المؤلفون: Ruilope, LM, Agarwal, R, Anker, SD, Bakris, GL, Filippatos, G, Nowack, C, Kolkhof, P, Joseph, A, Mentenich, N, Pitt, B, Aizenberg, D, Bartolacci, I, Besada, D, Bittar, J, Chahin, M, Elbert, A, Gelersztein, E, Liberman, A, Maffei, L, Manghi, FP, Sanabria, H, Vallejos, A, Vines, G, Wassermann, A, Abhayaratna, W, Colman, P, Colquhon, D, Ekinci, E, MacIsaac, R, Mah, PM, Nelson, C, Packham, D, Pape, A, Roger, S, Stephenson, H, Suranyi, M, Topliss, D, Vandeleur, J, Wittert, G, Wynne, KJ, Clodi, M, Drexel, H, Ebenbichler, C, Fliesser-Gorzer, E, Hanusch, U, Ludvik, B, Neudorfer, P, Paulweber, B, Prager, R, Preiss, W, Prischl, F, Schernthaner, GH, Schonherr, HR, Sourij, H, Doubel, P, Duyck, F, Engelen, W, Gillard, P, Hougardy, JM, Scheen, A, Speeckaert, M, Stas, K, van Gaal, L, Vanbelleghem, H, Antunes, D, Botelho, R, Brito, C, Canani, L, Canziani, ME, Cerqueira, M, de Paula, R, Eliaschewitz, F, Figueiredo, CE, Forti, A, Hissa, M, Leite, M, Noronha, I, Paolino, B, Paschoalin, N, Paschoalin, R, Pecoits, R, Pereira, M, Portes, E, Precoma, D, Rea, R, Riella, M, Salles, JE, Vasconcellos, E, Vencio, S, Boshnyashka, R, Farah, G, Georgiev, D, Gushterova, V, Klyuchkova, N, Lucheva, M, Manova, P, Minkova, D, Nonchev, B, Pichmanova, M, Prakova, Z, Rangelov, R, Rashkov, R, Stanchev, P, Stoyanovska-Elencheva, B, Tagarev, Z, Temelkova-Kurktschieva, T, Vasileva, S, Yoncheva-Mihaylova, M, Barre, P, Carlson, B, Conway, J, Cournoyer, S, Dumas, R, Fikry, S, Goluch, R, Hamet, P, Hart, R, Henein, S, Kelly, A, Liutkus, J, Madore, F, Martinho, V, Mazza, G, McFarlane, P, O'Keefe, D, Peterson, S, Schwartz, D, Shu, D, Steele, A, Teitelbaum, I, Tellier, G, Tennankore, K, Tobe, S, Tsoukas, G, Tytus, R, Vitou, L, Walsh, M, Weisnagel, S, Wilderman, I, Yale, JF, Cobos, J, Godoy, J, Gonzalez, F, Medina, M, Palma, JC, Prieto, JC, Reyes, E, Romero, C, Saavedra, V, Varleta, P, Bu, RF, Cai, HQ, Chen, N, Chen, QK, Chen, DJ, Cheng, JL, Dong, YP, Dong, JW, Du, YM, Fang, Y, Guan, TJ, Guo, WY, Hao, CM, Jiang, FF, Jian, S, Kuang, J, Lei, MX, Li, L, Li, DM, Li, HM, Li, JM, Li, Y, Li, YX, Li, ZH, Liu, F, Liu, J, Liu, YH, Liu, YT, Liu, ZH, Long, G, Lu, GY, Lu, WP, Lu, YB, Ma, JH, Mo, ZH, Niu, JY, Peng, A, Shen, JS, Shen, FX, Shi, BY, Su, Q, Sun, ZX, Tang, SF, Tong, NW, Wang, H, Wang, XJ, Wang, LH, Wang, JQ, Wang, L, Wei, JL, Wu, CQ, Wu, TF, Xing, CY, Xiong, F, Xu, XD, Xu, N, Yang, JK, Yin, AP, Zeng, LY, Zhang, H, Zhang, YL, Zhang, Y, Zhao, ZQ, Zheng, HG, Zhong, L, Zhong, LY, Zhu, DL, Arango, C, Arcos, E, Arcos, G, Barrera, S, Barreto, G, Lopez, NB, Benitez, D, Blanco, G, Botero, R, Cardenas, T, Coronel, J, Cure, C, Duran, C, Garcia, L, Guzman, G, Hernandez, E, Ibarra, J, Jaramillo, C, Jaramillo, N, Kattah, W, Molina, D, Sanchez, G, Terront, M, Trujillo, F, Urina, M, Villegas, I, Yupanqui, H, Alferi, D, Brada, M, Brezina, J, Bucek, P, Edelsberger, T, Gulakova, D, Zapletalova, JH, Hola, O, Hornova, L, Houdova, J, Hrmova, H, Karasek, D, Kopecka, S, Kovar, R, Krcova, E, Kuchar, J, 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Taschner, H, Toursarkissian, N, Tschope, D, Ulmer, A, van der Giet, M, Wanner, C, Winkelmann, BR, Boletis, I, Hatziagelaki, E, Ioannidis, I, Kounadi, T, Makriniotou, I, Papadopoulou, D, Papagianni, A, Passadakis, P, Stefanidis, I, Ip, TP, Lee, P, Ma, CWR, Yeung, V, Bajcsi, D, Danos, P, Harcsa, E, Kalina, A, Kazup, S, Keltai, K, Kirschner, R, Kiss, J, Kovacs, L, Lamboy, B, Literati-Nagy, B, Mileder, M, Nagy, L, Noori, E, Nyirati, G, Petro, G, Schneider, K, Szocs, A, Vasas, S, Wudi, K, Zilahi, Z, Zsom, M, Eustace, J, Hatunic, M, Holian, J, Reddan, D, O'Meara, Y, Ness, RA, Adawi, F, Armaly, Z, Atar, S, Bashkin, A, Ben Chetrit, S, Yanay, NB, Chernin, G, Darawsha, M, Efrati, S, Elias, M, Farber, E, Glandt, M, Grossman, E, Halabi, M, Liberty, I, Mosenzon, O, Nimer, A, Wainstein, J, Yagil, Y, Zukermann, R, Battaglia, GG, Bonora, E, Bossi, CA, Calabro, P, Cavalot, FL, Cimino, R, Emdin, M, Fiaccadori, E, Fiorina, P, Giorda, CB, Gregorini, MC, La Manna, G, Maggi, DC, Pani, A, Perico, N, Piatti, 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Madrzejewski, A, Madziarska, K, Mazur, S, Napora, P, Nowicki, M, Ocicka-Kozakiewicz, A, Rewerska, B, Rusicka, T, Ruxer, J, Skokowska, E, Stankiewicz, A, Stompor, T, Tiuryn-Petrulewicz, A, Wasilewska, K, Wierusz-Wysocka, B, Wnetrzak-Michalska, R, Almeida, E, Ballesteros, R, Barreto, C, Brandao, I, Carvalho, R, Esteves, C, Guia, J, Heitor, S, Matos, P, Melo, P, Nolasco, F, Pereira, A, Roque, C, Rosario, F, Silva, G, Silva, A, Costa, FTE, Lobos, AV, Cortes-Maisonet, G, Roman-Miranda, A, Albota, A, Bala, C, Barbonta, H, Caceaune, E, Catrinoui, D, Constantin, C, Dumitrescu, A, Mindrescu, N, Mistode, C, Negrisanu, G, Onaca, A, Paveliu, S, Pintilei, E, Pop, L, Popa, A, Popescu, A, Radulian, G, Szilagyi, I, Turcu, L, Vacaru, G, Vlad, A, Antsiferov, M, Arkhipov, M, Babkin, A, Baranov, V, Barbarash, O, Chernyavskaya, E, Demko, A, Dreval, A, Edin, A, Ermakova, P, Galyavich, A, Gaysina, L, Gordeev, I, Ipatko, I, Kalashnikova, M, Khalimov, Y, Klimontov, V, Kobalava, Z, Kosmacheva, E, Koziolova, N, Kvitkova, L, Levashov, S, Libis, R, Malykh, N, Malyutina, S, Marasaev, V, Mareev, V, Martynenko, V, Merai, I, Mkrtumyan, A, Nechaeva, G, Nikolaev, K, Palyutin, S, Petunina, N, Pimenov, L, Rechkova, E, Rodionova, T, Rymar, O, Sardinov, R, Semenova, O, Sherenkov, A, Smolyarchuk, E, Solovev, O, Strongin, L, Ukhanova, O, Verlan, N, Vorokhobina, N, Yakhontov, D, Zakharova, E, Zalevskaya, A, Zanozina, O, Zhdanova, E, Zhukova, L, Zykova, T, Bee, YM, Sum, CF, Tan, RS, Babikova, J, Buganova, I, Dzupina, A, Ochodnicka, Z, Sosovec, D, Spodniakova, D, Ahmed, F, Amod, A, Bhana, S, Distiller, L, van Rensburg, DJ, Joshi, M, Joshi, S, Lakha, D, Mitha, E, Podgorski, G, Ranjith, N, Rayner, B, Rheeder, P, Sarvan, M, Seeber, M, Siebert, H, Tayob, M, Trokis, J, Urbach, D, van Zyl, L, Cho, YM, Chung, C, Hwang, Y, Kang, J, Kim, H, Kim, S, Kim, I, Kim, J, Lee, W, Lee, B, Lim, S, Park, CY, Yu, JM, Bouarich, H, Calero, F, Castro, C, Castro, FC, Guldris, SC, Garrit, JC, de Alvaro, F, Galceran, J, Albarran, OG, Jaras, JH, Ibernon, M, Deben, FM, Esteban, MDM, Martins, J, Mediavilla, J, Michan, A, Izuel, JMP, Santos, JP, Poch, E, Rusillo, MP, Redon, J, Juan, CS, Olmo, RS, de la Morena, JJS, Seron, D, Soto, A, Troya, M, Bruchfeld, A, Curiac, D, Eliasson, K, Frank, M, Guron, G, Hellberg, O, Hellgren, M, Larnefeldt, H, Lindholm, CJ, Londahl, M, Rein-Hedin, E, Soveri, I, Spaak, J, Tengmark, BO, Bilz, S, Donath, M, Laimer, M, Pechere-Bertschi, A, Rudofsky, G, Strey, C, Wuerzner, G, Chang, CT, Hung, CC, Jiang, JY, Lee, CT, Tarng, DC, Tu, ST, Wu, MS, Wu, MJ, Deerochanawong, C, Kosachunhanan, N, Pongchaiyakul, C, Satirapoj, B, Sritara, P, Badak, O, Cayli, M, Eren, N, Gul, I, Kocyigit, I, Kumbasar, A, Oguz, A, Ozdogan, O, Sahin, I, Sari, R, Tavli, T, Temizhan, A, Tigen, M, Ustundag, S, Yenicerioglu, Y, Bondarets, I, Botsyurko, V, Chernikova, V, Donets, O, Fushtey, I, Grachova, M, Isayeva, A, Kogut, D, Komisarenko, J, Kravchun, N, Malyar, K, Mankovsky, B, Martynyuk, L, Maslyanko, V, Myshanych, H, Pererva, L, Pertseva, N, Serhiyenko, O, Smirnov, I, Sokolova, L, Stryzhak, V, Vlasenko, M, Arif, I, Dang, C, Hanna, F, Kahal, H, Kalathil, D, Kilvert, A, Kon, SP, Kyriakidou, C, McCafferty, K, Rice, S, Swift, P, Vijayaraman, A, Wong, YK, Acosta, I, Adams, A, Adler, S, Ajani, D, Alicic, R, Al-Karadsheh, A, Alla, S, Allison, D, Andrawis, N, Arif, A, Awad, A, Azizad, M, Bahrami, M, Bansal, S, Barag, S, Barakzoy, A, Barney, M, Bashir, K, Bautista, J, Beddhu, S, Benjamin, S, Berenji, R, Bertsch, J, Bhargava, A, Birriel, J, Bleich, D, Bornfreund, J, Brar, H, Brian, S, Brietzke, S, Brusco, O, Burgner, A, Busch, R, Canadas, R, Caramori, M, Cardona, J, Carpio, J, Case, C, Cruz, H, Dandillaya, R, Dhanireddy, S, Din, Z, Dixon, B, Doshi, A, El Shahawy, M, El-Shahawy, M, Evans, J, Fadda, G, Farooq, U, Fernando, R, Fink, R, First, B, Fitz-Patrick, D, Flack, J, Fluck, P, Fogelfeld, L, Fonseca, V, Frias, J, Galphin, C, Garcia-Mayol, L, Goldstein, G, Gonzalez, E, Gonzalez-Abreu, F, Gore, A, Grant, D, Habwe, V, Halpern, S, Hamilton, M, Hammoud, J, Handelsman, S, Hartman, I, Heigerick, G, Hernandez, G, Hernandez-Cassis, C, Herrera, C, Iranmanesh, A, Jackson, T, Jain, M, Jamerson, K, Johnson, K, Kayali, Z, Kaye, W, Khan, B, Khan, M, Kharait, S, Kirkman, MS, Koch, S, Kopyt, N, Korff, G, Kotzker, W, Kovesdy, C, Kreit, C, Krishna, A, Kronfli, S, Lee, K, LeJeune, D, Lemus, B, Lerman, S, Linfert, D, Lora, H, Lurie, A, Maddukuri, G, Magno, A, Maletz, L, Mandayam, S, Mandviwala, M, Markell, M, Martin, E, Mayfield, R, Mbogua, C, McMullen, D, Meisner, C, Meyer, J, Minton, S, Mocherla, B, Montero, M, Moustafa, M, Nadkarni, S, Nakhle, S, Navarro, J, Neyra, N, Nica, R, Nicol, P, Norwood, P, Numrungroad, V, O'Donovan, R, Odugbesan, A, Oliver, D, Oparil, S, Paoli-Bruno, J, Parikh, S, Patel, R, Peixoto, A, Pergola, P, Pettis, K, Pisoni, R, Ponduchi, M, Popeil, L, Posada, J, Prabhakar, S, Raina, R, Ramanathan, K, Ramon-Gonez, L, Rastogi, A, Reisin, E, Rendell, M, Rocco, M, Romeu, H, Rosas, S, Ross, 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المصدر: American journal of nephrology. 50(5):345-356

مصطلحات موضوعية: Medicin och hälsovetenskap

الوصول الحر: http://kipublications.ki.se/Default.aspx?queryparsed=id:142331844Test

المؤلفون: Chew, J, Wong, AC, Shinohara, K, III, Roach M, Hsu, ICJ

المصدر: INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS. 108(3)

مصطلحات موضوعية: Oncology & Carcinogenesis, Other Physical Sciences, Clinical Sciences, Oncology and Carcinogenesis

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/85r386w8Test

المؤلفون: Liu, M, Wong, AC, McPheeters, JT, Dixon, R, Madge, V, Basra, G, Sachdev, A, Veeranki, P

المصدر: Value in Health ; volume 25, issue 7, page S448-S449 ; ISSN 1098-3015

مصطلحات موضوعية: Public Health, Environmental and Occupational Health, Health Policy

الإتاحة: https://doi.org/10.1016/j.jval.2022.04.828Test
https://api.elsevier.com/content/article/PII:S1098301522010294?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1098301522010294?httpAccept=text/plainTest

المؤلفون: Zatreanu, D, Robinson, HMR, Alkhatib, O, Boursier, M, Finch, H, Geo, L, Grande, D, Grinkevich, V, Heald, RA, Langdon, S, Majithiya, J, McWhirter, C, Martin, NMB, Moore, S, Neves, J, Rajendra, E, Ranzani, M, Schaedler, T, Stockley, M, Wiggins, K, Brough, R, Sridhar, S, Gulati, A, Shao, N, Badder, LM, Novo, D, Knight, EG, Marlow, R, Haider, S, Callen, E, Hewitt, G, Schimmel, J, Prevo, R, Alli, C, Ferdinand, A, Bell, C, Blencowe, P, Bot, C, Calder, M, Charles, M, Curry, J, Ekwuru, T, Ewings, K, Krajewski, W, MacDonald, E, McCarron, H, Pang, L, Pedder, C, Rigoreau, L, Swarbrick, M, Wheatley, E, Willis, S, Wong, AC, Nussenzweig, A, Tijsterman, M, Tutt, A, Boulton, SJ, Higgins, GS, Pettitt, SJ, Smith, GCM, Lord, CJ

المساهمون: Haider, Syed, Pettitt, Stephen, Lord, Christopher

مصطلحات موضوعية: Organoids, Cell Line, Tumor, Animals, Humans, Mice, Rats, Ovarian Neoplasms, DNA Damage, Deoxyribonucleases, DNA-Directed DNA Polymerase, Cell Cycle Proteins, DNA-Binding Proteins, BRCA1 Protein, BRCA2 Protein, Nucleic Acid Synthesis Inhibitors, Drug Screening Assays, Antitumor, Inhibitory Concentration 50, Apoptosis, Cell Proliferation, Cell Survival, DNA Repair, Allosteric Regulation, Drug Resistance, Neoplasm, Female, Homologous Recombination, Poly(ADP-ribose) Polymerase Inhibitors, Tumor Suppressor p53-Binding Protein 1

الوصف: To identify approaches to target DNA repair vulnerabilities in cancer, we discovered nanomolar potent, selective, low molecular weight (MW), allosteric inhibitors of the polymerase function of DNA polymerase Polθ, including ART558. ART558 inhibits the major Polθ-mediated DNA repair process, Theta-Mediated End Joining, without targeting Non-Homologous End Joining. In addition, ART558 elicits DNA damage and synthetic lethality in BRCA1- or BRCA2-mutant tumour cells and enhances the effects of a PARP inhibitor. Genetic perturbation screening revealed that defects in the 53BP1/Shieldin complex, which cause PARP inhibitor resistance, result in in vitro and in vivo sensitivity to small molecule Polθ polymerase inhibitors. Mechanistically, ART558 increases biomarkers of single-stranded DNA and synthetic lethality in 53BP1-defective cells whilst the inhibition of DNA nucleases that promote end-resection reversed these effects, implicating these in the synthetic lethal mechanism-of-action. Taken together, these observations describe a drug class that elicits BRCA-gene synthetic lethality and PARP inhibitor synergy, as well as targeting a biomarker-defined mechanism of PARPi-resistance.

وصف الملف: Electronic; ?; application/pdf

العلاقة: Nature communications, 2021, 12 (1), pp. 3636 - ?; https://repository.icrTest.ac.uk/handle/internal/4762

الإتاحة: https://doi.org/10.1038/s41467-021-23463-8Test
https://repository.icrTest.ac.uk/handle/internal/4762

المؤلفون: Lin, S, Lo, KWK, Ngai, G, Chan, SCF, Kuo, AML, Wong, AC

المساهمون: Service-Learning and Leadership Office, Department of Computing

مصطلحات موضوعية: International eService-Learning, Solar energy, Tele-engineering

الوصف: 202306 bcww ; Accepted Manuscript ; Self-funded ; Published

العلاقة: IEEE Global Humanitarian Technology Conference (GHTC); http://hdl.handle.net/10397/98957Test; 169; 172; 2-s2.0-85123499630; a2070; 46460

الإتاحة: https://doi.org/10.1109/GHTC53159.2021.9612493Test
http://hdl.handle.net/10397/98957Test

المؤلفون: Perkovic, Vlado, Jardine, Meg J, Neal, Bruce, Bompoint, Severine, Heerspink, Hiddo J L, Charytan, David M, Edwards, Robert, Agarwal, Rajiv, Bakris, George, Bull, Scott, Cannon, Christopher P, Capuano, George, Chu, Pei-Ling, de Zeeuw, Dick, Greene, Tom, Levin, Adeera, Pollock, Carol, Wheeler, David C, Yavin, Yshai, Zhang, Hong, Zinman, Bernard, Meininger, Gary, Brenner, Barry M, Mahaffey, Kenneth W., Perkovic V, Mahaffey KW, Agarwal R, Bakris G, Brenner BM, Cannon CP, Charytan DM, de Zeeuw D, Greene T, Jardine MJ, Heerspink HJL, Levin A, Meininger G, Neal B, Pollock C, Wheeler DC, Zhang H, Zinman B, McGuire DK, Holman R, Home P, Scharfstein D, Parfrey P, Shahinfar S, August P, Chang T, Sinha AD, Januzzi J, Kolansky D, Amerena J, Hillis G, Gorelick P, Kissela B, Kasner S, Lindley R, Fulcher G, Ounadjela S, Hufert K, von Ingersleben G, Gaglia J, Harris R, Hudson M, Turchin A, Cheifetz A, Sheth S, Feuerstein J, Cohen S, Jardine M, Li N, Kolesnyk I, Aizenberg D, Pecoits-Filho R, Cherney D 3rd, Obrador G, Chertow G, Hawley C, Ji L, Wada T, Jha V, Lim SK, Lim-Abrahan MA, Santos F, Chae DW, Hwang SJ, Vazelov E, Rychlík I, Hadjadj S, Krane V, Rosivall L, De Nicola L, Dreval A, Nowicki M, Schiller A, Distiller L, Górriz JL, Kolesnyk M, Morren F, Goykhman S, David C, Yost L, Wang H, Hettiarachchi M, Thimmaiah R, Koppolu D, George S, Schmidt M, Ignjatovic J, Chapin L, Travis K, Destree M, Sood V, Coffee L, De Brouwer K, Zaviriukha V, Starzec A, Koizumi M, Lin G, Chen E, Lin P, Leia C, Mascaro D, Amigo A, Limos A, Abrahamsen I, Jaffer S, Ahuad Guerrero RA, Albisu JP, Alvarisqueta A, Bartolacci I, Berli MA, Bordonava A, Calella P, Cantero MC, Cartasegna LR, Cercos E, Coloma GC, Colombo H, Commendatore V, Cuadrado J, Cuneo CA, Cusumano AM, Douthat WG, Dran RD, Farias E, Fernandez MF, Finkelstein H, Fragale G, Fretes JO, Garcia NH, Gastaldi A, Gelersztein E, Glenny JA, Gonzalez JP, Gonzalez Colaso PDC, Goycoa C, Greloni GC, Guinsburg A, Hermida S, Juncos LI, Klyver MI, Kraft F, Krynski F, Lanchiotti PV, Leon de la Fuente RA, Marchetta N, Mele P, Nicolai S, Novoa PA, Orio SI, Otreras F, Oviedo A, Raffaele P, Resk JH, Rista L, Rodriguez Papini N, Sala J, Santos JC, Schiavi LB, Sessa H, Smith Casabella T, Ulla MR, Valdez M, Vallejos A, Villarino A, Visco VE, Wassermann A, Zaidman CJ, Cheung NW, Droste C, Fraser I, Johnson D, Mah PM, Nicholls K, Packham D, Proietto J, Roberts A, Roger S, Tsang V, Raduan RA, Alves da Costa FA, Amodeo C, Andreotti Turatti LA, Bregman R, Camelo Sanches FC, Canani LH, Chacra AR, Cunha Borges JL, Cunha Vêncio SA, da Silva Franco RJ, d'Avila D, de Souza Portes E, de Souza P, Deboni LM, Filho FF, Geloneze Neto B, Gomes M, Kohara SK, Keitel E, Kerr Saraiva JF, Kurtz Lisboa HR, de Carvalho Contieri FL, Milagres R, Montenegro Junior R, Moreira de Brito C, Nazzer Hissa M, Nazario Sabbag ÂR, Noronha I, Panarotto D, Pecoits Filho R, Pereira MA, Saporito W, Scotton AS, Schuch T, Simões de Almeida R, Slompo Ramos C, Soares Felício J, Thomé F, Tibes Hachmann JC, Yamada S, Yoiti Hayashida C, Zanata Petry TB, Zanella MT, Andreeva V, Angelova A, Dimitrov S, Genadieva V, Genova-Hristova G, Hristozov K, Kamenov Z, Koundurdjiev A, Lozanov L, Margaritov V, Nonchev B, Rangelov R, Shinkov A, Temelkova M, Velichkova E, Yakov A, Aggarwal N, Aronson R, Bajaj H, Chouinard G, Conway J, Cournoyer S, DaRoza G, De Serres S, Dubé F, Goldenberg R, Gupta A, Gupta M, Henein S, Khandwala H, Leiter L, Madore F, McMahon A, Muirhead N, Pichette V, Rabasa-Lhoret R, Steele A, Tangri N, Torshizi A, Woo V, Zalunardo N, Fernández Montenegro MA, Godoy Jorquera JG, Medina Fariña M, Saavedra Gajardo V, Vejar M, Chen N, Chen Q, Gan S, Kong Y, Li D, Li W, Li X, Lin H, Liu J, Lu W, Mao H, Ren Y, Song W, Sun J, Sun L, Tu P, Wang G, Yang J, Yin A, Yu X, Zhao M, Zheng H, Accini Mendoza JL, Arcos E, Avendano J, Diaz Ruiz JEA, Garcia Ortiz LH, Gonzalez A, Hernandez Triana E, Higuera JD, Malaver N, Molina de Salazar DI, Rosero R, Terront Lozano MA, Valderrama Cometa L, Valenzuela A, Vargas Alonso RD, Villegas I, Yupanqui H, Bartaskova D, Barton P, Belobradkova J, Dohnalova L, Drasnar T, Ferkl R, Halciakova K, Klokocnikova V, Kovar R, Lastuvka J, Lukac M, Pesickova S, Peterka K, Pumprla J, Rychlik I, Saudek F, Tesar V, Valis M, Weiner P, Zemek S, Alamartine E, Borot S, Cariou B, Dussol B, Fauvel JP, Gourdy P, Klein A, Le Meur Y, Penfornis A, Roussel R, Saulnier PJ, Thervet E, Zaoui P, Burst V, Faghih M, Faulmann G, Haller H, Jerwan-Keim R, Maxeiner S, Paschen B, Plassmann G, Rose L, Gonzalez Orellana RA, Haase FP, Moreira Diaz JP, Ramirez Roca LA, Sánchez Arenales JA, Sanchez Polo JV, Turcios Juarez E, Csecsei G, Csiky B, Danos P, Deak L, Dudas M, Harcsa E, Keltai K, Keresztesi S, Kiss K, Konyves L, Major L, Mileder M, Molnar M, Mucsi J, Oroszlan T, Ory I, Paragh G, Peterfai E, Petro G, Revesz K, Takacs R, Vangel S, Vasas S, Zsom M, Abraham O, Bhushan RS, Deepak D, Edwin FM, Gopalakrishnan N, Gracious N, Hansraj A, Jain D, Keshavamurthy CB, Khullar D, Manisha S, Peringat J, Prasad N, Satyanarayana RK, Sreedhar R, Sreelatha M, Sudhakar B, Vyasam RC, Bonadonna R, Castellino P, Ceriello A, Chiovato L, De Cosmo S, Derosa G, Di Carlo A, Di Cianni G, Frascà G, Fuiano G, Gambaro G, Garibotto G, Giorda C, Malberti F, Mandreoli M, Mannucci E, Orsi E, Piatti P, Santoro D, Sasso FC, Serviddio G, Stella A, Trevisan R, Veronelli AM, Zanoli L, Akiyama H, Aoki H, Asano A, Iitsuka T, Kajiyama S, Kashine S, Kawada T, Kodera T, Kono H, Koyama K, Kumeda Y, Miyauchi S, Mizuyama K, Niiya T, Oishi H, Ota S, Sakakibara T, Takai M, Tomonaga O, Tsujimoto M, Wakasugi M, Wakida Y, Watanabe T, Yamada M, Yanagida K, Yanase T, Yumita W, Gaupsiene E, Kozloviene D, Navickas A, Urbanaviciene E, Abdul Ghani R, Abdul Kadir K, Ali N, Che Yusof MD, Gan CL, Ismail M, Kong WY, Lam SW, Lee LY, Loh CL, Manocha AB, Ng KS, Nik Ahmad NNF, Ratnasingam V, Bin Shudim SS, Vengadasalam P, Abraira Munoz LD, Salazar MA, Cruz JB, Soto MB, Ramos JC, Wong AC, Correa Rotter JR, Diaz Escalante T, Enriquez Sosa FE, Flores Lozano F, Flota Cervera LF, Frenk Baron P, Garcia Ballesteros C, Gomez Rangel JD, Herrera Jimenez LE, Irizar Santana SS, Jimenez Florez F, Laviada Molina H, Luna Ceballos RI, Martin Del Camp Blanco B, Morales Franco G, Moreno Loza OT, Mustieles Rocha C, Obrador Vera G, Orozco Castellanos R, Peralta Calcaneo J, Reyes Rosano MA, Rodriguez Pattzi H, Rosas Guzman J, Rucker Joerg IE, Saaveddra Sanchez SB, Sanchez Mijangos JH, Serrano Sanson P, Tamayo Y Orozco JA, Tellez Chavez E, Valdes Depeda A, Venegas Carrillo L, Villagordoa Mesa J, Zamarripa Escobedo R, Baker J, Noonan P, Scott R, Walker R, Watson E, Williams M, Young S, Abejuela Z, Agra J, Aquitania G, Caringal C, Comia RS, Delos Santos L, Gomez O, Jimeno C, Tan G, Tolentino M, Yao C, Yap YE, Ygpuara MDL, Bijata-Bronisz R, Hotlos L, Januszewicz A, Kaczmarek B, Kaminska A, Lazuka L, Madej A, Mazur S, Mlodawska-Choluj D, Orlowska-Kowalik G, Popenda G, Rewerska B, Sowinski D, Angelescu LM, Anghel V, Avram RI, Busegeanu MM, Cif A, Cosma D, Crisan C, Demian LD, Ferariu IE, Halmagyi I, Hancu N, Munteanu M, Negru D, Onaca AG, Petrica L, Popa AR, Ranetti AE, Serafinceanu C, Toarba C, Agafyina A, Barbarash O, Barysheva O, Chizhov D, Dobronravov V, Glinkina I, Grineva E, Khirmanov V, Kolmakova E, Koroleva T, Kvitkova L, Marasaev V, Mkrtumyan A, Morugova T, Nagibovich G, Nagibovich O, Nedogoda S, Osipova I, Raskina T, Samoylova Y, Sazonova O, Shamkhalova M, Shutemova E, Shwartz Y, Uriasyev O, Vorobyev S, Zateyshchikova A, Zateyshshikov D, Zykova T, Antic S, Djordjevic M, Kendereski A, Lalic K, Lalic N, Popovic-Radinovic V, Babikova J, Benusova O, Buganova I, Culak J, Dzupina A, Dzuponova J, Fulop P, Ilavska A, Martinka E, Ochodnicka Z, Pella D, Smatanova I, Ahmed F, Badat A, Breedt J, Govender V, Govender R, Joshi M, Jurgens J, Latiff G, Lombard L, Mookadam M, Ngcakani N, Nortje H, Oosthuizen H, Pillay-Ramaya L, Prozesky H, Reddy J, Rheeder P, Seeber M, Cho YM, Jeong IK, Kim SG, Kim YH, Kwon HS, Kwon MJ, Lee BW, Lee J, Lee MK, Nam MS, Oh KH, Park CY, Park SH, Yoon KH, Alvarez Garcia P, Asmarats Mercadal L, Barrios C, Cereto Castro F, Cigarran Guldris S, Dominquez Lopez M, Egido de Los Rios J, Fernandez Fresnedo G, Galan Serrano A, Garcia I, Gonzalez Martinez FJ, Jodar Gimeno JE, Muñoz Lopez Mendoza M, Malek Marin T, Morales Portillo C, Munar Vila MA, Muñoz Torres M, Nieto Iglesias J, Pantoja Perez J, Perez Vera M, Portoles Perez JM, Quesada Simón MA, Simo Canonge R, Soto Gonzalez A, Terns Riera M, Tinahones Madueno FJ, Plaza MV, Chang CT, Chuang LM, Hsia TL, Hsieh CH, Lin CC, Lu YC, Sheu WH, Barna O, Bilyk SD, Botsyurko V, Dudar I, Fushtey I, Godlevska O, Golovchenko O, Gyrina O, Kazmirchuk A, Komisarenko I, Korzh O, Kravchun N, Legun O, Mankovskyy B, Martynyuk L, Mostovoy Y, Pashkovska N, Pererva L, Pertseva T, Samoylov O, Smirnov I, Svyshchenko Y, Tomashkevych H, Topchii I, Tryshchuk N, Tseluyko V, Vizir V, Vlasenko M, Zlova T, Zub L, Abusnana S, Railey M, Abouglila K, Ainsworth P, Ali Z, Arutchelvam V, Barnard M, Bellary S, Davies E, Davies M, Davies S, Dawson A, El Kossi M, English P, Fraser D, Gnudi L, Gunstone A, Hall T, Hanif W, Jackson A, Johnson A, Joseph F, Krishnan S, Kumwenda M, MacDougall I, Nixon P, O'Hare J, Philip S, Ramtoola S, Saxena M, Sennik D, Simon G, Singh B, Stephens J, Strzelecka A, Symonds R, Turner W, Wahba M, Wakeling J, Wheeler D, Winocour P, Abdallah J, Abdullah R, Abramowitz M, Acosta I, Aiello J, Akright L, Akyea-Djamson A, Alappan R, Alicic R, Al-Karadsheh A, Allison DC, Arauz-Pacheco C, Arfeen S, Arif A, Arvind M, Atray N, Awad A, Barnhill P, Barranco E, Barrera C, Beacom M, Behara V, Belo D, Bentley-Lewis R, Berenguer R, Bermudez L, Bernardo M, Biscoveanu M, Bowman-Stroud C, Brandon D, Brusco O, Busch R, Canaan Y, Chilito A, Christensen T, Christiano C, Christofides E, Chuateco C, Cohen K, Cohen R, Cohen-Stein D, Cook C, Coyne D, Daboul N, Darwish R, Daswani A, Deck K, Desouza C, Dev D, Dhillon M, Dua S, Eder F, Elosegui AM, El-Shahawy M, Ervin J, Esquenazi A, Evans J, Fishbane S, Frias J, Galindo-Ramos E, Galphin C, Ghazi A, Gonzalez E, Gorson D, Gowda A, Greco B, Grubb S, Gulati R, Hammoud J, Handelsman S, Hartman I, Hershon K, Hiser D, Hon G, Jacob R, Jaime M, Jamal A, Kaupke C, Keightley G, Kern E, Khanna R, Khitan Z, Kim S, Kopyt N, Kovesdy C, Krishna G, Kropp J, Kumar A, Kumar J, Kumar N, Kusnir J, Lane W, Lawrence M, Lehrner L, Lentz J, Levinson D, Lewis D, Liss K, Maddux A, Maheshwari H, Mandayam S, Marar I, Mehta B, Middleton J, Mordujovich J, Moreda R, Moustafa M, Mujica Trenche S, Narayanan M, Narvarte J, Nassar T, Newman G, Nichol B, Nicol P, Nisnisan J, Nossuli AK, Obialo C, Olelewe S, Oliver M, O'Shaughnessy A, Padron J, Pankhaniya R, Parker R, Patel D, Patel G, Patel N, Pavon H, Perez A, Perez C, Perlman A, Pettis K, Pharr W, Phillips A, Purighalla R, Quesada-Suarez L, Ranjan R, Rastogi S, Rendell M, Rich L, Robinson M, Rodriguez H, Rosas S, Saba F, Sankaram R, Sarin R, Schreiman R, Scott D, Sekkarie M, Sensenbrenner J, Shakeel M, Shanik M, Shaw S, Smith S, Solomon R, Sprague A, Spry L, Suchinda P, Sultan S, Surampudi P, Sussman S, Tan A, Terrelonge A, Thompson M, Trespalacios F, Trippe B, Trueba P, Twahirwa M, Updegrove J, Van Buren P, Vannorsdall M, Varghese F, Velasquez-Mieyer P, Ventrapragada S, Vukotic G, Wadud K, Warren M, Watson H, Watts R, Weiner D, Welker J, Welsh J, Williams S, Zaniewski-Singh M.

المساهمون: Perkovic, Vlado, Jardine, Meg J, Neal, Bruce, Bompoint, Severine, Heerspink, Hiddo J L, Charytan, David M, Edwards, Robert, Agarwal, Rajiv, Bakris, George, Bull, Scott, Cannon, Christopher P, Capuano, George, Chu, Pei-Ling, de Zeeuw, Dick, Greene, Tom, Levin, Adeera, Pollock, Carol, Wheeler, David C, Yavin, Yshai, Zhang, Hong, Zinman, Bernard, Meininger, Gary, Brenner, Barry M, Mahaffey, Kenneth W., Perkovic, V, Mahaffey, Kw, Agarwal, R, Bakris, G, Brenner, Bm, Cannon, Cp, Charytan, Dm, de Zeeuw, D, Greene, T, Jardine, Mj, Heerspink, Hjl, Levin, A, Meininger, G, Neal, B, Pollock, C, Wheeler, Dc, Zhang, H, Zinman, B, Mcguire, Dk, Holman, R, Home, P, Scharfstein, D, Parfrey, P, Shahinfar, S, August, P, Chang, T, Sinha, Ad, Januzzi, J, Kolansky, D, Amerena, J, Hillis, G, Gorelick, P, Kissela, B, Kasner, S, Lindley, R, Fulcher, G, Ounadjela, S, Hufert, K, von Ingersleben, G, Gaglia, J, Harris, R, Hudson, M, Turchin, A, Cheifetz, A, Sheth, S, Feuerstein, J, Cohen, S, Jardine, M, Li, N, Kolesnyk, I, Aizenberg, D, Pecoits-Filho, R, Cherney, D 3rd, Obrador, G, Chertow, G, Hawley, C, Ji, L, Wada, T, Jha, V, Lim, Sk, Lim-Abrahan, Ma, Santos, F, Chae, Dw, Hwang, Sj, Vazelov, E, Rychlík, I, Hadjadj, S, Krane, V, Rosivall, L, De Nicola, L, Dreval, A, Nowicki, M, Schiller, A, Distiller, L, Górriz, Jl, Kolesnyk, M

مصطلحات موضوعية: diabetic nephropathy

الوصف: BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to <90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], >300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or ...

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/30990260; info:eu-repo/semantics/altIdentifier/wos/WOS:000471299100008; volume:380 (24); firstpage:2295; lastpage:2306; numberofpages:12; journal:NEW ENGLAND JOURNAL OF MEDICINE; http://hdl.handle.net/11567/947620Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85066483412

الإتاحة: https://doi.org/10.1056/NEJMoa1811744Test
http://hdl.handle.net/11567/947620Test

المؤلفون: Wong AC, Tan, Alex

مصطلحات موضوعية: U.S, Philippines, security partnership, alliance institutionalisation, President Rodrigo Duterte, Fields of Research::44 - Human society::4408 - Political science::440804 - Defence studies, Fields of Research::44 - Human society::4408 - Political science::440808 - International relations

الوصف: This paper examines the security partnership of the United States-Philippines during the presidency of Rodrigo Duterte. Using the theoretical framework of alliance institutionalisation, we identified several factors that can determine the strength of alliances and security partnerships. Applying this framework, we suggest that because of deep alliance institutionalisation, the security partnership between the Philippines and the United States is actually quite resilient despite President Duterte’s position on this issue.

وصف الملف: application/octet-stream

العلاقة: Wong AC, Tan AC The Philippines’ Institutionalised Alliance with the US: Surviving Duterte’s China Appeasement Policy. National Security Journal. 3(1).; https://hdl.handle.net/10092/101896Test; http://doi.org/10.36878/nsj20210317.04Test

الإتاحة: https://doi.org/10.36878/nsj20210317.04Test
https://hdl.handle.net/10092/101896Test

المؤلفون: HSUEH Y. H, SOMERS E. B, LERECLUS D, GHELARDI, EMILIA, LEE WONG AC

المساهمون: Hsueh, Y. H., Somers, E. B., Lereclus, D, Ghelardi, Emilia, LEE WONG, Ac

الوصف: Bacillus cereus ATCC 14579 can respond to nutrient changes by adopting different forms of surface translocation. The B. cereus ATCC 14579 DeltaplcR mutant, but not the wild type, formed dendritic (branched) patterns on EPS [a low-nutrient medium that contains 7.0 g K(2)HPO(4), 3.0 g KH(2)PO(4), 0.1 g MgSO(4).7H(2)O, 0.1 g (NH(4))(2)SO(4), 0.01 g CaCl(2), 0.001 g FeSO(4), 0.1 g NaCl, 1.0 g glucose, and 125 mg yeast extract per liter] containing 0.7% agar. The dendritic patterns formed by sliding translocation of nonflagellated cells are enhanced under low-nutrient conditions and require sufficient production of a biosurfactant, which appears to be repressed by PlcR. The wild-type and complemented strains failed to slide on the surface of EPS agar because of the production of low levels of biosurfactant. Precoating EPS agar surfaces with surfactin (a biosurfactant produced by Bacillus subtilis) or biosurfactant purified from the DeltaplcR mutant rescued the ability of the wild-type and complemented strains to slide. When grown on a nutrient-rich medium like Luria-Bertani agar, both the wild-type and DeltaplcR mutant strains produced flagella. The wild type was hyperflagellated and elongated and exhibited swarming behavior, while the DeltaplcR mutant was multiflagellated and the cells often formed long chains but did not swarm. Thin-layer chromatography and mass spectrometry analyses suggested that the biosurfactant purified from the DeltaplcR mutant was a lipopeptide and had a mass of 1,278.1722 (m/z). This biosurfactant has hemolytic activity and inhibited the growth of several gram-positive bacteria.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/17921286; info:eu-repo/semantics/altIdentifier/wos/WOS:000251103300014; volume:73; firstpage:7225; lastpage:7231; numberofpages:7; journal:APPLIED AND ENVIRONMENTAL MICROBIOLOGY; https://hdl.handle.net/11568/110713Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-36649022885

الإتاحة: https://doi.org/10.1128/AEM.00690-07Test
https://hdl.handle.net/11568/110713Test

المؤلفون: Hall, WA, Paulson, E, Davis, BJ, Spratt, DE, Morgan, TM, Dearnaley, D, Tree, AC, Efstathiou, JA, Harisinghani, M, Jani, AB, Buyyounouski, MK, Pisansky, TM, Tran, PT, Karnes, RJ, Chen, RC, Cury, FL, Michalski, JM, Rosenthal, SA, Koontz, BF, Wong, AC, Nguyen, PL, Hope, TA, Feng, F, Sandler, HM, Lawton, CAF

المساهمون: Dearnaley, David

الوصف: PURPOSE: In 2009, the Radiation Therapy Oncology Group (RTOG) genitourinary members published a consensus atlas for contouring prostate pelvic nodal clinical target volumes (CTVs). Data have emerged further informing nodal recurrence patterns. The objective of this study is to provide an updated prostate pelvic nodal consensus atlas. METHODS AND MATERIALS: A literature review was performed abstracting data on nodal recurrence patterns. Data were presented to a panel of international experts, including radiation oncologists, radiologists, and urologists. After data review, participants contoured nodal CTVs on 3 cases: postoperative, intact node positive, and intact node negative. Radiation oncologist contours were analyzed qualitatively using count maps, which provided a visual assessment of controversial regions, and quantitatively analyzed using Sorensen-Dice similarity coefficients and Hausdorff distances compared with the 2009 RTOG atlas. Diagnostic radiologists generated a reference table outlining considerations for determining clinical node positivity. RESULTS: Eighteen radiation oncologists' contours (54 CTVs) were included. Two urologists' volumes were examined in a separate analysis. The mean CTV for the postoperative case was 302 cm3, intact node positive case was 409 cm3, and intact node negative case was 342 cm3. Compared with the original RTOG consensus, the mean Sorensen-Dice similarity coefficient for the postoperative case was 0.63 (standard deviation [SD] 0.13), the intact node positive case was 0.68 (SD 0.13), and the intact node negative case was 0.66 (SD 0.18). The mean Hausdorff distance (in cm) for the postoperative case was 0.24 (SD 0.13), the intact node positive case was 0.23 (SD 0.09), and intact node negative case was 0.33 (SD 0.24). Four regions of CTV controversy were identified, and consensus for each of these areas was reached. CONCLUSIONS: Discordance with the 2009 RTOG consensus atlas was seen in a group of experienced NRG Oncology and international genitourinary radiation ...

وصف الملف: Print-Electronic; 185; application/pdf

العلاقة: International journal of radiation oncology, biology, physics, 2021, 109 (1), pp. 174 - 185; https://repository.icrTest.ac.uk/handle/internal/4122

الإتاحة: https://doi.org/10.1016/j.ijrobp.2020.08.034Test
https://repository.icrTest.ac.uk/handle/internal/4122

المؤلفون: Kim, YS, Wong, AC, Power, J, Tadros, SF, Klugmann, M, Moorhouse, AJ, Bertrand, PP, Housley, GD

المصدر: urn:ISSN:0270-6474 ; urn:ISSN:1529-2401 ; The Journal of Neuroscience, 32, 33, 11414-11423

مصطلحات موضوعية: Neurosciences, Rare Diseases, Brain Disorders, Neurological, Alternative Splicing, Amino Acid Sequence, Analysis of Variance, Animals, Biophysical Phenomena, Calcium, Calmodulin, Carbachol, Cell Line, Transformed, Cerebellum, Cholinergic Agonists, Excitatory Amino Acid Agents, Female, Genistein, Guinea Pigs, Humans, Inositol 1,4,5-Trisphosphate Receptors, Male, Methoxyhydroxyphenylglycol, Mice, Inbred C57BL, Neurons, Patch-Clamp Techniques, Protein Binding, Protein Isoforms

الوصف: Canonical transient receptor potential (TRPC3) nonselective cation channels are effectors of G-protein-coupled receptors (GPCRs), activated via phospholipase C–diacylglycerol signaling. In cerebellar Purkinje cells, TRPC3 channels cause the metabotropic glutamate receptor (mGluR)-mediated slow EPSC (sEPSC). TRPC3 channels also provide negative feedback regulation of cytosolic Ca2 , mediated by a C terminus “calmodulin and inositol trisphosphate receptor binding” (CIRB) domain. Here we report the alternative splicing of the TRPC3mRNAtranscript (designated TRPC3c), resulting in omission of exon 9 (approximately half of the CIRB domain) in mice, rats, and guinea pigs. TRPC3c expression is brain region specific, with prevalence in the cerebellum and brainstem. The TRPC3c channels expressed in HEK293 cells exhibit increased basal and GPCR-activated channel currents, and increased Ca2 fluorescence responses, compared with the previously characterized (TRPC3b) isoform when activated via either the endogenous M3 muscarinic acetylcholine receptor, or via coexpressed mGluR1. GPCR-induced TRPC3c channel opening rate (cell-attached patch) matched the maximum activation achieved with inside-out patches with zero cytosolic Ca2+, whereas the GPCR-induced TRPC3b activation frequency was significantly less. Both TRPC3 channel isoforms were blocked with 2mM Ca2+, attributable to CIRB domain regulation. In addition, genistein blocked Purkinje cell (S)-2-amino-2-(3,5-dihydroxyphenyl) acetic acid (mGluR1)-activated TPRC3 current as for recombinant TRPC3c current. This novel TRPC3c ion channel therefore has enhanced efficacy as a neuronal GPCR-Ca2+ signaling effector, and is associated with sensorimotor coordination, neuronal development, and brain injury.

وصف الملف: application/pdf

العلاقة: http://hdl.handle.net/1959.4/unsworks_43535Test; https://unsworks.unsw.edu.au/bitstreams/99f6fbeb-4cba-4ce5-9ca9-e0dde380f653/downloadTest; https://doi.org/10.1523/JNEUROSCI.6446-11.2012Test

الإتاحة: https://doi.org/10.1523/JNEUROSCI.6446-11.2012Test
http://hdl.handle.net/1959.4/unsworks_43535Test
https://unsworks.unsw.edu.au/bitstreams/99f6fbeb-4cba-4ce5-9ca9-e0dde380f653/downloadTest