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1دورية أكاديمية
المؤلفون: Netanja I. Harlianto, BSc, Solaiman Ezzafzafi, BSc, Wouter Foppen, MD, PhD, Jonneke S. Kuperus, MD, PhD, Irene E. van der Horst-Bruinsma, MD, PhD, Pim A. de Jong, MD, PhD, Jorrit-Jan Verlaan, MD, PhD
المصدر: North American Spine Society Journal, Vol 17, Iss , Pp 100312- (2024)
مصطلحات موضوعية: Diffuse idiopathic skeletal hyperostosis, Ankylosing spondylitis, Spondylarthitis, Fracture, Vertebral fracture, Radiography, Orthopedic surgery, RD701-811, Neurology. Diseases of the nervous system, RC346-429
الوصف: Background: Subjects with ankylosing spinal disorders, including diffuse idiopathic skeletal hyperostosis (DISH) and ankylosing spondylitis (AS) are more prone to vertebral fractures and frequently present with neurological deficit compared to the patients without an ankylosed spine. Moreover, prevalent vertebral fractures are an important predictor for subsequent fracture risk. However, the pooled fracture prevalence for DISH is unknown and less recent for AS. We aimed to systematically investigate the prevalence and risk of vertebral fractures in DISH and AS populations. Methods: Publications in Medline and EMBASE were searched from January 1980 until July 2023 for cohort studies reporting vertebral fractures in AS and DISH. Data on prevalence were pooled with random effects modeling after double arcsine transformation. Heterogeneity was assessed with I2 statistics and we performed subgroup analysis and meta-regression to explore sources of heterogeneity. Results: We included 7 studies on DISH (n = 1,193, total fractures = 231) with a pooled vertebral fracture prevalence of 22.6% (95%CI: 13.4%–33.4%). For AS, 26 studies were included (n = 2,875, total fractures = 460) with a pooled vertebral fracture prevalence of 15.2% (95%CI: 11.6%–19.1%). In general, fracture prevalence for AS remained similar for several study-level and clinically relevant characteristics, including study design, diagnostic criteria, spine level, and patient characteristics in subgroup analysis. AS publications from 2010 to 2020 showed higher fracture prevalence compared to 1990 to 2010 (18.6% vs. 11.6%). Fractures in DISH were most common at the thoracolumbar junction, whereas for AS, the most common location was the mid-thoracic spine. Conclusions: Vertebral fractures are prevalent in AS and DISH populations. Differences in fracture distribution along the spinal axis exist between the 2 disorders. Additional longitudinal studies are needed for incident fracture assessment in patients with ankylosing spinal disorders.
وصف الملف: electronic resource
العلاقة: http://www.sciencedirect.com/science/article/pii/S2666548424000052Test; https://doaj.org/toc/2666-5484Test
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2دورية أكاديمية
المؤلفون: Pim A de Jong, Marloes W Heijstek, Julia Spierings, Karijn P M Suijkerbuijk, Nienke J Kleinrensink, Wouter Foppen, Harald E Vonkeman, Mylène P Jansen, Negina Seddiqi, Amin Herman
المصدر: RMD Open, Vol 10, Iss 1 (2024)
مصطلحات موضوعية: Medicine
الوصف: Background Patients with psoriatic arthritis (PsA) have an increased risk of cardiovascular disease, possibly due to a chronic inflammatory state.Objectives The main objective of this study was to investigate the difference in vascular inflammation, measured with 18-fluorodeoxyglucose positron emission tomography/CT (PET/CT), in PsA patients and controls. We conducted a secondary analysis to assess the association between clinical parameters of disease activity with vascular inflammation in PsA.Methods We included a total of 75 PsA patients with active peripheral arthritis (defined as ≥2 tender and swollen joints) from an ongoing clinical trial (EudraCT 2017-003900-28) and a retrospective group of 40 controls diagnosed with melanoma, without distant metastases and not receiving immunotherapy. The main outcome measure was aortic vascular inflammation which was measured on PET/CT scans using target-to-background ratios. Clinical disease activity in PsA was assessed with joint counts, body surface area and the Disease Activity index for PsA. Laboratory assessments included C reactive protein and erythrocyte sedimentation rate.Results Vascular inflammation was increased in patients with PsA in comparison with controls (mean target-to-background ratio for entire aorta, respectively, 1.63±0.17 vs 1.49±0.16; p=
وصف الملف: electronic resource
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3دورية أكاديمية
المؤلفون: Lize F. D. van Vulpen, Simon C. Mastbergen, Wouter Foppen, Kathelijn Fischer, Floris P. J. G. Lafeber, Roger E. G. Schutgens
المصدر: Journal of Personalized Medicine, Vol 14, Iss 2, p 145 (2024)
مصطلحات موضوعية: haemophilia, arthropathy, personalized medicine, HFE, HMOX1, Medicine
الوصف: The treatment landscape for haemophilia is changing rapidly, creating opportunities for personalized treatment. As major morbidity is still caused by haemophilic arthropathy, understanding the factors affecting joint damage and joint damage progression might lead to more individualized treatment regimens. We investigated the association of HFE mutations or HMOX1 polymorphisms affecting iron/heme handling with radiographic joint damage in 252 haemophilia patients (severe and moderate). Although iron levels and transferrin saturation were significantly increased in the 95 patients with an HFE mutation, neither carrying this mutation nor the HMOX1 polymorphism was associated with radiographic joint damage, and the same was true after adjustment for well-known factors associated with arthropathy. In conclusion, this study does not support the hypothesis that HFE mutations or HMOX1 polymorphisms can be used to predict the development of haemophilic arthropathy.
وصف الملف: electronic resource
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4دورية أكاديمية
المؤلفون: Wouter Foppen, Yvette Claassen, Debby Falck, Nardo J. M. van der Meer
المصدر: Journal of Clinical Medicine, Vol 12, Iss 16, p 5317 (2023)
مصطلحات موضوعية: trauma systems, polytrauma, outcome analysis, mortality, quality of healthcare, Medicine
الوصف: Background: Healthcare stakeholders in the Netherlands came to an agreement in 2022 to deal with present and future challenges in healthcare. Among others, this agreement contains clear statements regarding the concentration of trauma patients, including the minimal required number of annual severe trauma patients for Major Trauma Centers. This review investigates the effects of trauma patient volumes on several domains of the quality of healthcare. Methods: PubMed was searched; studies published during the last 10 years reporting quantitative data on trauma patient volume and quality of healthcare were included. Results were summarized and categorized into the quality domains of healthcare. Results: Seventeen studies were included with a total of 1,517,848 patients. A positive association between trauma patient volume and survival was observed in 11/13 studies with adjusted analyses. Few studies addressed other quality domains: efficiency (n = 5), safety (n = 2), and time aspects of care (n = 4). None covered people-centeredness, equitability, or integrated care. Conclusions: Most studies showed a better survival of trauma patients when treated in high-volume hospitals compared to lower volume hospitals. However, the ideal threshold could not be determined. The association between trauma volume and other domains of the quality of healthcare remains unclear.
وصف الملف: electronic resource
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5دورية أكاديمية
المؤلفون: Flora H. P. van Leeuwen, Beatrice Lena, Jaco J. M. Zwanenburg, Lize F. D. van Vulpen, Lambertus W. Bartels, Kathelijn Fischer, Frank J. Nap, Pim A. de Jong, Clemens Bos, Wouter Foppen
المصدر: European Radiology Experimental, Vol 5, Iss 1, Pp 1-10 (2021)
مصطلحات موضوعية: Haemarthrosis, Image interpretation (computer-assisted), Magnetic resonance imaging, Phantoms (imaging), Synovial fluid, Medical physics. Medical radiology. Nuclear medicine, R895-920
الوصف: Abstract Background Intra-articular blood causes irreversible joint damage, whilst clinical differentiation between haemorrhagic joint effusion and other effusions can be challenging. An accurate non-invasive method for the detection of joint bleeds is lacking. The aims of this phantom study were to investigate whether magnetic resonance imaging (MRI) T1 and T2 mapping allows for differentiation between simple and haemorrhagic joint effusion and to determine the lowest blood concentration that can be detected. Methods Solutions of synovial fluid with blood concentrations ranging from 0 to 100% were scanned at 1.5, 3, and 7 T. T1 maps were generated with an inversion recovery technique and T2 maps from multi spin-echo sequences. In both cases, the scan acquisition times were below 5 min. Regions of interest were manually drawn by two observers in the obtained T1 and T2 maps for each sample. The lowest detectable blood concentration was determined for all field strengths. Results At all field strengths, T1 and T2 relaxation times decreased with higher blood concentrations. The lowest detectable blood concentrations using T1 mapping were 10% at 1.5 T, 25% at 3 T, and 50% at 7 T. For T2 mapping, the detection limits were 50%, 5%, and 25%, respectively. Conclusions T1 and T2 mapping can detect different blood concentrations in synovial fluid in vitro at clinical field strengths. Especially, T2 measurements at 3 T showed to be highly sensitive. Short acquisition times would make these methods suitable for clinical use and therefore might be promising tools for accurate discrimination between simple and haemorrhagic joint effusion in vivo.
وصف الملف: electronic resource
العلاقة: https://doaj.org/toc/2509-9280Test
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6دورية أكاديمية
المؤلفون: Paco M J Welsing, Floris P J G Lafeber, Pim A de Jong, Janneke Tekstra, Marloes W Heijstek, Julia Spierings, Nienke J Kleinrensink, Wouter Foppen, Emmerik F A Leijten, Sarita A Y Hartgring, Mylène P Jansen, Juliëtte N Pouw, Frank T Perton, Nanette L A Vincken, Saeed Arbabi
المصدر: BMJ Open, Vol 12, Iss 10 (2022)
مصطلحات موضوعية: Medicine
الوصف: Introduction Psoriatic arthritis (PsA) is a chronic, inflammatory, musculoskeletal disease that affects up to 30% of patients with psoriasis. Current challenges in clinical care and research include personalised treatment, understanding the divergence of therapy response and unravelling the multifactorial pathophysiology of this complex disease. Moreover, there is an urgent clinical need to predict, assess and understand the cellular and molecular pathways underlying the response to disease-modifying antirheumatic drugs (DMARDs). The TOFA-PREDICT clinical trial addresses this need. Our primary objective is to determine key immunological factors predicting tofacitinib efficacy and drug-free remission in PsA.Methods and analysis In this investigator-initiated, phase III, multicentre, open-label, four-arm randomised controlled trial, we plan to integrate clinical, molecular and imaging parameters of 160 patients with PsA. DMARD-naïve patients are randomised to methotrexate or tofacitinib. Additionally, patients who are non-responsive to conventional synthetic (cs)DMARDs continue their current csDMARD and are randomised to etanercept or tofacitinib. This results in four arms each with 40 patients. Patients are followed for 1 year. Treatment response is defined as minimal disease activity at week 16. Clinical data, biosamples and images are collected at baseline, 4 weeks and 16 weeks; at treatment failure (treatment switch) and 52 weeks. For the first 80 patients, we will use a systems medicine approach to assess multiomics biomarkers and develop a prediction model for treatment response. Subsequently, data from the second 80 patients will be used for validation.Ethics and dissemination The study was approved by the Medical Research Ethics Committee in Utrecht, Netherlands, is registered in the European Clinical Trials Database and is carried out in accordance with the Declaration of Helsinki. The study’s progress is monitored by Julius Clinical, a science-driven contract research organisation.Trial registration number EudraCT: 2017-003900-28.
وصف الملف: electronic resource
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7دورية أكاديمية
المؤلفون: Nienke J. Kleinrensink, Wouter Foppen, Iris ten Katen, Emmerik F. A. Leijten, Pim A. de Jong, Julia Spierings
المصدر: Journal of Personalized Medicine, Vol 12, Iss 11, p 1765 (2022)
مصطلحات موضوعية: enthesitis, inflammation, magnetic resonance imaging, psoriatic arthritis, psoriasis, spondyloarthritis, Medicine
الوصف: Enthesitis is a common clinical feature of spondyloarthritis (SpA). For reliable assessment of enthesitis the Heel Enthesitis Magnetic Resonance Imaging Scoring System (HEMRIS) was developed. The aims of this study were to evaluate changes in HEMRIS over time and to evaluate whether these changes correlated with changes in clinical parameters. This single-center observational study followed patients with SpA and psoriasis, regardless of presence of clinical heel enthesitis, for two years. Clinical evaluation and ankle MRIs were performed annually. Changes in HEMRIS were compared at one-year intervals using the Wilcoxon signed-rank test. The association between changes in the HEMRIS with changes in clinical parameters was evaluated using Spearman’s correlation coefficient. In total, 38 patients were included. An increase in the inflammatory and structural HEMRIS was identified in, respectively, 12 (17.9%) and 4 (6.0%) patients in one-year intervals. We found non-significant changes in the HEMRIS during longitudinal follow-up. Changes in the HEMRIS did not correlate with changes in local or general disease activity. Our results show that MRI-findings of enthesitis assessed with HEMRIS changed in a small number of patients in a one-year interval in an observational setting. Changes in HEMRIS were not associated with changes in clinical disease activity.
وصف الملف: electronic resource
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8دورية أكاديمية
المؤلفون: Pim A de Jong, Nienke J Kleinrensink, Wouter Foppen, Iris Ten Katen, Pieternella H van der Veen, Bo de Klerk, Suzanne C E Diepstraten, Emmerik F A Leijten
المصدر: RMD Open, Vol 6, Iss 3 (2020)
مصطلحات موضوعية: Medicine
الوصف: Objective To compare the Heel Enthesitis MRI Scoring model (HEMRIS) with clinical and PET/CT outcomes in patients with cutaneous psoriasis (Pso), psoriatic arthritis (PsA) or ankylosing spondylitis (AS).Methods This prospective, observational study included 38 patients with Pso, PsA and AS. Patients were included regardless of presence or absence of clinical heel enthesitis. MRI-scans of both ankles and a whole-body 18F-FDG PET/CT were acquired. MRIs were assessed for enthesitis by two independent and blinded observers according to the HEMRIS. A physician, blinded for imaging results, performed clinical evaluations of enthesitis at the Achilles tendon and plantar fascia.Results In total, 146 entheses were scored according to the HEMRIS and clinically assessed for enthesitis (6 entheses were clinically affected). In Achilles tendons with clinical enthesitis, the HEMRIS structural damage score was significantly higher, compared to Achilles tendons without clinical enthesitis (respective median scores 1.0 and 0.5; p=0.04). In clinically unaffected entheses, HEMRIS abnormalities occurred in 44/70 (63%) of Achilles tendons and in 23/70 (33%) of plantar fascia. At the Achilles tendon, local metabolic activity measured on PET/CT was weakly associated with the structural (rs=0.25, p=0.03) and total HEMRIS (rs=0.26, p=0.03).Conclusion This study revealed a high prevalence of subclinical HEMRIS abnormalities and discrepancy between HEMRIS and clinical and PET/CT findings. This may suggest that the HEMRIS is a sensitive method for detection of inflammatory and structural disease of enthesitis at the Achilles tendon and plantar fascia, although the clinical significance of these MRI findings remains to be determined in longitudinal studies.
وصف الملف: electronic resource
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9دورية أكاديمية
المؤلفون: Wouter Foppen, Nelleke Tolboom, Pim A. de Jong
المصدر: Journal of Personalized Medicine, Vol 11, Iss 8, p 769 (2021)
الوصف: Medicine has evolved into a high level of specialization using the very detailed imaging of organs [...]
وصف الملف: electronic resource
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10دورية أكاديمية
المؤلفون: Netanja I. Harlianto, Jan Westerink, Wouter Foppen, Marjolein E. Hol, Rianne Wittenberg, Pieternella H. van der Veen, Bram van Ginneken, Jonneke S. Kuperus, Jorrit-Jan Verlaan, Pim A. de Jong, Firdaus A. A. Mohamed Hoesein, on behalf of the UCC-SMART-Study Group
المصدر: Journal of Personalized Medicine, Vol 11, Iss 7, p 663 (2021)
مصطلحات موضوعية: diffuse idiopathic skeletal hyperostosis, risk factors, adiposity, intra-abdominal fat, Medicine
الوصف: Background: Diffuse idiopathic skeletal hyperostosis (DISH) is associated with both obesity and type 2 diabetes. Our objective was to investigate the relation between DISH and visceral adipose tissue (VAT) in particular, as this would support a causal role of insulin resistance and low grade inflammation in the development of DISH. Methods: In 4334 patients with manifest vascular disease, the relation between different adiposity measures and the presence of DISH was compared using z-scores via standard deviation logistic regression analyses. Analyses were stratified by sex and adjusted for age, systolic blood pressure, diabetes, non-HDL cholesterol, smoking status, and renal function. Results: DISH was present in 391 (9%) subjects. The presence of DISH was associated with markers of adiposity and had a strong relation with VAT in males (OR: 1.35; 95%CI: 1.20–1.54) and females (OR: 1.43; 95%CI: 1.06–1.93). In males with the most severe DISH (extensive ossification of seven or more vertebral bodies) the association between DISH and VAT was stronger (OR: 1.61; 95%CI: 1.31–1.98), while increased subcutaneous fat was negatively associated with DISH (OR: 0.65; 95%CI: 0.49–0.95). In females, increased subcutaneous fat was associated with the presence of DISH (OR: 1.43; 95%CI: 1.14–1.80). Conclusion: Markers of adiposity, including VAT, are strongly associated with the presence of DISH. Subcutaneous adipose tissue thickness was negatively associated with more severe cases of DISH in males, while in females, increased subcutaneous adipose tissue was associated with the presence of DISH.
وصف الملف: electronic resource
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