المؤلفون: Peeters S. A., Engelen L., Buijs J., Chaturvedi N., Fuller J. H., Schalkwijk C. G., Stehouwer C. D., Karamanos B., Kofinis A., Petrou K., Giorgino F., Picca G., Angarano A., de Pergola. G., Laviola L., Giorgino R., Ionescu-Tirgoviste C., Coszma A., Guja C., Songini M., Casu A., Pedron M., Pintus S., Fossarello M., Ferriss J. B., Grealy G., O'Keefe D., Toeller M., Arden C., Rottiers R., Tuyttens C., Priem H., Ebeling P., Kylliainen M., Koivisto V. A., Idzior-Walus B., Sieradzki J., Cyganek K., Solnica B., Lemkes H. H. P. J., Lemkes-Stuffken J. C., Nunes-Correa J., Rogado M. C., Gardete-Correia L., Cardoso M. C., Silva A., Boavida J., Machado Sa Marques M., Michel G., Wirion R., Cardillo S., Pozza G., Mangili R., Asnaghi V., Standl E., Schaffler B., Brand H., Harms A., Ben Soussan M., Verier-Mine O., Fallas P., Fallas M. C., Holloway J., Asbury L., Betteridge D. J., Cathelineau G., Bouallouche A., Villatte Cathelineau B., Santeusanio F., Rosi G., D'Alessandro V., Cagini C., Bottini P., Reboldi G. P., Navalesi R., Penno G., Bandinelli S., Miccoli R., Nannipieri M., Ghirlanda G., Saponara C., Cotroneo P., Manto A., Minnella A., Ward J. D., Tesfaye S., Eaton S., Mody C., Borra M., Cavallo Perin P., Giunti S., Grassi G., Pagano G. F., Porta M., Sivieri R., Vitelli F., Veglio M., Papazoglou N., Manes G., Muggeo M., Iagulli M., Cacciatori V., Cattedra di Malattie del Metabolismo V., Irsigler K., Abrahamian H., Walford S., Sinclair J., Hughes S., McLelland V., Ward J., Roglic G., Metelko Z., Pepeonik Z. R.

المساهمون: Peeters, S. A., Engelen, L., Buijs, J., Chaturvedi, N., Fuller, J. H., Schalkwijk, C. G., Stehouwer, C. D., Karamanos, B., Kofinis, A., Petrou, K., Giorgino, F., Picca, G., Angarano, A., Pergola. G., De, Laviola, L., Giorgino, R., Ionescu-Tirgoviste, C., Coszma, A., Guja, C., Songini, M., Casu, A., Pedron, M., Pintus, S., Fossarello, M., Ferriss, J. B., Grealy, G., O'Keefe, D., Toeller, M., Arden, C., Rottiers, R., Tuyttens, C., Priem, H., Ebeling, P., Kylliainen, M., Koivisto, V. A., Idzior-Walus, B., Sieradzki, J., Cyganek, K., Solnica, B., Lemkes, H. H. P. J., Lemkes-Stuffken, J. C., Nunes-Correa, J., Rogado, M. C., Gardete-Correia, L., Cardoso, M. C., Silva, A., Boavida, J., Machado Sa Marques, M., Michel, G., Wirion, R., Cardillo, S., Pozza, G., Mangili, R., Asnaghi, V., Standl, E., Schaffler, B., Brand, H., Harms, A., Ben Soussan, M., Verier-Mine, O., Fallas, P., Fallas, M. C., Holloway, J., Asbury, L., Betteridge, D. J., Cathelineau, G., Bouallouche, A., Villatte Cathelineau, B., Santeusanio, F., Rosi, G., D'Alessandro, V., Cagini, C., Bottini, P., Reboldi, G. P., Navalesi, R., Penno, G., Bandinelli, S., Miccoli, R., Nannipieri, M., Ghirlanda, G., Saponara, C., Cotroneo, P., Manto, A., Minnella, A., Ward, J. D., Tesfaye, S., Eaton, S., Mody, C., Borra, M., Cavallo Perin, P., Giunti, S., Grassi, G., Pagano, G. F., Porta, M., Sivieri, R., Vitelli, F., Veglio, M., Papazoglou, N., Manes, G.

مصطلحات موضوعية: Albuminuria, Cardiovascular disease, Matrix metalloproteinase, Retinopathy, Tissue inhibitor of metalloproteinase, Type 1 diabete, Adult, Biomarker, Cohort Studie, Cross-Sectional Studie, Diabetes Complication, Diabetes Mellitus, Type 1, Europe, Female, Human, Male, Matrix Metalloproteinase 10, Matrix Metalloproteinase 2, Matrix Metalloproteinase 3, Middle Aged, Prospective Studie, Tissue Inhibitor of Metalloproteinase-1, Vascular Diseases

الوصف: Impaired regulation of extracellular matrix remodeling by matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinase (TIMP) may contribute to vascular complications in patients with type 1 diabetes. We investigated associations between plasma MMP-1, -2, -3, -9, -10 and TIMP-1, and cardiovascular disease (CVD) or microvascular complications in type 1 diabetic patients. We also evaluated to which extent these associations could be explained by low-grade inflammation (LGI) or endothelial dysfunction (ED). Methods: 493 type 1 diabetes patients (39.5 ± 9.9 years old, 51% men) from the EURODIAB Prospective Complications Study were included. Linear regression analysis was applied to investigate differences in plasma levels of MMP-1, -2, -3, -9, -10, and TIMP-1 between patients with and without CVD, albuminuria or retinopathy. All analyses were adjusted for age, sex, duration of diabetes, Hba1c and additionally for other cardiovascular risk factors including LGI and ED. Results: Patients with CVD (n = 118) showed significantly higher levels of TIMP-1 [β = 0.32 SD (95%CI: 0.12; 0.52)], but not of MMPs, than patients without CVD (n = 375). Higher plasma levels of MMP-2, MMP-3, MMP-10 and TIMP-1 were associated with higher levels of albuminuria (p-trends were 0.028, 0.004, 0.005 and 0.001, respectively). Severity of retinopathy was significantly associated with higher levels of MMP-2 (p-trend = 0.017). These associations remained significant after further adjustment for markers of LGI and ED. Conclusions: These data support the hypothesis that impaired regulation of matrix remodeling by actions of MMP-2, -3 and-10 and TIMP-1 contributes to the pathogenesis of vascular complications in type 1 diabetes.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/25848912; info:eu-repo/semantics/altIdentifier/wos/WOS:000350726000001; volume:14; issue:1; firstpage:31; journal:CARDIOVASCULAR DIABETOLOGY; http://hdl.handle.net/11586/353539Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84925234995

الإتاحة: https://doi.org/10.1186/s12933-015-0195-2Test
http://hdl.handle.net/11586/353539Test

المؤلفون: Soedamah Muthu SS, Chaturvedi N, Fuller JH, Toeller M, Karamanos B, Kofinis A, Petrou K, Giorgino F, Picca G, Angarano A, De Pergola G, Laviola L, Giorgino R, Ionescu Tirgoviste C, Coszma A, Guja C, Songini M, Casu A, Pedron M, Pintus S, FOSSARELLO, MAURIZIO, Ferriss J, O'Keefe D, Grealy G, Arden C, Rottiers R, Tuyttens C, Priem H, Ebeling P, Kyllia M, Koivisto V, Idzior Walus B, Sieradzki J, Cyganek K, Solnica B, Lemkes H, Lemkes Stuffken J, Rogado M, Gardete Correia L, Cardoso M, Silva A, Boavida J, Machado Sa Marques M, Michel G, Wirion R, Cardillo S, Pozza G, Mangili R, Asnaghi V, Standl E, Schaffler B, Brand H, Soussan D, Verier O, Fallas P, Fallas M, Fuller J, Holloway J, Asbury L, Betteridge D, Cathelineau G, Bouallouche A, Cathelineau B, Santeusanio F, Rosi G, D'Alessandro V, Cagini C, Bottini P, Reboldi G, Navalesi R, Penno G, Bandinelli S, Miccoli R, Nannipieri M, Ghirlanda G, Saponara C, Cotroneo P, Manto A, Ward J, Tesfaye S, Eaton S, Mody C, Borra M, Perin PC, Giunti S, Grassi G, Pagano G, Porta M, Sivieri R, Vitelli F, Veglio M, Papazoglou N, Manes G, Muggeo M, Iagulli M, Cacciatori V, Cattedra V, Irsigler K, Abrahamian H, Walford S, Sinclair J, Hughes S, McLelland V, Roglic G, Metelko Z, Pepeonik Z, Ferriss B, Webb D, Viberti GC, Swaminathan R, Lumb P, Collins A, Sankaralingham S, Crook MA, Aldington S, Mortemore T, Lipinski H, Scherbaum WA, Gries F.A.

المساهمون: Soedamah Muthu, S, Chaturvedi, N, Fuller, Jh, Toeller, M, Karamanos, B, Kofinis, A, Petrou, K, Giorgino, F, Picca, G, Angarano, A, De Pergola, G, Laviola, L, Giorgino, R, Ionescu Tirgoviste, C, Coszma, A, Guja, C, Songini, M, Casu, A, Pedron, M, Pintus, S, Fossarello, Maurizio, Ferriss, J, O'Keefe, D, Grealy, G, Arden, C, Rottiers, R, Tuyttens, C, Priem, H, Ebeling, P, Kyllia, M, Koivisto, V, Idzior Walus, B, Sieradzki, J, Cyganek, K, Solnica, B, Lemkes, H, Lemkes Stuffken, J, Rogado, M, Gardete Correia, L, Cardoso, M, Silva, A, Boavida, J, Machado Sa Marques, M, Michel, G, Wirion, R, Cardillo, S, Pozza, G, Mangili, R, Asnaghi, V, Standl, E, Schaffler, B, Brand, H, Soussan, D, Verier, O, Fallas, P, Fallas, M, Fuller, J, Holloway, J, Asbury, L, Betteridge, D, Cathelineau, G, Bouallouche, A, Cathelineau, B, Santeusanio, F, Rosi, G, D'Alessandro, V, Cagini, C, Bottini, P, Reboldi, G, Navalesi, R, Penno, G, Bandinelli, S, Miccoli, R, Nannipieri, M, Ghirlanda, G, Saponara, C, Cotroneo, P, Manto, A, Ward, J, Tesfaye, S, Eaton, S, Mody, C, Borra, M, Perin, Pc, Giunti, S, Grassi, G, Pagano, G, Porta, M, Sivieri, R, Vitelli, F, Veglio, M, Papazoglou, N, Manes, G, Muggeo, M, Iagulli, M, Cacciatori, V, Cattedra, V, Irsigler, K, Abrahamian, H

الوصف: BACKGROUND/OBJECTIVES: Individuals with type 1 diabetes have a high risk of developing cardiovascular diseases, and it has been reported that they consume a high atherogenic diet. We examined how nutrient intake and adherence to current European nutritional recommendations evolved in a large cohort of European individuals with type 1 diabetes over a period of 7 years. SUBJECTS/METHODS: We analysed data from the EURODIAB Prospective Complications Study, a European multicentre prospective cohort study. Standardized 3-day dietary records were employed in individuals with type 1 diabetes. One thousand one hundred and two patients (553 men, 549 women, baseline age 33 ± 10 years, duration 15 ± 9 years) had complete nutritional data available at baseline and after 7 years. We calculated mean differences in reported nutrients over time and adjusted these for age, gender, HbA1c and BMI with ANOVA models. RESULTS: Compared to baseline, there were minor changes in nutrients. Reported protein (-0.35% energy (en), fat (-1.07% en), saturated fat (-0.25% en) and cholesterol (-7.42 mg/1000 kcal) intakes were lower, whereas carbohydrate (+1.23% en) and fibre (+0.46 g/1000 kcal) intakes were higher at the 7-year follow-up. European recommendations for adequate nutrient intakes were followed in individuals with type 1 diabetes for protein (76% at baseline and 78% at follow-up), moderately for fat (34, 40%), carbohydrate (34, 41%) and cholesterol (39, 47%), but poorly for fibre (1.4, 2.4%) and saturated fat (11, 13%). CONCLUSION: European individuals with type 1 diabetes consume a high atherogenic diet as few patients met recommendations for dietary fibre and saturated fat. This study showed minor changes in dietary nutrients and energy intakes over a period of 7 years. Nutrition education needs particular focus on strategies to increase dietary fibre and reduce saturated fat to exploit their potential benefit

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/23224030; info:eu-repo/semantics/altIdentifier/wos/WOS:000324833000002; volume:52; issue:7; firstpage:1701; lastpage:1710; numberofpages:10; journal:EUROPEAN JOURNAL OF NUTRITION; http://hdl.handle.net/11584/59760Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84885471550

الإتاحة: https://doi.org/10.1007/s00394-012-0473-7Test
http://hdl.handle.net/11584/59760Test

المؤلفون: van Bussel BC, Soedamah Muthu SS, Henry RM, Schalkwijk CG, Ferreira I, Karamanos B, Kofinis A, Petrou K, Giorgino F, Picca G, Angarano A, De Pergola G, Laviola L, Giorgino R, Ionescu Tirgoviste C, Coszma A, Guja C, Songini M, Casu A, Pedron M, Pintus S, FOSSARELLO, MAURIZIO, Ferriss J, Grealy G, O'Keefe D, Toeller M, Arden C, Rottiers R, Tuyttens C, Priem H, Ebeling P, Kylliäinen M, Koivisto V, Idzior Walus B, Sieradzki J, Cyganek K, Solnica B, Lemkes H, Lemkes Stuffken J, Nunes Correa J, Rogado M, Gardete Correia L, Cardoso M, Silva A, Boavida J, Machado Sa Marques M, Michel G, Wirion R, Cardillo S, Pozza G, Mangili R, Asnaghi V, Standl E, Schaffler B, Brand H, Harms A, Ben Soussan D, Verier Mine O, Fallas P, Fallas M, Fuller J, Holloway J, Asbury L, Betteridge D, Cathelineau G, Bouallouche A, Villatte Cathelineau B, Santeusanio F, Rosi G, D'Alessandro V, Cagini C, Bottini P, Reboldi G, Navalesi R, Penno G, Bandinelli S, Miccoli R, Nannipieri M, Ghirlanda G, Saponara C, Cotroneo P, Manto A, Minnella A, Ward J, Tesfaye S, Eaton S, Mody C, Borra M, Cavallo Perin P, Giunti S, Grassi G, Pagano G, Porta M, Sivieri R, Vitelli F, Veglio M, Papazoglou N, Manes G, Muggeo M, Iagulli M, Cacciatori V, Irsigler K, Abrahamian H, Walford S, Sinclair J, Hughes S, McLelland V, Roglic G, Metelko Z, Pepeonik Z, Sjolie A., Chaturvedi N, Ferriss B, Webb D, Viberti G., Swaminathan R, Lumb P, Collins A, Sankaralingham S, Crook MA, Aldington S, Mortemore T, Lipinski H, Scherbaum WA, Gries FA

المساهمون: van Bussel, Bc, Soedamah Muthu, S, Henry, Rm, Schalkwijk, Cg, Ferreira, I, Karamanos, B, Kofinis, A, Petrou, K, Giorgino, F, Picca, G, Angarano, A, De Pergola, G, Laviola, L, Giorgino, R, Ionescu Tirgoviste, C, Coszma, A, Guja, C, Songini, M, Casu, A, Pedron, M, Pintus, S, Fossarello, Maurizio, Ferriss, J, Grealy, G, O'Keefe, D, Toeller, M, Arden, C, Rottiers, R, Tuyttens, C, Priem, H, Ebeling, P, Kylliäinen, M, Koivisto, V, Idzior Walus, B, Sieradzki, J, Cyganek, K, Solnica, B, Lemkes, H, Lemkes Stuffken, J, Nunes Correa, J, Rogado, M, Gardete Correia, L, Cardoso, M, Silva, A, Boavida, J, Machado Sa Marques, M, Michel, G, Wirion, R, Cardillo, S, Pozza, G, Mangili, R, Asnaghi, V, Standl, E, Schaffler, B, Brand, H, Harms, A, Ben Soussan, D, Verier Mine, O, Fallas, P, Fallas, M, Fuller, J, Holloway, J, Asbury, L, Betteridge, D, Cathelineau, G, Bouallouche, A, Villatte Cathelineau, B, Santeusanio, F, Rosi, G, D'Alessandro, V, Cagini, C, Bottini, P, Reboldi, G, Navalesi, R, Penno, G, Bandinelli, S, Miccoli, R, Nannipieri, M, Ghirlanda, G, Saponara, C, Cotroneo, P, Manto, A, Minnella, A, Ward, J, Tesfaye, S, Eaton, S, Mody, C, Borra, M, Cavallo Perin, P, Giunti, S, Grassi, G, Pagano, G, Porta, M, Sivieri, R, Vitelli, F, Veglio, M, Papazoglou, N, Manes, G, Muggeo, M, Iagulli, M

مصطلحات موضوعية: Diet, Endothelial dysfunction, Epidemiologu

الوصف: BACKGROUND AND AIMS: A healthy diet has been inversely associated with endothelial dysfunction (ED) and low-grade inflammation (LGI). We investigated the association between nutrient consumption and biomarkers of ED and LGI in type 1 diabetes. METHODS AND RESULTS: We investigated 491 individuals. Nutrient consumption and lifestyle risk factors were measured in 1989 and 1997. Biomarkers of ED (von Willebrand factor, soluble vascular cell adhesion molecule-1 and soluble endothelial selectin) and LGI (C-reactive protein, interleukin 6 and tumour necrosis factor α) were measured in 1997 and averaged into Z-scores. The nutrient residual method was used to adjust individual nutrient intake for energy intake. Data were analysed with generalised estimation equations. We report increments/decrements in nutrient consumption, averaged over time, per +1 standard deviation (SD) of 1997 ED or LGI Z-scores, after adjustment for sex, age, duration of diabetes, investigation centre, body mass index, energy intake, smoking behaviour, alcohol consumption, and each of the other nutrients. One SD elevation in ED Z-score was associated with a diet lower in fibre [β(95%CI);-0.09(-0.18;-0.004)], polyunsaturated fat [-0.18(-0.31;-0.05)] and vegetable protein [-0.10(-0.20;-0.001)]. For the LGI Z-score results showed associations with fibre [-0.09(-0.17;-0.01)], polyunsaturated fat [-0.14(-0.24;-0.03)] and cholesterol [0.10(0.01; 0.18)]. CONCLUSION: In type 1 diabetes, consumption of less fibre, polyunsaturated fat and vegetable protein, and more cholesterol over the study period was associated with more ED and LGI. Following dietary guidelines in type 1 diabetes may reduce cardiovascular disease risk by favourably affecting ED and LGI.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/22795869; info:eu-repo/semantics/altIdentifier/wos/WOS:000321551300012; volume:23; issue:8; firstpage:758; lastpage:764; numberofpages:7; journal:NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES; http://hdl.handle.net/11584/58062Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84880046493

الإتاحة: https://doi.org/10.1016/j.numecd.2012.04.005Test
http://hdl.handle.net/11584/58062Test

المؤلفون: Toeller, M, Buyken, A, Heitkamp, G, Brämswig, S, Mann, J, Milne, R, Gries, F. A, Keen, H, Karamanos, B, Tountas, C, Kofinis, A, Petrou, K, Katsilambros, N, Roussipenessi, D, Cignarelli, M, Giorgino, R, Degeco, Ml, Ramunni, I, Ionescutirgoviste, C, Strachinariu, R, Nicolau, A, Tamas, G, Kerenyi, Z, Ahmed, Am, Toth, J, Kempler, P, Muntoni, S, Songini, M, Stabilini, M, Fossarello, M, Pintus, S, Ferriss, B, Cronin, Cc, Humphreys, M, Klischan, A, Forst, T, Schumacher, W, Rottiers, R, Priem, H, Deschoolmeester, Mj, Ebeling, P, Sinisalo, M, Koivisto, Va, Idziorwalus, B, Solnica, B, Szopinskaciba, L, Solnica, K, Krans, Hmj, Lemkes, Hhpj, Jansen, Jj, Eltedewever, Bm, Nunescorrea, J, Boavida, J, Carvalho, R, Afonso, Mj, Monteiro, M, Mitchell, DAVID ROSS, Jepson, E, Mchardyyoung, S, Fuller, Jh, Betteridge, Dj, Milne, M, Thompson, T, Michel, G, Wirion, R, Paquet, S, Hornick, H, Boulton, Ajm, Ashe, H, Fernando, Djs, Curwell, J, Pozza, G, Slaviero, G, Comi, G, Fattor, B, Bandello, F, Marchi, Manuel, Mehnert, H, Nuber, A, Janka, H, Nichting, M, Standl, E, Crepaldi, G, Nosadini, R, Cathelineau, G, Cathelineau, Bv, Jellal, M, Grodner, N, Feiss, Pg, Baclet, N, Santeusanio, F, Rosi, G, Ventura, Mrm, Cagini, C, Marino, C, Navalesi, R, Penno, G, Miccoli, R, Nannipieri, M, Manfredi, S, Bertolotto, A, Ghirlanda, G, Cotroneo, P, Manto, A, Teodonio, C, Minnella, A, Careddu, G, Ward, Jd, Tesfaye, S, Mody, C, Rudd, C, Molinatti, Gm, Vitelli, F, Porta, M, Pagano, Gf, Estivi, Sivieri, P., R, Carta, Q, Petraroli, G, Papazoglu, N, Goutzourela, M, Manes, C, Bensoussan, D, Fallas, Mc, Fallas, P, Dhanaeus, C, Muggeo, M, Cacciatori, V, Bellavere, F, Galante, P, Gemma, Ml, Branzi, P, Irsigler, K, Abrahamian, H, Gurdet, C, Hornlein, B, Willinger, C, Strohner, H, Just, M, Walford, S, Wardle, Henio, Ev, S, Cooke, H, Roglic, G, Resman, Z, Metelko, Z, Skrabalo, Z, Vrhovac, V.

المساهمون: Toeller, M, Buyken, A, Heitkamp, G, Bramswig, S, Mann, J, Milne, R, Gries, Fa, Keen, H, Karamanos, B, Tountas, C, Kofinis, A, Petrou, K, Katsilambros, N, Roussipenessi, D, Cignarelli, M, Giorgino, R, Degeco, Ml, Ramunni, I, Ionescutirgoviste, C, Strachinariu, R, Nicolau, A, Tamas, G, Kerenyi, Z, Ahmed, Am, Toth, J, Kempler, P, Muntoni, S, Songini, M, Stabilini, M, Fossarello, M, Pintus, S, Ferriss, B, Cronin, Cc, Humphreys, M, Klischan, A, Forst, T, Schumacher, W, Rottiers, R, Priem, H, Deschoolmeester, Mj, Ebeling, P, Sinisalo, M, Koivisto, Va, Idziorwalus, B, Solnica, B, Szopinskaciba, L, Solnica, K, Krans, Hmj, Lemkes, Hhpj, Jansen, Jj, Eltedewever, Bm, Nunescorrea, J, Boavida, J, Carvalho, R, Afonso, Mj, Monteiro, M, David, R, Jepson, E, Mchardyyoung, S, Fuller, Jh, Betteridge, Dj, Milne, M, Thompson, T, Michel, G, Wirion, R, Paquet, S, Hornick, H, Boulton, Ajm, Ashe, H, Fernando, Dj, Curwell, J, Pozza, G, Slaviero, G, Comi, G, Fattor, B, Bandello, F, Marchi, M, Mehnert, H, Nuber, A, Janka, H, Nichting, M, Standl, E, Crepaldi, G, Nosadini, R, Cathelineau, G, Cathelineau, Bv, Jellal, M, Grodner, N, Feiss, Pg, Baclet, N, Santeusanio, F, Rosi, G, Ventura, Mrm, Cagini, C, Marino, C, Navalesi, R, Penno, G, Miccoli, R, Nannipieri, M, Manfredi, S, Bertolotto, A, Ghirlanda, G, Cotroneo, P, Manto, A, Teodonio, C, Minnella, A, Careddu, G, Ward, Jd, Tesfaye, S, Mody, C, Rudd, C, Molinatti, Gm, Vitelli, F, Porta, M, Pagano, Gf, Estivi, P, Sivieri, R, Carta, Q, Petraroli, G, Papazoglu, N, Goutzourela, M, Manes, C, Bensoussan, D, Fallas, Mc, Fallas, P, Dhanaeus, C, Muggeo, M, Cacciatori, V, Bellavere, F, Galante, P, Gemma, Ml, Branzi, P, Irsigler, K, Abrahamian, H, Gurdet, C, Hornlein, B, Willinger, C, Strohner, H, Just, M, Walford, S, Wardle, Ev, Henio, S, Cooke, H, Roglic, G, Resman, Z, Metelko, Z, Skrabalo, Z, Vrhovac, V

المصدر: Diabetologia. 40:1219-1226

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Adolescent, endocrine system diseases, Endocrinology, Diabetes and Metabolism, Urinary system, Physiology, Albuminuria, Cross-Sectional Studies, Diabetes Mellitus, Type 1, Diabetic Nephropathies, Dietary Proteins, Europe, Female, Humans, Middle Aged, Nephropathy, Protein intake, urinary albumin, Diabetic nephropathy, Excretion, Diabetes mellitus, Internal medicine, Diabetes Mellitus, Internal Medicine, Medicine, Proteinuria, business.industry, medicine.disease, Endocrinology, Blood pressure, medicine.symptom, business, Type 1, Kidney disease

الوصف: For people with insulin-dependent diabetes mellitus (IDDM) renal disease represents a life-threatening and costly complication. The EURODIAB IDDM Complications Study, a cross-sectional, clinic-based study, was designed to determine the prevalence of renal complications and putative risk factors in stratified samples of European individuals with IDDM. The present study examined the relationship between dietary protein intake and urinary albumin excretion rate (AER). Food intake was assessed centrally by a standardized 3-day dietary record. Urinary AER was determined in a central laboratory from a timed 24-h urine collection. Complete data were available from 2696 persons with IDDM from 30 centres in 16 European countries. In individuals who reported protein consumption less than 20 % of total food energy intake, mean AER was below 20 μg/min. In those in whom protein intake constituted more than 20 %, mean AER increased, a trend particularly pronounced in individuals with hypertension and/or poor metabolic control. Trends reached statistical significance for intakes of total protein (% of energy, p = 0.01) and animal protein (% of energy, p = 0.02), while no association was seen for vegetable protein (p = 0.83). These findings support the current recommendation for people with diabetes not to exceed a protein intake of 20 % of total energy. Monitoring and adjustment of dietary protein appears particularly desirable for individuals with AER exceeding 20 μg/min (approximately 30 mg/24 h), especially when arterial pressure is raised and/or diabetic control is poor. [Diabetologia (1997) 40: 1219–1226]

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eea3d2526b82541805d1309de7e8f03Test
https://doi.org/10.1007/s001250050810Test

المؤلفون: Toeller M, Buyken A, Heitkamp G, Milne R, Klischan A, Gries FA, Fuller JH, Keen H, Krans HMJ, Navalesi R, Sjolie AK, Stephenson JM, Viberti GC, Karamanos B, Tountas C, Kofinis A, Petrou K, Katsilambros N, RoussiPenessi D, Cignarelli M, Giorgino R, DeGeco ML, Ramunni I, IonescuTirgoviste C, Strachinariu R, Nicolau A, Tamas G, Kerenyi Z, Ahmed AM, Toth J, Kempler P, Muntoni S, Songini M, Stabilini M, Fossarello M, Pintus S, Ferriss B, Cronin CC, Humphreys M, Forst T, Schumacher W, Wagener W, Venhaus A, Rottiers R, Priem H, Deschoolmeester MJ, Ebeling P, Sinisalo M, Koivisto VA, IdziorWalus B, Solnica B, SzopinskaCiba L, Solnica K, Lemkes HHPJ, Jansen JJ, EltedeWever BM, NunesCorrea J, Boavida J, Carvalho R, Afonso MJ, Monteiro M, David R, Jepson E, McHardyYoung S, Betteridge DJ, Milne M, Thompson T, Michel G, Wirion R, Paquet S, Hornick H, Boulton AJM, Ashe H, Fernando DJS, Curwell J, Pozza G, Slaviero G, Comi G, Fattor B, Marchi M, Mehnert H, Nuber A, Janka H, Nichting M, Standl E, Crepaldi G, Nosadini R, Cathelineau G, Cathelineau BV, Jellal M, Grodner N, Feiss PG, Baclet N, Santeusanio F, Rosi G, Ventura MRM, Cagini C, Marino C, Penno G, Miccoli R, Nannipieri M, Manfredi S, Bertolotto A, Ghirlanda G, Manto A, Cotroneo P, Ward JD, Tesfaye S, Mody C, Rudd C, Papazoglou N, Goutzourela M, Manes C, Molinatti GM, Vitelli F, Porta M, Pagano GF, Estivi P, Sivieri R, Carta Q, Petraroli G, BenSoussan D, Fallas MC, Fallas P, Dhanaeus C, Bourgeois MD, Muggeo M, Cacciatori V, Bellavere F, Galante P, Gemma ML, Branzi P, Irsigler K, Abrahamian H, Gurdet C, Hornlein B, Willinger C, Strohner H, Just M, Walford S, Wardle EV, Henio S, Cooke H, Roglic G, Resman Z, Metelko Z, Skrabalo Z., BANDELLO , FRANCESCO

المساهمون: Toeller, M, Buyken, A, Heitkamp, G, Milne, R, Klischan, A, Gries, Fa, Fuller, Jh, Keen, H, Krans, Hmj, Navalesi, R, Sjolie, Ak, Stephenson, Jm, Viberti, Gc, Karamanos, B, Tountas, C, Kofinis, A, Petrou, K, Katsilambros, N, Roussipenessi, D, Cignarelli, M, Giorgino, R, Degeco, Ml, Ramunni, I, Ionescutirgoviste, C, Strachinariu, R, Nicolau, A, Tamas, G, Kerenyi, Z, Ahmed, Am, Toth, J, Kempler, P, Muntoni, S, Songini, M, Stabilini, M, Fossarello, M, Pintus, S, Ferriss, B, Cronin, Cc, Humphreys, M, Forst, T, Schumacher, W, Wagener, W, Venhaus, A, Rottiers, R, Priem, H, Deschoolmeester, Mj, Ebeling, P, Sinisalo, M, Koivisto, Va, Idziorwalus, B, Solnica, B, Szopinskaciba, L, Solnica, K, Lemkes, Hhpj, Jansen, Jj, Eltedewever, Bm, Nunescorrea, J, Boavida, J, Carvalho, R, Afonso, Mj, Monteiro, M, David, R, Jepson, E, Mchardyyoung, S, Betteridge, Dj, Milne, M, Thompson, T, Michel, G, Wirion, R, Paquet, S, Hornick, H, Boulton, Ajm, Ashe, H, Fernando, Dj, Curwell, J, Pozza, G, Slaviero, G, Comi, G, Fattor, B, Bandello, Francesco, Marchi, M, Mehnert, H, Nuber, A, Janka, H, Nichting, M, Standl, E, Crepaldi, G, Nosadini, R, Cathelineau, G, Cathelineau, Bv, Jellal, M, Grodner, N, Feiss, Pg, Baclet, N, Santeusanio, F, Rosi, G, Ventura, Mrm, Cagini, C, Marino, C, Penno, G, Miccoli, R, Nannipieri, M, Manfredi, S, Bertolotto, A, Ghirlanda, G, Manto, A, Cotroneo, P, Ward, Jd, Tesfaye, S, Mody, C, Rudd, C, Papazoglou, N, Goutzourela, M, Manes, C, Molinatti, Gm, Vitelli, F, Porta, M, Pagano, Gf, Estivi, P, Sivieri, R, Carta, Q, Petraroli, G, Bensoussan, D, Fallas, Mc, Fallas, P, Dhanaeus, C, Bourgeois, Md, Muggeo, M, Cacciatori, V, Bellavere, F, Galante, P, Gemma, Ml, Branzi, P, Irsigler, K, Abrahamian, H, Gurdet, C, Hornlein, B, Willinger, C, Strohner, H, Just, M, Walford, S, Wardle, Ev, Henio, S, Cooke, H, Roglic, G, Resman, Z, Metelko, Z, Skrabalo, Z.

المصدر: Scopus-Elsevier

مصطلحات موضوعية: Dietary Fiber, medicine.medical_specialty, Alcohol Drinking, European community, Saturated fat, Population, Medicine (miscellaneous), the EURODIAB IDDM Study, Diabetes mellitus, Dietary Carbohydrates, medicine, Humans, education, education.field_of_study, Nutrition and Dietetics, business.industry, Reproducibility of Results, Repeatability, medicine.disease, Dietary Fats, Diet Records, Confidence interval, Surgery, Europe, three-day dietary records, Diabetes Mellitus, Type 1, Nutrition Assessment, Quartile, Cohort, Dietary Proteins, Energy Intake, business, Demography

الوصف: Objectives: Repeatability of a dietary method is important in determining the quality of nutritional data. It should be assessed in the population of interest. This study evaluated the repeatability of nutritional data from standardized three-day dietary records, from the clinic-based, cross-sectional multi-centre EURODIAB IDDM Complications Study. Design and Subjects: 15% of the total EURODIAB cohort was randomly selected to test the repeatability of nutritional intake data. Two three-day records, completed three weeks apart, were available for 216 diabetic patients (7.5%) representative of the total cohort. All records were analysed centrally, for intakes of protein (animal and vegetable), fat (saturated fat and cholesterol), carbohydrate, fibre, alcohol and energy. Repeatability was measured comparing mean intakes, determining the proportion of patients classified into the same/opposite quartile by the two three-day records and assessing mean differences with standard deviations (s.d.d). Results: There were no significant differences in mean energy and nutrient intakes between the first and second records. Classification of individuals into the opposite quartile occurred only in 0–4% of patients and overall about 50% (range 44–74%) of the subjects were classified into the same quartiles of intakes. Only small mean differences were found for energy intake (−156 (1633) kJ; 95% confidence limits −375, 63 kJ) and nutrients with s.d.ds comparable to intra-individual variations in the general population. The differences in energy intake were randomly distributed over the range of intakes. Conclusions: The present study demonstrates that standardized three day dietary records show a high degree of repeatability within a short period of time in a sample of European IDDM patients. The good repeatability strengthens the conclusions drawn from the nutritional data in the EURODIAB IDDM Complications Study. Sponsorship: Nutrition Co-ordinating Centre research funds, Diabetes Research Institute at Heinrich-Heine University, Dusseldorf. The EURODIAB IDDM Complications Study was supported by the European Community.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33ec27a16ea466dbe1b714a1fcb6e07cTest
https://doi.org/10.1038/sj.ejcn.1600364Test

المؤلفون: Nin JW, Ferreira I, Schalkwijk CG, Prins MH, Chaturvedi N, Fuller JH, Stehouwer CD, Karamanos B, Kofinis A, Petrou K, Giorgino F, Picca G, Angarano A, De Pergola G, Laviola L, Giorgino R, Ionescu Tirgoviste C, Coszma A, Guja C, Songini M, Casu A, Pedron M, Pintus S, FOSSARELLO, MAURIZIO, Ferriss JB, Grealy G, Keefe DO, Toeller M, Arden C, Rottiers R, Tuyttens C, Priem H, Ebeling P, Kylliäinen M, Koivisto VA, Idzior Walus B, Sieradzki J, Cyganek K, Solnica B, Lemkes HH, Lemkes Stuffken JC, Nunes Correa J, Rogado MC, Gardete Correia L, Cardoso MC, Silva A, Boavida J, Machado Sa Marques M, Michel G, Wirion R, Cardillo S, Pozza G, Mangili R, Asnaghi V, Standl E, Schaffler B, Brand H, Harms A, Ben Soussan D, Verier Mine O, Fallas P, Fallas MC, Holloway J, Asbury L, Betteridge DJ, Cathelineau G, Bouallouche A, Villatte Cathelineau B, Santeusanio F, Rosi G, D'Alessandro V, Cagini C, Bottini P, Reboldi GP, Navalesi R, Penno G, Bandinelli S, Miccoli R, Nannipieri M, Ghirlanda G, Saponara C, Cotroneo P, Manto A, Minnella A, Ward JD, Tesfaye S, Eaton S, Mody C, Borra M, Cavallo Perin P, Giunti S, Grassi G, Pagano GF, Porta M, Sivieri R, Vitelli F, Veglio M, Papazoglou N, Manes G, Muggeo M, Iagulli M, Irsigler K, Abrahamian H, Walford S, Sinclair J, Hughes S, McLelland V, Ward J, Roglic G, Metelko Z, Pepeonik ZR, Sjolie AK, Ferriss B, Webb D, Viberti GC, Swaminathan R, Lumb P, Collins A, Sankaralingham S, Aldington S, Mortemore T, Lipinski H.

المساهمون: Nin, Jw, Ferreira, I, Schalkwijk, Cg, Prins, Mh, Chaturvedi, N, Fuller, Jh, Stehouwer, Cd, Karamanos, B, Kofinis, A, Petrou, K, Giorgino, F, Picca, G, Angarano, A, De Pergola, G, Laviola, L, Giorgino, R, Ionescu Tirgoviste, C, Coszma, A, Guja, C, Songini, M, Casu, A, Pedron, M, Pintus, S, Fossarello, Maurizio, Ferriss, Jb, Grealy, G, Keefe, Do, Toeller, M, Arden, C, Rottiers, R, Tuyttens, C, Priem, H, Ebeling, P, Kylliäinen, M, Koivisto, Va, Idzior Walus, B, Sieradzki, J, Cyganek, K, Solnica, B, Lemkes, Hh, Lemkes Stuffken, Jc, Nunes Correa, J, Rogado, Mc, Gardete Correia, L, Cardoso, Mc, Silva, A, Boavida, J, Machado Sa Marques, M, Michel, G, Wirion, R, Cardillo, S, Pozza, G, Mangili, R, Asnaghi, V, Standl, E, Schaffler, B, Brand, H, Harms, A, Ben Soussan, D, Verier Mine, O, Fallas, P, Fallas, Mc, Holloway, J, Asbury, L, Betteridge, Dj, Cathelineau, G, Bouallouche, A, Villatte Cathelineau, B, Santeusanio, F, Rosi, G, D'Alessandro, V, Cagini, C, Bottini, P, Reboldi, Gp, Navalesi, R, Penno, G, Bandinelli, S, Miccoli, R, Nannipieri, M, Ghirlanda, G, Saponara, C, Cotroneo, P, Manto, A, Minnella, A, Ward, Jd, Tesfaye, S, Eaton, S, Mody, C, Borra, M, Cavallo Perin, P, Giunti, S, Grassi, G, Pagano, Gf, Porta, M, Sivieri, R, Vitelli, F, Veglio, M, Papazoglou, N, Manes, G

الوصف: CONTEXT AND OBJECTIVE: High-mobility group box-1 (HMGB1) is a pro-inflammatory cytokine that may contribute to the pathogenesis of micro- and macrovascular complications commonly observed in diabetes. We investigated whether HMGB1 is associated with: i) markers of low-grade inflammation (LGI) and endothelial dysfunction (ED) and pulse pressure (PP, a marker of arterial stiffness); ii) prevalent nephropathy, retinopathy and cardiovascular disease (CVD) in type 1 diabetes; and iii) the potential mediating roles of LGI, ED and PP therein. DESIGN AND METHODS: This was a cross-sectional nested case-control study of 463 patients (226 women; mean age 40±10 years) with type 1 diabetes from the EURODIAB Prospective Complications Study. We used linear and binary or multinomial logistic regression analyses adjusted for traditional risk factors. RESULTS: Serum Ln-HMGB1 levels were positively associated with LGI and ED (standardised β=0.07 (95% confidence interval (CI): 0.02-0.12) and β=0.08 (95% CI: 0.02-0.14) respectively), but not with PP. Higher Ln-HMGB1 (per unit) was associated with greater odds of micro- and macroalbuminuria: odds ratio (OR)=1.24 (95% CI: 0.90-1.71) and OR=1.61 (95% CI: 1.15-2.25) respectively, P for trend=0.004. Further adjustments for LGI or ED did not attenuate these associations. No such associations were found between Ln-HMGB1 and estimated glomerular filtration rate (eGFR), retinopathy or CVD, however. CONCLUSIONS: In type 1 diabetes, higher serum HMGB1 levels are associated with greater prevalence and severity of albuminuria, though not with eGFR, retinopathy and CVD. Prospective studies are needed to clarify the causal role of HMGB1, if any, in the pathogenesis of vascular complications in type 1 diabetes.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/22127490; info:eu-repo/semantics/altIdentifier/wos/WOS:000300295000023; volume:166; issue:2; firstpage:325; lastpage:332; numberofpages:8; journal:EUROPEAN JOURNAL OF ENDOCRINOLOGY; http://hdl.handle.net/11584/58104Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84856078195

الإتاحة: https://doi.org/10.1530/EJE-11-0662Test
http://hdl.handle.net/11584/58104Test

المؤلفون: Schoenaker DA1, Toeller M, Chaturvedi N, Fuller JH, Soedamah Muthu SS, Karamanos B, Kofinis A, Petrou K, Giorgino F, Picca G, Angarano A, De Pergola G, Laviola L, Giorgino R, Ionescu Tirgoviste C, Coszma A, Guja C, Songini M, Casu A, Pedron M, Pintus S, FOSSARELLO, MAURIZIO, Ferriss J, Grealy G, Arden C, Rottiers R, Tuyttens C, Priem H, Ebeling P, Kylliäinen M, Koivisto V, Idzior Walus B, Sieradzki J, Cyganek K, Solnica B, Lemkes H, Lemkes Stuffken J, Nunes Correa J, Rogado M, Gardete Correia L, Cardoso M, Silva A, Boavida J, Marques M, Michel G, Wirion R, Cardillo S, Pozza G, Mangili R, Asnaghi V, Standl E, Schaffler B, Brand H, Harms A, Soussan D, Verier Mine O, Fallas P, Fallas M, Fuller J, Holloway J, Asbury L, Betteridge D, Cathelineau G, Bouallouche A, Cathelineau B, Santeusanio F, Rosi G, D'Alessandro V, Cagini C, Bottini P, Reboldi G, Navalesi R, Penno G, Bandinelli S, Miccoli R, Nannipieri M, Ghirlanda G, Saponara C, Cotroneo P, Manto A, Minnella A, Ward J, Tesfaye S, Eaton S, Mody C, Borra M, Perin P, Giunti S, Grassi G, Pagano G, Porta M, Sivieri R, Vitelli F, Veglio M, Papazoglou N, Manes G, Muggeo M, Iagulli M, Cacciatori V, Irsigler K, Abrahamian H, Walford S, Sinclair J, Hughes S, McLelland V, Roglic G, Metelko Z, Pepeonik Z, Ferriss B, Webb D, Viberti G., Swaminathan R, Lumb P, Collins A, Sankaralingham S, Crook MA, Aldington S, Mortemore T, Lipinski H, Scherbaum WA, Gries F.A.

المساهمون: Schoenaker, Da1, Toeller, M, Chaturvedi, N, Fuller, Jh, Soedamah Muthu, S, Karamanos, B, Kofinis, A, Petrou, K, Giorgino, F, Picca, G, Angarano, A, De Pergola, G, Laviola, L, Giorgino, R, Ionescu Tirgoviste, C, Coszma, A, Guja, C, Songini, M, Casu, A, Pedron, M, Pintus, S, Fossarello, Maurizio, Ferriss, J, Grealy, G, Arden, C, Rottiers, R, Tuyttens, C, Priem, H, Ebeling, P, Kylliäinen, M, Koivisto, V, Idzior Walus, B, Sieradzki, J, Cyganek, K, Solnica, B, Lemkes, H, Lemkes Stuffken, J, Nunes Correa, J, Rogado, M, Gardete Correia, L, Cardoso, M, Silva, A, Boavida, J, Marques, M, Michel, G, Wirion, R, Cardillo, S, Pozza, G, Mangili, R, Asnaghi, V, Standl, E, Schaffler, B, Brand, H, Harms, A, Soussan, D, Verier Mine, O, Fallas, P, Fallas, M, Fuller, J, Holloway, J, Asbury, L, Betteridge, D, Cathelineau, G, Bouallouche, A, Cathelineau, B, Santeusanio, F, Rosi, G, D'Alessandro, V, Cagini, C, Bottini, P, Reboldi, G, Navalesi, R, Penno, G, Bandinelli, S, Miccoli, R, Nannipieri, M, Ghirlanda, G, Saponara, C, Cotroneo, P, Manto, A, Minnella, A, Ward, J, Tesfaye, S, Eaton, S, Mody, C, Borra, M, Perin, P, Giunti, S, Grassi, G, Pagano, G, Porta, M, Sivieri, R, Vitelli, F, Veglio, M, Papazoglou, N, Manes, G, Muggeo, M, Iagulli, M, Cacciatori, V

الوصف: AIMS/HYPOTHESIS: Low adherence to recommendations for dietary saturated fatty acid (SFA) and fibre intake in patients with type 1 diabetes mellitus may heighten their increased risk of cardiovascular disease (CVD) and mortality. We examined the relationship of SFA and total, soluble and insoluble fibre with incident CVD and all-cause mortality in type 1 diabetic patients. METHODS: A prospective cohort analysis was performed in 2,108 European type 1 diabetic patients aged 15-60 years who were free of CVD at baseline and enrolled in the EURODIAB Prospective Complications Study (51% male). Diet was assessed from a standardised 3 day dietary record. HR were calculated using Cox proportional hazards models. RESULTS: During a mean follow-up of 7.3 years, 148 incident cases of fatal and non-fatal CVD and 46 all-cause deaths were documented. No statistically significant association was found between SFA and CVD and all-cause mortality. Total dietary fibre, per 5 g/day, was associated with lower all-cause mortality risk (HR 0.72; 95% CI 0.55, 0.95). This association was stronger for soluble fibre (per 5 g/day, HR 0.34; 95% CI 0.14, 0.80) compared with insoluble fibre (per 5 g/day; HR 0.66; 95% CI 0.45, 0.97). Similar results were found for the association with CVD. CONCLUSIONS/INTERPRETATION: This study suggests that reported dietary SFA is not significantly associated with CVD and all-cause mortality in type 1 diabetic patients. On the contrary, higher dietary fibre consumption, especially soluble fibre, within the range commonly consumed by type 1 diabetic patients, may contribute to the prevention of CVD and all-cause mortality in type 1 diabetic patients.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/22526612; info:eu-repo/semantics/altIdentifier/wos/WOS:000306122600008; volume:55; issue:8; firstpage:2132; lastpage:2141; numberofpages:10; journal:DIABETOLOGIA; http://hdl.handle.net/11584/58063Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84866364919

الإتاحة: https://doi.org/10.1007/s00125-012-2550-0Test
http://hdl.handle.net/11584/58063Test

المؤلفون: Soedamah Muthu, Sabita S., Chaturvedi, Nish, Witte, Daniel R., Stevens, Lynda K., Porta, Massimo, Fuller, John H. Karamanos B, Kofinis A, Petrou K, GIORGINO, Francesco, Picca G, Angarano A, De Pergola G, LAVIOLA, Luigi, Giorgino R, Songini M, Casu A, Pedron M, Pintus S, Fossarello M, Ferriss JB, Grealy G, Keefe DO, Toeller M, Arden C, Rottiers R, Tuyttens C, Priem H, Ebeling P, Kylliäinen M, Koivisto VA, Idzior Walus B, Sieradzki J, Cyganek K, Lemkes HH, Lemkes Stuffken JC, Nunes Correa J, Rogado MC, Gardete Correia L, Cardoso MC, Silva A, Boavida J, Sa Marques MM, Michel G, Wirion R, Cardillo S, Pozza G, Mangili R, Asnaghi V, Standl E, Schaffler B, Brand H, Harms A, Soussan B, Verier Mine O, Fallas P, Fallas MC, Fuller JH, Holloway J, Asbury L, Betteridge DJ, Cathelineau G, Bouallouche A, Cathelineau BV, Santeusanio F, Rosi G, D'Alessandro V, Cagini C, Bottini P, Reboldi P, Navalesi R, Penno G, Bandinelli S, Miccoli R, Nannipieri M, Ghirlanda G, Saponara C, Cotroneo P, Manto A, Minnella A, Ward JD, Tesfaye S, Eaton S, Mody C, Borra M, Perin PC, Giunti S, Grassi G, Pagano GF, Porta M, Sivieri R, Vitelli F, Ferrari D, Papazoglou N, Manes G, Muggeo M, Iagulli M, Irsigler K, Abrahamian H, Walford S, Sinclair J, Hughes S, McLelland V, Ward J, Roglic G, Metelko Z, Pepeonik ZR, Babic Z, Ionescu Tirgoviste C, Coszma A, Guja C, Karamanos B, Sjolie AK, Chaturvedi B, Ferriss B, Chaturvedi N, Webb D, Shipley M, Livingstone SJ, Viberti GC, Swaminathan R, Lumb P, Collins A, Sankaralingham S, Crook M.A.

المساهمون: Soedamah Muthu, Sabita S., Chaturvedi, Nish, Witte, Daniel R., Stevens, Lynda K., Porta, Massimo, Fuller, John H., Karamanos B, Kofinis, A, Petrou, K, Giorgino, Francesco, Picca, G, Angarano, A, De Pergola, G, Laviola, Luigi, Giorgino, R, Songini, M, Casu, A, Pedron, M, Pintus, S, Fossarello, M, Ferriss, Jb, Grealy, G, Keefe, Do, Toeller, M, Arden, C, Rottiers, R, Tuyttens, C, Priem, H, Ebeling, P, Kylliäinen, M, Koivisto, Va, Idzior Walus, B, Sieradzki, J, Cyganek, K, Lemkes, Hh, Lemkes Stuffken, Jc, Nunes Correa, J, Rogado, Mc, Gardete Correia, L, Cardoso, Mc, Silva, A, Boavida, J, Sa Marques, Mm, Michel, G, Wirion, R, Cardillo, S, Pozza, G, Mangili, R, Asnaghi, V, Standl, E, Schaffler, B, Brand, H, Harms, A, Soussan, B, Verier Mine, O, Fallas, P, Fallas, Mc, Fuller, Jh, Holloway, J, Asbury, L, Betteridge, Dj, Cathelineau, G, Bouallouche, A, Cathelineau, Bv, Santeusanio, F, Rosi, G, D'Alessandro, V, Cagini, C, Bottini, P, Reboldi, P, Navalesi, R, Penno, G, Bandinelli, S, Miccoli, R, Nannipieri, M, Ghirlanda, G, Saponara, C, Cotroneo, P, Manto, A, Minnella, A, Ward, Jd, Tesfaye, S, Eaton, S, Mody, C, Borra, M, Perin, Pc, Giunti, S, Grassi, G, Pagano, Gf, Porta, M, Sivieri, R, Vitelli, F, Ferrari, D, Papazoglou, N, Manes, G, Muggeo, M, Iagulli, M, Irsigler, K, Abrahamian, H, Walford, S

مصطلحات موضوعية: Adolescent, Adult, Albuminuria, Cohort Studie, Diabetes Mellitus, Type 1, Diabetic Neuropathie, Diabetic Retinopathy, Europe, Female, Human, Hypotension, Orthostatic, Male, Middle Aged, Proportional Hazards Model, Risk Factor, Internal Medicine, Endocrinology, Diabetes and Metabolism, Advanced and Specialized Nursing

الوصف: OBJECTIVE: The purpose of this study was to examine risk factors for mortality in patients with type 1 diabetes. RESEARCH DESIGN AND METHODS: Baseline risk factors were measured in the EURODIAB Prospective Cohort Study with 2,787 type 1 diabetic patients (51% men and 49% women) recruited from 16 European countries. Mortality data were collected during a 7-year follow-up. RESULTS: There was an annual mortality rate of 5 per 1,000 person-years in patients with type 1 diabetes (mean age at baseline 33 years, range 15-61 years); of the total 2,787 subjects, 102 died. The final multivariable model contained age at baseline (standardized hazard ratio 1.78 [95% CI 1.44-2.20]), A1C (1.18 [0.95-1.46]), waist-to-hip ratio (WHR) (1.32 [1.14-1.52]), pulse pressure (1.33 [1.13-1.58]), and non-HDL cholesterol (1.33 [1.12-1.60]) as risk factors for all-cause mortality. Macroalbuminuria (2.39 [1.19-4.78]) and peripheral (1.88 [1.06-3.35]) and autonomic neuropathy (2.40 [1.32-4.36]) were the most important risk markers for mortality. Similar risk factors were found for all-cause, non-cardiovascular disease (CVD), unknown-cause, and CVD mortality. CONCLUSIONS: Important risk factors for the increased total and non-CVD mortality in type 1 diabetic patients are age, WHR, pulse pressure, and non-HDL cholesterol. Microvascular complications from macroalbuminuria and peripheral and autonomic neuropathy are strong risk markers for future mortality exceeding the effect of the traditional risk factors.

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000257421000017; volume:31; issue:7; firstpage:1360; lastpage:1366; numberofpages:7; journal:DIABETES CARE; http://hdl.handle.net/11586/198842Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-49649102891; http://care.diabetesjournals.org/cgi/reprint/31/7/1360Test

الإتاحة: https://doi.org/10.2337/dc08-0107Test
http://hdl.handle.net/11586/198842Test
http://care.diabetesjournals.org/cgi/reprint/31/7/1360Test

المؤلفون: Chaturvedi, Nish, Bandinelli, Simona, Mangili, Ruggero, Penno, Guiseppe, Rottiers, Raoul E., Fuller, John H., Karamanos, B., Kofinis, A., Petrou, K., Giorgino, R., Giorgino, F., Picca, G., Angarano, A., De Pergola, G., Ionescu-Tirgoviste, C., Coszma, A., Songini, M., Casu, A., Pedron, M., Fossarello, M., Ferriss, J. B., Grealy, G., Keefe, D. O., White, A., Cleary, P. E., Toeller, M., Arden, C., Rottiers, R., Tuyttens, C., Priem, H., Ebeling, P., Kylliainen, M., Kyostio-Renvall, T., Idzior-Walus, B., Sieradzki, J., Cyganek, K., Lemkes, H. H. P. J., Roest, C., Nunes-Correa, J., Rogado, M. C., Gardete-Correia, L., Cardoso, M. C., Michel, G., Wirion, R., Cardillo, S., Pozza, G., Mangili, R., Asnaghi, V., Lattanzio, Rosangela, Galardi, G., Standl, E., Schaffler, B., Brand, H., Harms, A., Ben Soussan, D., Verier-Mine, O., Fuller, J. H., Holloway, J., Asbury, L., Betteridge, D. J., Cathelineau, G., Bouallouche, A., Villatte Cathelineau, B., Santeusanio, F., Rosi, G., D’ Alessandro, V., Cagini, C., Navalesi, R., Penno, G., Bandinelli, S., Miccoli, R., Ghirlanda, G., Saponara, C., Cotroneo, P., Manto, A., Minnella, A., Ward, J. D., Tesfaye, S., Eaton, S., Mody, C., Porta, M., Perin, P. Cavallo, Borra, M., Giunti, S., Papazoglou, N., Manes, Gianfranco, Muggeo, M., Iagulli, M., Irsigler, K., Abrahamian, H., Walford, S., Wardle, E. V., Sinclair, J., Hughes, S., Roglic, G., Metelko, Z., Resman, Z., Sjolie, A. -. K., Chaturvedi, N., Ferriss, B., Webb, D., Viberti, G. -. C., Swaminathan, R., Lumb, P., Collins, A., Sankaralingham, S., Aldington, S., Mortemore, T., Lipinski, H.

المصدر: Kidney International. 60:219-227

مصطلحات موضوعية: Albuminuria, Blood sugar control, Cardiovascular disease, Insulin resistance, Renal disease, Adolescent, Adult, Blood Glucose, Body Constitution, Cohort Studies, Diabetes Mellitus, Type 1, Differential Threshold, Disease Progression, Europe, Female, Follow-Up Studies, Humans, Incidence, Insulin Resistance, Male, Middle Aged, Prospective Studies, Reference Values, Risk Factors, Triglycerides, Nephrology, endocrine system diseases, urologic and male genital diseases, Gastroenterology, Waist–hip ratio, Proteinuria, Settore MED/30 - MALATTIE APPARATO VISIVO, female genital diseases and pregnancy complications, medicine.symptom, Type 1, medicine.medical_specialty, Internal medicine, Diabetes mellitus, Diabetes Mellitus, medicine, Risk factor, Glycemic, Type 1 diabetes, business.industry, nutritional and metabolic diseases, medicine.disease, Endocrinology, Microalbuminuria, business

الوصف: Microalbuminuria in type 1 diabetes: Rates, risk factors and glycemic threshold.BackgroundThe occurrence of microalbuminuria in type 1 diabetes is strongly predictive of renal and cardiovascular disease and is still likely to occur despite improvements in glycemic control. A better understanding of microalbuminuria is required to inform new interventions. We determined the incidence and risk factors for microalbuminuria [albumin excretion rate (AER) 20 to 200 μg/min] in the EURODIAB Prospective Complications Study.MethodsThis is a seven-year follow-up (between 1988 and 1991) of 1134 normoalbuminuric men and women (aged 15 to 60) with type 1 diabetes from 31 European centers. Risk factors and AER were measured centrally.ResultsThe incidence of microalbuminuria was 12.6% over 7.3 years. Independent baseline risk factors were HbA1c (7.1 vs. 6.2%, P = 0.0001) and AER (9.6 vs. 7.8 μg/min, P = 0.0001) and, independent of these, fasting triglyceride (0.99 vs. 0.88 mmol/L, P = 0.01), low-density lipoprotein cholesterol (3.5 vs. 3.2 mmol/L, P = 0.02), body mass index (24.0 vs. 23.4 kg/m2, P = 0.01), and waist to hip ratio (WHR; 0.85 vs. 0.83, P = 0.009). Triglyceride and WHR risk factors were nearly as strong as AER in predicting microalbuminuria (standardized regression effects of 1.3 for triglyceride and WHR and 1.5 for AER). Blood pressure at follow-up, but not at baseline, was also raised in those who progressed. There was no evidence of a threshold of HbA1c on microalbuminuria risk.ConclusionsThe incidence of microalbuminuria in patients with type 1 diabetes remains high, and there is no apparent glycemic threshold for it. Markers of insulin resistance, such as triglyceride and WHR, are strong risk factors. Systemic blood pressure is not raised prior to the onset of microalbuminuria.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2556bd8b447ca8ee9908bb7998f9d141Test
https://doi.org/10.1046/j.1523-1755.2001.00789.xTest

المؤلفون: Greaves M, Malia RG, Goodfellow K, Mattock M, Stevens LK, Stephenson JM, Fuller JH, Karamanos B, Tountas C, Kofinis A, Petrou K, Katsilambros N, Giorgino R, Cignarelli M, DeCicco ML, Ramunni I, IonescuTirgoviste C, Iosif CM, Pitei D, Buligescu S, Tamas G, Kerenyi Z, Ahmed AM, Toth J, Kempler P, Muntoni S, Songini M, Stabilini M, Fossarello M, Pintus S, Ferriss JB, Cronin CC, Whyte AE, Cleary PE, Toeller M, Klischan A, Forst T, Gries FA, Rottiers R, Priem H, Ebeling P, Sinisalo M, Koivisto VA, IdziorWalus B, Solnica B, SzopinskaCiba L, Solnica K, Krans HMJ, Lemkes HHPJ, Jansen JJ, Brachter J, NunesCorrea J, Boavida J, Michel G, Wirion R, Boulton AJM, Ashe H, Fernando DJS, Pozza G, Slaviero G, Comi G, Fattor B, Janka HU, Nuber A, Mehnert H, BenSoussan D, Fallas MC, Fallas P, Jepson E, McHardyYoung S, Betteridge DJ, Milne M, Crepaldi G, Nosadini R, Segato T, Midena E, Cipollina MR, Fedele D, Cathelineau G, Cathelineau BV, Jellal M, Grodner N, Feiss PG, Santeusanio F, Rosi G, Ventura MRM, Cagini C, Marino C, Navalesi R, Penno G, Miccoli R, Nannipieri M, Manfredi S, Ghirlanda G, Cotroneo P, Manto A, Teodonio C, Minnella A, Ward JD, Tesfaye S, Mody C, Rudd C, Molinatti GM, Vitelli F, Porta M, Pagano GF, Perin PC, Estivi P, Sivieri R, Carta Q, Petraroli G, Papazoglou N, Manes G, Triantaphyllou G, Ioannides A, Skazagar G, Kontogiannis I, Muggeo M, Cacciatori V, Bellavere F, Galante P, Gemma ML, Irsigler K, Abrahamian H, Gurdet C, Hornlein B, Willinger C, Walford S, Wardle EV, Hughes S, Roglic G, Resman Z, Metelko Z, Skrabalo Z, Keen H, Navelesi R, Sjolie AK, Viberti GC, Ward J, Partridge T, John WG, Collins A, Dredge A, Sharp R, Kohner E, Aldington S, Cockley S., BANDELLO , FRANCESCO

المساهمون: Greaves, M, Malia, Rg, Goodfellow, K, Mattock, M, Stevens, Lk, Stephenson, Jm, Fuller, Jh, Karamanos, B, Tountas, C, Kofinis, A, Petrou, K, Katsilambros, N, Giorgino, R, Cignarelli, M, Decicco, Ml, Ramunni, I, Ionescutirgoviste, C, Iosif, Cm, Pitei, D, Buligescu, S, Tamas, G, Kerenyi, Z, Ahmed, Am, Toth, J, Kempler, P, Muntoni, S, Songini, M, Stabilini, M, Fossarello, M, Pintus, S, Ferriss, Jb, Cronin, Cc, Whyte, Ae, Cleary, Pe, Toeller, M, Klischan, A, Forst, T, Gries, Fa, Rottiers, R, Priem, H, Ebeling, P, Sinisalo, M, Koivisto, Va, Idziorwalus, B, Solnica, B, Szopinskaciba, L, Solnica, K, Krans, Hmj, Lemkes, Hhpj, Jansen, Jj, Brachter, J, Nunescorrea, J, Boavida, J, Michel, G, Wirion, R, Boulton, Ajm, Ashe, H, Fernando, Dj, Pozza, G, Slaviero, G, Comi, G, Fattor, B, Bandello, Francesco, Janka, Hu, Nuber, A, Mehnert, H, Bensoussan, D, Fallas, Mc, Fallas, P, Jepson, E, Mchardyyoung, S, Betteridge, Dj, Milne, M, Crepaldi, G, Nosadini, R, Segato, T, Midena, E, Cipollina, Mr, Fedele, D, Cathelineau, G, Cathelineau, Bv, Jellal, M, Grodner, N, Feiss, Pg, Santeusanio, F, Rosi, G, Ventura, Mrm, Cagini, C, Marino, C, Navalesi, R, Penno, G, Miccoli, R, Nannipieri, M, Manfredi, S, Ghirlanda, G, Cotroneo, P, Manto, A, Teodonio, C, Minnella, A, Ward, Jd

الوصف: The interrelationships between fibrinogen, von Willebrand factor, a marker of vascular endothelial cell damage, and serum lipids were explored in well-characterised subjects with insulin-dependent diabetes mellitus. The 2091 subjects were enrolled into a cross-sectional, clinic-based study of complications, from 16 European countries: the EURODIAB IDDM Complications study. The anticipated significant relationships between both plasma fibrinogen and plasma von Willebrand factor concentrations and age and glycaemic control, and between fibrinogen and body mass index, were noted. Fibrinogen, adjusted for age and glycated haemoglobin concentration, was also related to smoking habits and was higher in the quartiles with highest systolic and diastolic blood pressures. There was a clustering of vascular risk factors, with a positive relationship between plasma fibrinogen and serum triglyceride concentrations in both genders and between fibrinogen and total cholesterol in males. An inverse relationship between fibrinogen and high density lipoprotein cholesterol was also apparent in males. A prominent feature was a positive relationship between both fibrinogen and von Willebrand factor and albumin excretion rate (p < 0.001 and p < 0.003 respectively) in those with retinopathy but not in these without this complication. In view of previous observations on blood pressure and albuminuria in these subjects the findings are consistent with the hypothesis that microalbuminuria and increased plasma von Willebrand factor are due to endothelial cell perturbation in response to mildly raised blood pressure in subjects with retinopathy. Fibrinogen may also contribute to microvascular disease and its relationships to lipid vascular risk factors suggest a possible pathogenic role in arterial disease in diabetes.

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:A1997XF83500012; volume:40; issue:6; firstpage:698; lastpage:705; numberofpages:8; journal:DIABETOLOGIA; http://hdl.handle.net/20.500.11768/15700Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-0030743530

الإتاحة: https://doi.org/20.500.11768/15700Test
https://doi.org/10.1007/s001250050736Test
https://hdl.handle.net/20.500.11768/15700Test