المؤلفون: Hambridge, K., Banerjee, S., Winfield, L., Gripton, J.

المصدر: BMC Nursing ; volume 22, issue 1 ; ISSN 1472-6955

مصطلحات موضوعية: General Nursing

الوصف: Background Worldwide there are concerns about the supply of nurses into health systems. Understanding and balancing the supply of and demand for healthcare professionals is crucial to efficient healthcare delivery, yet there is relatively little research that examines in detail where nursing students come from and where they go after qualification. Objectives To investigate the demographic characteristics of applicants to nursing and midwifery programmes in England, those that are enrolled, attrition during study, and their career intentions on graduation. Methods A descriptive case study was conducted in south west England drawing on a complementary set of analyses of routinely collected application and enrolment data from 2017–2020. These were augmented by derivation of student deprivation indices and a follow-up study of nursing and midwifery students qualifying between May 2020 and April 2021. Results The percentage of males applying for nursing doubled and the mean age of all enrolled students (except midwifery) increased during the study period. The mean level of deprivation of applicants increased from the 51 st to the 55 th centile indicating widening of participation. Most applying and enrolled students originated from the same region as the nursing school and remained working there on qualification. Successively more males than females were lost from the system at each stage from application to qualification. Qualifying students most common job choice was within acute Trusts, with Medical, District nursing and surgical being the most common choices. The most important factors regarding job choice were location, the characteristics of the Trust, having been there as a student, and family considerations. Conclusions The data provide useful information on the nursing educational pipeline. The data discussed here raise questions that would benefit from further regional and national empirical research.

الإتاحة: https://doi.org/10.1186/s12912-023-01210-2Test

المؤلفون: Finno, CJ, Estell, KE, Katzman, S, Winfield, L, Rendahl, A, Textor, J, Bannasch, DL, Puschner, B

المصدر: Journal of Veterinary Internal Medicine. 29(6)

مصطلحات موضوعية: Veterinary Sciences, Agricultural, Veterinary and Food Sciences, Neurosciences, Complementary and Integrative Health, Brain Disorders, Animals, Animals, Newborn, Female, Genetic Predisposition to Disease, Horse Diseases, Horses, Male, Neuroaxonal Dystrophies, Selenium, alpha-Tocopherol, Ataxia, Equine, Genetics, Vitamin E, Veterinary sciences

الوصف: BackgroundEquine neuroaxonal dystrophy/equine degenerative myeloencephalopathy (NAD/EDM) is a neurodegenerative disorder affecting genetically predisposed foals maintained on α-tocopherol (α-TP)-deficient diet.ObjectiveIntramuscular α-TP and selenium (Se) administration at 4 days of age would have no significant effect on serum or cerebrospinal fluid (CSF) α-TP in healthy foals. Serum and CSF α-TP, but not Se, would be significantly decreased in NAD/EDM-affected foals during first year of life.AnimalsFourteen Quarter horse foals; 10 healthy foals supplemented with 0.02 mL/kg injectable α-TP and Se (n = 5) or saline (n = 5) at 4 days of age and 4 unsupplemented NAD/EDM-affected foals.MethodsComplete neurologic examinations were performed, blood and CSF were collected before (4 days of age) and after supplementation at 10, 30, 60, 120, 180, 240, and 360 days of age. Additional blood collections occurred at 90, 150, 210, and 300 days. At 540 days, NAD/EDM-affected foals and 1 unsupplemented healthy foal were euthanized and necropsies performed.ResultsSignificant decreases in blood, CSF α-TP and Se found in the first year of life in all foals, with most significant changes in serum α-TP from 4-150 days. Dam α-TP and Se significantly influenced blood concentrations in foals. Injection of α-TP and Se did not significantly increase CSF Se, blood or CSF α-TP in healthy foals. NAD/EDM-affected foals had significantly lower CSF α-TP through 120 days.Conclusions and clinical importanceInjection of α-TP and Se at 4 days of age does not significantly increase blood or CSF α-TP. Despite all 14 foals remaining deficient in α-TP, only the 4 genetically predisposed foals developed NAD/EDM.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/1gw2j205Test

المؤلفون: Davis, R D, Winfield, L, Spivak, D, Wilson-Kennedy, Z S

المصدر: Faculty Publications

الوصف: As undergraduate students cultivate their scientific knowledge and abilities, several high-impact educational practices such as undergraduate research and global experiences have proven exponentially beneficial for their development and success. Current literature on underrepresented racial and ethnic minorities has focused primarily on the impact of undergraduate research on this subpopulation. However, fewer studies have explored the impact of global research experiences and women of color in international research experiences. Grounded in the theoretical frameworks of Social Cognitive Career Theory, Intersectionality, and Community Cultural Wealth, this present study explored the impact of international undergraduate research experiences on women of color from groups underrepresented in chemistry. We found that, after participating in international research, women of color from historically underrepresented groups (1) were aware of the realities of being a woman and a minority in STEM, (2) had utilized a wealth of cultural capital to navigate the international research experience, (3) had recognized the value of the international research experience on their personal growth, and (4) had recognized the benefits of their international research experience on postundergraduate pursuits. The findings suggest that international research experiences contribute substantially to the holistic development of women of color in scientific disciplines such as chemistry.

وصف الملف: application/pdf

العلاقة: https://digitalcommons.lsu.edu/chemistry_pubs/2943Test; https://digitalcommons.lsu.edu/context/chemistry_pubs/article/3944/viewcontent/Mk3K3Ugd5E1U1Ycd9Wlwltzpmjjcrsi1.pdfTest

الإتاحة: https://digitalcommons.lsu.edu/chemistry_pubs/2943Test
https://digitalcommons.lsu.edu/context/chemistry_pubs/article/3944/viewcontent/Mk3K3Ugd5E1U1Ycd9Wlwltzpmjjcrsi1.pdfTest

المؤلفون: Pai, A., Eck, K., Renoe, S., Brown Clarke, J., Brown, B., Coley, C., Collier- Youngblood, M., Fields, H., Hammonds-Odie, L., Hendrickson, T., Hollowell, G., Huizinga, D., Inniss, T., Maglia, A., Nader, R., Talley, C., Vassmer, S., Washington, T., Weintraub, J., Williams, K., Winfield, L.

الوصف: To address systemic barriers to inclusion, including bias, inequitable partnerships, and limited research support and service capacity, Spelman College, NORDP, and ARIS brought together leaders at MSIs to discuss their research experiences. The process convened 34 representatives across two virtual listening sessions in March and April 2023, and an in-person convening in June 2023 at Spelman College. Participants elevated the importance of celebrating successes at MSIs while also acknowledging the systemic barriers and challenges MSIs continue to face. The project was funded by the National Science Foundation through grant MCB-2236057.

العلاقة: https://hdl.handle.net/10355/98061Test; https://doi.org/10.32469/10355/98061Test

الإتاحة: https://doi.org/10.32469/10355/98061Test
https://hdl.handle.net/10355/98061Test

المؤلفون: Finno, C. J., Estell, Krista, Katzman, S., Winfield, L., Rendahl, A., Textor, J., Bannasch, D. L., Puschner, B.

مصطلحات موضوعية: Ataxia, Equine, Genetics, Vitamin E, Animals, Newborn, Female, Genetic Predisposition to Disease, Horse Diseases, Horses, Male, Neuroaxonal Dystrophies, Selenium, alpha-Tocopherol

جغرافية الموضوع: United States

الوصف: BACKGROUND: Equine neuroaxonal dystrophy/equine degenerative myeloencephalopathy (NAD/EDM) is a neurodegenerative disorder affecting genetically predisposed foals maintained on -tocopherol (-TP)-deficient diet. OBJECTIVE: Intramuscular -TP and selenium (Se) administration at 4 days of age would have no significant effect on serum or cerebrospinal fluid (CSF) -TP in healthy foals. Serum and CSF -TP, but not Se, would be significantly decreased in NAD/EDM-affected foals during first year of life. ANIMALS: Fourteen Quarter horse foals; 10 healthy foals supplemented with 0.02 mL/kg injectable -TP and Se (n = 5) or saline (n = 5) at 4 days of age and 4 unsupplemented NAD/EDM-affected foals. METHODS: Complete neurologic examinations were performed, blood and CSF were collected before (4 days of age) and after supplementation at 10, 30, 60, 120, 180, 240, and 360 days of age. Additional blood collections occurred at 90, 150, 210, and 300 days. At 540 days, NAD/EDM-affected foals and 1 unsupplemented healthy foal were euthanized and necropsies performed. RESULTS: Significant decreases in blood, CSF -TP and Se found in the first year of life in all foals, with most significant changes in serum -TP from 4-150 days. Dam -TP and Se significantly influenced blood concentrations in foals. Injection of -TP and Se did not significantly increase CSF Se, blood or CSF -TP in healthy foals. NAD/EDM-affected foals had significantly lower CSF -TP through 120 days. CONCLUSIONS AND CLINICAL IMPORTANCE: Injection of -TP and Se at 4 days of age does not significantly increase blood or CSF -TP. Despite all 14 foals remaining deficient in -TP, only the 4 genetically predisposed foals developed NAD/EDM. ; Published version

وصف الملف: 1667 - 1675 page(s); application/pdf

العلاقة: http://www.ncbi.nlm.nih.gov/pubmed/26391904Test; http://hdl.handle.net/10919/77598Test; https://doi.org/10.1111/jvim.13618Test; 29; Estell, KE [0000-0002-9321-1952]

الإتاحة: https://doi.org/10.1111/jvim.13618Test
http://hdl.handle.net/10919/77598Test

المؤلفون: Goodman, R R, Kim, B, McClelland, S, Senatus, P B, Winfield, L M, Pullman, S L, Yu, Q, Ford, B, McKhann, G M

مصطلحات موضوعية: Papers

الوصف: Objective: Subthalamic nucleus (STN) stimulation for patients with medically refractory Parkinson disease (PD) is expanding. Reported experience has provided some indication of techniques, efficacy, and morbidity, but few centres have reported more than 50 patients. To expand this knowledge, we reviewed our experience with a large series of consecutive patients. Methods: From March 1999 to September 2003, 191 subthalamic stimulator devices (19 unilateral) were implanted in 100 patients with PD at New York Presbyterian Hospital/Columbia University Medical Center. Sixteen patients had undergone a prior surgery for PD (pallidotomy, thalamotomy, or fetal transplant). Microelectrode guided implantations were performed using techniques similar to those described previously. Electrode implantation occurred 1–2 weeks before outpatient pulse generator implantation. Results: Reductions of dyskinesias and off severity/duration were similar to prior published reports. Morbidity included: 7 device infections (3.7%), 1 cerebral infarct, 1 intracerebral haematoma, 1 subdural haematoma, 1 air embolism, 2 wound haematomas requiring drainage (1.0%), 2 skin erosions over implanted hardware (1.0%), 3 periprocedural seizures (1.6%), 6 brain electrode revisions (3.1%), postoperative confusion in 13 patients (6.8%), and 16 battery failures (8.4%). Of the 100 patients, there were no surgical deaths or permanent new neurological deficits. The average hospital stay for all 100 patients was 3.1 days. Conclusion: Subthalamic stimulator implantation in a large consecutive series of patients with PD produced significant clinical improvement without mortality or major neurological morbidity. Morbidity primarily involved device infections and hardware/wound revisions.

وصف الملف: text/html

العلاقة: http://jnnp.bmj.com/cgi/content/short/77/1/12Test; http://dx.doi.org/10.1136/jnnp.2005.069161Test

الإتاحة: https://doi.org/10.1136/jnnp.2005.069161Test
http://jnnp.bmj.com/cgi/content/short/77/1/12Test

المؤلفون: Ford, B, Winfield, L, Pullman, S L, Frucht, S J, Du, Y, Greene, P, Cheringal, J H, Yu, Q, Cote, L J, Fahn, S, McKhann, G M, Goodman, R R

مصطلحات موضوعية: Papers

الوصف: Objective: To measure the effect of deep brain stimulation (DBS) of the subthalamic nucleus in patients with advanced Parkinson’s disease. Design: Open label follow up using blinded ratings of videotaped neurological examinations. Patients: 30 patients with advanced Parkinson’s disease (19 male, 11 female; mean age 58.8 years; mean disease duration 12.8 years), complicated by intractable wearing off motor fluctuations and dopaminergic dyskinesias. Main outcome measures: Unified Parkinson’s disease rating scale (UPDRS), part III (motor), score at one year, from blinded reviews of videotaped neurological examinations. Secondary outcomes included the other UPDRS subscales, Hoehn and Yahr scale, activities of daily living (ADL) scale, mini-mental state examination (MMSE), estimates of motor fluctuations and dyskinesia severity, drug intake, and patient satisfaction questionnaire. Results: Subthalamic nucleus stimulation was associated with a 29.5% reduction in motor scores at one year (p<0.0001). The only important predictors of improvement in UPDRS part III motor scores were the baseline response to dopaminergic drugs (p = 0.015) and the presence of tremor (p = 0.027). Hoehn and Yahr scores and ADL scores in the “on” and “off” states did not change, nor did the mean MMSE score. Weight gain occurred in the year after surgery, from (mean) 75.8 kg to 78.5 kg (p = 0.028). Duration of daily wearing off episodes was reduced by 69%. Dyskinesia severity was reduced by 60%. Drug requirements (in levodopa equivalents) declined by 30%. Conclusions: The 30% improvement in UPDRS motor scores was a more modest result than previously reported. DBS did not improve functional capacity independent of drug use. Its chief benefits were reduction in wearing off duration and dyskinesia severity.

وصف الملف: text/html

العلاقة: http://jnnp.bmj.com/cgi/content/short/75/9/1255Test; http://dx.doi.org/10.1136/jnnp.2003.027557Test

الإتاحة: https://doi.org/10.1136/jnnp.2003.027557Test
http://jnnp.bmj.com/cgi/content/short/75/9/1255Test

المؤلفون: Trott, C. T., Fahn, S., Greene, P., Dillon, S., Winfield, H., Winfield, L., Kao, R., Eidelberg, D., Freed, C. R., Breeze, R. E., Stern, Yaakov

مصطلحات موضوعية: Neurology, Cognition

الوصف: Objectives: To determine if bilateral transplantation of embryonic mesencephalic dopamine cells into the putamen of patients with PD significantly affected their cognitive functioning when compared with patients receiving sham surgery and to examine the effect of age on cognitive performance after implantation. Methods: Forty patients (19 women, 21 men; age 34 to 75 years) with idiopathic PD of at least 7 years’ duration (mean 14 years) who had disabling motor signs despite optimal drug management were randomly assigned to tissue implants or sham craniotomies in a double-blind design. Neuropsychological tests assessing orientation, attention, language, verbal and visual memory, abstract reasoning, executive function, and visuospatial and construction abilities were administered before and 1 year after surgery. Treatment groups did not differ at baseline in demographic, neuropsychological, motor, depression, or levodopa equivalent measures. Results: Postsurgical change in cognitive performance was not significantly different for real or sham surgery groups. Performance in both groups remained unchanged at follow-up for most measures. Conclusions: Embryonic dopamine producing neurons can be implanted safely into the putamen bilaterally without impairing cognition in patients with PD, but within the first year, improved cognition should not be expected.

العلاقة: https://doi.org/10.7916/ddba-5182Test

الإتاحة: https://doi.org/10.7916/ddba-5182Test

المؤلفون: Rocío Fernández Lorenzo, Cano S, Catalan I, Rubio O, Subira C, Masclans J, Rognoni G, Ventura L, Macharete C, Winfield L, Alcoverro JM

المصدر: Journal of Intensive Care
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu

مصطلحات موضوعية: Mortality prediction, Scoring systems, Biomarkers

الوصف: BACKGROUND: High red blood cell distribution width (RDW) is associated with worse outcome in diverse scenarios, including in critical illness. The Sabadell score (SS) predicts in-hospital survival after ICU discharge. We aimed to determine RDW's association with survival after ICU discharge and whether RDW can improve the accuracy of the SS. DESIGN: Retrospective cohort study. Setting: general ICU at a university hospital. PATIENTS: We included all patients discharged to wards from January 2010 to October 2016. METHODS: We analyzed associations between RDW and variables recorded on admission (age, comorbidities, severity score), during the ICU stay (treatments, complications, length of stay (LOS)), and at ICU discharge (SS). The primary outcome was hospital mortality. Statistical analysis included multivariable logistic regression and receiver operating characteristic curve (ROC) analyses. RESULTS: We discharged 3366 patients to wards; median ward LOS was 7 [4-13] days; ward mortality was 5.2%. Mean RDW at ICU discharge was 15.4 ± 2.5%. Ward mortality was higher at each quartile of RDW (0.7%, 2.9%, 7.5%, 10.3%; area under ROC 0.81). A logistic regression model with Sabadell score obtained an excellent accuracy for ward mortality (area under ROC 0.863), and the addition of RDW slightly improved accuracy (AUROC 0.890, p < 0.05). Recursive partitioning demonstrated higher mortality in patients with high RDW at each SS level (1.6% vs. 0.3% in SS0, 9.7% vs. 1.1% in SS1, 21.9% vs. 9.7% in SS2), but not in SS3. CONCLUSION: High RDW is a marker of severity at ICU discharge and improves the accuracy of Sabadell score in predicting ward mortality except in the more extreme SS3.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::2c754da63898ec284fba3f21ec2e0520Test
http://fundanet.fsjd.org/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=15339Test

المؤلفون: Dechant, J. E., Winfield, L. S.

المصدر: Equine Veterinary Education ; volume 29, issue 12, page 677-682 ; ISSN 0957-7734 2042-3292

الوصف: Summary Gastrointestinal rupture is an important cause and complication of equine colic. The stomach is the most commonly affected segment in the gastrointestinal tract involved in gastrointestinal rupture. Gastric rupture can be primary or secondary; however, unless prodromal clinical signs are identified, localised and corrected, the resulting peritoneal contamination with feed, intestinal secretions and bacteria is invariably fatal. Causes for gastric rupture may be known or idiopathic; however, factors that predispose a horse to gastric rupture are poorly understood. Further research is needed to identify underlying causes and pathophysiology of gastric rupture to prevent it from occurring.

الإتاحة: https://doi.org/10.1111/eve.12516Test