PFS and OS, only MTV, indicating the size of the active tumour, was identified as a strong independent prognostic factor. [ABSTRACT FROM AUTHOR]

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المؤلفون: Ding, Jiheng, Wang, Youyong, Xi, Tianshu, Zhao, Jinglei, Sun, Yi, Wang, Min, Pu, Huayan, Peng, Yan, Luo, Jun, Zhu, Tao, Ouyang, Qi

المساهمون: National Natural Science Foundation of China, Shanghai Sailing Program, National Key Research and Development Program of China

المصدر: IEEE/ASME Transactions on Mechatronics ; volume 27, issue 6, page 5824-5834 ; ISSN 1083-4435 1941-014X

الإتاحة: https://doi.org/10.1109/tmech.2022.3189406Test
http://xplorestaging.ieee.org/ielx7/3516/9985402/09842358.pdf?arnumber=9842358Test

المؤلفون: Xi, Tianshu, Chen, Changqi

المصدر: 2021 IEEE International Conference on Data Science and Computer Application (ICDSCA)

الإتاحة: https://doi.org/10.1109/icdsca53499.2021.9650189Test
http://xplorestaging.ieee.org/ielx7/9649650/9649725/09650189.pdf?arnumber=9650189Test